IT1271703B - "derivati 6-o 7-sostituiti del 4-aminoandrostadienone e procedimento per la loro preparazione" - Google Patents
"derivati 6-o 7-sostituiti del 4-aminoandrostadienone e procedimento per la loro preparazione"Info
- Publication number
- IT1271703B IT1271703B ITMI942233A ITMI942233A IT1271703B IT 1271703 B IT1271703 B IT 1271703B IT MI942233 A ITMI942233 A IT MI942233A IT MI942233 A ITMI942233 A IT MI942233A IT 1271703 B IT1271703 B IT 1271703B
- Authority
- IT
- Italy
- Prior art keywords
- hydrogen
- formula
- group
- aminoandrostadienone
- procedure
- Prior art date
Links
- ONQIIHXPPFUGMC-PRRIXCOJSA-N (8S,9S,10R,13R,14S)-4-amino-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthren-3-one Chemical class O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CCC2=C1N ONQIIHXPPFUGMC-PRRIXCOJSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0011—Unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
La presente invenzione fornisce nuovi composti con la seguente formula generale (I) (FORMULA I) nella quale x rappresenta un legame singolo o doppio;A rappresenta un gruppo C-O3 oppure (FORMULA).ciascun sostituente R ed R rappresenta, indipendentemente, un idrogeno o un acile;R1 rappresenta un idrogeno o un gruppo -(CH2)n(FORMULA)R2 rappresenta un idrogeno o un gruppo -(CH2)n(FORMULA) o un gruppo -S-(CH2)n(FORMULA)R4 rappresenta un idrogeno, un alogeno, un alchile C1-C6, un alcossi C1-C6, o un trifluorometile;n rappresenta 1, 2 o 3; e m rappresenta 0, 1 o 2;A patto che, tra i sostituenti R1 e R2, uno sia un idrogeno e l'altro sia diverso dall'idrogeno, e i suoi sali farmaceuticamente accettabili.I composti dell'invenzione sono utili come inibitori dell'aromatasi.1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9325244A GB2284605A (en) | 1993-12-09 | 1993-12-09 | 6-or 7-substituted 4-aminoandrostadienone derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI942233A0 ITMI942233A0 (it) | 1994-11-03 |
| ITMI942233A1 ITMI942233A1 (it) | 1996-05-03 |
| IT1271703B true IT1271703B (it) | 1997-06-04 |
Family
ID=10746367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI942233A IT1271703B (it) | 1993-12-09 | 1994-11-03 | "derivati 6-o 7-sostituiti del 4-aminoandrostadienone e procedimento per la loro preparazione" |
Country Status (2)
| Country | Link |
|---|---|
| GB (1) | GB2284605A (it) |
| IT (1) | IT1271703B (it) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8503940D0 (en) * | 1985-02-15 | 1985-03-20 | Erba Farmitalia | 4-substituted androstendione derivatives |
-
1993
- 1993-12-09 GB GB9325244A patent/GB2284605A/en not_active Withdrawn
-
1994
- 1994-11-03 IT ITMI942233A patent/IT1271703B/it active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI942233A1 (it) | 1996-05-03 |
| GB2284605A (en) | 1995-06-14 |
| GB9325244D0 (en) | 1994-02-09 |
| ITMI942233A0 (it) | 1994-11-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2219180C2 (ru) | Производные 1,5-дигидропиразоло[3,4-d]-пиримидинона | |
| EA200100755A1 (ru) | 4-оксо-1,4-дигидро-3-хинолинкарбоксамиды как антивирусные агенты | |
| NO20034595D0 (no) | Kinolin- og kinazolinderivater med azolylgruppe | |
| MX9203165A (es) | Derivados de succinimida y composicion farmaceutica que los contiene . | |
| YU49312B (sh) | Kristalni hidratni derivati 3,4,4-trisupstituisanih - peperidinil-n-alkilkarboksilata, njihovi intermedijari i postupak za dobijanje | |
| YU48390B (sh) | Novi derivati 2-anilinopirimidina, postupak za njihovo dobijanje i sredstva za uništavanje štetočina, koja sadrže ove derivate | |
| DE69232093D1 (de) | Methylenoxindolderivate und verfahren zu ihrer herstellung | |
| FI970317A0 (fi) | Antiproliferatiivisina aineina ja Garft-inhibiittoreina käyttökelpoisia yhdisteitä | |
| WO2001072708A3 (en) | OXINDOLE INHIBITORS OF FACTOR Xa | |
| DE69925472D1 (de) | Benzoheterocyclische distamycinderivate, verfahren zu ihrer herstellung und ihre verwendung als antitumormittel | |
| DE69918465D1 (de) | Sulfonamidhydroxamate | |
| IS4206A (is) | Hliðstæðar aðferðir til framleiðslu á andróstenónafleiðu og milliefni notuð í aðferðunum | |
| DK160098C (da) | Tricycliske oxindolcarboxamid-derivater | |
| HRP20030610B1 (en) | Process for the preparation of mesylates of piperazine derivatives | |
| EP0725068A4 (en) | INDOLDER DERIVATIVES | |
| ATE203012T1 (de) | 4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen | |
| NO890440D0 (no) | Fremgangsmaate for fremstilling av terapeutisk aktive isokinolinderivater. | |
| ATE187448T1 (de) | Morpholinderivate | |
| MY131544A (en) | Fluorinated 4-aminoandrostadienone derivatives and process for their preparation | |
| ES2140552T3 (es) | Derivados indol como inhibidores de la 5-alfa-reductasa-1. | |
| DK0782574T3 (da) | Bicycliske carboxiamider som 5-HT1A-receptorligander | |
| ES472591A1 (es) | Procedimiento para la obtencion de derivados de 1-fenileta- nolamina | |
| HRP20050617A2 (en) | Imidazol derivatives having affinity for alpha 2 receptors activity | |
| AR008920A1 (es) | Proceso para la preparacion de los derivados de 2-amino-2-imidaxolina, guanidina, y 2-amino-3,4,5,6-tetrahidropiridimina | |
| NO910198L (no) | Anti-inflammatoriske 4-aminofenolderivater. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |