IT1270612B - Derivati eterociclo-condensatori di morfinoidi - Google Patents

Derivati eterociclo-condensatori di morfinoidi

Info

Publication number
IT1270612B
IT1270612B ITMI941463A ITMI941463A IT1270612B IT 1270612 B IT1270612 B IT 1270612B IT MI941463 A ITMI941463 A IT MI941463A IT MI941463 A ITMI941463 A IT MI941463A IT 1270612 B IT1270612 B IT 1270612B
Authority
IT
Italy
Prior art keywords
morphinoid
heterocycle
condenser
derivatives
compounds
Prior art date
Application number
ITMI941463A
Other languages
English (en)
Inventor
Giulio Dondio
Silvano Ronzoni
Original Assignee
Smithkline Beecham Farma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Farma filed Critical Smithkline Beecham Farma
Publication of ITMI941463A0 publication Critical patent/ITMI941463A0/it
Priority to ITMI941463A priority Critical patent/IT1270612B/it
Priority to DE69530205T priority patent/DE69530205T2/de
Priority to CZ9798A priority patent/CZ9897A3/cs
Priority to BR9508406A priority patent/BR9508406A/pt
Priority to HU9700073A priority patent/HUT76812A/hu
Priority to MX9700373A priority patent/MX9700373A/es
Priority to US08/776,134 priority patent/US5981540A/en
Priority to PL95318148A priority patent/PL182747B1/pl
Priority to AT95925855T priority patent/ATE236169T1/de
Priority to CN95194912A priority patent/CN1051086C/zh
Priority to PCT/EP1995/002694 priority patent/WO1996002545A1/en
Priority to JP50467196A priority patent/JP3480936B2/ja
Priority to AU29824/95A priority patent/AU686413B2/en
Priority to ES95925855T priority patent/ES2196069T3/es
Priority to CA002194877A priority patent/CA2194877A1/en
Priority to EP95925855A priority patent/EP0770081B1/en
Priority to NZ289858A priority patent/NZ289858A/en
Priority to ZA955782A priority patent/ZA955782B/xx
Publication of ITMI941463A1 publication Critical patent/ITMI941463A1/it
Priority to NO19970142A priority patent/NO315119B1/no
Application granted granted Critical
Publication of IT1270612B publication Critical patent/IT1270612B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)

Abstract

Si descrivono composti di formula generale (I) (FORMULA I) nella quale i gruppi hanno i significati descritti di seguito. Questi composti sono potenti e selettivi agonisti e antagonisti del recettore delta - oppioidi, e sono utili come agenti farmacologicamente attivi.
ITMI941463A 1994-07-14 1994-07-14 Derivati eterociclo-condensatori di morfinoidi IT1270612B (it)

Priority Applications (19)

Application Number Priority Date Filing Date Title
ITMI941463A IT1270612B (it) 1994-07-14 1994-07-14 Derivati eterociclo-condensatori di morfinoidi
PCT/EP1995/002694 WO1996002545A1 (en) 1994-07-14 1995-07-07 Heterocycle-condensed morphinoid derivatives
AU29824/95A AU686413B2 (en) 1994-07-14 1995-07-07 Heterocycle-condensed morphinoid derivatives
BR9508406A BR9508406A (pt) 1994-07-14 1995-07-07 Uso de um composto e método para o tratamento e/ou profilaxia em mamíferos
HU9700073A HUT76812A (en) 1994-07-14 1995-07-07 Heterocycle-condensed morphinoid derivatives and pharmaceutical compositions containing them
MX9700373A MX9700373A (es) 1994-07-14 1995-07-07 Derivados morfinoides de heterociclo condensado.
US08/776,134 US5981540A (en) 1994-07-14 1995-07-07 Heterocycle-condensed morphinoid derivatives
PL95318148A PL182747B1 (pl) 1994-07-14 1995-07-07 Nowe pochodne morfiny ze skondensowanym pierścieniem heterocyklicznym i kompozycja farmaceutyczna je zawierająca
AT95925855T ATE236169T1 (de) 1994-07-14 1995-07-07 Heterocyclisch kondensierte morphinoid-derivate
CN95194912A CN1051086C (zh) 1994-07-14 1995-07-07 杂环稠合的类吗啡衍生物及其应用
DE69530205T DE69530205T2 (de) 1994-07-14 1995-07-07 Heterocyclisch kondensierte morphinoid-derivate
JP50467196A JP3480936B2 (ja) 1994-07-14 1995-07-07 ヘテロ環縮合モルヒノイド誘導体
CZ9798A CZ9897A3 (en) 1994-07-14 1995-07-07 Heterocyclic condensed morphinoid derivatives, pharmaceutical composition containing such compounds and application of said compounds
ES95925855T ES2196069T3 (es) 1994-07-14 1995-07-07 Derivados morfinoides condensados con heterociclos.
CA002194877A CA2194877A1 (en) 1994-07-14 1995-07-07 Heterocycle-condensed morphinoid derivatives
EP95925855A EP0770081B1 (en) 1994-07-14 1995-07-07 Heterocycle-condensed morphinoid derivatives
NZ289858A NZ289858A (en) 1994-07-14 1995-07-07 Heterocycle-condensed morphinoids; medicaments
ZA955782A ZA955782B (en) 1994-07-14 1995-07-22 Heterocycle-condensed morphinoid derivatives
NO19970142A NO315119B1 (no) 1994-07-14 1997-01-13 Heterocyklus-kondenserte morfin-derivater, anvendelse derav og farmasöytiske blandinger inneholdende dem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI941463A IT1270612B (it) 1994-07-14 1994-07-14 Derivati eterociclo-condensatori di morfinoidi

Publications (3)

Publication Number Publication Date
ITMI941463A0 ITMI941463A0 (it) 1994-07-14
ITMI941463A1 ITMI941463A1 (it) 1996-01-14
IT1270612B true IT1270612B (it) 1997-05-07

Family

ID=11369271

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI941463A IT1270612B (it) 1994-07-14 1994-07-14 Derivati eterociclo-condensatori di morfinoidi

Country Status (19)

Country Link
US (1) US5981540A (it)
EP (1) EP0770081B1 (it)
JP (1) JP3480936B2 (it)
CN (1) CN1051086C (it)
AT (1) ATE236169T1 (it)
AU (1) AU686413B2 (it)
BR (1) BR9508406A (it)
CA (1) CA2194877A1 (it)
CZ (1) CZ9897A3 (it)
DE (1) DE69530205T2 (it)
ES (1) ES2196069T3 (it)
HU (1) HUT76812A (it)
IT (1) IT1270612B (it)
MX (1) MX9700373A (it)
NO (1) NO315119B1 (it)
NZ (1) NZ289858A (it)
PL (1) PL182747B1 (it)
WO (1) WO1996002545A1 (it)
ZA (1) ZA955782B (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985880A (en) * 1996-06-05 1999-11-16 Delta Pharmaceuticals Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds
ATE229958T1 (de) * 1996-01-10 2003-01-15 Glaxosmithkline Spa Heterocyclische kondensierte morphin-derivate
US6103722A (en) * 1997-07-23 2000-08-15 The Medical College Of Wisconsin Research Foundation Inc. Ischemic preconditioning
IT1312083B1 (it) * 1999-04-20 2002-04-04 Smithkline Beecham Spa Derivati morfinoidi, procedimento per la loro preparazione e loroimpiego terapeutico.
EP1210084A4 (en) * 1999-08-13 2002-11-13 Southern Res Inst PYRIDOMORPHINANS, THIENOMORPHINANS AND THEIR USE
US7015326B1 (en) * 1999-08-13 2006-03-21 Southern Research Institute Pyridomorphinans, thienomorphinans and use thereof
DE60010891T2 (de) * 1999-08-13 2005-06-09 Southern Research Institute, Birmingham Pyridomorphinanen und ihre verwendung
GB0025056D0 (en) * 2000-10-12 2000-11-29 Smithkline Beecham Spa Novel compounds
EP1660088A4 (en) * 2003-08-27 2009-04-29 Southern Res Inst PYRIDOMORPHINANE, PYRIDAZINOMORPHINANE AND ITS USE
EP2844661B1 (en) 2012-05-02 2019-01-09 Southern Research Institute Heterocycle-fused morphinans, use thereof and preparation thereof
AU2013381199A1 (en) * 2013-03-08 2015-10-29 Nippon Chemiphar Co., Ltd. Morphinan derivative
WO2015192039A1 (en) * 2014-06-13 2015-12-17 Purdue Pharma L.P. Heterocyclic morphinan derivatives and use thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816586A (en) 1987-07-29 1989-03-28 Regents Of The University Of Minnesota Delta opioid receptor antagonists
US5223507A (en) * 1992-01-21 1993-06-29 G. D. Searle & Co. Method of using opioid compounds as delta opioid selective agonist analgesics
US5225417A (en) * 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds

Also Published As

Publication number Publication date
EP0770081A1 (en) 1997-05-02
AU2982495A (en) 1996-02-16
AU686413B2 (en) 1998-02-05
JPH10502657A (ja) 1998-03-10
HUT76812A (en) 1997-11-28
WO1996002545A1 (en) 1996-02-01
BR9508406A (pt) 1997-12-23
PL182747B1 (pl) 2002-02-28
MX9700373A (es) 1998-03-31
CN1051086C (zh) 2000-04-05
JP3480936B2 (ja) 2003-12-22
NO970142D0 (no) 1997-01-13
ATE236169T1 (de) 2003-04-15
US5981540A (en) 1999-11-09
CZ9897A3 (en) 1997-07-16
EP0770081B1 (en) 2003-04-02
DE69530205D1 (de) 2003-05-08
NO970142L (no) 1997-03-12
CA2194877A1 (en) 1996-02-01
ES2196069T3 (es) 2003-12-16
NZ289858A (en) 1998-01-26
ITMI941463A1 (it) 1996-01-14
ZA955782B (en) 1996-02-26
DE69530205T2 (de) 2004-02-05
HU9700073D0 (en) 1997-02-28
CN1161041A (zh) 1997-10-01
NO315119B1 (no) 2003-07-14
PL318148A1 (en) 1997-05-12
ITMI941463A0 (it) 1994-07-14

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