IT1404145B1 - Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi - Google Patents

Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi

Info

Publication number: IT1404145B1
Authority: IT; Italy
Prior art keywords: enzymes; degradation; compositions; heat; hyaluronic acid
Prior art date: 2010-12-27

Application number

ITMI2010A002404A

Other languages

English (en)

Inventor

Stefano Togni

Carlo Vernasca

Andrea Maria Giori

Original Assignee

Altergon Sa

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-12-27

Filing date

2010-12-27

Publication date

2013-11-15

2010-12-27 Priority to ITMI2010A002404A priority Critical patent/IT1404145B1/it

2010-12-27 Application filed by Altergon Sa, Indena Spa filed Critical Altergon Sa

2011-12-16 Priority to CA2823052A priority patent/CA2823052A1/en

2011-12-16 Priority to PCT/EP2011/073079 priority patent/WO2012089537A1/en

2011-12-16 Priority to CN2011800628689A priority patent/CN103314047A/zh

2011-12-16 Priority to US13/976,113 priority patent/US20140094430A1/en

2011-12-16 Priority to KR1020137016624A priority patent/KR20130132503A/ko

2011-12-16 Priority to RU2013129206/05A priority patent/RU2013129206A/ru

2011-12-16 Priority to JP2013546659A priority patent/JP2014506876A/ja

2011-12-16 Priority to AU2011351661A priority patent/AU2011351661A1/en

2011-12-16 Priority to EP11799424.4A priority patent/EP2658914A1/en

2011-12-16 Priority to BR112013018745A priority patent/BR112013018745A2/pt

2012-06-28 Publication of ITMI20102404A1 publication Critical patent/ITMI20102404A1/it

2013-11-15 Application granted granted Critical

2013-11-15 Publication of IT1404145B1 publication Critical patent/IT1404145B1/it

Links

KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title 1
102000004190 Enzymes Human genes 0.000 title 1
108090000790 Enzymes Proteins 0.000 title 1
230000015556 catabolic process Effects 0.000 title 1
238000006731 degradation reaction Methods 0.000 title 1
229920002674 hyaluronan Polymers 0.000 title 1
229960003160 hyaluronic acid Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/505—Stabilizers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Oral & Maxillofacial Surgery (AREA)
Transplantation (AREA)
Polymers & Plastics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Dispersion Chemistry (AREA)
Inorganic Chemistry (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Ophthalmology & Optometry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Materials For Medical Uses (AREA)
Compositions Of Macromolecular Compounds (AREA)

ITMI2010A002404A 2010-12-27 2010-12-27 Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi IT1404145B1 (it)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
ITMI2010A002404A IT1404145B1 (it)	2010-12-27	2010-12-27	Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi
PCT/EP2011/073079 WO2012089537A1 (en)	2010-12-27	2011-12-16	Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
CN2011800628689A CN103314047A (zh)	2010-12-27	2011-12-16	对热或酶的降解作用稳定的透明质酸组合物
US13/976,113 US20140094430A1 (en)	2010-12-27	2011-12-16	Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
CA2823052A CA2823052A1 (en)	2010-12-27	2011-12-16	Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
KR1020137016624A KR20130132503A (ko)	2010-12-27	2011-12-16	열 또는 효소의 분해 효과에 대해 안정화된 히알루론산 조성물
RU2013129206/05A RU2013129206A (ru)	2010-12-27	2011-12-16	Композиции гиалуроновой кислоты, стабилизированные против разрушающего действия тепла или ферментов
JP2013546659A JP2014506876A (ja)	2010-12-27	2011-12-16	熱または酵素の分解作用に対して安定化されたヒアルロン酸組成物
AU2011351661A AU2011351661A1 (en)	2010-12-27	2011-12-16	Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
EP11799424.4A EP2658914A1 (en)	2010-12-27	2011-12-16	Hyaluronic acid compositions stabilised against the degrading effect of heat or enzymes
BR112013018745A BR112013018745A2 (pt)	2010-12-27	2011-12-16	composições de ácido hialurônico estabilizadas contra o efeito de degradação de calor ou de enzimas

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITMI2010A002404A IT1404145B1 (it)	2010-12-27	2010-12-27	Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi

Publications (2)

Publication Number	Publication Date
ITMI20102404A1 ITMI20102404A1 (it)	2012-06-28
IT1404145B1 true IT1404145B1 (it)	2013-11-15

Family

ID=43737057

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ITMI2010A002404A IT1404145B1 (it)	2010-12-27	2010-12-27	Composizioni di acido ialuronico stabilizzate verso l'azione di degradazione del calore o degli enzimi

Country Status (11)

Country	Link
US (1)	US20140094430A1 (it)
EP (1)	EP2658914A1 (it)
JP (1)	JP2014506876A (it)
KR (1)	KR20130132503A (it)
CN (1)	CN103314047A (it)
AU (1)	AU2011351661A1 (it)
BR (1)	BR112013018745A2 (it)
CA (1)	CA2823052A1 (it)
IT (1)	IT1404145B1 (it)
RU (1)	RU2013129206A (it)
WO (1)	WO2012089537A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1402382B1 (it) †	2010-09-09	2013-09-04	Ibsa Inst Biochimique Sa	Complessi cooperativi ibridi di acido ialuronico
ITMI20130221A1 (it) *	2013-02-18	2014-08-19	Novagenit S R L	Formulazione a base di polisaccaridi biocompatibili e biodegradabili da impiegare in chirurgia
TW201609145A (zh) *	2013-12-25	2016-03-16	參天製藥股份有限公司	注射劑及形成緩釋（ｄｅｐｏｔ）之方法
KR102336699B1 (ko)	2015-02-23	2021-12-08	주식회사 파마리서치	소듐 2-메르캅토에탄 설포네이트를 함유하는 히알루론산의 분해억제제 및 이를 포함하는 조성물
KR102329495B1 (ko)	2015-02-23	2021-11-24	주식회사 파마리서치	소듐 2-메르캅토에탄 설포네이트를 삼투압 조절제로서 함유하는 생체투여 또는 미용성형용 생분해성 고분자 조성물
MX2021000665A (es) *	2018-07-18	2021-03-25	Atg 20 S R L	Composicion que comprende glicirrina y usos cosmeticos y farmaceuticos de la misma.
IT202000022042A1 (it) *	2020-09-18	2022-03-18	Ricerfarma Srl	Composizioni topiche antivirali comprendenti acido ialuronico e carragenina
IT202100013787A1 (it) *	2021-05-27	2022-11-27	Farmigea Spa	Composizione per l’uso nel trattamento di affezioni oculari, quali sindrome dell’occhio secco, specialmente post-chirurgico oftalmico / a composition for use in the treatment of ocular affections, such as dry eye disease, especially after eye surgery
CN113831551B (zh) *	2021-10-13	2023-04-21	江苏集萃新型药物制剂技术研究所有限公司	水基分散体系

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US5612321A (en) *	1995-06-22	1997-03-18	Hercules Incorporated	Antioxidant grafted polysaccharides
JP3807782B2 (ja) *	1995-06-22	2006-08-09	ライオン株式会社	ヒアルロニダーゼ阻害剤
JPH1180004A (ja) *	1997-09-01	1999-03-23	Kanebo Ltd	ヒアルロン酸分解阻害剤、ヒアルロン酸異常分解疾患改善・治療剤、及び歯肉炎防止剤、並びに乾燥肌又は荒れ肌防止剤
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JP2003342166A (ja) *	2002-05-29	2003-12-03	Japan Science & Technology Corp	眼内疾患用製剤
FR2850282B1 (fr) *	2003-01-27	2007-04-06	Jerome Asius	Implant injectable a base de ceramique pour le comblement de rides, depressions cutanees et cicatrices, et sa preparation
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ITPD20060202A1 (it) *	2006-05-22	2007-11-23	Univ Degli Studi Trieste	Miscele polimeriche di polisaccaridi anionici e cationici e loro impiego
JP5254572B2 (ja) *	2007-06-22	2013-08-07	エステー株式会社	精製カラギーナン及びその製造方法
US20090087569A1 (en) *	2007-09-27	2009-04-02	Fenchem Enterprises Ltd.	Methods for Preparing Highly Stable Hyaluronic Acid
ITRM20070510A1 (it) *	2007-10-02	2009-04-03	Rmfa Trading S A	Composizioni oftalmiche a base di polisaccaride del seme di tamarindo e acido ialuronico.
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2010
- 2010-12-27 IT ITMI2010A002404A patent/IT1404145B1/it active
2011
- 2011-12-16 KR KR1020137016624A patent/KR20130132503A/ko not_active Withdrawn
- 2011-12-16 RU RU2013129206/05A patent/RU2013129206A/ru not_active Application Discontinuation
- 2011-12-16 US US13/976,113 patent/US20140094430A1/en not_active Abandoned
- 2011-12-16 JP JP2013546659A patent/JP2014506876A/ja active Pending
- 2011-12-16 BR BR112013018745A patent/BR112013018745A2/pt not_active IP Right Cessation
- 2011-12-16 CA CA2823052A patent/CA2823052A1/en not_active Abandoned
- 2011-12-16 CN CN2011800628689A patent/CN103314047A/zh active Pending
- 2011-12-16 EP EP11799424.4A patent/EP2658914A1/en not_active Withdrawn
- 2011-12-16 WO PCT/EP2011/073079 patent/WO2012089537A1/en not_active Ceased
- 2011-12-16 AU AU2011351661A patent/AU2011351661A1/en not_active Abandoned

Also Published As

Publication number	Publication date
BR112013018745A2 (pt)	2016-10-25
EP2658914A1 (en)	2013-11-06
US20140094430A1 (en)	2014-04-03
RU2013129206A (ru)	2015-01-10
WO2012089537A1 (en)	2012-07-05
JP2014506876A (ja)	2014-03-20
KR20130132503A (ko)	2013-12-04
ITMI20102404A1 (it)	2012-06-28
AU2011351661A1 (en)	2013-07-11
CN103314047A (zh)	2013-09-18
CA2823052A1 (en)	2012-07-05

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