IT1320162B1 - Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico. - Google Patents

Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico.

Info

Publication number: IT1320162B1
Authority: IT; Italy
Prior art keywords: group; independently; fluoro; chloro; carbon atoms
Prior art date: 2000-02-09

Application number

IT2000TO000127A

Other languages

English (en)

Inventor

Francesco Makovec

Walter Peris

Lucio Rovati

Original Assignee

Rotta Research Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-09

Filing date

2000-02-09

Publication date

2003-11-18

2000-02-09 Priority to IT2000TO000127A priority Critical patent/IT1320162B1/it

2000-02-09 Application filed by Rotta Research Lab filed Critical Rotta Research Lab

2001-02-07 Priority to US10/203,424 priority patent/US6605722B2/en

2001-02-07 Priority to AT01905744T priority patent/ATE354571T1/de

2001-02-07 Priority to DE60126745T priority patent/DE60126745T2/de

2001-02-07 Priority to JP2001558442A priority patent/JP4817577B2/ja

2001-02-07 Priority to PT01905744T priority patent/PT1255749E/pt

2001-02-07 Priority to ES01905744T priority patent/ES2282234T3/es

2001-02-07 Priority to AU33742/01A priority patent/AU776214B2/en

2001-02-07 Priority to CA002399451A priority patent/CA2399451C/en

2001-02-07 Priority to EP01905744A priority patent/EP1255749B1/en

2001-02-07 Priority to PCT/EP2001/001315 priority patent/WO2001058892A1/en

2001-08-09 Publication of ITTO20000127A1 publication Critical patent/ITTO20000127A1/it

2003-11-18 Application granted granted Critical

2003-11-18 Publication of IT1320162B1 publication Critical patent/IT1320162B1/it

Links

238000000034 method Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000004432 carbon atom Chemical group C* 0.000 abstract 3
125000001309 chloro group Chemical group Cl* 0.000 abstract 3
125000001153 fluoro group Chemical group F* 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
125000004093 cyano group Chemical group *C#N 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
125000005390 cinnolyl group Chemical group N1=NC(=CC2=CC=CC=C12)* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
-1 cyano, amino Chemical group 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Quinoline Compounds (AREA)
Medicinal Preparation (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

IT2000TO000127A 2000-02-09 2000-02-09 Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico. IT1320162B1 (it)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
IT2000TO000127A IT1320162B1 (it)	2000-02-09	2000-02-09	Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico.
AT01905744T ATE354571T1 (de)	2000-02-09	2001-02-07	Tyrosin derivate mit leukotriene antagonistischer wirkung
DE60126745T DE60126745T2 (de)	2000-02-09	2001-02-07	Tyrosin derivate mit leukotriene antagonistischer wirkung
JP2001558442A JP4817577B2 (ja)	2000-02-09	2001-02-07	抗ロイコトリエン活性を持つチロシン誘導体
US10/203,424 US6605722B2 (en)	2000-02-09	2001-02-07	Tyrosine derivatives with anti-leukotrienen activity
PT01905744T PT1255749E (pt)	2000-02-09	2001-02-07	Derivados de tirosina com actividade anti-leucotrieno
ES01905744T ES2282234T3 (es)	2000-02-09	2001-02-07	Derivados de la tirosina con actividad anti-leucotrienos.
AU33742/01A AU776214B2 (en)	2000-02-09	2001-02-07	Tyrosine derivatives with anti-leukotriene activity
CA002399451A CA2399451C (en)	2000-02-09	2001-02-07	Tyrosine derivatives with anti-leukotriene activity
EP01905744A EP1255749B1 (en)	2000-02-09	2001-02-07	Tyrosine derivatives with anti-leukotriene activity
PCT/EP2001/001315 WO2001058892A1 (en)	2000-02-09	2001-02-07	Tyrosine derivatives with anti-leukotriene activity

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000TO000127A IT1320162B1 (it)	2000-02-09	2000-02-09	Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico.

Publications (2)

Publication Number	Publication Date
ITTO20000127A1 ITTO20000127A1 (it)	2001-08-09
IT1320162B1 true IT1320162B1 (it)	2003-11-18

Family

ID=11457397

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT2000TO000127A IT1320162B1 (it)	2000-02-09	2000-02-09	Derivati della tirosina ad attivita' anti leucotrienica, procedimentoper la loro preparazione e loro uso farmaceutico.

Country Status (11)

Country	Link
US (1)	US6605722B2 (it)
EP (1)	EP1255749B1 (it)
JP (1)	JP4817577B2 (it)
AT (1)	ATE354571T1 (it)
AU (1)	AU776214B2 (it)
CA (1)	CA2399451C (it)
DE (1)	DE60126745T2 (it)
ES (1)	ES2282234T3 (it)
IT (1)	IT1320162B1 (it)
PT (1)	PT1255749E (it)
WO (1)	WO2001058892A1 (it)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2001261654A (ja) *	2000-03-21	2001-09-26	Mitsui Chemicals Inc	キノリン誘導体およびそれを有効成分として含有する核内レセプター作動薬
AU2003284001A1 (en) *	2002-10-07	2004-05-04	Bristol-Myers Squibb Company	Triazolone and triazolethione derivatives
KR100932169B1 (ko)	2003-06-06	2009-12-16	피브로겐, 인크.	질소-함유 헤테로아릴 화합물 및 내인성 적혈구생성소의증가에서의 그들의 사용
WO2007090068A2 (en)	2006-01-27	2007-08-09	Fibrogen, Inc.	Cyanoisoquinoline compounds that stabilize hypoxia inducible factor (hif)
EP2016078B1 (en)	2006-04-04	2016-06-15	Fibrogen, Inc.	Pyrrolo- and thiazolo-pyridine compounds as hif modulators
US7687705B2 (en) *	2006-04-10	2010-03-30	Alabama A&M University Institute	Efficient thermoelectric device
CN102272117B (zh)	2008-11-14	2015-06-17	菲布罗根有限公司	作为hif羟化酶抑制剂的苯并噻喃衍生物
SG11201405574UA (en)	2012-03-09	2014-10-30	Fibrogen Inc	4 -hydroxy- isoquinoline compounds as hif hydroxylase inhibitors
US8883823B2 (en)	2012-07-16	2014-11-11	Fibrogen, Inc.	Crystalline forms of a prolyl hydroxylase inhibitor
US9340511B2 (en)	2012-07-16	2016-05-17	Fibrogen, Inc.	Process for making isoquinoline compounds
US9115085B2 (en)	2012-07-16	2015-08-25	Fibrogen, Inc.	Crystalline forms of a prolyl hydroxylase inhibitor
WO2014116849A1 (en)	2013-01-24	2014-07-31	Fibrogen, Inc.	Crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid
CN109996541A (zh) *	2016-09-07	2019-07-09	普利安特治疗公司	N-酰基氨基酸化合物及其使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1261835A (en)	1984-08-20	1989-09-26	Masaaki Toda	(fused) benz(thio)amides
GB8607294D0 (en)	1985-04-17	1986-04-30	Ici America Inc	Heterocyclic amide derivatives
IL89713A0 (en)	1988-03-29	1989-09-28	Ciba Geigy Ag	Novel alkanophenones
CA2053209C (en)	1990-10-12	1998-12-08	Michel L. Belley	Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
US5508408A (en)	1993-09-10	1996-04-16	Ciba-Geigy Corporation	Quinoline compound
ES2103180B1 (es)	1994-08-01	1998-04-01	Menarini Lab	Fenilacetamidas con accion antagonista de los leucotrienos.
AU5347496A (en)	1995-04-21	1996-11-07	Daiichi Pharmaceutical Co., Ltd.	Ethynylthiazole derivative
DE19823722A1 (de)	1998-05-27	1999-12-02	Merckle Gmbh	Chinolinylmethoxyaryl-Verbindungen als duale Inhibitoren der Cyclooxygenase und 5-Lipoxygenase

2000
- 2000-02-09 IT IT2000TO000127A patent/IT1320162B1/it active
2001
- 2001-02-07 ES ES01905744T patent/ES2282234T3/es not_active Expired - Lifetime
- 2001-02-07 WO PCT/EP2001/001315 patent/WO2001058892A1/en not_active Ceased
- 2001-02-07 CA CA002399451A patent/CA2399451C/en not_active Expired - Fee Related
- 2001-02-07 AT AT01905744T patent/ATE354571T1/de not_active IP Right Cessation
- 2001-02-07 JP JP2001558442A patent/JP4817577B2/ja not_active Expired - Fee Related
- 2001-02-07 US US10/203,424 patent/US6605722B2/en not_active Expired - Fee Related
- 2001-02-07 PT PT01905744T patent/PT1255749E/pt unknown
- 2001-02-07 DE DE60126745T patent/DE60126745T2/de not_active Expired - Lifetime
- 2001-02-07 AU AU33742/01A patent/AU776214B2/en not_active Ceased
- 2001-02-07 EP EP01905744A patent/EP1255749B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP4817577B2 (ja)	2011-11-16
ITTO20000127A1 (it)	2001-08-09
AU776214B2 (en)	2004-09-02
US6605722B2 (en)	2003-08-12
AU3374201A (en)	2001-08-20
US20030087910A1 (en)	2003-05-08
EP1255749A1 (en)	2002-11-13
ATE354571T1 (de)	2007-03-15
WO2001058892A1 (en)	2001-08-16
JP2003522768A (ja)	2003-07-29
CA2399451C (en)	2009-09-22
ES2282234T3 (es)	2007-10-16
PT1255749E (pt)	2007-05-31
DE60126745D1 (de)	2007-04-05
DE60126745T2 (de)	2007-10-31
EP1255749B1 (en)	2007-02-21
CA2399451A1 (en)	2001-08-16

Publication	Publication Date	Title
KR950704313A (ko)	1995-11-17	5-아릴인돌 유도체 및 세로토닌(5-ht₁)작용물질로서의 그의 용도(5-arylindole derivatives and their use as serotonin(5-ht₁)agonists)
EA200201056A1 (ru)	2003-04-24	Новые, обладающие продолжительным действием бетамиметики, способ их получения и их применение в качестве лекарственных средств
HUP0100615A2 (hu)	2001-10-28	Szubsztituált 2-(2,6-dioxo-3-fluoro-piperidin-3-il)-izoindolinok és ezek alkalmazása TNFalfa-szint csökkentésére
MY140012A (en)	2009-11-30	Heterocylic substituted phenyl methanones
ATE88182T1 (de)	1993-04-15	Antidepressive n-substitierte nikotinamidverbindungen.
EA199901062A1 (ru)	2000-08-28	Производные хинолин-4-карбоксамида как антагонисты рецепторов нк-2 и нк-3
ATE354571T1 (de)	2007-03-15	Tyrosin derivate mit leukotriene antagonistischer wirkung
DE60008917D1 (de)	2004-04-15	Neue 1,8-naphtyridin-2(1h)-on-derivate
ATE182889T1 (de)	1999-08-15	Bicyclische amidinderivate als no-synthetase inhibitoren
EA199800987A1 (ru)	1999-06-24	Бензоксазиноновые антагонисты рецептора допамина d4
ATE348813T1 (de)	2007-01-15	Chinolinderivate als nk-2 und nk-3 rezeptor- liganden
MXPA04003278A (es)	2004-07-23	Derivados de 5-metoxi-8-aril-?1,2,4?triazolo?1,5-a?piridina como antagonistas del receptor de adenosina.
DK1430034T3 (da)	2005-05-30	Substituerede alkylaminopyridazinonderivater, fremgangsmåde til fremstilling deraf og en farmaceutisk sammensætning indeholdende disse
DE69914803D1 (de)	2004-03-18	Benzoxazol-derivate zur verwendung als integrin-inhibitoren
EA200500237A1 (ru)	2005-10-27	Новый способ синтеза соединений 1,3-дигидро-2h-3-бензазепин-2-она и применение при синтезе ивабрадина и его солей присоединения с фармацевтически приемлемой кислотой
MY133207A (en)	2007-10-31	Substituted benzolactam compaunds
AU2925799A (en)	1999-08-23	2-aminoquinoline derivatives having d4-agonistic activity
HUP9800889A1 (hu)	2000-11-28	Új naftil-piperazin-származékok
BR9812928A (pt)	2000-08-08	Novos derivados de 3-oxo-(2h) -1,2,4-triazina, processo de preparação de compostos quìmicos, e, composição farmacêutica
BR9807701A (pt)	2000-05-02	Derivados de 4-aminoalcóxi-1h-benzimidazol, seu preparo e seu uso como agonistas do auto-receptor (d2) de dopamina
BR9807840A (pt)	2000-09-19	Derivados de 4-aminoalcóxi-1,3-dihidrobenzoimidazol-2-tionas, sua preparação e seu uso como agonistas de auto-receptor de dopamina (d2)