IT1282219B1 - Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa - Google Patents

Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Info

Publication number: IT1282219B1
Authority: IT; Italy
Prior art keywords: molecular weight; hyaluronic acid; low; preparation; pct
Prior art date: 1995-12-20

Application number

IT95PD000244A

Other languages

English (en)

Inventor

Davide Renier

Lanfranco Callegaro

Original Assignee

Fidia Advanced Biopolymers Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-20

Filing date

1995-12-20

Publication date

1998-03-16

1995-12-20 Application filed by Fidia Advanced Biopolymers Srl filed Critical Fidia Advanced Biopolymers Srl

1995-12-20 Publication of ITPD950244A0 publication Critical patent/ITPD950244A0/it

1995-12-20 Priority to IT95PD000244A priority Critical patent/IT1282219B1/it

1996-12-19 Priority to IL12490996A priority patent/IL124909A/en

1996-12-19 Priority to US09/096,646 priority patent/US6020484A/en

1996-12-19 Priority to CA002240682A priority patent/CA2240682C/en

1996-12-19 Priority to EP96944007A priority patent/EP0868437B1/en

1996-12-19 Priority to PCT/EP1996/005701 priority patent/WO1997022629A1/en

1996-12-19 Priority to DE69604087T priority patent/DE69604087T2/de

1996-12-19 Priority to HU9903666A priority patent/HU226949B1/hu

1996-12-19 Priority to AU13749/97A priority patent/AU703332B2/en

1996-12-19 Priority to ES96944007T priority patent/ES2139402T3/es

1996-12-19 Priority to JP52251197A priority patent/JP4094059B2/ja

1996-12-19 Priority to AT96944007T priority patent/ATE184024T1/de

1996-12-19 Priority to DK96944007T priority patent/DK0868437T3/da

1996-12-19 Priority to CZ19981889A priority patent/CZ291394B6/cs

1996-12-19 Priority to IL14123096A priority patent/IL141230A/en

1996-12-19 Priority to SI9630118T priority patent/SI0868437T1/xx

1997-06-20 Publication of ITPD950244A1 publication Critical patent/ITPD950244A1/it

1998-03-16 Application granted granted Critical

1998-03-16 Publication of IT1282219B1 publication Critical patent/IT1282219B1/it

1999-10-26 Priority to US09/426,536 priority patent/US6232303B1/en

1999-11-29 Priority to GR990403066T priority patent/GR3031973T3/el

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 3
229920002674 hyaluronan Polymers 0.000 title abstract 3
229960003160 hyaluronic acid Drugs 0.000 title abstract 3
239000000061 acid fraction Substances 0.000 title abstract 2
239000005708 Sodium hypochlorite Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 abstract 1
238000002604 ultrasonography Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Materials Engineering (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

IT95PD000244A 1995-12-20 1995-12-20 Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa IT1282219B1 (it)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
IT95PD000244A IT1282219B1 (it)	1995-12-20	1995-12-20	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
AU13749/97A AU703332B2 (en)	1995-12-20	1996-12-19	A process for preparing a hyaluronic acid fraction having a low polydispersion index
JP52251197A JP4094059B2 (ja)	1995-12-20	1996-12-19	低い多分散指数を有するヒアルロン酸分画の調整方法
CA002240682A CA2240682C (en)	1995-12-20	1996-12-19	A process for preparing a hyaluronic acid fraction having a low polydispersion index
EP96944007A EP0868437B1 (en)	1995-12-20	1996-12-19	A process for preparing a hyaluronic acid fraction having a low polydispersion index
PCT/EP1996/005701 WO1997022629A1 (en)	1995-12-20	1996-12-19	A process for preparing a hyaluronic acid fraction having a low polydispersion index
DE69604087T DE69604087T2 (de)	1995-12-20	1996-12-19	Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex
HU9903666A HU226949B1 (en)	1995-12-20	1996-12-19	A process for preparing a hyaluronic acid fraction having a low polydispersion index
IL12490996A IL124909A (en)	1995-12-20	1996-12-19	The process involving ultrasound and sodium hypochlorite in the preparation of a fraction of hyaluronic acid with a low polydispersity index
ES96944007T ES2139402T3 (es)	1995-12-20	1996-12-19	Un proceso para preparar una fraccion del acido hialuronico con un bajo indice de polidispersion.
US09/096,646 US6020484A (en)	1995-12-20	1996-12-19	Process for preparing a hyaluronic acid fraction having a low polydispersion index
AT96944007T ATE184024T1 (de)	1995-12-20	1996-12-19	Verfahren zur herstellung von einer hyaluronsäurefraktion mit niedrigem polydispersionindex
DK96944007T DK0868437T3 (da)	1995-12-20	1996-12-19	Fremgangsmåde til fremstilling af hyaluronsyrefraktion med et lavt polydispersionsindeks
CZ19981889A CZ291394B6 (cs)	1995-12-20	1996-12-19	Způsob přípravy frakce hyaluronové kyseliny s nízkým polydisperzním indexem
IL14123096A IL141230A (en)	1995-12-20	1996-12-19	Hyaluronic acid derivatives obtained from hyaluronic acid fraction having a low polydispersion index and pharmaceutical compositions and healthcare products containing them
SI9630118T SI0868437T1 (en)	1995-12-20	1996-12-19	A process for preparing a hyaluronic acid fraction having a low polydispersion index
US09/426,536 US6232303B1 (en)	1995-12-20	1999-10-26	Process for preparing a hyaluronic acid fraction having a low polydispersion index
GR990403066T GR3031973T3 (en)	1995-12-20	1999-11-29	A process for preparing a hyaluronic acid fraction having a low polydispersion index

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT95PD000244A IT1282219B1 (it)	1995-12-20	1995-12-20	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Publications (3)

Publication Number	Publication Date
ITPD950244A0 ITPD950244A0 (it)	1995-12-20
ITPD950244A1 ITPD950244A1 (it)	1997-06-20
IT1282219B1 true IT1282219B1 (it)	1998-03-16

Family

ID=11391198

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT95PD000244A IT1282219B1 (it)	1995-12-20	1995-12-20	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

Country Status (14)

Country	Link
US (2)	US6020484A (it)
EP (1)	EP0868437B1 (it)
JP (1)	JP4094059B2 (it)
AT (1)	ATE184024T1 (it)
AU (1)	AU703332B2 (it)
CZ (1)	CZ291394B6 (it)
DE (1)	DE69604087T2 (it)
DK (1)	DK0868437T3 (it)
ES (1)	ES2139402T3 (it)
GR (1)	GR3031973T3 (it)
HU (1)	HU226949B1 (it)
IL (1)	IL124909A (it)
IT (1)	IT1282219B1 (it)
WO (1)	WO1997022629A1 (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1282219B1 (it) *	1995-12-20	1998-03-16	Fidia Advanced Biopolymers Srl	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
IT1291452B1 (it)	1997-04-14	1999-01-11	Fidia Advanced Biopolymers Srl	Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni
US20020172712A1 (en) *	2001-03-19	2002-11-21	Alan Drizen	Antiemetic, anti-motion sustained release drug delivery system
JPWO2003084571A1 (ja) *	2002-04-08	2005-08-11	電気化学工業株式会社	骨感染症治療用組成物
RU2308954C2 (ru) *	2002-05-09	2007-10-27	Медиджинез	Фармацевтическая композиция для лечения ран, содержащая плазму или сыворотку крови
WO2003099992A2 (en) *	2002-05-17	2003-12-04	Wyeth	Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
EP1534215A1 (en) *	2002-07-02	2005-06-01	Procyte Corporation	Compositions containing peptide copper complexes and soft tissue fillers
US20060183709A1 (en) *	2005-02-15	2006-08-17	Ahmad Alkayali	Preparation of low molecular weight hyaluronic acid as a food supplement
JP4576583B2 (ja) *	2005-03-22	2010-11-10	キユーピー株式会社	ヒアルロン酸またはその塩、およびその製造方法、ならびにこれを含有する化粧料および食品組成物
US7323184B2 (en) *	2005-08-22	2008-01-29	Healagenics, Inc.	Compositions and methods for the treatment of wounds and the reduction of scar formation
JP5289936B2 (ja) *	2006-02-24	2013-09-11	キユーピー株式会社	新規な低分子ヒアルロン酸および／またはその塩、ならびにこれを用いた化粧料、医薬組成物および食品組成物
JP2009541372A (ja) *	2006-06-28	2009-11-26	ノボザイムスバイオファーマデーコーアクティーゼルスカブ	複数のヒアルロン酸画分を含む化粧用と医療用の組成物
WO2008003321A2 (en) *	2006-07-07	2008-01-10	Novozymes Biopolymer A/S	Compositions with several hyaluronic acid fractions for cosmetic use
WO2008014787A1 (en)	2006-08-04	2008-02-07	Novozymes Biopolymer A/S	Branched hyaluronic acid and method of manufacture
US8529951B1 (en)	2007-02-21	2013-09-10	Anand Ramamurthi	Elastogenic cues and methods for using same
CA2705850C (en) *	2007-11-13	2016-07-19	Bio-Technology General (Israel) Ltd.	Dilute filtration sterilization process for viscoelastic biopolymers
US20130209531A1 (en) *	2010-06-08	2013-08-15	University Of Utah Research Foundation	Applications of partially and fully sulfated hyaluronan
CN113512134B (zh)	2021-07-30	2022-05-20	梅晔生物医药股份有限公司	一种全分子量分布的透明质酸钠及其制备方法和应用
JP7503278B1 (ja)	2024-02-09	2024-06-20	株式会社ブルー・スターR&D	低分子ヒアルロン酸の製造方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5166331A (en) *	1983-10-10	1992-11-24	Fidia, S.P.A.	Hyaluronics acid fractions, methods for the preparation thereof, and pharmaceutical compositions containing same
FR2553099B1 (fr) *	1983-10-11	1989-09-08	Fidia Spa	Fractions d'acide hyaluronique ayant une activite pharmaceutique, procedes pour leur preparation et compositions pharmaceutiques les contenant
US4851521A (en) *	1985-07-08	1989-07-25	Fidia, S.P.A.	Esters of hyaluronic acid
GB8713747D0 (en) *	1987-06-12	1987-07-15	Unilever Plc	Skin treatment composition
IT1219587B (it) *	1988-05-13	1990-05-18	Fidia Farmaceutici	Polisaccaridi carbossiilici autoreticolati
JPH0675512B2 (ja) *	1989-03-20	1994-09-28	株式会社紀文食品	低重合度ヒアルロン酸アルカリ塩の製造方法
IT1247175B (it) *	1991-04-19	1994-12-12	Fidia Spa	Procedimento per la purificazione di acido ialuronico e frazione di acido ialuronico puro per uso oftalmico.
IT1260148B (it) *	1992-04-17	1996-03-28	Fidia Spa	Impiego di preparazioni di acido ialuronico per la formazione di tessuto osseo
IT1268954B1 (it) *	1994-03-11	1997-03-18	Fidia Advanced Biopolymers Srl	Processo per la preparazione di acido ialuronico mediante sintesienzimatica e relative composizioni farmaceutiche
ITPD940054A1 (it) *	1994-03-23	1995-09-23	Fidia Advanced Biopolymers Srl	Polisaccaridi solfatati
IT1282219B1 (it) *	1995-12-20	1998-03-16	Fidia Advanced Biopolymers Srl	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa

1995
- 1995-12-20 IT IT95PD000244A patent/IT1282219B1/it active IP Right Grant
1996
- 1996-12-19 JP JP52251197A patent/JP4094059B2/ja not_active Expired - Fee Related
- 1996-12-19 US US09/096,646 patent/US6020484A/en not_active Expired - Lifetime
- 1996-12-19 HU HU9903666A patent/HU226949B1/hu not_active IP Right Cessation
- 1996-12-19 ES ES96944007T patent/ES2139402T3/es not_active Expired - Lifetime
- 1996-12-19 WO PCT/EP1996/005701 patent/WO1997022629A1/en not_active Ceased
- 1996-12-19 CZ CZ19981889A patent/CZ291394B6/cs not_active IP Right Cessation
- 1996-12-19 AT AT96944007T patent/ATE184024T1/de active
- 1996-12-19 AU AU13749/97A patent/AU703332B2/en not_active Ceased
- 1996-12-19 DE DE69604087T patent/DE69604087T2/de not_active Expired - Lifetime
- 1996-12-19 IL IL12490996A patent/IL124909A/en not_active IP Right Cessation
- 1996-12-19 EP EP96944007A patent/EP0868437B1/en not_active Expired - Lifetime
- 1996-12-19 DK DK96944007T patent/DK0868437T3/da active
1999
- 1999-10-26 US US09/426,536 patent/US6232303B1/en not_active Expired - Lifetime
- 1999-11-29 GR GR990403066T patent/GR3031973T3/el unknown

Also Published As

Publication number	Publication date
CZ188998A3 (cs)	1998-09-16
ITPD950244A0 (it)	1995-12-20
JP2000502141A (ja)	2000-02-22
CZ291394B6 (cs)	2003-02-12
ITPD950244A1 (it)	1997-06-20
DK0868437T3 (da)	2000-03-13
AU703332B2 (en)	1999-03-25
HUP9903666A3 (en)	2001-03-28
DE69604087T2 (de)	2000-02-24
ATE184024T1 (de)	1999-09-15
HUP9903666A2 (hu)	2000-03-28
IL124909A0 (en)	1999-01-26
EP0868437A1 (en)	1998-10-07
HU226949B1 (en)	2010-03-29
GR3031973T3 (en)	2000-03-31
DE69604087D1 (de)	1999-10-07
ES2139402T3 (es)	2000-02-01
US6020484A (en)	2000-02-01
US6232303B1 (en)	2001-05-15
JP4094059B2 (ja)	2008-06-04
IL124909A (en)	2002-09-12
WO1997022629A1 (en)	1997-06-26
EP0868437B1 (en)	1999-09-01
AU1374997A (en)	1997-07-14

Legal Events

Date	Code	Title	Description
1998-03-16	0001	Granted
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19981001

Publication	Publication Date	Title
IT1282219B1 (it)	1998-03-16	Processo chimico fisico combinato per la preparazione di frazioni di acido ialuronico a basso peso molecolare caratterizzate da bassa
TW283716B (it)	1996-08-21
UA27229C2 (uk)	2000-08-15	Фракція гіалуронової кислоти або її солі для застосування в офтальмології, спосіб одержання фракції натрієвої солі гіалуронової кислоти та фармацевтичний препарат для використання в офтальмології
IL126029A (en)	2001-01-11	Agent for increasing the production of/in breeding and production mammals
NO874203D0 (no)	1987-10-07	Soetvareprodukt og fremgangsmaate ved dets fremstilling.
GR3022510T3 (en)	1997-05-31	Lyospheres comprising gonadotropin
AU3518395A (en)	1996-03-22	Topical ketoconazole emulsions
BR9508480A (pt)	1997-10-28	Fibra inorgânica e processo para sua formação
BR9509095A (pt)	1998-06-23	Processo para a preparaçao de produtos de degradaçao de amido
GB9512854D0 (en)	1995-08-23	Novel formulation
NO964465L (no)	1996-10-21	Heparinbindende protein for behandling av sepsis, og fremgangsmåter for dets fremtilling
DE69403087D1 (de)	1997-06-12	Verfahren zur herstellung von 9-(2-hydroxy)-ethoxy-guanin
BR9609654A (pt)	1999-03-02	Processo para preparar diretamente uma solução de formiator de celulose solução objeto de formiato de celulose ou de celulose regenerada montagem de reforço e artigo
BR9608038A (pt)	1999-01-12	Fenilamidinas substituídas compostos que contêm estes medicamentos e processo para sua preparação
ATE156842T1 (de)	1997-08-15	Oligosaccharide mit biologischer aktivität und verfahren zur herstellung aus glykosaminoglykanen
WO1992009573A3 (de)	1994-01-06	Cyclopentanetherderivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
PT937094E (pt)	2002-09-30	Processo para a preparacao de ivermectina
ATE328088T1 (de)	2006-06-15	Transketolase-verwandtes protein
CA2240682A1 (en)	1997-06-26	A process for preparing a hyaluronic acid fraction having a low polydispersion index
NO974687L (no)	1997-12-11	Kondenserte <beta>-carboliner
BR9807188A (pt)	2000-01-25	Processo para separação de 2-amino-metil-ciclo-pentil-amina de uma mistura compreendendo hexametileno-diamina e 2-amino-etil-ciclo-pentil-amina.