IT1274482B - Procedimento biocatalitico per l'ottenimento degli enantiomeri otticamente puri del flurbiprofen - Google Patents

Procedimento biocatalitico per l'ottenimento degli enantiomeri otticamente puri del flurbiprofen

Info

Publication number: IT1274482B
Authority: IT; Italy
Prior art keywords: flurbiprofen; optically pure; pure enantiomers; biocatalytic process; obtaining optically
Prior art date: 1995-05-12

Application number

ITMI950959A

Other languages

English (en)

Inventor

Giovanni Nicolosi

Mario Piatteli

Raffaele Morrone

Angela Patti

Original Assignee

Consiglio Nazionale Ricerche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-12

Filing date

1995-05-12

Publication date

1997-07-17

1995-05-12 Application filed by Consiglio Nazionale Ricerche filed Critical Consiglio Nazionale Ricerche

1995-05-12 Priority to ITMI950959A priority Critical patent/IT1274482B/it

1995-05-12 Publication of ITMI950959A0 publication Critical patent/ITMI950959A0/it

1996-11-12 Publication of ITMI950959A1 publication Critical patent/ITMI950959A1/it

1997-07-17 Application granted granted Critical

1997-07-17 Publication of IT1274482B publication Critical patent/IT1274482B/it

Links

HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title abstract 2
SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 title abstract 2
229960002390 flurbiprofen Drugs 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
230000002210 biocatalytic effect Effects 0.000 title 1
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
102000004882 Lipase Human genes 0.000 abstract 1
108090001060 Lipase Proteins 0.000 abstract 1
239000004367 Lipase Substances 0.000 abstract 1
241001661345 Moesziomyces antarcticus Species 0.000 abstract 1
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric Acid Chemical compound [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
235000019421 lipase Nutrition 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1
230000003319 supportive effect Effects 0.000 abstract 1

Landscapes

Preparation Of Compounds By Using Micro-Organisms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

ITMI950959A 1995-05-12 1995-05-12 Procedimento biocatalitico per l'ottenimento degli enantiomeri otticamente puri del flurbiprofen IT1274482B (it)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
ITMI950959A IT1274482B (it)	1995-05-12	1995-05-12	Procedimento biocatalitico per l'ottenimento degli enantiomeri otticamente puri del flurbiprofen

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI950959A IT1274482B (it)	1995-05-12	1995-05-12	Procedimento biocatalitico per l'ottenimento degli enantiomeri otticamente puri del flurbiprofen

Publications (3)

Publication Number	Publication Date
ITMI950959A0 ITMI950959A0 (it)	1995-05-12
ITMI950959A1 ITMI950959A1 (it)	1996-11-12
IT1274482B true IT1274482B (it)	1997-07-17

Family

ID=11371583

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITMI950959A IT1274482B (it)	1995-05-12	1995-05-12	Procedimento biocatalitico per l'ottenimento degli enantiomeri otticamente puri del flurbiprofen

Country Status (1)

Country	Link
IT (1)	IT1274482B (it)

1995
- 1995-05-12 IT ITMI950959A patent/IT1274482B/it active IP Right Grant

Also Published As

Publication number	Publication date
ITMI950959A0 (it)	1995-05-12
ITMI950959A1 (it)	1996-11-12

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Legal Events

Date	Code	Title	Description
1997-07-17	0001	Granted