IT8119321A0 - Procedimento per ottenere eparine di basso peso molecolare dotate di proprieta' farmacologiche elevate, e prodotto cosi' ottenuto. - Google Patents

Procedimento per ottenere eparine di basso peso molecolare dotate di proprieta' farmacologiche elevate, e prodotto cosi' ottenuto.

Info

Publication number
IT8119321A0
IT8119321A0 IT8119321A IT1932181A IT8119321A0 IT 8119321 A0 IT8119321 A0 IT 8119321A0 IT 8119321 A IT8119321 A IT 8119321A IT 1932181 A IT1932181 A IT 1932181A IT 8119321 A0 IT8119321 A0 IT 8119321A0
Authority
IT
Italy
Prior art keywords
procedure
molecular weight
low molecular
product obtained
pharmacological properties
Prior art date
Application number
IT8119321A
Other languages
English (en)
Other versions
IT1141954B (it
Inventor
Fussi Fernando
Original Assignee
Hepar Ind Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hepar Ind Inc filed Critical Hepar Ind Inc
Publication of IT8119321A0 publication Critical patent/IT8119321A0/it
Application granted granted Critical
Publication of IT1141954B publication Critical patent/IT1141954B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
IT19321/81A 1980-01-28 1981-01-26 Procedimento per ottenere eparine di basso peso molecolare dotate di proprieta' farmacologiche elevate,e prodotto cosi' ottenuto IT1141954B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11577880A 1980-01-28 1980-01-28
US06/155,674 US4281108A (en) 1980-01-28 1980-06-02 Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained

Publications (2)

Publication Number Publication Date
IT8119321A0 true IT8119321A0 (it) 1981-01-26
IT1141954B IT1141954B (it) 1986-10-08

Family

ID=26813554

Family Applications (1)

Application Number Title Priority Date Filing Date
IT19321/81A IT1141954B (it) 1980-01-28 1981-01-26 Procedimento per ottenere eparine di basso peso molecolare dotate di proprieta' farmacologiche elevate,e prodotto cosi' ottenuto

Country Status (7)

Country Link
US (1) US4281108A (it)
DE (1) DE3102621A1 (it)
DK (1) DK168297B1 (it)
FR (1) FR2474508B1 (it)
GB (1) GB2068011B (it)
IT (1) IT1141954B (it)
NL (1) NL189043C (it)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2619136A (en) * 1950-07-10 1952-11-25 John D Nash Rectangular framework clamp
US2670773A (en) * 1950-12-18 1954-03-02 Edward L Avery Concrete form clamp and anchor holder
US3262595A (en) * 1963-09-27 1966-07-26 Johns Manville Lift truck clamp attachment
DE2827772C3 (de) * 1978-06-24 1981-02-26 Peter Strasser Rahmenspannvorrichtung für die Herstellung rechteckiger Rahmen, insbesondere Bilderrahmen
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
USRE35770E (en) * 1978-11-06 1998-04-14 Choay, S.A. Oligosaccharides having anti-Xa activity and pharmaceutical compositions containing them
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
US4438261A (en) 1980-05-19 1984-03-20 Riker Laboratories, Inc. Anticoagulant substance
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
ZA829463B (en) * 1982-07-19 1983-10-26 Hepar Ind Inc Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
DE3236578A1 (de) * 1982-10-02 1984-04-26 Bessey & Sohn Gmbh & Co, 7000 Stuttgart Rahmenspanngeraet
FR2538404B1 (it) * 1982-12-28 1985-08-23 Anic Spa
US4533549A (en) * 1983-01-04 1985-08-06 Lasker Sigmund E Antithrombotic agent
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
FR2543145B1 (fr) * 1983-03-24 1986-10-17 Sanofi Sa Nouveaux sulfates de xylanes, leur procede de preparation et leur activite anti-thrombotique et hypolipemiante
FR2553287B1 (fr) * 1983-10-18 1986-09-12 Choay Sa Compositions a base de mucopolysaccharides ou d'oligosaccharides, notamment a base de fractions ou fragments d'heparine, appropriees au traitement de desordres de la proliferation cellulaire
IT1214609B (it) * 1985-05-17 1990-01-18 Opocrin Spa Esosaminoglicani solfati depolimerizzati ad attivita'antitrombotica, fibrinolitica, antinfiammatoria, loro procedimento di preparazione e composizioni farmaceutiche che li contengono.
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
US4745105A (en) * 1986-08-20 1988-05-17 Griffin Charles C Low molecular weight heparin derivatives with improved permeability
US4745107A (en) * 1986-08-20 1988-05-17 Foley Kevin M Heparin derivatives with improved permeability
US4942156A (en) * 1986-08-20 1990-07-17 Hepar Industries, Inc. Low molecular weight heparin derivatives having improved anti-Xa specificity
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
SK120193A3 (en) * 1991-05-02 1994-07-06 Yeda Res & Dev Pharmaceutical composition for the prevention and/or treatment of pathological processes
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5744457A (en) * 1995-03-31 1998-04-28 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US5763427A (en) * 1995-03-31 1998-06-09 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
US6217863B1 (en) 1995-10-30 2001-04-17 Massachusetts Institute Of Technology Rationally designed polysaccharide lyases derived from heparinase I
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
JP2003527822A (ja) * 1998-08-27 2003-09-24 マサチューセッツ インスティテュート オブ テクノロジー ヘパリナーゼｉおよびｉｉ由来の合理的に設計されたヘパリナーゼ
US7056504B1 (en) 1998-08-27 2006-06-06 Massachusetts Institute Of Technology Rationally designed heparinases derived from heparinase I and II
CA2370539C (en) * 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
CA2402160C (en) * 2000-03-08 2012-02-14 Massachusetts Institute Of Technology Heparinase iii and uses thereof
KR20000053816A (ko) * 2000-04-20 2000-09-05 조석형 저분자 다당류 및 그의 올리고당 제조방법
DE60138115D1 (de) * 2000-09-12 2009-05-07 Massachusetts Inst Technology Verfahren und produkte, die mit niedermolekularem heparin assoziiert sind
AU2002224408B2 (en) * 2000-10-18 2007-08-23 Massachusetts Institute Of Technology Methods and products related to pulmonary delivery of polysaccharides
US7084118B2 (en) 2002-02-22 2006-08-01 Genentech, Inc. Combination treatment with t-PA variant and low molecular weight heparin
US20040122354A1 (en) * 2002-09-05 2004-06-24 Semba Charles P. Infusion catheter having an integrated doppler transducer
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
CA3144968A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB867064A (en) * 1959-05-16 1961-05-03 Roussel Uclaf New derivatives of heparin and processes for their production
NL286444A (it) * 1961-12-08
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche

Also Published As

Publication number Publication date
DE3102621C2 (it) 1992-08-06
NL189043B (nl) 1992-07-16
FR2474508B1 (fr) 1986-03-07
DE3102621A1 (de) 1981-12-10
DK36881A (da) 1981-07-29
IT1141954B (it) 1986-10-08
NL8100354A (nl) 1981-08-17
DK168297B1 (da) 1994-03-07
FR2474508A1 (fr) 1981-07-31
US4281108A (en) 1981-07-28
GB2068011B (en) 1983-07-27
NL189043C (nl) 1992-12-16
GB2068011A (en) 1981-08-05

Similar Documents

Publication Publication Date Title
IT8119321A0 (it) Procedimento per ottenere eparine di basso peso molecolare dotate di proprieta' farmacologiche elevate, e prodotto cosi' ottenuto.
ES510572A0 (es) "procedimiento para tenir en masa material organico de peso molecular alto".
ES486263A0 (es) Un procedimiento para purificar proteinas con pesos moleculares superiores a 12.000,en particular interferon
FI864925A7 (fi) Komposition, i vilken de hydrofoba delarna associeras och vilken innehaoller en polymer av en vattenloeslig monomer och en amfifil monomer.
NL191789C (nl) Acetylaminoalkaansulfonzuurderivaten met farmacologische eigenschappen.
IT7919927A0 (it) Procedimento per produrre carbone di elevata resistenza fisica e bassa formazione di polvere eprodotto ottenuto.
FI872808A7 (fi) Uudet tooppisesti annostettavat farmaseuttiset koostumukset, joilla on systeeminen vaikutus.
BE783044A (fr) Nouvelles thieno(3,2-d) pyrimidines
IT1145403B (it) Derivati di 1,2-diidro-2-osso-4-fenil-3-chinolin-carbonitrile dotati di proprieta' anti-infiammatorie
NL7806208A (nl) 7 alfa-methoxy-7 beta-(1,3-dithietan-2-carboxamide) ce- falosporanzuurderivaten en de bereiding, alsmede de toepassing ervan.
IT8020294A0 (it) Basso peso molecolare. copolimeri isocianato-acrilici di
DE3853920D1 (de) Gegossenes polymer mit hohem widerstand gegen wärmeschocks.
IT8424162A0 (it) Produzione di idrotalcite dotata di proprieta' migliorate.
IT7927503A0 (it) Derivati del progesterone adattivita' anti-acne e anti-seborrea.
DE3576960D1 (de) Fluorelastomer mit hohem molekulargewicht.
ES2069543T3 (es) Procedimiento para la obtencion de poliglicoleteres cerrados en los grupos terminales.
IT1164906B (it) Derivati indolici dotati di proprieta' farmacologiche
ES2024503B3 (es) Mejoras en, o relacionadas con, el reforzamiento del terreno.
ATE85185T1 (de) 1,4-naphthochinonderivate enthaltende rodentizide zusammensetzungen.
JPS5438389A (en) Preparation of highly crystalline polyolefin
FR2358403A1 (fr) Nouveaux 2-imino-1,3-benzodithiolannes utiles notamment comme anti-inflammatoires
JPS5312804A (en) Preparation of halohydrin and glycol
IT8619830A0 (it) Eparine "fast moving", procedimento di preparazione e loro proprieta'farmaceutiche.
IT7830738A0 (it) Nuove 2-fenilammino-imidazoline-(2) sostituite, dotate di particolari proprieta' terapeutiche, loro processo di sintesi e composizioni farmaceutiche.
児玉実英 The East-West Review, Vol. Ill, No. 3.

Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960129