IT1271461B - Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso. - Google Patents

Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.

Info

Publication number
IT1271461B
IT1271461B ITFI930246A ITFI930246A IT1271461B IT 1271461 B IT1271461 B IT 1271461B IT FI930246 A ITFI930246 A IT FI930246A IT FI930246 A ITFI930246 A IT FI930246A IT 1271461 B IT1271461 B IT 1271461B
Authority
IT
Italy
Prior art keywords
production
egfr monoclonal
body antibody
antibody
monoclonal anti
Prior art date
Application number
ITFI930246A
Other languages
English (en)
Inventor
Antonio Mele
Santis Rita De
Marsal Cristina Ferrer
Original Assignee
Menarini Ricerche Sud Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Ricerche Sud Spa filed Critical Menarini Ricerche Sud Spa
Priority to ITFI930246A priority Critical patent/IT1271461B/it
Publication of ITFI930246A0 publication Critical patent/ITFI930246A0/it
Priority to PCT/EP1994/003995 priority patent/WO1995016037A1/en
Priority to AU12417/95A priority patent/AU1241795A/en
Publication of ITFI930246A1 publication Critical patent/ITFI930246A1/it
Application granted granted Critical
Publication of IT1271461B publication Critical patent/IT1271461B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
ITFI930246A 1993-12-01 1993-12-01 Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso. IT1271461B (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ITFI930246A IT1271461B (it) 1993-12-01 1993-12-01 Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.
PCT/EP1994/003995 WO1995016037A1 (en) 1993-12-01 1994-12-01 Anti-egf-r/anti-cd3 bispecific monoclonal antibody, method for its production and its use
AU12417/95A AU1241795A (en) 1993-12-01 1994-12-01 Anti-egf-r/anti-cd3 bispecific monoclonal antibody, method for its production and its use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI930246A IT1271461B (it) 1993-12-01 1993-12-01 Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.

Publications (3)

Publication Number Publication Date
ITFI930246A0 ITFI930246A0 (it) 1993-12-01
ITFI930246A1 ITFI930246A1 (it) 1995-06-01
IT1271461B true IT1271461B (it) 1997-05-28

Family

ID=11350667

Family Applications (1)

Application Number Title Priority Date Filing Date
ITFI930246A IT1271461B (it) 1993-12-01 1993-12-01 Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.

Country Status (3)

Country Link
AU (1) AU1241795A (it)
IT (1) IT1271461B (it)
WO (1) WO1995016037A1 (it)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6018031A (en) * 1989-10-20 2000-01-25 Trustees Of Dartmouth College Binding agents specific for IgA receptor
CZ292061B6 (cs) * 1994-03-17 2003-07-16 Merck Patent Gmbh Jednořetězcové fragmenty protilátek a protilátky proti receptoru epidermálního růstového faktoru, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
US6465253B1 (en) 1994-09-08 2002-10-15 Genvec, Inc. Vectors and methods for gene transfer to cells
US5846782A (en) 1995-11-28 1998-12-08 Genvec, Inc. Targeting adenovirus with use of constrained peptide motifs
US5559099A (en) * 1994-09-08 1996-09-24 Genvec, Inc. Penton base protein and methods of using same
US6127525A (en) * 1995-02-21 2000-10-03 Cornell Research Foundation, Inc. Chimeric adenoviral coat protein and methods of using same
US5770442A (en) * 1995-02-21 1998-06-23 Cornell Research Foundation, Inc. Chimeric adenoviral fiber protein and methods of using same
US6783980B2 (en) 1995-06-15 2004-08-31 Crucell Holland B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US5922845A (en) * 1996-07-11 1999-07-13 Medarex, Inc. Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
US20030017138A1 (en) 1998-07-08 2003-01-23 Menzo Havenga Chimeric adenoviruses
US6929946B1 (en) 1998-11-20 2005-08-16 Crucell Holland B.V. Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US6913922B1 (en) 1999-05-18 2005-07-05 Crucell Holland B.V. Serotype of adenovirus and uses thereof
DE60138403D1 (de) 2000-09-26 2009-05-28 Crucell Holland Bv Adenovirale vektoren für die übertragung von genen in zellen der skelettmuskulatur oder myoblasten
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
NZ530212A (en) 2001-06-13 2006-09-29 Genmab As An isolated human monoclonal antibody that binds to human epidermal growth factor receptor (EGFR)
KR101021387B1 (ko) 2002-04-25 2011-03-14 크루셀 홀란드 비.브이. 아데노바이러스 벡터를 생산하기 위한 수단 및 방법
JP3803790B2 (ja) 2003-02-17 2006-08-02 株式会社東北テクノアーチ 新規なダイアボディ型二重特異性抗体
TWI391399B (zh) 2005-05-25 2013-04-01 Hoffmann La Roche 測定溶離多肽之鹽濃度之方法
AU2006301492B2 (en) 2005-10-11 2011-06-09 Amgen Research (Munich) Gmbh Compositions comprising cross-species-specific antibodies and uses thereof
WO2008119566A2 (en) * 2007-04-03 2008-10-09 Micromet Ag Cross-species-specific bispecific binders
BRPI0812288A2 (pt) 2007-06-01 2014-11-25 Hoffmann La Roche Purificação de imunoglobulina.
CN101307109B (zh) * 2008-06-04 2010-11-17 张传林 鼠抗人t淋巴细胞cd3表面抗原单克隆抗体及其制备方法和用途
ES2488542T3 (es) 2008-12-22 2014-08-27 F. Hoffmann-La Roche Ag Purificación de inmunoglobulinas
CN105722859B (zh) 2013-07-25 2021-05-07 西托姆克斯治疗公司 多特异性抗体、多特异性可活化抗体及其使用方法
BR112016030740A2 (pt) 2014-07-01 2018-02-20 Pfizer Inc. diacorpos heterodiméricos biespecíficos e seus usos
JP7020909B2 (ja) 2014-07-25 2022-02-16 シトムクス セラピューティクス，インコーポレイティド 抗－ｃｄ３抗体、活性化可能抗－ｃｄ３抗体、多重特異的抗－ｃｄ３抗体、多重特異的活性化可能抗－ｃｄ３抗体、及びそれらの使用方法
CA3287794A1 (en) 2017-10-14 2025-10-27 Cytomx Therapeutics, Inc. Antibodies, activatable antibodies, bispecific antibodies, and bispecific activatable antibodies and methods of use thereof
JP2023545099A (ja) 2020-10-08 2023-10-26 アフィメド ゲーエムベーハー 三重特異性バインダー
CA3216098A1 (en) 2021-07-30 2023-02-02 Uwe Reusch Duplexbodies

Also Published As

Publication number Publication date
AU1241795A (en) 1995-06-27
WO1995016037A1 (en) 1995-06-15
ITFI930246A1 (it) 1995-06-01
ITFI930246A0 (it) 1993-12-01

Similar Documents

Publication Publication Date Title
IT1271461B (it) Anticorpo monoclonale bispecifico anti-cd3/anti-egfr,processo per la produzione e suo uso.
BR9606706A (pt) Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo
NO924279D0 (no) Lyofilisert, monoklonalt antistoffpreparat
NO955167L (no) Monoklonalt anti-V-integrin-antistoff
EP0618929A4 (en) BISPECIFIC HETERODIMER ANTIBODIES.
DE68914244D1 (de) Monoklonaler Antikörper.
FI963004L (fi) Vasta-aineen muodostumista kiihottavia monoklonaalivasta-aineita
EP0671951A4 (en) HUMANIZED ANTIBODIES REACTING WITH L-SELECTIN.
FI964845A7 (fi) CD44v6:n vastaiset monoklonaaliset vasta-aineet
FI960567L (fi) Monoklonaalinen vasta-aine, joka indusoi apoptoosin
EP0585224A4 (en) Monoclonal antibodies which bind to secreted and membrane-bound ige, but not to ige on basophils
EP0578515A3 (en) Humanized monoclonal antibodies.
DE59608073D1 (de) Antikörper gegen ein, einen histidin-anteil aufweisendes fusionspolypeptid
KR950700390A (ko) 강화 탄화수소, 그 제조방법 및 사용방법(fortified hydrocarbon and process for making and using the same)
FI885169L (fi) Monoklonaalinen vasta-aine, joka tunnistaa N-asetyylineuramiinihapon -järjestyksessä, sen käyttö ja sitä tuottava hybridooma
FI945877L (fi) Menetelmä proteiini C:n tuottamiseksi
FI934963A7 (fi) CTAA 81AV78, monoklonaalisen 81AV78-humaanivasta-aineen tunnistama ant igeeni
EP0554458A4 (en) Immunoassay, monoclonal antibody and hybridoma
NO890116L (no) Monoklonale antistoffer.
EP0667395A4 (en) MONOCLONAL ANTIBODIES, APPLICATION AND PRODUCTION METHOD.
DE69023717D1 (de) Monoklonaler Antikörper.
NO894555L (no) Monoklonalt antistoff som spesifikt gjenkjenner n-glycolyl type gm2, hybridom som produserer antistoff og fremgangsmaate for fremstilling av hybridomet.
EP0654532A4 (en) ANTIMUCOGLYCOPROTEIN MONOCLONAL ANTIBODIES.
FI960566L (fi) Monoklonaalinen vasta-aine, joka tunnistaa välisolun pinta-antigeenin
DE69020315D1 (de) Monoklonaler antikörper gegen c-reaktives protein.

Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19961230