IT1289939B1 - Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua - Google Patents

Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua

Info

Publication number
IT1289939B1
IT1289939B1 IT97MI000363A ITMI970363A IT1289939B1 IT 1289939 B1 IT1289939 B1 IT 1289939B1 IT 97MI000363 A IT97MI000363 A IT 97MI000363A IT MI970363 A ITMI970363 A IT MI970363A IT 1289939 B1 IT1289939 B1 IT 1289939B1
Authority
IT
Italy
Prior art keywords
pharmaceutical composition
active substance
composition including
water insoluble
highly water
Prior art date
Application number
IT97MI000363A
Other languages
English (en)
Inventor
Giovanni Cavallo
Leonardo Marchitto
Original Assignee
Angelini Ricerche Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI000363A priority Critical patent/IT1289939B1/it
Application filed by Angelini Ricerche Spa filed Critical Angelini Ricerche Spa
Priority to US09/367,699 priority patent/US6337087B1/en
Priority to PCT/EP1998/000816 priority patent/WO1998036735A1/en
Priority to CNB98802733XA priority patent/CN1135969C/zh
Priority to EA199900750A priority patent/EA002281B1/ru
Priority to JP53622798A priority patent/JP4299369B2/ja
Priority to PL335208A priority patent/PL190987B1/pl
Priority to ES98909460T priority patent/ES2213894T3/es
Priority to AT98909460T priority patent/ATE257374T1/de
Priority to CA002285985A priority patent/CA2285985C/en
Priority to EP98909460A priority patent/EP0973505B1/en
Priority to KR10-1999-7007539A priority patent/KR100515249B1/ko
Priority to IL13135498A priority patent/IL131354A0/xx
Priority to PT98909460T priority patent/PT973505E/pt
Priority to AU63987/98A priority patent/AU740619B2/en
Priority to CZ0292699A priority patent/CZ296700B6/cs
Priority to HU0000910A priority patent/HU225594B1/hu
Priority to DE69821001T priority patent/DE69821001T2/de
Priority to DK98909460T priority patent/DK0973505T3/da
Priority to TR1999/01987T priority patent/TR199901987T2/xx
Priority to SI9830600T priority patent/SI0973505T1/xx
Priority to GEAP19984992A priority patent/GEP20022751B/en
Priority to SK1111-99A priority patent/SK282905B6/sk
Priority to ZA981354A priority patent/ZA981354B/xx
Priority to ARP980100755A priority patent/AR011682A1/es
Publication of ITMI970363A1 publication Critical patent/ITMI970363A1/it
Application granted granted Critical
Publication of IT1289939B1 publication Critical patent/IT1289939B1/it
Priority to UA99095151A priority patent/UA63939C2/uk
Priority to IL131354A priority patent/IL131354A/en
Priority to BG103739A priority patent/BG64367B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S977/00—Nanotechnology
    • Y10S977/902—Specified use of nanostructure
    • Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
    • Y10S977/906—Drug delivery
    • Y10S977/907—Liposome

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT97MI000363A 1997-02-20 1997-02-20 Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua IT1289939B1 (it)

Priority Applications (28)

Application Number Priority Date Filing Date Title
IT97MI000363A IT1289939B1 (it) 1997-02-20 1997-02-20 Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua
CZ0292699A CZ296700B6 (cs) 1997-02-20 1998-02-12 Zpusob prípravy vodného farmaceutického prípravku
CNB98802733XA CN1135969C (zh) 1997-02-20 1998-02-12 含有极难溶于水的活性组分的含水药物组合物
EA199900750A EA002281B1 (ru) 1997-02-20 1998-02-12 Способ получения водной фармацевтической композиции, включающей активный ингредиент, в высшей степени нерастворимый в воде
JP53622798A JP4299369B2 (ja) 1997-02-20 1998-02-12 水に高度に不溶性の有効成分を含む水性医薬組成物
PL335208A PL190987B1 (pl) 1997-02-20 1998-02-12 Sposób wytwarzania wodnej kompozycji farmaceutycznej
ES98909460T ES2213894T3 (es) 1997-02-20 1998-02-12 Composicion farmaceutica acuosa que comprende un principio activo que es altamente insoluble en agua.
AT98909460T ATE257374T1 (de) 1997-02-20 1998-02-12 Wässriges arzneimittel, das einen in wasser sehr schwerlöslichen aktivbestandteil enthält
CA002285985A CA2285985C (en) 1997-02-20 1998-02-12 A method for preparing aqueous liposomal compositions comprising an active ingredient which is highly insoluble in water
EP98909460A EP0973505B1 (en) 1997-02-20 1998-02-12 Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water
KR10-1999-7007539A KR100515249B1 (ko) 1997-02-20 1998-02-12 고 수불용성의 활성 성분을 함유한 수용성 약학적 조성물
IL13135498A IL131354A0 (en) 1997-02-20 1998-02-12 Aqueous pharmaceutical composition comprising an active ingredient shich is highly insoluble in water
PT98909460T PT973505E (pt) 1997-02-20 1998-02-12 Composicao farmaceutica aquosa que compreende um imgrediente activo que e muito insoluvel em agua
AU63987/98A AU740619B2 (en) 1997-02-20 1998-02-12 Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water
US09/367,699 US6337087B1 (en) 1997-02-20 1998-02-12 Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water
GEAP19984992A GEP20022751B (en) 1997-02-20 1998-02-12 Aqueous Pharmaceutical Composition Comprising an Active Ingredient Which Is Highly Insoluble in Water
HU0000910A HU225594B1 (en) 1997-02-20 1998-02-12 Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water
DK98909460T DK0973505T3 (da) 1997-02-20 1998-02-12 Vandigt farmaceutisk præparat, der omfatter en aktiv ingrediens, som er meget tungt opløselig i vand
TR1999/01987T TR199901987T2 (xx) 1997-02-20 1998-02-12 Suda ��z�nmezli�i y�ksek bir etken madde ihtiva eden sulu farmakolojik bile�im.
SI9830600T SI0973505T1 (en) 1997-02-20 1998-02-12 Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water
PCT/EP1998/000816 WO1998036735A1 (en) 1997-02-20 1998-02-12 Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water
SK1111-99A SK282905B6 (sk) 1997-02-20 1998-02-12 Spôsob prípravy vodného farmaceutického prípravku
DE69821001T DE69821001T2 (de) 1997-02-20 1998-02-12 Wässriges arzneimittel, das einen in wasser sehr schwerlöslichen aktivbestandteil enthält
ZA981354A ZA981354B (en) 1997-02-20 1998-02-18 Aqueous pharmaceutical composition comprising an active ingredient which is highly insoluble in water
ARP980100755A AR011682A1 (es) 1997-02-20 1998-02-20 UN MÉTODO PARA LA PREPARACIoN DE UNA COMPOSICIoN FARMACÉUTICA ACUOSA CON UN INGREDIENTE ACTIVO QUE TIENE UNA SOLUBILIDAD EN AGUA NO MAYOR QUE 0,01% (P/V) QUE ESTÁ DISPERSO EN LIPOSOMAS
UA99095151A UA63939C2 (uk) 1997-02-20 1998-12-02 Водна фармацевтична композиція, яка містить активний інгредієнт з високим ступенем нерозчинності у воді та спосіб її приготування
IL131354A IL131354A (en) 1997-02-20 1999-08-11 Aphrodisiac preparation containing an active ingredient that is insoluble in water
BG103739A BG64367B1 (bg) 1997-02-20 1999-09-16 Метод за получаване на воден фармацевтичен състав

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI000363A IT1289939B1 (it) 1997-02-20 1997-02-20 Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua

Publications (2)

Publication Number Publication Date
ITMI970363A1 ITMI970363A1 (it) 1998-08-20
IT1289939B1 true IT1289939B1 (it) 1998-10-19

Family

ID=11376099

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI000363A IT1289939B1 (it) 1997-02-20 1997-02-20 Composizione farmaceutica acquosa comprendente un principio attivo altamente insolubile in acqua

Country Status (26)

Country Link
US (1) US6337087B1 (it)
EP (1) EP0973505B1 (it)
JP (1) JP4299369B2 (it)
KR (1) KR100515249B1 (it)
CN (1) CN1135969C (it)
AR (1) AR011682A1 (it)
AT (1) ATE257374T1 (it)
AU (1) AU740619B2 (it)
BG (1) BG64367B1 (it)
CA (1) CA2285985C (it)
CZ (1) CZ296700B6 (it)
DE (1) DE69821001T2 (it)
DK (1) DK0973505T3 (it)
EA (1) EA002281B1 (it)
ES (1) ES2213894T3 (it)
GE (1) GEP20022751B (it)
HU (1) HU225594B1 (it)
IL (2) IL131354A0 (it)
IT (1) IT1289939B1 (it)
PL (1) PL190987B1 (it)
PT (1) PT973505E (it)
SK (1) SK282905B6 (it)
TR (1) TR199901987T2 (it)
UA (1) UA63939C2 (it)
WO (1) WO1998036735A1 (it)
ZA (1) ZA981354B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804192D0 (sv) * 1998-12-03 1998-12-03 Scotia Lipidteknik Ab New formulation
US6075045A (en) * 1999-04-28 2000-06-13 Ajinomoto Co., Inc. Method of treating paralysis of the extremities caused by cerebral infarction
JP4894119B2 (ja) * 2001-09-26 2012-03-14 日油株式会社 脂肪酸含有リポソーム分散液
US20040115226A1 (en) * 2002-12-12 2004-06-17 Wenji Li Free-flowing solid formulations with improved bio-availability of poorly water soluble drugs and process for making the same
EP1592430A4 (en) * 2003-01-17 2006-05-31 Threshold Pharmaceuticals Inc TREATMENT OF GOOD PROSTATE HYPERPLASIA BY MEANS OF ENERGYSTIC ACTIVE SUBSTANCES
WO2005105040A2 (en) * 2004-04-26 2005-11-10 Micelle Products, Inc. Water-soluble formulations of fat soluble vitamins and pharmaceutical agents and their applications
US8999292B2 (en) 2012-05-01 2015-04-07 Translatum Medicus Inc. Methods for treating and diagnosing blinding eye diseases
CA3119037A1 (en) * 2018-12-11 2020-06-18 Disruption Labs Inc. Compositions for the delivery of therapeutic agents and methods of use and making thereof
CN111759807B (zh) * 2019-04-01 2021-06-01 上海谷森医药有限公司 一种环孢素脂质体及其制备方法
EP3990433A4 (en) 2019-06-25 2023-07-26 Translatum Medicus Inc. METHODS FOR THE MANUFACTURE OF 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1264668A (en) * 1984-06-20 1990-01-23 Pieter R. Cullis Extrusion techniques for producing liposomes
DE4038075C1 (en) * 1990-11-29 1992-03-19 B. Braun Melsungen Ag, 3508 Melsungen, De Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
IT1254995B (it) * 1992-06-24 1995-10-11 Farmaco contenente melatonina e/o agonisti, con somministrazione particolarmente efficace nelle patologie che interferiscono con i ritmi circandiani
AT396755B (de) * 1992-07-09 1993-11-25 Oesko Gmbh Verfahren zum reinigen eines rauchgasstromes mit hilfe einer waschflüssigkeit
FR2716110B1 (fr) * 1994-02-16 1996-04-05 Roussel Uclaf Compositions cosmétiques ou pharmaceutiques comprenant des liposomes.
DE4447770C2 (de) * 1994-08-20 2002-12-19 Max Delbrueck Centrum Verfahren zur Herstellung von liposomal verkapseltem Taxol
WO1996040064A1 (en) * 1995-06-07 1996-12-19 Nexstar Pharmaceuticals, Inc. Liposomal cyclosporin formulations as agents for immunosuppression and multiple drug resistant indications

Also Published As

Publication number Publication date
KR100515249B1 (ko) 2005-09-16
EP0973505A1 (en) 2000-01-26
CN1135969C (zh) 2004-01-28
HUP0000910A2 (hu) 2000-10-28
BG64367B1 (bg) 2004-12-30
CZ296700B6 (cs) 2006-05-17
CN1255057A (zh) 2000-05-31
CA2285985A1 (en) 1998-08-27
CA2285985C (en) 2008-01-29
ATE257374T1 (de) 2004-01-15
HUP0000910A3 (en) 2000-11-28
DE69821001D1 (de) 2004-02-12
DE69821001T2 (de) 2004-11-11
AU6398798A (en) 1998-09-09
DK0973505T3 (da) 2004-05-03
CZ292699A3 (cs) 2000-01-12
ZA981354B (en) 1998-08-17
JP4299369B2 (ja) 2009-07-22
PL335208A1 (en) 2000-04-10
UA63939C2 (uk) 2004-02-16
SK111199A3 (en) 2000-06-12
IL131354A0 (en) 2001-01-28
HU225594B1 (en) 2007-05-02
AR011682A1 (es) 2000-08-30
JP2001519775A (ja) 2001-10-23
US6337087B1 (en) 2002-01-08
ES2213894T3 (es) 2004-09-01
ITMI970363A1 (it) 1998-08-20
KR20000075480A (ko) 2000-12-15
IL131354A (en) 2010-06-30
EA199900750A1 (ru) 2000-04-24
AU740619B2 (en) 2001-11-08
BG103739A (en) 2000-06-30
GEP20022751B (en) 2002-08-26
TR199901987T2 (xx) 1999-11-22
EP0973505B1 (en) 2004-01-07
EA002281B1 (ru) 2002-02-28
PL190987B1 (pl) 2006-02-28
PT973505E (pt) 2004-05-31
SK282905B6 (sk) 2003-01-09
WO1998036735A1 (en) 1998-08-27

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Legal Events

Date Code Title Description
0001 Granted