ATE203012T1 - 4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen - Google Patents

4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen

Info

Publication number: ATE203012T1
Authority: AT; Austria
Prior art keywords: lower alkyl; reductases; represents hydrogen; adrenergic receptors; alpha1
Prior art date: 1994-03-30

Application number

AT95913377T

Other languages

English (en)

Inventor

Kiyoshi Yoshida

Tadashi Kurimoto

Mineo Takei

Hiroki Sato

Original Assignee

Zeria Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-03-30

Filing date

1995-03-29

Publication date

2001-07-15

1995-03-29 Application filed by Zeria Pharm Co Ltd filed Critical Zeria Pharm Co Ltd

2001-07-15 Application granted granted Critical

2001-07-15 Publication of ATE203012T1 publication Critical patent/ATE203012T1/de

Links

102000030619 alpha-1 Adrenergic Receptor Human genes 0.000 title abstract 2
108020004102 alpha-1 Adrenergic Receptor Proteins 0.000 title abstract 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 title 2
MQLJZFAKVWTELE-UHFFFAOYSA-N 4-indol-1-ylbutanoic acid Chemical class C1=CC=C2N(CCCC(=O)O)C=CC2=C1 MQLJZFAKVWTELE-UHFFFAOYSA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
229960003604 testosterone Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 6
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
NVKAWKQGWWIWPM-ABEVXSGRSA-N 17-β-hydroxy-5-α-Androstan-3-one Chemical compound C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@H]21 NVKAWKQGWWIWPM-ABEVXSGRSA-N 0.000 abstract 1
108010029908 3-oxo-5-alpha-steroid 4-dehydrogenase Proteins 0.000 abstract 1
102000001779 3-oxo-5-alpha-steroid 4-dehydrogenase Human genes 0.000 abstract 1
208000002874 Acne Vulgaris Diseases 0.000 abstract 1
201000004384 Alopecia Diseases 0.000 abstract 1
206010004446 Benign prostatic hyperplasia Diseases 0.000 abstract 1
208000004403 Prostatic Hyperplasia Diseases 0.000 abstract 1
208000025844 Prostatic disease Diseases 0.000 abstract 1
208000028938 Urination disease Diseases 0.000 abstract 1
206010000496 acne Diseases 0.000 abstract 1
229960003473 androstanolone Drugs 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002475 indoles Chemical class 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
238000012261 overproduction Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003449 preventive effect Effects 0.000 abstract 1
201000004240 prostatic hypertrophy Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT95913377T 1994-03-30 1995-03-29 4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen ATE203012T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP8262094		1994-03-30
PCT/JP1995/000599 WO1995026955A1 (en)	1994-03-30	1995-03-29	Indole derivative and medicine containing the same

Publications (1)

Publication Number	Publication Date
ATE203012T1 true ATE203012T1 (de)	2001-07-15

Family

ID=13779508

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95913377T ATE203012T1 (de)	1994-03-30	1995-03-29	4-indol-1-yl-buttersäure derivate, deren herstellung und deren verwendung als inhibitoren für alpha1-adrenerge rezeptoren und testosteron 5alpha-reduktasen

Country Status (14)

Country	Link
US (1)	US5760040A (de)
EP (1)	EP0753511B1 (de)
KR (1)	KR100349634B1 (de)
CN (1)	CN1067985C (de)
AT (1)	ATE203012T1 (de)
AU (1)	AU681021B2 (de)
CA (1)	CA2186499A1 (de)
DE (1)	DE69521687T2 (de)
DK (1)	DK0753511T3 (de)
ES (1)	ES2160158T3 (de)
GR (1)	GR3036735T3 (de)
PT (1)	PT753511E (de)
UY (1)	UY25970A1 (de)
WO (1)	WO1995026955A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH1135558A (ja) *	1997-07-18	1999-02-09	Zeria Pharmaceut Co Ltd	３−ベンゾイルインドール誘導体及びそれらを含有する医薬
MXPA00010805A (es)	1998-05-06	2002-05-08	Univ Duke	Metodo para el tratamiento de sindromes de la vejiga y del tracto urinario inferior.
HUP0102609A3 (en) *	1998-06-30	2002-12-28	Zeria Pharm Co Ltd	N-phenyl-n'-phenylpropylpiperazine derivatives and process for the preparation thereof, and pharmaceutical compositions containing them
KR100368297B1 (ko) *	2000-05-31	2003-01-24	이승기	양성 전립선 비대증 치료용 메나퀴논 7
TWI317634B (en) *	2001-12-13	2009-12-01	Nat Health Research Institutes	Aroyl indoles compounds
US7632955B2 (en) *	2001-12-13	2009-12-15	National Health Research Institutes	Indole compounds
US7528165B2 (en) *	2001-12-13	2009-05-05	National Health Research Institutes	Indole compounds
JP2008521831A (ja) *	2004-11-30	2008-06-26	プレキシコン，インコーポレーテッド	Ｐｐａｒ活性化合物
US7456289B2 (en) *	2004-12-31	2008-11-25	National Health Research Institutes	Anti-tumor compounds
WO2007030559A2 (en) *	2005-09-07	2007-03-15	Plexxikon, Inc.	1, 3-disubstituted indole derivatives for use as ppar modulators
PE20090159A1 (es) *	2007-03-08	2009-02-21	Plexxikon Inc	COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
US9771316B2 (en)	2013-01-21	2017-09-26	Osaka University	Phenoxyalkylamine compound

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4935240A (en)	1987-06-04	1990-06-19	Ono Pharmaceutical Co., Ltd.	Benzoylaminophenoxybutanoic acid derivatives
FR2632641B1 (fr)	1988-06-13	1990-10-12	Irceba	((aryl-4-piperazinyl-1)-2 ethoxy)-3 p-cymene, les derives ortho, meta, para monosubstitues ou disubstitues sur le noyau phenyle dudit produit, le procede de preparation desdits derives, et les medicaments contenant lesdits composes comme principe actif
FR2637596B1 (fr)	1988-10-11	1992-09-04	Irceba	Methyl-4 ((aryl-4 piperazinyl-1)-2 ethyl)-5 thiazole et ses derives, leur procede de preparation et les medicaments en contenant
FR2658514B1 (fr) *	1990-02-19	1992-06-19	Irceba	Nouveaux derives du methyl-4 thiazole, leurs procedes de preparation et les compositions pharmaceutiques en contenant.
GB9011335D0 (en) *	1990-05-21	1990-07-11	Fujisawa Pharmaceutical Co	Indolebutyric acid derivatives and process for preparation thereof
GB9115951D0 (en) *	1991-07-24	1991-09-11	Pfizer Ltd	Indoles
JPH07501790A (ja) *	1991-09-11	1995-02-23	藤沢薬品工業株式会社	５−アルファレダクターゼ阻害剤としてのインドール誘導体
GB9204024D0 (en) *	1992-02-25	1992-04-08	Fujisawa Pharmaceutical Co	Indole derivatives
HRP930210A2 (en) *	1992-02-25	1995-06-30	Recordati Chem Pharm	Heterobicyclic compounds and pharmaceutical preparations containing them
EP0675109A1 (de) *	1992-12-21	1995-10-04	Taisho Pharmaceutical Co. Ltd	N-substituiertes indolderivat

1995
- 1995-03-29 DE DE69521687T patent/DE69521687T2/de not_active Expired - Fee Related
- 1995-03-29 US US08/714,079 patent/US5760040A/en not_active Expired - Fee Related
- 1995-03-29 WO PCT/JP1995/000599 patent/WO1995026955A1/ja not_active Ceased
- 1995-03-29 CN CN95192344A patent/CN1067985C/zh not_active Expired - Fee Related
- 1995-03-29 DK DK95913377T patent/DK0753511T3/da active
- 1995-03-29 ES ES95913377T patent/ES2160158T3/es not_active Expired - Lifetime
- 1995-03-29 PT PT95913377T patent/PT753511E/pt unknown
- 1995-03-29 KR KR1019960705309A patent/KR100349634B1/ko not_active Expired - Fee Related
- 1995-03-29 AU AU20841/95A patent/AU681021B2/en not_active Ceased
- 1995-03-29 AT AT95913377T patent/ATE203012T1/de not_active IP Right Cessation
- 1995-03-29 EP EP95913377A patent/EP0753511B1/de not_active Expired - Lifetime
- 1995-03-29 CA CA002186499A patent/CA2186499A1/en not_active Abandoned
2000
- 2000-01-17 UY UY25970A patent/UY25970A1/es unknown
2001
- 2001-09-27 GR GR20010401592T patent/GR3036735T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2084195A (en)	1995-10-23
AU681021B2 (en)	1997-08-14
CA2186499A1 (en)	1995-10-12
PT753511E (pt)	2001-11-30
EP0753511A1 (de)	1997-01-15
DK0753511T3 (da)	2001-09-24
DE69521687T2 (de)	2001-10-25
DE69521687D1 (de)	2001-08-16
UY25970A1 (es)	2001-08-27
ES2160158T3 (es)	2001-11-01
KR970702273A (ko)	1997-05-13
EP0753511A4 (de)	1997-07-23
GR3036735T3 (en)	2001-12-31
KR100349634B1 (ko)	2003-01-08
WO1995026955A1 (en)	1995-10-12
US5760040A (en)	1998-06-02
EP0753511B1 (de)	2001-07-11
CN1145617A (zh)	1997-03-19
CN1067985C (zh)	2001-07-04

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Legal Events

Date	Code	Title	Description
2001-09-15	UEP	Publication of translation of european patent specification
2003-12-15	REN	Ceased due to non-payment of the annual fee