IT1319663B1 - Processo per la preparazione di fluoro-steroidi. - Google Patents

Processo per la preparazione di fluoro-steroidi.

Info

Publication number
IT1319663B1
IT1319663B1 IT2000MI002475A ITMI20002475A IT1319663B1 IT 1319663 B1 IT1319663 B1 IT 1319663B1 IT 2000MI002475 A IT2000MI002475 A IT 2000MI002475A IT MI20002475 A ITMI20002475 A IT MI20002475A IT 1319663 B1 IT1319663 B1 IT 1319663B1
Authority
IT
Italy
Prior art keywords
preparation
steroids
fluoro
alpha
formula
Prior art date
Application number
IT2000MI002475A
Other languages
English (en)
Inventor
Filippo La Loggia
Marco Da Col
Original Assignee
Farmabios Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmabios Srl filed Critical Farmabios Srl
Priority to IT2000MI002475A priority Critical patent/IT1319663B1/it
Priority to US09/858,692 priority patent/US6794503B2/en
Priority to AT01112124T priority patent/ATE374205T1/de
Priority to SI200130793T priority patent/SI1207166T1/sl
Priority to DE60130615T priority patent/DE60130615T2/de
Priority to DK01112124T priority patent/DK1207166T3/da
Priority to ES01112124T priority patent/ES2293945T3/es
Priority to PT01112124T priority patent/PT1207166E/pt
Priority to EP01112124A priority patent/EP1207166B1/en
Priority to CA002348223A priority patent/CA2348223C/en
Priority to JP2001160638A priority patent/JP4934249B2/ja
Publication of ITMI20002475A1 publication Critical patent/ITMI20002475A1/it
Application granted granted Critical
Publication of IT1319663B1 publication Critical patent/IT1319663B1/it
Priority to CY20071101620T priority patent/CY1107105T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
IT2000MI002475A 2000-11-17 2000-11-17 Processo per la preparazione di fluoro-steroidi. IT1319663B1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT2000MI002475A IT1319663B1 (it) 2000-11-17 2000-11-17 Processo per la preparazione di fluoro-steroidi.
US09/858,692 US6794503B2 (en) 2000-11-17 2001-05-16 Process for the preparation of fluorosteroids
SI200130793T SI1207166T1 (sl) 2000-11-17 2001-05-17 Postopek za pripravo 6-alfa-fluoro,9,11-beta-epoksi-steroidov
DE60130615T DE60130615T2 (de) 2000-11-17 2001-05-17 Verfahren zur Herstellung von 6-Alpha-Fluoro,9,11-Beta-Epoxy-Steroide
DK01112124T DK1207166T3 (da) 2000-11-17 2001-05-17 Fremgangsmåde til fremstilling af 6alpha-fluoro,9,11beta-epoxy-steroider
ES01112124T ES2293945T3 (es) 2000-11-17 2001-05-17 Procedimiento para la preparacion de 6alfa-fluoro-9beta,11beta-epoxiesteroides.
AT01112124T ATE374205T1 (de) 2000-11-17 2001-05-17 Verfahren zur herstellung von 6-alpha-fluoro,9,11-beta-epoxy-steroide
PT01112124T PT1207166E (pt) 2000-11-17 2001-05-17 Processo para a preparação de 6-alfa-fluoro-9,11-beta-epoxi- esteróides
EP01112124A EP1207166B1 (en) 2000-11-17 2001-05-17 Process for the preparation of 6.alpha.-fluoro,9,11.beta.-epoxy-steroids
CA002348223A CA2348223C (en) 2000-11-17 2001-05-23 Process for the preparation of fluorosteroids
JP2001160638A JP4934249B2 (ja) 2000-11-17 2001-05-29 フルオロステロイド類の製造方法
CY20071101620T CY1107105T1 (el) 2000-11-17 2007-12-20 Διαδικασια για την προετοιμασια των 6. αλφα.-φλουορο,9,11.βητα.-εποξυ-στεροειδων

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI002475A IT1319663B1 (it) 2000-11-17 2000-11-17 Processo per la preparazione di fluoro-steroidi.

Publications (2)

Publication Number Publication Date
ITMI20002475A1 ITMI20002475A1 (it) 2002-05-17
IT1319663B1 true IT1319663B1 (it) 2003-10-23

Family

ID=11446116

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI002475A IT1319663B1 (it) 2000-11-17 2000-11-17 Processo per la preparazione di fluoro-steroidi.

Country Status (12)

Country Link
US (1) US6794503B2 (it)
EP (1) EP1207166B1 (it)
JP (1) JP4934249B2 (it)
AT (1) ATE374205T1 (it)
CA (1) CA2348223C (it)
CY (1) CY1107105T1 (it)
DE (1) DE60130615T2 (it)
DK (1) DK1207166T3 (it)
ES (1) ES2293945T3 (it)
IT (1) IT1319663B1 (it)
PT (1) PT1207166E (it)
SI (1) SI1207166T1 (it)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
ES2184628B1 (es) * 2001-07-26 2005-02-01 Ragactives, S.L. Procedimiento estereoselectivo para la produccion de 6alfa-fluorpregnanos intermedios.
AU2002359523A1 (en) * 2001-11-29 2003-06-17 Taro Pharmaceuticals U.S.A., Inc. Method for the preparation of 6-alpha-fluoro corticosteroids
JP4481831B2 (ja) * 2002-12-09 2010-06-16 シコール インコーポレイティド プレグナン類の製造方法
CN100429221C (zh) * 2005-10-31 2008-10-29 浙江仙琚制药股份有限公司 皮质激素的合成方法
CN101759761B (zh) * 2008-11-28 2012-08-08 天津金耀集团有限公司 含有6α-F的甾体化合物的制备方法
CN102272304B (zh) 2009-01-07 2013-10-23 三菱化学株式会社 切断固醇侧链的酶蛋白质及其应用
ITMI20122200A1 (it) * 2012-12-20 2014-06-21 Trifarma Spa Processo per la preparazione di 6-alfa-fluoro pregnani

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838545A (en) * 1958-02-19 1958-06-10 Upjohn Co 6 alpha-fluoro-16 alpha-hydroxy steroids
US3207751A (en) * 1959-08-26 1965-09-21 Pfizer & Co C 6-fluoro-16beta-methyl corticosteroids
US2961441A (en) 1959-08-07 1960-11-22 Pfizer & Co C Process for producing 6beta-fluorosteroids
US3557158A (en) * 1962-01-22 1971-01-19 Upjohn Co 6alpha-fluoro-16-methyl - 4 - pregnene 3,20-diones and intermediates produced in the synthesis thereof
US3980778A (en) 1973-10-25 1976-09-14 The Upjohn Company Anti-inflammatory steroid
DE2655570A1 (de) * 1975-12-12 1977-06-16 Ciba Geigy Ag Neue polyhalogensteroide und verfahren zu ihrer herstellung
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
JPS606700A (ja) * 1983-06-23 1985-01-14 Mitsubishi Chem Ind Ltd 含フツ素ステロイド化合物の製法
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.

Also Published As

Publication number Publication date
DE60130615D1 (de) 2007-11-08
US6794503B2 (en) 2004-09-21
EP1207166A3 (en) 2004-12-08
DE60130615T2 (de) 2008-06-19
ES2293945T3 (es) 2008-04-01
SI1207166T1 (sl) 2008-04-30
ATE374205T1 (de) 2007-10-15
EP1207166B1 (en) 2007-09-26
CA2348223C (en) 2009-02-17
EP1207166A2 (en) 2002-05-22
JP2002155098A (ja) 2002-05-28
JP4934249B2 (ja) 2012-05-16
US20020062021A1 (en) 2002-05-23
ITMI20002475A1 (it) 2002-05-17
CY1107105T1 (el) 2012-10-24
DK1207166T3 (da) 2008-01-21
PT1207166E (pt) 2008-01-04
CA2348223A1 (en) 2002-05-17

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