IT1281877B1 - Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici - Google Patents
Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeuticiInfo
- Publication number
- IT1281877B1 IT1281877B1 IT95PD000090A ITPD950090A IT1281877B1 IT 1281877 B1 IT1281877 B1 IT 1281877B1 IT 95PD000090 A IT95PD000090 A IT 95PD000090A IT PD950090 A ITPD950090 A IT PD950090A IT 1281877 B1 IT1281877 B1 IT 1281877B1
- Authority
- IT
- Italy
- Prior art keywords
- heavy metal
- hyaluronic acid
- metal salts
- salt
- therapeutic agents
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title abstract 5
- 229910001385 heavy metal Inorganic materials 0.000 title abstract 4
- 229920002674 hyaluronan Polymers 0.000 title abstract 3
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 3
- 229940124606 potential therapeutic agent Drugs 0.000 title 1
- 125000002730 succinyl group Chemical class C(CCC(=O)*)(=O)* 0.000 title 1
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 abstract 1
- 230000001476 alcoholic effect Effects 0.000 abstract 1
- 239000000010 aprotic solvent Substances 0.000 abstract 1
- 229910002091 carbon monoxide Inorganic materials 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 abstract 1
- RPACBEVZENYWOL-XFULWGLBSA-M sodium;(2r)-2-[6-(4-chlorophenoxy)hexyl]oxirane-2-carboxylate Chemical compound [Na+].C=1C=C(Cl)C=CC=1OCCCCCC[C@]1(C(=O)[O-])CO1 RPACBEVZENYWOL-XFULWGLBSA-M 0.000 abstract 1
- 239000001384 succinic acid Substances 0.000 abstract 1
- 229940014800 succinic anhydride Drugs 0.000 abstract 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 abstract 1
- 125000005497 tetraalkylphosphonium group Chemical group 0.000 abstract 1
- 238000001291 vacuum drying Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95PD000090A IT1281877B1 (it) | 1995-05-10 | 1995-05-10 | Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici |
| AU58944/96A AU695512B2 (en) | 1995-05-10 | 1996-05-08 | Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions |
| PCT/EP1996/001979 WO1996035720A1 (en) | 1995-05-10 | 1996-05-08 | Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions |
| EP96916030A EP0827514B1 (en) | 1995-05-10 | 1996-05-08 | Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions |
| JP53376996A JP4264671B2 (ja) | 1995-05-10 | 1996-05-08 | ヒアルロン酸との又はヒアルロン酸エステルとのコハク酸ヘミエステルの重金属塩類、それらの製造方法及びその医薬組成物 |
| CA002220682A CA2220682C (en) | 1995-05-10 | 1996-05-08 | Heavy metal salts of succinic acid hemiesters with hyaluronic acid, or hyaluronic acid esters, a process for their preparation, and relative pharmaceutical compositions |
| AT96916030T ATE183206T1 (de) | 1995-05-10 | 1996-05-08 | Schwermetallsalze von bernsteinsäurehalbester mit hyaluronsäure oder hyaluronsäureester, verfahren zu ihrer herstellung und verbundene pharmazeutische zusammensetzungen |
| DE69603721T DE69603721T2 (de) | 1995-05-10 | 1996-05-08 | Schwermetallsalze von bernsteinsäurehalbester mit hyaluronsäure oder hyaluronsäureester, verfahren zu ihrer herstellung und verbundene pharmazeutische zusammensetzungen |
| ES96916030T ES2137694T3 (es) | 1995-05-10 | 1996-05-08 | Sales de metales pesados de los semiesteres del acido succinico con el acido hialuronico, o con los esteres del acido hialuronico. un proceso para la preparacion y composiciones farmaceuticas relacionadas. |
| US08/966,636 US6017901A (en) | 1995-05-10 | 1997-11-10 | Heavy metal salts of succinic acid hemiesters with hyaluronic acid or hyaluronic acid esters, a process for their preparation and relative pharmaceutical compositions |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95PD000090A IT1281877B1 (it) | 1995-05-10 | 1995-05-10 | Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITPD950090A0 ITPD950090A0 (it) | 1995-05-10 |
| ITPD950090A1 ITPD950090A1 (it) | 1996-11-10 |
| IT1281877B1 true IT1281877B1 (it) | 1998-03-03 |
Family
ID=11391041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT95PD000090A IT1281877B1 (it) | 1995-05-10 | 1995-05-10 | Sali di metalli pesanti di succinil derivati dell'acido ialuronico e loro impiego come potenziali agenti terapeutici |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0827514B1 (it) |
| JP (1) | JP4264671B2 (it) |
| AT (1) | ATE183206T1 (it) |
| AU (1) | AU695512B2 (it) |
| CA (1) | CA2220682C (it) |
| DE (1) | DE69603721T2 (it) |
| ES (1) | ES2137694T3 (it) |
| IT (1) | IT1281877B1 (it) |
| WO (1) | WO1996035720A1 (it) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0781566B1 (en) * | 1995-12-26 | 2004-07-28 | Toyo Boseki Kabushiki Kaisha | Organic solvent-soluble mucopolysaccharide, antibacterial antithrombogenic composition and medical material |
| IT1291452B1 (it) | 1997-04-14 | 1999-01-11 | Fidia Advanced Biopolymers Srl | Rivestimento a base di acido ialuronico e suoi derivati per la protezione di parti elettroniche da agenti esterni |
| IT1294797B1 (it) * | 1997-07-28 | 1999-04-15 | Fidia Advanced Biopolymers Srl | Uso dei derivati dell'acido ialuronico nella preparazione di biomateriali aventi attivita' emostatica fisica e tamponante |
| US6872819B1 (en) * | 1998-05-27 | 2005-03-29 | Fidia Advanced Biopolymers S.R.L. | Biomaterials containing hyaluronic acid derivatives in the form of three-dimensional structures free from cellular components or products thereof for the in vivo regeneration of tissue cells |
| ITPD980149A1 (it) | 1998-06-17 | 1999-12-17 | Fidia Advanced Biopolymers Srl | Protesi tridimensionali comprendenti derivati dell'acido ialuronico per riparare o ricostruire i tessuti danneggiati e processo per la |
| JP2003089647A (ja) * | 1999-03-10 | 2003-03-28 | Takada Seiyaku Kk | 関節性疾患治療剤 |
| HK1047884A1 (zh) * | 1999-06-18 | 2003-03-14 | Ml Laboratories Plc | 生物活性材料 |
| GB2392913B (en) * | 2002-09-11 | 2007-04-04 | Johnson & Johnson Medical Ltd | Wound dressings comprising complexes of oxidised celluloses with silver |
| AU2003263344B2 (en) | 2002-09-11 | 2009-01-08 | Johnson & Johnson Medical Limited | Wound dressing materials comprising complexes of anionic polysaccharides with silver |
| DK200301128A (da) | 2003-08-05 | 2005-02-06 | Thomsen Joern Oddershede | Tilskudspræparat |
| US7993678B2 (en) * | 2005-09-26 | 2011-08-09 | Novozymes Biopolymer A/S | Hyaluronic acid derivatives |
| IT1402786B1 (it) * | 2010-11-19 | 2013-09-18 | Fidia Farmaceutici | Composizioni farmaceutiche ad attivita' antibatterica e cicatrizzante |
| CZ304654B6 (cs) | 2012-11-27 | 2014-08-20 | Contipro Biotech S.R.O. | Nanomicelární kompozice na bázi C6-C18-acylovaného hyaluronanu, způsob přípravy C6-C18-acylovaného hyaluronanu, způsob přípravy nanomicelární kompozice a stabilizované nanomicelární kompozice a použití |
| PT3226905T (pt) | 2014-02-27 | 2022-01-19 | Synartro Ab | Conjugados de hialuronano com substâncias farmaceuticamente ativas, métodos e composições |
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| MA41912A (fr) * | 2015-04-07 | 2018-02-13 | Hyalblue S R L | Esters de glycosaminoglycane, procédés pour leur préparation et leur utilisation dans des formulations à usage ophtalmique |
| CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
| WO2019121488A1 (en) * | 2017-12-21 | 2019-06-27 | Nicox S.A. | Nitric oxide releasing hyaluronic esters |
| JP7066909B1 (ja) * | 2020-12-25 | 2022-05-13 | 参天製薬株式会社 | 高分子化合物、銀塩およびイオン性等張化剤を含有する水性点眼液 |
| IT202100012737A1 (it) | 2021-05-18 | 2022-11-18 | Jointherapeutics S R L | Miscele di polisaccaridi e poliamminosaccaridi con proprietà reologiche migliorate |
| IT202100013787A1 (it) | 2021-05-27 | 2022-11-27 | Farmigea Spa | Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery |
| IT202200004613A1 (it) | 2022-03-10 | 2023-09-10 | Cmed Aesthetics S R L | “procedimento di preparazione di prodotti sterili” |
| WO2024038087A1 (en) | 2022-08-16 | 2024-02-22 | Synartro Ab | Method for preparing sterile compositions |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5436388A (en) * | 1977-08-26 | 1979-03-17 | Sumitomo Electric Ind Ltd | Porous polysaccharide and its preparation |
| EP0066283B1 (en) * | 1981-06-02 | 1986-09-10 | Eupan Corporation | Eustatic composition for nonspecifically facilitating and amplifying the generalized homeostatic regulation and maintenance, compensation and repair in living organisms |
| CA1291034C (en) * | 1987-10-19 | 1991-10-22 | Mostafa S. Fahim | Composition for promoting epithelial regeneration |
| US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
| US4746504A (en) * | 1986-03-14 | 1988-05-24 | Bio-Technology General Corp. | Heavy metal salts of hyaluronic acid and their use as antimicrobial agents |
-
1995
- 1995-05-10 IT IT95PD000090A patent/IT1281877B1/it active IP Right Grant
-
1996
- 1996-05-08 ES ES96916030T patent/ES2137694T3/es not_active Expired - Lifetime
- 1996-05-08 JP JP53376996A patent/JP4264671B2/ja not_active Expired - Fee Related
- 1996-05-08 AT AT96916030T patent/ATE183206T1/de not_active IP Right Cessation
- 1996-05-08 EP EP96916030A patent/EP0827514B1/en not_active Expired - Lifetime
- 1996-05-08 DE DE69603721T patent/DE69603721T2/de not_active Expired - Lifetime
- 1996-05-08 AU AU58944/96A patent/AU695512B2/en not_active Ceased
- 1996-05-08 CA CA002220682A patent/CA2220682C/en not_active Expired - Fee Related
- 1996-05-08 WO PCT/EP1996/001979 patent/WO1996035720A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP4264671B2 (ja) | 2009-05-20 |
| EP0827514A1 (en) | 1998-03-11 |
| ES2137694T3 (es) | 1999-12-16 |
| EP0827514B1 (en) | 1999-08-11 |
| ATE183206T1 (de) | 1999-08-15 |
| DE69603721D1 (de) | 1999-09-16 |
| CA2220682A1 (en) | 1996-11-14 |
| ITPD950090A0 (it) | 1995-05-10 |
| AU5894496A (en) | 1996-11-29 |
| AU695512B2 (en) | 1998-08-13 |
| DE69603721T2 (de) | 2000-01-13 |
| WO1996035720A1 (en) | 1996-11-14 |
| JPH11504668A (ja) | 1999-04-27 |
| ITPD950090A1 (it) | 1996-11-10 |
| CA2220682C (en) | 2006-10-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19990614 |