IT8123602A0 - Sali stabili della s-adenosilmetionina, processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo. - Google Patents

Sali stabili della s-adenosilmetionina, processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo.

Info

Publication number: IT8123602A0
Authority: IT; Italy
Prior art keywords: adenosylmethionine; preparation; active ingredient; therapeutic compositions; stable salts
Prior art date: 1981-08-24

Application number

IT8123602A

Other languages

English (en)

Other versions

IT1137640B (it

Inventor

Federico Gennari

Original Assignee

Bioresearch Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-08-24

Filing date

1981-08-24

Publication date

1981-08-24

1981-08-24 Application filed by Bioresearch Srl filed Critical Bioresearch Srl

1981-08-24 Priority to IT23602/81A priority Critical patent/IT1137640B/it

1981-08-24 Publication of IT8123602A0 publication Critical patent/IT8123602A0/it

1982-08-12 Priority to EP82107334A priority patent/EP0072980B1/en

1982-08-12 Priority to DE8282107334T priority patent/DE3267039D1/de

1982-08-12 Priority to AT82107334T priority patent/ATE16191T1/de

1982-08-16 Priority to US06/408,683 priority patent/US4465672A/en

1982-08-24 Priority to JP57145583A priority patent/JPS5843996A/ja

1986-09-10 Application granted granted Critical

1986-09-10 Publication of IT1137640B publication Critical patent/IT1137640B/it

Links

MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical class O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 title 1
239000004480 active ingredient Substances 0.000 title 1
229960001570 ademetionine Drugs 0.000 title 1
239000000203 mixture Substances 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

IT23602/81A 1981-08-24 1981-08-24 Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo IT1137640B (it)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
IT23602/81A IT1137640B (it)	1981-08-24	1981-08-24	Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo
EP82107334A EP0072980B1 (en)	1981-08-24	1982-08-12	Stable s-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle
DE8282107334T DE3267039D1 (en)	1981-08-24	1982-08-12	Stable s-adenosylmethionine salts, the process for their preparation and therapeutic compositions which contain them as active principle
AT82107334T ATE16191T1 (de)	1981-08-24	1982-08-12	Stabile salze von s-adenosinylmethionin, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen welche als aktive substanz diese derivate enthalten.
US06/408,683 US4465672A (en)	1981-08-24	1982-08-16	Stable S-adenosylmethionine salts, the process for their preparation, and therapeutic compositions which contain them as active principle
JP57145583A JPS5843996A (ja)	1981-08-24	1982-08-24	安定なｓ−アデノシルメチオニン塩、それらの製造法及び活性成分としてこれらを含む治療組成物

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT23602/81A IT1137640B (it)	1981-08-24	1981-08-24	Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo

Publications (2)

Publication Number	Publication Date
IT8123602A0 true IT8123602A0 (it)	1981-08-24
IT1137640B IT1137640B (it)	1986-09-10

Family

ID=11208476

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT23602/81A IT1137640B (it)	1981-08-24	1981-08-24	Sali stabili della s-adenosilmetionina,processo per la loro preparazione e composizioni terapeutiche che li comprendono come principio attivo

Country Status (6)

Country	Link
US (1)	US4465672A (it)
EP (1)	EP0072980B1 (it)
JP (1)	JPS5843996A (it)
AT (1)	ATE16191T1 (it)
DE (1)	DE3267039D1 (it)
IT (1)	IT1137640B (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1169773B (it) *	1983-08-24	1987-06-03	Bioresearch Spa	Processo per la produzione di sali stabili della solfo-adenosil-l-metionina
IT1177373B (it) *	1984-12-06	1987-08-26	Bioresearch Spa	Sali della 5'-metiltio-5'-deossiadenosina con acidi solfonici a lunga catena alchilica
US4894454A (en) *	1986-08-07	1990-01-16	Medice Chem.-Pharm. Fabrik, Putter Gmbh & Co., Kg	Pharmaceutical preparations
WO1989003389A1 (en) *	1987-10-09	1989-04-20	Vincenzo Zappia	Lipophilic salts of s-adenosyl-l-methionine (sam) with acylated taurine derivatives
FR2623396B1 (fr) *	1987-11-25	1990-03-30	Sanofi Sa	Utilisation de l'ademetionine contre le vieillissement de la peau
IT1229477B (it) *	1989-03-13	1991-09-03	Bioresearch Spa	Impiego di 5' deossi - 5' metiltioadenosina, s adenosilmetionina e dei loro sali per la preparazione di composizioni farmaceutiche atte a ridurre la seborrea e composizioni farmaceutiche relative
JPH02290896A (ja) *	1989-04-28	1990-11-30	Fuji Kagaku Kogyo Kk	新規なｓ―アデノシルメチオニン誘導体
US6492349B1 (en)	1993-03-31	2002-12-10	Nutramax Laboratories, Inc.	Aminosugar and glycosaminoglycan composition for the treatment and repair of connective tissue
WO1996033703A2 (en)	1995-04-25	1996-10-31	Oridigm Corporation	S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US6020139A (en) *	1995-04-25	2000-02-01	Oridigm Corporation	S-adenosyl methionine regulation of metabolic pathways and its use in diagnosis and therapy
US6255295B1 (en)	1996-12-23	2001-07-03	Nutramax Laboratories, Inc.	Aminosugar, glycosaminoglycan or glycosaminoglycan-like compounds, and s-adenosylmethionine composition for the protection, treatment, repair, and reduction of inflammation of connective tissue
DE69935140T2 (de) *	1998-06-05	2007-05-31	Nutramax Laboratories, Inc.	Verwendung von anabolika, anti-katabolischen mitteln, antioxidanzien und analgetika zum schutz, zur behandlung und reparation von bindegeweben in menschen und tieren
IT1317920B1 (it) *	2000-10-20	2003-07-15	Univ Roma	S-adenosilmetionina e suoi derivati per il trattamento e laprevenzione della malattia di alzheimer.
US6649753B2 (en)	2001-06-07	2003-11-18	Orchid Chemicals & Pharmaceuticals Ltd.	Stable salts of S-adenosyl-L-methionine (SAMe) and the process for their preparation
US20050272687A1 (en) *	2004-06-08	2005-12-08	Hebert Rolland F	Stable S-adenosyl-l-methionine
US20090012036A1 (en) *	2005-05-24	2009-01-08	Hebert Rolland F	Stable S-adenosyl-L-methionine
WO2007083631A1 (ja)	2006-01-17	2007-07-26	Mitsubishi Gas Chemical Company, Inc.	Ｓ－アデノシル－ｌ－メチオニンの安定化法及び安定化された組成物
ITMI20060629A1 (it)	2006-03-31	2007-10-01	Daniele Giovannone	Composizioni solide orali a base di s-adenosilmetionina e processo per il loro ottenimento
WO2007132831A1 (ja)	2006-05-16	2007-11-22	Mitsubishi Gas Chemical Company, Inc.	保存安定性に優れたｓ－アデノシル－ｌ－メチオニン含有乾燥酵母の製造方法、その製造物及び経口摂取用組成物
WO2008090905A1 (ja)	2007-01-25	2008-07-31	Mitsubishi Gas Chemical Company, Inc.	保存安定性に優れたｓ－アデノシル－ｌ－メチオニン含有乾燥酵母の製造方法、その製造物及びその成型された組成物
US20100004191A1 (en) *	2008-07-01	2010-01-07	Rolland F Hebert	Compositions of S-adenosyl-L-methionine.
EP2189154A1 (en)	2008-11-25	2010-05-26	Gnosis S.p.A.	Effervescent tablets and mouth-soluble granulates of S-adenosyl methionine and process for the preparation thereof
IT1393331B1 (it)	2009-02-09	2012-04-20	Graal S R L	Composizioni orosolubili e/o effervescenti contenenti almeno un sale di s-adenosilmetionina (same)
EP2945959B1 (en)	2013-01-16	2020-05-13	Hebert Sam-E LLC	Stable indole-3-propionate salts of s-adenosyl-l-methionine
ITMI20130426A1 (it) *	2013-03-20	2014-09-21	Gnosis Spa	S-adenosilmetionina sterile ad alto contenuto di isomero attivo per soluzioni iniettabili e procedimento per ottenerla
FR3059327B1 (fr) *	2016-11-25	2021-10-15	Arkema France	Composition acide pour le traitement d'acides gras
CN116115577A (zh) *	2023-02-17	2023-05-16	无锡福祈制药有限公司	一种存储丁二磺酸腺苷蛋氨酸的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2969353A (en)	1957-02-06	1961-01-24	Merck & Co Inc	Process for the preparation of "active methionine" and products obtained thereby
DE1803978C2 (de)	1968-10-18	1985-05-02	Boehringer Mannheim Gmbh, 6800 Mannheim	Verfahren zur Gewinnung von S-Adenosyl-l-methionin und S-Adenosyl-l-ethionin
IE37913B1 (en) *	1972-08-02	1977-11-09	Bioresearch Sas	Salt of s-adenosyl-l-methionine
IE39517B1 (en)	1973-06-27	1978-10-25	Bioresearch Sas	Double salts of s-adenosyl-l-methhionine
AR221676A1 (es)	1974-07-12	1981-03-13	Bioresearch Sas	Procedimiento para la preparacion de sales estables sulfonicas y/o sulfuricas de la s-adenosil-l-metionina,particularmente utiles como donadores especificos de metilo para las reacciones bioquimicas de transferencia del grupo ch3;asi como tambien las reacciones fundamentales en el metabolismo lipilico,protilico y glucidico
JPS53107485A (en) *	1977-02-28	1978-09-19	Yamasa Shoyu Co Ltd	Preparation of s-adenosyl-l-methionine salt
GB2064523B (en)	1979-12-04	1983-06-29	Kanegafuchi Chemical Ind	Stable composition of s-adenosyl-l-methionine
JPS57192399A (en) *	1981-05-18	1982-11-26	Kanegafuchi Chem Ind Co Ltd	Composition containing s-adenosyl-l-methionine and its preparation

1981
- 1981-08-24 IT IT23602/81A patent/IT1137640B/it active
1982
- 1982-08-12 EP EP82107334A patent/EP0072980B1/en not_active Expired
- 1982-08-12 AT AT82107334T patent/ATE16191T1/de active
- 1982-08-12 DE DE8282107334T patent/DE3267039D1/de not_active Expired
- 1982-08-16 US US06/408,683 patent/US4465672A/en not_active Expired - Lifetime
- 1982-08-24 JP JP57145583A patent/JPS5843996A/ja active Granted

Also Published As

Publication number	Publication date
ATE16191T1 (de)	1985-11-15
EP0072980B1 (en)	1985-10-23
EP0072980A1 (en)	1983-03-02
IT1137640B (it)	1986-09-10
US4465672A (en)	1984-08-14
JPS5843996A (ja)	1983-03-14
DE3267039D1 (en)	1985-11-28
JPH0149275B2 (it)	1989-10-24

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Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19960830