IT1293807B1 - Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico - Google Patents

Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico

Info

Publication number
IT1293807B1
IT1293807B1 IT97MI001864A ITMI971864A IT1293807B1 IT 1293807 B1 IT1293807 B1 IT 1293807B1 IT 97MI001864 A IT97MI001864 A IT 97MI001864A IT MI971864 A ITMI971864 A IT MI971864A IT 1293807 B1 IT1293807 B1 IT 1293807B1
Authority
IT
Italy
Prior art keywords
phenylaminoalkyl
derivatives substituted
phenyl ring
piperazine derivatives
novel compounds
Prior art date
Application number
IT97MI001864A
Other languages
English (en)
Inventor
Amedeo Leonardi
Gianni Motta
Carlo Riva
Rodolfo Testa
Original Assignee
Recordati Chem Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT97MI001864A priority Critical patent/IT1293807B1/it
Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm
Priority to HU0004926A priority patent/HUP0004926A3/hu
Priority to CA002297095A priority patent/CA2297095A1/en
Priority to PCT/EP1998/004804 priority patent/WO1999006384A1/en
Priority to IL13408998A priority patent/IL134089A0/xx
Priority to NZ502804A priority patent/NZ502804A/xx
Priority to KR1020007001096A priority patent/KR20010022509A/ko
Priority to RU2000105266/04A priority patent/RU2199533C2/ru
Priority to PL98338352A priority patent/PL338352A1/xx
Priority to DE69820632T priority patent/DE69820632D1/de
Priority to JP2000505143A priority patent/JP2001512112A/ja
Priority to BR9811482-4A priority patent/BR9811482A/pt
Priority to AT98943815T priority patent/ATE256671T1/de
Priority to AU91578/98A priority patent/AU737456B2/en
Priority to EP98943815A priority patent/EP1000047B1/en
Priority to US09/127,057 priority patent/US6071920A/en
Priority to CN98807820A priority patent/CN1127493C/zh
Publication of ITMI971864A1 publication Critical patent/ITMI971864A1/it
Application granted granted Critical
Publication of IT1293807B1 publication Critical patent/IT1293807B1/it
Priority to NO20000521A priority patent/NO315232B1/no
Priority to US09/532,505 priority patent/US6399614B1/en
Priority to US10/132,677 priority patent/US20020193383A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
IT97MI001864A 1997-08-01 1997-08-01 Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico IT1293807B1 (it)

Priority Applications (20)

Application Number Priority Date Filing Date Title
IT97MI001864A IT1293807B1 (it) 1997-08-01 1997-08-01 Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico
BR9811482-4A BR9811482A (pt) 1997-08-01 1998-07-31 Derivados de 1-(n-fenilaminoalquil)-piperazina substituìda na posição 2 do anel fenìlico
PCT/EP1998/004804 WO1999006384A1 (en) 1997-08-01 1998-07-31 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
IL13408998A IL134089A0 (en) 1997-08-01 1998-07-31 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
NZ502804A NZ502804A (en) 1997-08-01 1998-07-31 1-(N-(2-substituted phenyl)aminoalkyl)-piperazine derivatives
KR1020007001096A KR20010022509A (ko) 1997-08-01 1998-07-31 페닐 고리의 2번 위치에서 치환된1-(ｎ-페닐아미노알킬)-피페라진 유도체
RU2000105266/04A RU2199533C2 (ru) 1997-08-01 1998-07-31 Производные 1-(n-фениламиноалкил)пиперазина и фармацевтическая композиция
PL98338352A PL338352A1 (en) 1997-08-01 1998-07-31 Derivatives of 1-(n-phenylaminoalkyl)-piperazine substituted at position 2 of its phenyl ring
DE69820632T DE69820632D1 (de) 1997-08-01 1998-07-31 2-phenyl-substituierte 1-(n-phenylaminoalkyl)-piperazin-derivate
AU91578/98A AU737456B2 (en) 1997-08-01 1998-07-31 1-(N-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
HU0004926A HUP0004926A3 (en) 1997-08-01 1998-07-31 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring, pharmaceutical compositions containing them and their use
CA002297095A CA2297095A1 (en) 1997-08-01 1998-07-31 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
JP2000505143A JP2001512112A (ja) 1997-08-01 1998-07-31 フェニル環の２位で置換された１−（ｎ−フェニルアミノアルキル）−ピペラジン誘導体
EP98943815A EP1000047B1 (en) 1997-08-01 1998-07-31 1-(n-phenylaminoalkyl)-piperazine derivatives substituted at position 2 of the phenyl ring
US09/127,057 US6071920A (en) 1997-08-01 1998-07-31 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
CN98807820A CN1127493C (zh) 1997-08-01 1998-07-31 苯环的2－位被取代的1－(n－苯氨基烷基)－哌嗪衍生物
AT98943815T ATE256671T1 (de) 1997-08-01 1998-07-31 2-phenyl-substituierte 1-(n-phenylaminoalkyl)- piperazin-derivate
NO20000521A NO315232B1 (no) 1997-08-01 2000-02-01 1-(N-fenylaminoalkyl)-piperazin derivater substituert i posisjon 2 på fenylringen, samt anvendelse derav ved fremstilling av et legemiddelfor behandling av nevromuskul¶r dysfunksjon i lavere urinveier i et pattedyr
US09/532,505 US6399614B1 (en) 1997-08-01 2000-03-21 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US10/132,677 US20020193383A1 (en) 1997-08-01 2002-04-22 1-(N-phenylalkylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT97MI001864A IT1293807B1 (it) 1997-08-01 1997-08-01 Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico

Publications (2)

Publication Number Publication Date
ITMI971864A1 ITMI971864A1 (it) 1999-02-01
IT1293807B1 true IT1293807B1 (it) 1999-03-10

Family

ID=11377708

Family Applications (1)

Application Number Title Priority Date Filing Date
IT97MI001864A IT1293807B1 (it) 1997-08-01 1997-08-01 Derivati 1- (n-fenilaminoalchil) piperazinici sostituiti alla posizione 2 dell'anello fenilico

Country Status (18)

Country Link
US (1) US6071920A (it)
EP (1) EP1000047B1 (it)
JP (1) JP2001512112A (it)
KR (1) KR20010022509A (it)
CN (1) CN1127493C (it)
AT (1) ATE256671T1 (it)
AU (1) AU737456B2 (it)
BR (1) BR9811482A (it)
CA (1) CA2297095A1 (it)
DE (1) DE69820632D1 (it)
HU (1) HUP0004926A3 (it)
IL (1) IL134089A0 (it)
IT (1) IT1293807B1 (it)
NO (1) NO315232B1 (it)
NZ (1) NZ502804A (it)
PL (1) PL338352A1 (it)
RU (1) RU2199533C2 (it)
WO (1) WO1999006384A1 (it)

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US6399614B1 (en) * 1997-08-01 2002-06-04 Recordati S.A. Chemical And Pharmaceutical Company 1-(N-phenylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
US20020193383A1 (en) * 1997-08-01 2002-12-19 Recordati S.A., Chemical And Pharmaceutical Comoany 1-(N-phenylalkylaminoalkyl)piperazine derivatives substituted at position 2 of the phenyl ring
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
CN1137878C (zh) 1997-08-04 2004-02-11 大正制药株式会社 芳氧基苯胺衍生物
UA62015C2 (en) 1998-12-28 2003-12-15 Pfizer Prod Inc Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants)
US6387909B1 (en) 1999-07-30 2002-05-14 Recordati S.A. Chemical And Pharmaceutical Company Thienopyranecarboxamide derivatives
IT1313581B1 (it) * 1999-07-30 2002-09-09 Recordati Chem Pharm Derivati tienopirancarbossamidici.
US6306861B1 (en) 1999-07-30 2001-10-23 Recordati S.A. Chemical And Pharmaceutical Company Thienopyrancecarboxamide derivatives
US6403594B1 (en) 1999-10-18 2002-06-11 Recordati, S.A. Chemical And Pharmaceutical Company Benzopyran derivatives
IT1314192B1 (it) * 1999-10-18 2002-12-06 Recordati Chem Pharm Derivati benzopiranici
KR100333500B1 (ko) * 2000-01-19 2002-04-25 박호군 아릴피페라진 화합물 및 그의 제조방법
TW200400035A (en) 2002-03-28 2004-01-01 Glaxo Group Ltd Novel compounds
CN1627946A (zh) * 2002-04-08 2005-06-15 兰贝克赛实验室有限公司 用作尿－选择性α1A肾上腺素能受体阻滞剂的羧酰亚胺衍生物
AU2003235442A1 (en) * 2002-04-12 2003-10-27 Sepracor, Inc. 3-aza- and 1,4-diaza-bicyclo(4.3.0)nonanes, and methods of use thereof
US20040072839A1 (en) * 2002-06-14 2004-04-15 Amedeo Leonardi 1-Phenylalkylpiperazines
US20040058962A1 (en) * 2002-06-14 2004-03-25 Amedeo Leonardi Phenylalkylamines and pyridylalkylamines
ITMI20030151A1 (it) * 2003-01-30 2004-07-31 Recordati Ind Chimica E Farma Ceutica S P A Uso di antagonisti selettivi del recettore mglu5 per il trattamento di disfunzioni neuromuscolari del tratto urinario inferiore.
US20040215284A1 (en) * 2003-01-30 2004-10-28 Recordati S.A. Treatment of neuromuscular dysfunction of the lower urinary tract with selective mGlu5 antagonists
TW200507841A (en) * 2003-03-27 2005-03-01 Glaxo Group Ltd Antibacterial agents
RU2241442C1 (ru) * 2003-09-17 2004-12-10 Научный центр акушерства, гинекологии и перинатологии РАМН Вагинальные суппозитории для лечения императивного недержания мочеиспускания
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
TWI391387B (zh) * 2004-05-12 2013-04-01 Eisai R&D Man Co Ltd 具有哌啶環之吲哚衍生物
US20080119518A1 (en) * 2005-02-04 2008-05-22 Yuichi Suzuki 1-(Piperidin-4- Yl)-1H-Indole Derivatives
CN101171249B (zh) 2005-05-11 2010-11-10 卫材R&D管理有限公司 制备具有哌啶环的吲哚衍生物的方法
US20080227815A1 (en) * 2005-05-11 2008-09-18 Takahisa Sakaguchi Crystal of Indole Derivative Having Piperidine Ring and Process for Production Thereof
KR20080007649A (ko) * 2005-05-11 2008-01-22 에자이 알앤드디 매니지먼트 가부시키가이샤 피페리딘환을 가지는 인돌 유도체의 결정 및 그의 제조방법
EP1880995B1 (en) 2005-05-11 2011-12-21 Eisai R&D Management Co., Ltd. Method for producing indole derivative having piperidine ring
AU2006336504C9 (en) * 2005-12-28 2015-05-14 Vertex Pharmaceuticals Incorporated 1-(benzo [D] [1,3] dioxol-5-yl) -N- (phenyl) cyclopropane- carboxamide derivatives and related compounds as modulators of ATP-Binding Cassette transporters for the treatment of Cystic Fibrosis
US7671221B2 (en) * 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
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CN113402467B (zh) * 2021-06-18 2022-05-13 山东汇海医药化工有限公司 一种氟班色林的合成方法

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EP1000047A1 (en) 2000-05-17
HUP0004926A3 (en) 2002-01-28
WO1999006384A1 (en) 1999-02-11
CN1265654A (zh) 2000-09-06
NO20000521D0 (no) 2000-02-01
IL134089A0 (en) 2001-04-30
ITMI971864A1 (it) 1999-02-01
PL338352A1 (en) 2000-10-23
US6071920A (en) 2000-06-06
EP1000047B1 (en) 2003-12-17
RU2199533C2 (ru) 2003-02-27
BR9811482A (pt) 2002-01-22
NZ502804A (en) 2001-02-23
HUP0004926A2 (hu) 2001-11-28
AU9157898A (en) 1999-02-22
NO20000521L (no) 2000-02-01
CN1127493C (zh) 2003-11-12
AU737456B2 (en) 2001-08-23
NO315232B1 (no) 2003-08-04
DE69820632D1 (de) 2004-01-29
ATE256671T1 (de) 2004-01-15
KR20010022509A (ko) 2001-03-15
CA2297095A1 (en) 1999-02-11
JP2001512112A (ja) 2001-08-21

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