IT1299263B1 - 5-aril-4-isossazolcarbonitrili 3 sostituiti ad attivita' antivirale - Google Patents

5-aril-4-isossazolcarbonitrili 3 sostituiti ad attivita' antivirale

Info

Publication number
IT1299263B1
IT1299263B1 IT98MI001072A ITMI981072A IT1299263B1 IT 1299263 B1 IT1299263 B1 IT 1299263B1 IT 98MI001072 A IT98MI001072 A IT 98MI001072A IT MI981072 A ITMI981072 A IT MI981072A IT 1299263 B1 IT1299263 B1 IT 1299263B1
Authority
IT
Italy
Prior art keywords
isossazolcarbonitrili
aril
replaced
antiviral activity
activity
Prior art date
Application number
IT98MI001072A
Other languages
English (en)
Inventor
Ernesto Geremia
Gianna Tempera
Angelo Castro
Adriana Garozzo
Francesco Guerrera
Rossella Maria Campagna
Original Assignee
Univ Catania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT98MI001072A priority Critical patent/IT1299263B1/it
Application filed by Univ Catania filed Critical Univ Catania
Priority to SI9930690T priority patent/SI1077956T1/xx
Priority to JP2000549603A priority patent/JP2002515496A/ja
Priority to AU41402/99A priority patent/AU4140299A/en
Priority to PCT/EP1999/003153 priority patent/WO1999059984A1/en
Priority to ES99924906T priority patent/ES2229711T3/es
Priority to PT99924906T priority patent/PT1077956E/pt
Priority to DK99924906T priority patent/DK1077956T3/da
Priority to US09/708,857 priority patent/US6414004B1/en
Priority to AT99924906T priority patent/ATE279400T1/de
Priority to DE69921118T priority patent/DE69921118T2/de
Priority to EP99924906A priority patent/EP1077956B1/en
Publication of ITMI981072A1 publication Critical patent/ITMI981072A1/it
Application granted granted Critical
Publication of IT1299263B1 publication Critical patent/IT1299263B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
IT98MI001072A 1998-05-15 1998-05-15 5-aril-4-isossazolcarbonitrili 3 sostituiti ad attivita' antivirale IT1299263B1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT98MI001072A IT1299263B1 (it) 1998-05-15 1998-05-15 5-aril-4-isossazolcarbonitrili 3 sostituiti ad attivita' antivirale
US09/708,857 US6414004B1 (en) 1998-05-15 1999-05-07 3-substituted 5-aryl-4-isoxazolecarbonitriles having antiviral activity
AU41402/99A AU4140299A (en) 1998-05-15 1999-05-07 3-substituted 5-aryl-4-isoxazolecarbonitriles having antiviral activity
PCT/EP1999/003153 WO1999059984A1 (en) 1998-05-15 1999-05-07 3-substituted 5-aryl-4-isoxazolecarbonitriles having antiviral activity
ES99924906T ES2229711T3 (es) 1998-05-15 1999-05-07 5-aril-4-isoxazolcarbonitrilos sustituidos en la posicion 3 con actividad antiviral.
PT99924906T PT1077956E (pt) 1998-05-15 1999-05-07 5-aril-4-isoxazolecarbonitrilos substituidos na posicao 3 com actividade antiviral
SI9930690T SI1077956T1 (en) 1998-05-15 1999-05-07 3-substituted 5-aryl-4-isoxazolecarbonitriles having antiviral activity
JP2000549603A JP2002515496A (ja) 1998-05-15 1999-05-07 抗ウイルス活性を有する３−置換５−アリール−４−イソキサゾールカルボニトリル
AT99924906T ATE279400T1 (de) 1998-05-15 1999-05-07 3-substituierte 5-aryl-4-isoxazolcarbonitrile mit antiviraler wirkung
DE69921118T DE69921118T2 (de) 1998-05-15 1999-05-07 3-substituierte 5-aryl-4-isoxazolcarbonitrile mit antiviraler wirkung
EP99924906A EP1077956B1 (en) 1998-05-15 1999-05-07 3-substituted 5-aryl-4-isoxazolecarbonitriles having antiviral activity
DK99924906T DK1077956T3 (da) 1998-05-15 1999-05-07 3-substituerede 5-aryl-4-isoxazolcarbonitriler, der har en anti-viral aktivitet

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT98MI001072A IT1299263B1 (it) 1998-05-15 1998-05-15 5-aril-4-isossazolcarbonitrili 3 sostituiti ad attivita' antivirale

Publications (2)

Publication Number Publication Date
ITMI981072A1 ITMI981072A1 (it) 1999-11-15
IT1299263B1 true IT1299263B1 (it) 2000-02-29

Family

ID=11380033

Family Applications (1)

Application Number Title Priority Date Filing Date
IT98MI001072A IT1299263B1 (it) 1998-05-15 1998-05-15 5-aril-4-isossazolcarbonitrili 3 sostituiti ad attivita' antivirale

Country Status (12)

Country Link
US (1) US6414004B1 (it)
EP (1) EP1077956B1 (it)
JP (1) JP2002515496A (it)
AT (1) ATE279400T1 (it)
AU (1) AU4140299A (it)
DE (1) DE69921118T2 (it)
DK (1) DK1077956T3 (it)
ES (1) ES2229711T3 (it)
IT (1) IT1299263B1 (it)
PT (1) PT1077956E (it)
SI (1) SI1077956T1 (it)
WO (1) WO1999059984A1 (it)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof

Also Published As

Publication number Publication date
US6414004B1 (en) 2002-07-02
DE69921118T2 (de) 2006-02-02
AU4140299A (en) 1999-12-06
ES2229711T3 (es) 2005-04-16
ATE279400T1 (de) 2004-10-15
DE69921118D1 (de) 2004-11-18
JP2002515496A (ja) 2002-05-28
SI1077956T1 (en) 2005-02-28
EP1077956B1 (en) 2004-10-13
PT1077956E (pt) 2005-01-31
ITMI981072A1 (it) 1999-11-15
WO1999059984A1 (en) 1999-11-25
EP1077956A1 (en) 2001-02-28
DK1077956T3 (da) 2005-01-31

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Legal Events

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0001 Granted