IT8348129A1 - Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazione di glucosio ottenute senza bisogno di prelievi del sangue del paziente - Google Patents

Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazione di glucosio ottenute senza bisogno di prelievi del sangue del paziente

Info

Publication number
IT8348129A1
IT8348129A1 ITRM1983A048129A IT4812983A IT8348129A1 IT 8348129 A1 IT8348129 A1 IT 8348129A1 IT RM1983A048129 A ITRM1983A048129 A IT RM1983A048129A IT 4812983 A IT4812983 A IT 4812983A IT 8348129 A1 IT8348129 A1 IT 8348129A1
Authority
IT
Italy
Prior art keywords
glucose
patient
glucose concentration
need
blood sampling
Prior art date
Application number
ITRM1983A048129A
Other languages
English (en)
Other versions
IT1170375B (it
IT8348129A0 (it
Original Assignee
Bombardieri Giuseppe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bombardieri Giuseppe filed Critical Bombardieri Giuseppe
Priority to IT8348129A priority Critical patent/IT1170375B/it
Publication of IT8348129A0 publication Critical patent/IT8348129A0/it
Priority to US06/598,787 priority patent/US4633878A/en
Priority to EP84830120A priority patent/EP0134758A3/en
Publication of IT8348129A1 publication Critical patent/IT8348129A1/it
Application granted granted Critical
Publication of IT1170375B publication Critical patent/IT1170375B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14525—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using microdialysis
    • A61B5/14528—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using microdialysis invasively
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/686—Permanently implanted devices, e.g. pacemakers, other stimulators, biochips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
    • A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • External Artificial Organs (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Description

DESCRIZIONE
a corredo di una domanda di brevetto per invenzione al titolo:
APPARECCHIO CHE INFONDE INSULINA 0 GLUCOSIO NEL SOGGETTO DIABETICO SULLA BASE DI DETERMINAZIONI DI CONCENTRAZIONI DI GLUCOSIO OTTENUTE SENZA BISOGNO DI PRELIEVI DEL SANGUE DEL PAZIENTE"
'RIASSUMO
parecchio che a mezzo di una pompa preleva da un serbatoio una soluzione salina fisiologica e la fa circolare entro un sistemi, di fibre cave,permeabile alle piccole molecole, inserite nello organismo umano, finch? tale soluzione si pone in equilibrio con i soluti dializzabili dell'organismo stesso e che misura su tale soluzione la concentrazione di glucosio e infonde nell'organismo in base a tale rilievo opportune quantit? di insulina o glucosio.
DESCRIZIONE
invenzione appresso descritta costituisce una innovazione lei campo degli apparecchi attualmente in uso o in studio per la somministrazione automatizzata dell'insulina o del glucosio ? o del glucagone ) nell'individuo diabetico, sulla base di dei terminazioni continue della glicemia, apparecchi noti col nome did" pancreas artificiale".
Tali apparecchi sono schematicamente costituiti da un sensore che determina la concentrazione di glucosio neipaziente 3 da un computer che, sulla base di tali determinazioni e delle
loro variazioni comanda, secondo mn opportuno algoritmo, 1'infu
sione,di idonee quantit? d? insulina o di glucosio. I pochi
apparecchi finora realizzati a tale-scopo incontrano la massima difficolt? e il principale limite alla loro applicazione nell'ot tenere,per un tempo sufficientemente lungo una.attendibile misu fazione continua dei livelli di glucosio del soggetto. Infatti 3ssi-sono dotati di-sensori di glucosio che misurano la glicemijasu prelievo,continuo di sangue venoso, o che vengono-infissi ?iTe^'?^Tnen"^e nel tessuto sottocutaneo, dove determinano la zoncentrazione locale di glucosio. In entrambi-i casi la formazione di.un coagulo sanguigno o di un deposito-di fibrina sulla membrana semipermeabile del sensore rende instabile e precaria
;iel tempo la misura della concentrazione di glucosio.Una solu-
zione parziale di questo problema ? offerta dall?impiego della filtrazione del prelievo sanguigno;che precede la determinazio ne.della glicemia.Anche in questo caso per?..si ha la necessit? li prelevare il sangue e di mantenere la sua.circolazione attra-
verso raccordi ed emofiltri;? inevitabile che,-pur con 1!impie
go di sostanze anticoagulanti, si formino.alla lunga trombi o zoaguli sia.nelle vene del_j?aziente..sottoposte.,a.cateterismo, sia entro il circuito ematico extravascolare.
L?originalit? della presente innovazione consiste nel fatto che con essa viene infusa-,una soluzione salina fisiologica in un circuito di fibre cave (permeabili alle piccole molecole ) impiantate,all'interno dell'organismo del paziente.Nel passaggio attraverso tali fibre cave la soluzione si pone in equilibrio con i soluti dializzabili presenti nell'organismo;una volta che tale equilibrio,? raggiunto, la misurazione di oarametro biochimico della soluzione circolante corrisponde alla misura dello stesso parametro nell'?jrganismo in esame.
Tale principio pu? bene applicarsi alla determinazione continua della concentrazione di glucosio nell'uomo,per la realizzazione di un pancreas.artificiale.
Il vantaggio dell'applicazione della presente invenzione consiste nel fatto che per la determinazione in continuo della concentrazione di glucosio nel soggetto in esame non ? necessario alcun prelievo di sangue,n? l'impiego di sostanze antico^ gulanti, le quali possono provocare nel paziente disturbi nellq coagulazione d?l'Lasangueiezrare regioni?allergiche. Inoltre 1'aoplicazione di un pancreas artificiale realizzato in base alla presente invenzione pu? durare por funghi periodi,non essendovi il pericolo di ostruziori1e1-ildel/l1)'''ciirc?uiti n? malfunzionamento del sensore di glucosiQ.fpqfr fonazione di coaguli sangui gni o depositi di fibrill?i S?u t-a|lefapparecchio\ir?fatti,coaguli ematici e deposizioni?d? fibrina potranno'formarsi-solo all'estemo delle fibre c'avd impiantate;"tuttavia essi .non potranno. n? ostruire.la-.ilibbra circolazione,della,.soluzione?salina allo?? interno delle fibre-impiantate,-n? impedire-i-l raggiungimento iell?equilibrio delle concentrazioni djLglucosio tra.ambiente1. intemp.:ed ambiente esterno,alle fibreii'eavp?, date ;le piccol^.di mensio?ni della motlecola-del-glucos??io,? .1-?jOpportuna lunghezza lei circuito che.consente un!ampia?superficie di scambio.
Ouest'ultima caratteristica del presente apparecbhio rappre senta un decisivo vantaggio rispetto agli 'apparecchi che impiegano un elettrodo sensore di glucosio direttamente infisso nel sottocutaneo, fornito di una piccolissima |uperficie.permeabile al glucosio su cui la deposizione di coaguli o di fibrina compromette la funzionalit? del sensore.
Il circuito di^fibre cave entro il quale circola la^soluzio?-e pu? essere varamente impiantato^osservando.le owip regole d:. sterilit? ed aseps/i entro l?organismo del paziente. a seconda che l'impiego del pancreas artificiale oggetto della presente nvenzione debba essere di lunga o di breve durata, Se ? previa sta una durata breve (di alcuni giorni ) il circuito di.fibre cave pu? essere.comodamente inserito in una vena periferic| come un comune catetere venoso. Se invece ?.previsto un i?pie~ $o pi? prolungato ( settimane o mesi ), il circuito pu?^essere applicato nel sottpcutaneo al?-'modo di!un catetere-elettrodo di pace-maker cardiaco,o spinto pel cavo peritoneale sotto la guida di un tr?-quarti.^ ?nseritO'?in cavit?1pr?vio pneumoperitoneo Le fibre possono anche essere avvolte a forma di una spirale, allogiate in un dischetto-supporto di materiale plastico biocompatibile, impiantabile nel sottqciitaneo,previa incisione dei tegumenti in anestesia locale.
COMPONENTI DELL'APPARECCHIO
Ilmodello di pancreas artificiale.funzionante in base alla invenzione sop:rav?sp;osta ? cost'itu*itoid?4'(Vve.di fig:u?ra ) :
1) Circuito imoiantabile di fibre*cavel^eminermeabili^-in materia? le biocompatibile '(tes1.1poliacriI?nitrile?;;o polietilene'),gi? sopradescritto,da.inserire entro?l'organismo del pazienter? Esso ? connesso?in entrata e in uscitala due condottici raccoi do in materialejplastico biocompatibile, che fuoriescono*$al corpo del pazienta. II.raccordo di entrata ? collegato a,
2) Una micropompa a solenoide o piezoelettrica per m?zzo1della quale una soluzi?ne salina fisiologica1'sterile ? prelevata da 5)?Un serbatoio,e>fatta circolare entro il circuito di fibre :ave permeabili,ialle piccole molecole?.1'Dal raccordo di,uscita la soluzione, ormai!equilibrata con la;concentrazione dilglqfco?io del paziente ? convogliata ad ,
l?) Uh sensore,,djiglucosio che nella presente realizzazione ? ii tipo enzimaticQ-potjsnzianetricQ. Superato il sensore,.la solu-:ione ? raccolta in un
-5)-Recipiente collettore apparecchio acitcuito aperto-) oppure ? reimmessa pel serbatoio 3) per?rientrare in circolo apparecchio a.circuito chiuso). I segnali,jprovenienti dal-senore di glucosio sono elaborati da
) Uh computer che in base ad algoritm>?o ntrotco dalla letteratura omanda
) Una micropompa solenoide
precisione opportune quantit? di insulina,^oppure
Un?altra microjjompa,che infonde gl'jiposio,prelevando tali
31.e-10) due-appositi,serbatoi. I-.condottft!tper.1'infusione di
L?llbullllct O- g--X1-UL-Ub-XOj -J--? iUd--LcI-Xd-.1-L?-plastdc^biocanpatibile; si riuniscono in S
il) Un catetere;a*1doppio lume a "canine diVfucile ",che viene introdotto nel cavo peritoneale del paziente. '
?2) Un visore a??cristalli liquidi mostra ih1ogni momento la con centrazione'di glucosib misurata.Sono;'pred?sposti cqllegamenti per un registratore delle concentrazioni,di.glucosio m^prae e delle quantit? di insulina e glucosio-infuse.
13) Batterie ricariqabili alimentano il^sieterna.
Questo modello di pancreas artif?q.ial? ? facilmente realizzabile in volumi idonei per un uso port?tile, che non costringa il paziente a stare a letto e gli consenta invece un'attivit? pressoch? normale?. Il circuito sopra descritto,nel suo tipo RIVENDICAZIONI
1) apparecchio ,che,'a.mezzo di una pompa,'/preleva da un.serbate una soluzione.salinaifisiologica sterile e??la fa circolare,entro un sistemaci fibpe cave, inserite'dentro l'organismo umano,permeabili'alle piccole molecole,.'finche tale soluzione si pone in*equilibrio
lili dell'organiamo stesso,e che'.misufa'su tale soluzione^ D pi? parametri biiochimici, rapresentativi..degli stessi pararne tri de11'organismo in esame ed eventualmente infonde medicamenti sulla base del monitoraggio effettuato?

Claims (1)

  1. 2) Apparecchio .tome,?da rivendicazioneil che.misura dOra conce-n-dtra zione di glucosio^dell,'organismo,'umano e'somministra .automatic
    mente insulina.p glucosio,in relazione,ai tassi di..glucosio,,;c|e terminati. fi-'i '
    3) Apparecchio^ccme,da rivendicazioneil.realizzato in forma,poi
    fatile durante?le abituali.attivit? dell.'u?mo, o in forma Impian
    tabile entro l*organismo umano.
    4) Apparecchi? ?pome?da-rivendicazione?2jre?lizzato in forma portatile durante?'ie normalr-attivit?ia?ll^uomo?, o'in forma impiantabile entro.1'organismo umano.
IT8348129A 1983-04-18 1983-04-19 Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazioni di glucosio ottenute senza bisogno di prelievi del sangue del paziente IT1170375B (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT8348129A IT1170375B (it) 1983-04-19 1983-04-19 Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazioni di glucosio ottenute senza bisogno di prelievi del sangue del paziente
US06/598,787 US4633878A (en) 1983-04-18 1984-04-10 Device for the automatic insulin or glucose infusion in diabetic subjects, based on the continuous monitoring of the patient's glucose, obtained without blood withdrawal
EP84830120A EP0134758A3 (en) 1983-04-18 1984-04-17 Device for the controlled insulin or glucose infusion in diabetic subjects

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8348129A IT1170375B (it) 1983-04-19 1983-04-19 Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazioni di glucosio ottenute senza bisogno di prelievi del sangue del paziente

Publications (3)

Publication Number Publication Date
IT8348129A0 IT8348129A0 (it) 1983-04-19
IT8348129A1 true IT8348129A1 (it) 1984-10-19
IT1170375B IT1170375B (it) 1987-06-03

Family

ID=11264708

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8348129A IT1170375B (it) 1983-04-18 1983-04-19 Apparecchio che infonde insulina o glucosio nel soggetto diabetico sulla base di determinazioni di concentrazioni di glucosio ottenute senza bisogno di prelievi del sangue del paziente

Country Status (3)

Country Link
US (1) US4633878A (it)
EP (1) EP0134758A3 (it)
IT (1) IT1170375B (it)

Families Citing this family (335)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3614821A1 (de) * 1986-05-02 1987-11-05 Siemens Ag Implantierbare, eichbare messvorrichtung fuer eine koerpersubstanz sowie eichverfahren
AU8041987A (en) * 1986-10-30 1988-05-05 Lejus Medical Aktiebolag Method for the determination of the concentration of substances in intercellular tissue fluids
AT391998B (de) * 1987-02-02 1990-12-27 Falko Dr Skrabal Vorrichtung zur bestimmung der konzentration zumindest einer medizinischen substanz in lebenden organismen
US4854322A (en) * 1987-02-25 1989-08-08 Ash Medical Systems, Inc. Capillary filtration and collection device for long-term monitoring of blood constituents
US5002054A (en) * 1987-02-25 1991-03-26 Ash Medical Systems, Inc. Interstitial filtration and collection device and method for long-term monitoring of physiological constituents of the body
US4777953A (en) * 1987-02-25 1988-10-18 Ash Medical Systems, Inc. Capillary filtration and collection method for long-term monitoring of blood constituents
US4832034A (en) * 1987-04-09 1989-05-23 Pizziconi Vincent B Method and apparatus for withdrawing, collecting and biosensing chemical constituents from complex fluids
WO1989001794A1 (en) * 1987-08-28 1989-03-09 Regents Of The University Of Minnesota Metabolic sensor for a drug delivery system
NL8702370A (nl) * 1987-10-05 1989-05-01 Groningen Science Park Werkwijze en stelsel voor glucosebepaling en daarvoor bruikbaar meetcelsamenstel.
US4890621A (en) * 1988-01-19 1990-01-02 Northstar Research Institute, Ltd. Continuous glucose monitoring and a system utilized therefor
DE3812584A1 (de) * 1988-04-13 1989-10-26 Mic Medical Instr Corp Vorrichtung zur biofeedbackkontrolle von koerperfunktionen
US5011472A (en) * 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
AT393213B (de) * 1989-02-08 1991-09-10 Avl Verbrennungskraft Messtech Vorrichtung zur bestimmung zumindest einer medizinischen messgroesse
US4953552A (en) * 1989-04-21 1990-09-04 Demarzo Arthur P Blood glucose monitoring system
DE3915251A1 (de) * 1989-05-10 1990-11-22 Annemarie Schloegl Ges M B H Implantierbare vorrichtung zur dosierten abgabe von medikamenten in den menschlichen koerper
IT1231916B (it) * 1989-05-29 1992-01-15 Ampliscientifica S R L Pancreas artificiale indossabile
US5078135A (en) * 1989-05-31 1992-01-07 Board Of Regents, The University Of Texas System Apparatus for in vivo analysis of biological compounds in blood or tissue by microdialysis and mass spectrometry
US4979509A (en) * 1989-07-19 1990-12-25 Northstar Research Institute, Ltd. Continuous glucose monitoring and a system utilized therefor
US5190041A (en) * 1989-08-11 1993-03-02 Palti Yoram Prof System for monitoring and controlling blood glucose
US5101814A (en) * 1989-08-11 1992-04-07 Palti Yoram Prof System for monitoring and controlling blood glucose
US5109850A (en) * 1990-02-09 1992-05-05 Massachusetts Institute Of Technology Automatic blood monitoring for medication delivery method and apparatus
WO1991016416A1 (en) * 1990-04-26 1991-10-31 Markwell Medical Institute, Inc. Wearable blood glucose monitor
US5593852A (en) 1993-12-02 1997-01-14 Heller; Adam Subcutaneous glucose electrode
JPH04278450A (ja) 1991-03-04 1992-10-05 Adam Heller バイオセンサー及び分析物を分析する方法
US5258314A (en) * 1991-03-18 1993-11-02 Paradigm Biotechnologies Partnership Microprocessor-based biomedical monitoring apparatus and method
US5387327A (en) * 1992-10-19 1995-02-07 Duquesne University Of The Holy Ghost Implantable non-enzymatic electrochemical glucose sensor
US5448992A (en) * 1992-12-10 1995-09-12 Sunshine Medical Instruments, Inc. Method and apparatus for non-invasive phase sensitive measurement of blood glucose concentration
US5398681A (en) * 1992-12-10 1995-03-21 Sunshine Medical Instruments, Inc. Pocket-type instrument for non-invasive measurement of blood glucose concentration
WO1995010975A1 (en) * 1993-10-18 1995-04-27 Washington Research Foundation Device and method for monitoring and normalizing physiological parameters
DE69322968T2 (de) * 1993-10-22 1999-07-08 Rijksuniversiteit Te Groningen, Groningen Verfahren und Vorrichtung zur kontinuierlichen Überwachung eines Anolytpegels
DE4401400A1 (de) * 1994-01-19 1995-07-20 Ernst Prof Dr Pfeiffer Verfahren und Anordnung zur kontinuierlichen Überwachung der Konzentration eines Metaboliten
US5569186A (en) * 1994-04-25 1996-10-29 Minimed Inc. Closed loop infusion pump system with removable glucose sensor
US5474552A (en) * 1994-06-27 1995-12-12 Cb-Carmel Biotechnology Ltd. Implantable drug delivery pump
US5665065A (en) * 1995-05-26 1997-09-09 Minimed Inc. Medication infusion device with blood glucose data input
US5995860A (en) * 1995-07-06 1999-11-30 Thomas Jefferson University Implantable sensor and system for measurement and control of blood constituent levels
AU3596597A (en) * 1996-07-08 1998-02-02 Animas Corporation Implantable sensor and system for in vivo measurement and control of fluid constituent levels
AU6157898A (en) * 1997-02-06 1998-08-26 E. Heller & Company Small volume (in vitro) analyte sensor
US6134461A (en) * 1998-03-04 2000-10-17 E. Heller & Company Electrochemical analyte
US6103033A (en) 1998-03-04 2000-08-15 Therasense, Inc. Process for producing an electrochemical biosensor
US8688188B2 (en) 1998-04-30 2014-04-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US9066695B2 (en) * 1998-04-30 2015-06-30 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US8465425B2 (en) 1998-04-30 2013-06-18 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8974386B2 (en) 1998-04-30 2015-03-10 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US8480580B2 (en) * 1998-04-30 2013-07-09 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
US8346337B2 (en) * 1998-04-30 2013-01-01 Abbott Diabetes Care Inc. Analyte monitoring device and methods of use
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6251260B1 (en) 1998-08-24 2001-06-26 Therasense, Inc. Potentiometric sensors for analytic determination
US6591125B1 (en) 2000-06-27 2003-07-08 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
US6338790B1 (en) 1998-10-08 2002-01-15 Therasense, Inc. Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator
EP1130996B1 (en) 1998-11-20 2005-04-13 The University of Connecticut Generic integrated implantable potentiostat telemetry unit for electrochemical sensors
US6198966B1 (en) * 1999-02-26 2001-03-06 Medtronic, Inc. Recirculating implantable drug delivery system
US6669663B1 (en) * 1999-04-30 2003-12-30 Medtronic, Inc. Closed loop medicament pump
US6654625B1 (en) 1999-06-18 2003-11-25 Therasense, Inc. Mass transport limited in vivo analyte sensor
US6535523B1 (en) * 1999-09-30 2003-03-18 Qualcomm Incorporated System and method for persistence vector based rate assignment
US6616819B1 (en) * 1999-11-04 2003-09-09 Therasense, Inc. Small volume in vitro analyte sensor and methods
US20060091006A1 (en) * 1999-11-04 2006-05-04 Yi Wang Analyte sensor with insertion monitor, and methods
IT1314759B1 (it) 2000-05-08 2003-01-03 Menarini Farma Ind Strumentazione per la misura ed il controllo del contenuto di glucosiolattato o altri metaboliti in fluidi biologici
US6459917B1 (en) 2000-05-22 2002-10-01 Ashok Gowda Apparatus for access to interstitial fluid, blood, or blood plasma components
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US6560471B1 (en) * 2001-01-02 2003-05-06 Therasense, Inc. Analyte monitoring device and methods of use
US6699234B2 (en) 2001-03-16 2004-03-02 Show-Way Yeh Light, thin, and flexible medication infusion apparatuses attachable to user's skin
AU2002309528A1 (en) * 2001-04-02 2002-10-15 Therasense, Inc. Blood glucose tracking apparatus and methods
ATE352334T1 (de) * 2001-05-18 2007-02-15 Deka Products Lp Infusionsvorrichtung für eine flüssigkeitspumpe
US8034026B2 (en) * 2001-05-18 2011-10-11 Deka Products Limited Partnership Infusion pump assembly
EP1552146B1 (en) * 2002-10-09 2011-04-20 Abbott Diabetes Care Inc. Fluid delivery device, system and method
US7993108B2 (en) * 2002-10-09 2011-08-09 Abbott Diabetes Care Inc. Variable volume, shape memory actuated insulin dispensing pump
US7727181B2 (en) * 2002-10-09 2010-06-01 Abbott Diabetes Care Inc. Fluid delivery device with autocalibration
US7381184B2 (en) 2002-11-05 2008-06-03 Abbott Diabetes Care Inc. Sensor inserter assembly
JP2006507841A (ja) * 2002-11-14 2006-03-09 ダーマコン， インコーポレイテッド 機能的ｓｉＲＮＡおよび超機能的ｓｉＲＮＡ
NZ541365A (en) * 2002-12-27 2009-09-25 Diobex Inc Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US7655618B2 (en) * 2002-12-27 2010-02-02 Diobex, Inc. Compositions and methods for the prevention and control of insulin-induced hypoglycemia
US8771183B2 (en) 2004-02-17 2014-07-08 Abbott Diabetes Care Inc. Method and system for providing data communication in continuous glucose monitoring and management system
AU2003303597A1 (en) 2002-12-31 2004-07-29 Therasense, Inc. Continuous glucose monitoring system and methods of use
US7679407B2 (en) * 2003-04-28 2010-03-16 Abbott Diabetes Care Inc. Method and apparatus for providing peak detection circuitry for data communication systems
US8066639B2 (en) * 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
US7306641B2 (en) * 2003-09-12 2007-12-11 Hewlett-Packard Development Company, L.P. Integral fuel cartridge and filter
US9123077B2 (en) 2003-10-07 2015-09-01 Hospira, Inc. Medication management system
US8065161B2 (en) 2003-11-13 2011-11-22 Hospira, Inc. System for maintaining drug information and communicating with medication delivery devices
WO2005044088A2 (en) * 2003-11-03 2005-05-19 Children's Medical Center Corporation Continuous analyte monitor and method of using same
USD914881S1 (en) 2003-11-05 2021-03-30 Abbott Diabetes Care Inc. Analyte sensor electronic mount
SG179411A1 (en) * 2003-11-06 2012-04-27 Lifescan Inc Drug delivery pen with event notification means
US20050261561A1 (en) * 2004-05-24 2005-11-24 Christopher W. Jones Blood testing and therapeutic compound delivery system
KR100636336B1 (ko) * 2004-11-04 2006-10-19 이홍규 혈당의 효율적 조절을 가능케 하는 삼중 기능을 갖는인슐린 펌프 및 이를 보조하는 생리수 시린지를 포함하는인슐린 투여 시스템
US7731657B2 (en) 2005-08-30 2010-06-08 Abbott Diabetes Care Inc. Analyte sensor introducer and methods of use
US20110060196A1 (en) * 2009-08-31 2011-03-10 Abbott Diabetes Care Inc. Flexible Mounting Unit and Cover for a Medical Device
US9351669B2 (en) 2009-09-30 2016-05-31 Abbott Diabetes Care Inc. Interconnect for on-body analyte monitoring device
US8545403B2 (en) 2005-12-28 2013-10-01 Abbott Diabetes Care Inc. Medical device insertion
US7883464B2 (en) 2005-09-30 2011-02-08 Abbott Diabetes Care Inc. Integrated transmitter unit and sensor introducer mechanism and methods of use
US9398882B2 (en) * 2005-09-30 2016-07-26 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor and data processing device
US20070027381A1 (en) * 2005-07-29 2007-02-01 Therasense, Inc. Inserter and methods of use
US8512243B2 (en) 2005-09-30 2013-08-20 Abbott Diabetes Care Inc. Integrated introducer and transmitter assembly and methods of use
US9259175B2 (en) 2006-10-23 2016-02-16 Abbott Diabetes Care, Inc. Flexible patch for fluid delivery and monitoring body analytes
US8571624B2 (en) * 2004-12-29 2013-10-29 Abbott Diabetes Care Inc. Method and apparatus for mounting a data transmission device in a communication system
US20090105569A1 (en) 2006-04-28 2009-04-23 Abbott Diabetes Care, Inc. Introducer Assembly and Methods of Use
US10226207B2 (en) 2004-12-29 2019-03-12 Abbott Diabetes Care Inc. Sensor inserter having introducer
US9572534B2 (en) 2010-06-29 2017-02-21 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
US9743862B2 (en) 2011-03-31 2017-08-29 Abbott Diabetes Care Inc. Systems and methods for transcutaneously implanting medical devices
US20110054275A1 (en) * 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Mounting Unit Having a Sensor and Associated Circuitry
US8333714B2 (en) 2006-09-10 2012-12-18 Abbott Diabetes Care Inc. Method and system for providing an integrated analyte sensor insertion device and data processing unit
US7697967B2 (en) 2005-12-28 2010-04-13 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US7775966B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. Non-invasive pressure measurement in a fluid adjustable restrictive device
US20060166629A1 (en) * 2005-01-24 2006-07-27 Therasense, Inc. Method and apparatus for providing EMC Class-B compliant RF transmitter for data monitoring an detection systems
US7785258B2 (en) 2005-10-06 2010-08-31 Optiscan Biomedical Corporation System and method for determining a treatment dose for a patient
US8251907B2 (en) 2005-02-14 2012-08-28 Optiscan Biomedical Corporation System and method for determining a treatment dose for a patient
US8956291B2 (en) 2005-02-22 2015-02-17 Admetsys Corporation Balanced physiological monitoring and treatment system
US7658196B2 (en) 2005-02-24 2010-02-09 Ethicon Endo-Surgery, Inc. System and method for determining implanted device orientation
US8016744B2 (en) 2005-02-24 2011-09-13 Ethicon Endo-Surgery, Inc. External pressure-based gastric band adjustment system and method
US7699770B2 (en) 2005-02-24 2010-04-20 Ethicon Endo-Surgery, Inc. Device for non-invasive measurement of fluid pressure in an adjustable restriction device
US7927270B2 (en) * 2005-02-24 2011-04-19 Ethicon Endo-Surgery, Inc. External mechanical pressure sensor for gastric band pressure measurements
US8066629B2 (en) 2005-02-24 2011-11-29 Ethicon Endo-Surgery, Inc. Apparatus for adjustment and sensing of gastric band pressure
US7775215B2 (en) 2005-02-24 2010-08-17 Ethicon Endo-Surgery, Inc. System and method for determining implanted device positioning and obtaining pressure data
CN101180093B (zh) 2005-03-21 2012-07-18 雅培糖尿病护理公司 用于提供结合的药剂输液以及分析物监测系统的方法和系统
US8112240B2 (en) * 2005-04-29 2012-02-07 Abbott Diabetes Care Inc. Method and apparatus for providing leak detection in data monitoring and management systems
US7768408B2 (en) 2005-05-17 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing data management in data monitoring system
US7509156B2 (en) * 2005-05-18 2009-03-24 Clarian Health Partners, Inc. System for managing glucose levels in patients with diabetes or hyperglycemia
US7620437B2 (en) 2005-06-03 2009-11-17 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US7756561B2 (en) 2005-09-30 2010-07-13 Abbott Diabetes Care Inc. Method and apparatus for providing rechargeable power in data monitoring and management systems
US9521968B2 (en) * 2005-09-30 2016-12-20 Abbott Diabetes Care Inc. Analyte sensor retention mechanism and methods of use
WO2007047279A1 (en) * 2005-10-18 2007-04-26 Richards Cynthia C Dispenser having a first pump for insulin and a second pump for glucose or glucagon
US7583190B2 (en) 2005-10-31 2009-09-01 Abbott Diabetes Care Inc. Method and apparatus for providing data communication in data monitoring and management systems
US20090054747A1 (en) * 2005-10-31 2009-02-26 Abbott Diabetes Care, Inc. Method and system for providing analyte sensor tester isolation
US7766829B2 (en) 2005-11-04 2010-08-03 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US11298058B2 (en) 2005-12-28 2022-04-12 Abbott Diabetes Care Inc. Method and apparatus for providing analyte sensor insertion
US8344966B2 (en) * 2006-01-31 2013-01-01 Abbott Diabetes Care Inc. Method and system for providing a fault tolerant display unit in an electronic device
MX2008010341A (es) 2006-02-09 2008-11-18 Deka Products Lp Sistemas y metodos adhesivos y perifericos para dispositivos medicos.
US12151080B2 (en) 2006-02-09 2024-11-26 Deka Products Limited Partnership Adhesive and peripheral systems and methods for medical devices
US11027058B2 (en) 2006-02-09 2021-06-08 Deka Products Limited Partnership Infusion pump assembly
US11478623B2 (en) 2006-02-09 2022-10-25 Deka Products Limited Partnership Infusion pump assembly
US11364335B2 (en) 2006-02-09 2022-06-21 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US11497846B2 (en) 2006-02-09 2022-11-15 Deka Products Limited Partnership Patch-sized fluid delivery systems and methods
US12070574B2 (en) 2006-02-09 2024-08-27 Deka Products Limited Partnership Apparatus, systems and methods for an infusion pump assembly
US11318249B2 (en) 2006-02-09 2022-05-03 Deka Products Limited Partnership Infusion pump assembly
US12274857B2 (en) 2006-02-09 2025-04-15 Deka Products Limited Partnership Method and system for shape-memory alloy wire control
EP1993637A2 (en) * 2006-02-15 2008-11-26 Medingo Ltd. Systems and methods for sensing analyte and dispensing therapeutic fluid
US7885698B2 (en) 2006-02-28 2011-02-08 Abbott Diabetes Care Inc. Method and system for providing continuous calibration of implantable analyte sensors
US7620438B2 (en) 2006-03-31 2009-11-17 Abbott Diabetes Care Inc. Method and system for powering an electronic device
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
US8870742B2 (en) 2006-04-06 2014-10-28 Ethicon Endo-Surgery, Inc. GUI for an implantable restriction device and a data logger
US20080249806A1 (en) * 2006-04-06 2008-10-09 Ethicon Endo-Surgery, Inc Data Analysis for an Implantable Restriction Device and a Data Logger
US20080250341A1 (en) * 2006-04-06 2008-10-09 Ethicon Endo-Surgery, Inc. Gui With Trend Analysis for an Implantable Restriction Device and a Data Logger
US8152710B2 (en) * 2006-04-06 2012-04-10 Ethicon Endo-Surgery, Inc. Physiological parameter analysis for an implantable restriction device and a data logger
US20080071158A1 (en) * 2006-06-07 2008-03-20 Abbott Diabetes Care, Inc. Analyte monitoring system and method
GB0616566D0 (en) * 2006-08-19 2006-09-27 Rolls Royce Plc An alloy and method of treating titanium aluminide
WO2008038274A1 (en) * 2006-09-29 2008-04-03 Medingo Ltd. Fluid delivery system with electrochemical sensing of analyte concentration levels
US20080091466A1 (en) 2006-10-16 2008-04-17 Hospira, Inc. System and method for comparing and utilizing activity information and configuration information from multiple device management systems
US20080119710A1 (en) * 2006-10-31 2008-05-22 Abbott Diabetes Care, Inc. Medical devices and methods of using the same
US8579853B2 (en) 2006-10-31 2013-11-12 Abbott Diabetes Care Inc. Infusion devices and methods
US20080195045A1 (en) 2007-02-09 2008-08-14 Lanigan Richard J Automated insertion assembly
US8930203B2 (en) 2007-02-18 2015-01-06 Abbott Diabetes Care Inc. Multi-function analyte test device and methods therefor
US8732188B2 (en) 2007-02-18 2014-05-20 Abbott Diabetes Care Inc. Method and system for providing contextual based medication dosage determination
US8123686B2 (en) 2007-03-01 2012-02-28 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US8461985B2 (en) * 2007-05-08 2013-06-11 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8665091B2 (en) 2007-05-08 2014-03-04 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US8456301B2 (en) 2007-05-08 2013-06-04 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US20080281179A1 (en) * 2007-05-08 2008-11-13 Abbott Diabetes Care, Inc. Analyte monitoring system and methods
US7928850B2 (en) 2007-05-08 2011-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US8417311B2 (en) * 2008-09-12 2013-04-09 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
WO2008150917A1 (en) 2007-05-31 2008-12-11 Abbott Diabetes Care, Inc. Insertion devices and methods
EP3868284A1 (en) 2007-10-10 2021-08-25 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
US8187163B2 (en) * 2007-12-10 2012-05-29 Ethicon Endo-Surgery, Inc. Methods for implanting a gastric restriction device
US8100870B2 (en) 2007-12-14 2012-01-24 Ethicon Endo-Surgery, Inc. Adjustable height gastric restriction devices and methods
US9026370B2 (en) 2007-12-18 2015-05-05 Hospira, Inc. User interface improvements for medical devices
US8142452B2 (en) * 2007-12-27 2012-03-27 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US8377079B2 (en) 2007-12-27 2013-02-19 Ethicon Endo-Surgery, Inc. Constant force mechanisms for regulating restriction devices
US20090171379A1 (en) * 2007-12-27 2009-07-02 Ethicon Endo-Surgery, Inc. Fluid logic for regulating restriction devices
US12447265B2 (en) 2007-12-31 2025-10-21 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
CN114796703B (zh) 2007-12-31 2025-10-21 德卡产品有限公司 输注泵组件
US8881774B2 (en) 2007-12-31 2014-11-11 Deka Research & Development Corp. Apparatus, system and method for fluid delivery
US10080704B2 (en) 2007-12-31 2018-09-25 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US9456955B2 (en) 2007-12-31 2016-10-04 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US10188787B2 (en) 2007-12-31 2019-01-29 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
US8900188B2 (en) 2007-12-31 2014-12-02 Deka Products Limited Partnership Split ring resonator antenna adapted for use in wirelessly controlled medical device
WO2009088956A2 (en) * 2007-12-31 2009-07-16 Deka Products Limited Partnership Infusion pump assembly
US8192350B2 (en) 2008-01-28 2012-06-05 Ethicon Endo-Surgery, Inc. Methods and devices for measuring impedance in a gastric restriction system
US8337389B2 (en) 2008-01-28 2012-12-25 Ethicon Endo-Surgery, Inc. Methods and devices for diagnosing performance of a gastric restriction system
US8591395B2 (en) 2008-01-28 2013-11-26 Ethicon Endo-Surgery, Inc. Gastric restriction device data handling devices and methods
US20090192534A1 (en) * 2008-01-29 2009-07-30 Ethicon Endo-Surgery, Inc. Sensor trigger
US7844342B2 (en) 2008-02-07 2010-11-30 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using light
US20090204179A1 (en) * 2008-02-07 2009-08-13 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using temperature
US8221439B2 (en) * 2008-02-07 2012-07-17 Ethicon Endo-Surgery, Inc. Powering implantable restriction systems using kinetic motion
US8114345B2 (en) * 2008-02-08 2012-02-14 Ethicon Endo-Surgery, Inc. System and method of sterilizing an implantable medical device
US8057492B2 (en) * 2008-02-12 2011-11-15 Ethicon Endo-Surgery, Inc. Automatically adjusting band system with MEMS pump
US8591532B2 (en) 2008-02-12 2013-11-26 Ethicon Endo-Sugery, Inc. Automatically adjusting band system
US8034065B2 (en) * 2008-02-26 2011-10-11 Ethicon Endo-Surgery, Inc. Controlling pressure in adjustable restriction devices
US20090228063A1 (en) * 2008-03-06 2009-09-10 Ethicon Endo-Surgery, Inc. System and method of communicating with an implantable antenna
US8187162B2 (en) * 2008-03-06 2012-05-29 Ethicon Endo-Surgery, Inc. Reorientation port
US8233995B2 (en) 2008-03-06 2012-07-31 Ethicon Endo-Surgery, Inc. System and method of aligning an implantable antenna
WO2010011805A1 (en) * 2008-07-24 2010-01-28 Admetsys Corporation Device and method for automatically sampling and measuring blood analytes
US7959598B2 (en) 2008-08-20 2011-06-14 Asante Solutions, Inc. Infusion pump systems and methods
US8784364B2 (en) 2008-09-15 2014-07-22 Deka Products Limited Partnership Systems and methods for fluid delivery
US12370327B2 (en) 2008-10-10 2025-07-29 Deka Products Limited Partnership Infusion pump methods, systems and apparatus
US8223028B2 (en) 2008-10-10 2012-07-17 Deka Products Limited Partnership Occlusion detection system and method
US8267892B2 (en) 2008-10-10 2012-09-18 Deka Products Limited Partnership Multi-language / multi-processor infusion pump assembly
US8708376B2 (en) * 2008-10-10 2014-04-29 Deka Products Limited Partnership Medium connector
US8066672B2 (en) 2008-10-10 2011-11-29 Deka Products Limited Partnership Infusion pump assembly with a backup power supply
US9180245B2 (en) 2008-10-10 2015-11-10 Deka Products Limited Partnership System and method for administering an infusible fluid
US8262616B2 (en) * 2008-10-10 2012-09-11 Deka Products Limited Partnership Infusion pump assembly
US12186531B2 (en) 2008-10-10 2025-01-07 Deka Products Limited Partnership Infusion pump assembly
US8016789B2 (en) * 2008-10-10 2011-09-13 Deka Products Limited Partnership Pump assembly with a removable cover assembly
US8103456B2 (en) * 2009-01-29 2012-01-24 Abbott Diabetes Care Inc. Method and device for early signal attenuation detection using blood glucose measurements
US8560082B2 (en) 2009-01-30 2013-10-15 Abbott Diabetes Care Inc. Computerized determination of insulin pump therapy parameters using real time and retrospective data processing
US20100198196A1 (en) * 2009-01-30 2010-08-05 Abbott Diabetes Care, Inc. Therapy Delivery Device Programming Tool
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
US20100213057A1 (en) * 2009-02-26 2010-08-26 Benjamin Feldman Self-Powered Analyte Sensor
US8271106B2 (en) 2009-04-17 2012-09-18 Hospira, Inc. System and method for configuring a rule set for medical event management and responses
WO2010129375A1 (en) * 2009-04-28 2010-11-11 Abbott Diabetes Care Inc. Closed loop blood glucose control algorithm analysis
US9226701B2 (en) * 2009-04-28 2016-01-05 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
US8438898B2 (en) * 2009-07-01 2013-05-14 Edwards Lifesciences Corporation Calibrant infusion fluid source preparation
CA2768011C (en) 2009-07-15 2018-07-24 Deka Products Limited Partnership Apparatus, systems and methods for an infusion pump assembly
EP4276652A3 (en) 2009-07-23 2024-01-31 Abbott Diabetes Care, Inc. Real time management of data relating to physiological control of glucose levels
WO2011025999A1 (en) * 2009-08-29 2011-03-03 Abbott Diabetes Care Inc. Analyte sensor
WO2011026130A1 (en) * 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Inserter device including rotor subassembly
EP2473099A4 (en) 2009-08-31 2015-01-14 Abbott Diabetes Care Inc ANALYTICAL MONITORING SYSTEM AND METHOD FOR POWERFUL AND NOISE MANAGEMENT
WO2011026147A1 (en) 2009-08-31 2011-03-03 Abbott Diabetes Care Inc. Analyte signal processing device and methods
EP2482720A4 (en) * 2009-09-29 2014-04-23 Abbott Diabetes Care Inc METHOD AND APPARATUS FOR PROVIDING NOTIFICATION FUNCTION IN SUBSTANCE MONITORING SYSTEMS
EP2482870B1 (en) 2009-09-29 2017-12-27 Admetsys Corporation System and method for differentiating containers in medication delivery
WO2011041449A1 (en) * 2009-09-29 2011-04-07 Abbott Diabetes Care Inc. Sensor inserter having introducer
US20110082484A1 (en) * 2009-10-07 2011-04-07 Heber Saravia Sensor inserter assembly having rotatable trigger
US8771251B2 (en) * 2009-12-17 2014-07-08 Hospira, Inc. Systems and methods for managing and delivering patient therapy through electronic drug delivery systems
FR2955179B1 (fr) * 2010-01-13 2019-11-08 Universite De Bordeaux 1 Capteur pour la mesure des besoins d'insuline d'un patient et procede de fabrication de celui-ci
EP2525848B1 (en) 2010-01-22 2016-08-03 DEKA Products Limited Partnership System for shape-memory alloy wire control
USD924406S1 (en) 2010-02-01 2021-07-06 Abbott Diabetes Care Inc. Analyte sensor inserter
CA2766685A1 (en) 2010-03-24 2011-12-29 Abbott Diabetes Care Inc. Medical device inserters and processes of inserting and using medical devices
US11064921B2 (en) 2010-06-29 2021-07-20 Abbott Diabetes Care Inc. Devices, systems and methods for on-skin or on-body mounting of medical devices
WO2013028497A1 (en) 2011-08-19 2013-02-28 Hospira, Inc. Systems and methods for a graphical interface including a graphical representation of medical data
WO2013059615A1 (en) 2011-10-21 2013-04-25 Hospira, Inc. Medical device update system
EP2775918B1 (en) 2011-11-07 2020-02-12 Abbott Diabetes Care Inc. Analyte monitoring device and methods
WO2013090215A2 (en) 2011-12-11 2013-06-20 Abbot Diabetes Care Inc. Analyte sensor devices, connections, and methods
US10022498B2 (en) 2011-12-16 2018-07-17 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
WO2013134519A2 (en) 2012-03-07 2013-09-12 Deka Products Limited Partnership Apparatus, system and method for fluid delivery
EP2830687B1 (en) 2012-03-30 2019-07-24 ICU Medical, Inc. Air detection system and method for detecting air in a pump of an infusion system
CA3089257C (en) 2012-07-31 2023-07-25 Icu Medical, Inc. Patient care system for critical medications
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
WO2014138446A1 (en) 2013-03-06 2014-09-12 Hospira,Inc. Medical device communication method
EP2884896B1 (en) * 2013-04-17 2016-05-25 Fluisense Aps Improved fluid sampling system
CA2913421C (en) 2013-05-24 2022-02-15 Hospira, Inc. Multi-sensor infusion system for detecting air or an occlusion in the infusion system
AU2014274122A1 (en) 2013-05-29 2016-01-21 Icu Medical, Inc. Infusion system and method of use which prevents over-saturation of an analog-to-digital converter
ES2838450T3 (es) 2013-05-29 2021-07-02 Icu Medical Inc Sistema de infusión que utiliza uno o más sensores e información adicional para hacer una determinación de aire en relación con el sistema de infusión
EP4309699A3 (en) 2013-07-03 2024-04-24 DEKA Products Limited Partnership Apparatus and system for fluid delivery
US9561324B2 (en) 2013-07-19 2017-02-07 Bigfoot Biomedical, Inc. Infusion pump system and method
EP3039596A4 (en) 2013-08-30 2017-04-12 Hospira, Inc. System and method of monitoring and managing a remote infusion regimen
US9662436B2 (en) 2013-09-20 2017-05-30 Icu Medical, Inc. Fail-safe drug infusion therapy system
US10311972B2 (en) 2013-11-11 2019-06-04 Icu Medical, Inc. Medical device system performance index
TR201908852T4 (tr) 2013-11-19 2019-07-22 Icu Medical Inc İnfüzyon pompası otomasyon sistemi ve yöntemi.
GB2523989B (en) 2014-01-30 2020-07-29 Insulet Netherlands B V Therapeutic product delivery system and method of pairing
EP3110474B1 (en) 2014-02-28 2019-12-18 ICU Medical, Inc. Infusion system and method which utilizes dual wavelength optical air-in-line detection
EP3138032B1 (en) 2014-04-30 2024-07-24 ICU Medical, Inc. Patient care system with conditional alarm forwarding
JP2017517302A (ja) 2014-05-29 2017-06-29 ホスピーラ インコーポレイテッド 構成可能閉ループ送達速度キャッチアップを有する注入システムおよびポンプ
US9724470B2 (en) 2014-06-16 2017-08-08 Icu Medical, Inc. System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy
US9539383B2 (en) 2014-09-15 2017-01-10 Hospira, Inc. System and method that matches delayed infusion auto-programs with manually entered infusion programs and analyzes differences therein
US11344668B2 (en) 2014-12-19 2022-05-31 Icu Medical, Inc. Infusion system with concurrent TPN/insulin infusion
US10737024B2 (en) 2015-02-18 2020-08-11 Insulet Corporation Fluid delivery and infusion devices, and methods of use thereof
US10850024B2 (en) 2015-03-02 2020-12-01 Icu Medical, Inc. Infusion system, device, and method having advanced infusion features
AU2016260547B2 (en) 2015-05-14 2020-09-03 Abbott Diabetes Care Inc. Compact medical device inserters and related systems and methods
US10213139B2 (en) 2015-05-14 2019-02-26 Abbott Diabetes Care Inc. Systems, devices, and methods for assembling an applicator and sensor control device
CA2988094A1 (en) 2015-05-26 2016-12-01 Icu Medical, Inc. Infusion pump system and method with multiple drug library editor source capability
WO2017123525A1 (en) 2016-01-13 2017-07-20 Bigfoot Biomedical, Inc. User interface for diabetes management system
US10610643B2 (en) 2016-01-14 2020-04-07 Bigfoot Biomedical, Inc. Occlusion resolution in medication delivery devices, systems, and methods
US10780223B2 (en) 2016-01-14 2020-09-22 Bigfoot Biomedical, Inc. Adjusting insulin delivery rates
EP3454922B1 (en) 2016-05-13 2022-04-06 ICU Medical, Inc. Infusion pump system with common line auto flush
US12383166B2 (en) 2016-05-23 2025-08-12 Insulet Corporation Insulin delivery system and methods with risk-based set points
AU2017277804B2 (en) 2016-06-10 2022-05-26 Icu Medical, Inc. Acoustic flow sensor for continuous medication flow measurements and feedback control of infusion
NZ750032A (en) 2016-07-14 2020-05-29 Icu Medical Inc Multi-communication path selection and security system for a medical device
US10765807B2 (en) 2016-09-23 2020-09-08 Insulet Corporation Fluid delivery device with sensor
US11096624B2 (en) 2016-12-12 2021-08-24 Bigfoot Biomedical, Inc. Alarms and alerts for medication delivery devices and systems
US10500334B2 (en) 2017-01-13 2019-12-10 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
EP3568860B1 (en) 2017-01-13 2025-12-10 Insulet Corporation Insulin delivery methods, systems and devices
US10583250B2 (en) 2017-01-13 2020-03-10 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
US10758675B2 (en) 2017-01-13 2020-09-01 Bigfoot Biomedical, Inc. System and method for adjusting insulin delivery
EP3568862B1 (en) 2017-01-13 2026-03-18 Insulet Corporation System and method for adjusting insulin delivery
WO2018132765A1 (en) 2017-01-13 2018-07-19 Mazlish Bryan Insulin delivery methods, systems and devices
CN115444410B (zh) 2017-01-23 2025-08-15 雅培糖尿病护理公司 用于插入体内分析物传感器的施加器及组件
US10089055B1 (en) 2017-12-27 2018-10-02 Icu Medical, Inc. Synchronized display of screen content on networked devices
USD928199S1 (en) 2018-04-02 2021-08-17 Bigfoot Biomedical, Inc. Medication delivery device with icons
CA3098372A1 (en) 2018-04-24 2019-10-31 Deka Products Limited Partnership Apparatus and system for fluid delivery
CN118750687A (zh) 2018-05-04 2024-10-11 英赛罗公司 基于控制算法的药物输送系统的安全约束
US12562251B1 (en) 2018-05-09 2026-02-24 Bigfoot Biomedical, Inc. Computing architecture for assuring the provenance of medication therapy related parameters, and related systems, methods and devices
US10964428B2 (en) 2018-07-17 2021-03-30 Icu Medical, Inc. Merging messages into cache and generating user interface using the cache
AU2019306490B2 (en) 2018-07-17 2024-11-21 Icu Medical, Inc. Updating infusion pump drug libraries and operational software in a networked environment
NZ772135A (en) 2018-07-17 2022-11-25 Icu Medical Inc Systems and methods for facilitating clinical messaging in a network environment
US10861592B2 (en) 2018-07-17 2020-12-08 Icu Medical, Inc. Reducing infusion pump network congestion by staggering updates
US10692595B2 (en) 2018-07-26 2020-06-23 Icu Medical, Inc. Drug library dynamic version management
AU2019309766B2 (en) 2018-07-26 2024-06-13 Icu Medical, Inc. Drug library management system
JP2022501139A (ja) 2018-09-28 2022-01-06 インスレット コーポレイション 人工膵臓システム用活動モード
US11565039B2 (en) 2018-10-11 2023-01-31 Insulet Corporation Event detection for drug delivery system
WO2020131159A1 (en) 2018-12-21 2020-06-25 Abbott Diabetes Care Inc. Systems, devices, and methods for analyte sensor insertion
USD920343S1 (en) 2019-01-09 2021-05-25 Bigfoot Biomedical, Inc. Display screen or portion thereof with graphical user interface associated with insulin delivery
WO2020227403A1 (en) 2019-05-08 2020-11-12 Icu Medical, Inc. Threshold signature based medical device management
US11801344B2 (en) 2019-09-13 2023-10-31 Insulet Corporation Blood glucose rate of change modulation of meal and correction insulin bolus quantity
US11935637B2 (en) 2019-09-27 2024-03-19 Insulet Corporation Onboarding and total daily insulin adaptivity
US11278671B2 (en) 2019-12-04 2022-03-22 Icu Medical, Inc. Infusion pump with safety sequence keypad
US11957875B2 (en) 2019-12-06 2024-04-16 Insulet Corporation Techniques and devices providing adaptivity and personalization in diabetes treatment
US11833329B2 (en) 2019-12-20 2023-12-05 Insulet Corporation Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns
JP7512395B2 (ja) 2020-01-06 2024-07-08 インスレット コーポレイション 持続する残差に基づく食事および／または運動行為の予測
EP4100958A1 (en) 2020-02-03 2022-12-14 Insulet Corporation Use of fuzzy logic in predicting user behavior affecting blood glucose concentration
US11536685B2 (en) 2020-02-06 2022-12-27 Trustees Of Boston University High throughput assay for identifying microbial redox enzymes
US11331020B2 (en) 2020-02-06 2022-05-17 Trustees Of Boston University Enzyme-based electrochemical nicotine biosensor
US11551802B2 (en) 2020-02-11 2023-01-10 Insulet Corporation Early meal detection and calorie intake detection
US11986630B2 (en) 2020-02-12 2024-05-21 Insulet Corporation Dual hormone delivery system for reducing impending hypoglycemia and/or hyperglycemia risk
US11547800B2 (en) 2020-02-12 2023-01-10 Insulet Corporation User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system
US11324889B2 (en) 2020-02-14 2022-05-10 Insulet Corporation Compensation for missing readings from a glucose monitor in an automated insulin delivery system
US12495994B2 (en) 2020-02-20 2025-12-16 Insulet Corporation Meal bolus subcategories in model based insulin therapy
US11590057B2 (en) 2020-04-03 2023-02-28 Icu Medical, Inc. Systems, methods, and components for transferring medical fluids
US11607493B2 (en) 2020-04-06 2023-03-21 Insulet Corporation Initial total daily insulin setting for user onboarding
EP4175621A4 (en) 2020-07-02 2024-07-17 ICU Medical, Inc. Location-based reconfiguration of infusion pump settings
WO2022020184A1 (en) 2020-07-21 2022-01-27 Icu Medical, Inc. Fluid transfer devices and methods of use
US12121700B2 (en) 2020-07-22 2024-10-22 Insulet Corporation Open-loop insulin delivery basal parameters based on insulin delivery records
US11684716B2 (en) 2020-07-31 2023-06-27 Insulet Corporation Techniques to reduce risk of occlusions in drug delivery systems
CN115942909A (zh) 2020-08-31 2023-04-07 雅培糖尿病护理公司 用于分析物传感器插入的系统、装置和方法
AU2021337529A1 (en) 2020-09-05 2023-05-18 Icu Medical, Inc. Identity-based secure medical device communications
ES3000715T3 (en) 2020-09-15 2025-03-03 Abbott Diabetes Care Inc Device for analyte monitoring
US12569619B2 (en) 2020-09-21 2026-03-10 Insulet Corporation Techniques for determining automated insulin delivery dosages
US12128215B2 (en) 2020-09-30 2024-10-29 Insulet Corporation Drug delivery device with integrated optical-based glucose monitor
EP4221588A1 (en) 2020-09-30 2023-08-09 Insulet Corporation Secure wireless communications between a glucose monitor and other devices
US11135360B1 (en) 2020-12-07 2021-10-05 Icu Medical, Inc. Concurrent infusion with common line auto flush
US11160925B1 (en) 2021-01-29 2021-11-02 Insulet Corporation Automatic drug delivery system for delivery of a GLP-1 therapeutic
US11904140B2 (en) 2021-03-10 2024-02-20 Insulet Corporation Adaptable asymmetric medicament cost component in a control system for medicament delivery
US12431229B2 (en) 2021-03-10 2025-09-30 Insulet Corporation Medicament delivery device with an adjustable and piecewise analyte level cost component to address persistent positive analyte level excursions
US12592306B2 (en) 2021-04-28 2026-03-31 Insulet Corporation Devices and methods for initialization of drug delivery devices using measured analyte sensor information
US12496398B2 (en) 2021-05-28 2025-12-16 Insulet Corporation Threshold based automatic glucose control response
US12406760B2 (en) 2021-06-07 2025-09-02 Insulet Corporation Exercise safety prediction based on physiological conditions
US12514980B2 (en) 2021-06-30 2026-01-06 Insulet Corporation Adjustment of medicament delivery by a medicament delivery device based on menstrual cycle phase
US12521486B2 (en) 2021-07-16 2026-01-13 Insulet Corporation Method for modification of insulin delivery during pregnancy in automatic insulin delivery systems
MY202051A (en) 2021-07-16 2024-03-30 Abbott Diabetes Care Inc Systems, devices, and methods for analyte monitoring
EP4409581A1 (en) 2021-09-27 2024-08-07 Insulet Corporation Techniques enabling adaptation of parameters in aid systems by user input
US12599716B2 (en) 2021-10-12 2026-04-14 Icu Medical, Inc. Intravenous infusion pump with cassette insertion and pump control user interface
USD1091564S1 (en) 2021-10-13 2025-09-02 Icu Medical, Inc. Display screen or portion thereof with graphical user interface for a medical device
US11439754B1 (en) 2021-12-01 2022-09-13 Insulet Corporation Optimizing embedded formulations for drug delivery
AU2022407460A1 (en) 2021-12-10 2024-06-27 Icu Medical, Inc. Medical fluid compounding systems with coordinated flow control
EP4243030A1 (en) 2022-03-09 2023-09-13 Insulet Corporation Adjusting medicament delivery parameters in an open loop medicament delivery mode
CN120457493A (zh) 2023-01-06 2025-08-08 英赛罗公司 自动或手动启动的随餐推注输送及随后的自动安全约束放宽

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3837339A (en) * 1972-02-03 1974-09-24 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
US3983864A (en) * 1974-08-01 1976-10-05 Airco, Inc. Method and apparatus for in vivo blood gas analysis
US4311789A (en) * 1975-12-31 1982-01-19 Gambro Ag Method for sampling and measuring the content of a low-molecular weight compound in a complex fluid medium
DE2734247C2 (de) * 1977-07-29 1984-07-19 Fresenius AG, 6380 Bad Homburg Vorrichtung zur fortlaufenden chemischen Analyse im lebenden Körper
DE2737922A1 (de) * 1977-08-23 1979-03-08 Fresenius Chem Pharm Ind Kuenstliche endokrine druese
DE2807367A1 (de) * 1978-02-21 1979-08-30 Nikkiso Co Ltd Kuenstliche betazelle
US4403984A (en) * 1979-12-28 1983-09-13 Biotek, Inc. System for demand-based adminstration of insulin
US4381775A (en) * 1980-02-05 1983-05-03 Takeda Chemical Industries, Ltd. Method for low pressure filtration of plasma from blood
US4437856A (en) * 1981-02-09 1984-03-20 Alberto Valli Peritoneal catheter device for dialysis
US4436094A (en) * 1981-03-09 1984-03-13 Evreka, Inc. Monitor for continuous in vivo measurement of glucose concentration
JPS5861251U (ja) * 1981-10-22 1983-04-25 石川　惣二 注射針
US4447191A (en) * 1981-12-15 1984-05-08 Baxter Travenol Laboratories, Inc. Control circuit for a blood fractionation apparatus

Also Published As

Publication number Publication date
IT1170375B (it) 1987-06-03
IT8348129A0 (it) 1983-04-19
EP0134758A2 (en) 1985-03-20
US4633878A (en) 1987-01-06
EP0134758A3 (en) 1986-03-19

Similar Documents

Publication Publication Date Title
US4633878A (en) Device for the automatic insulin or glucose infusion in diabetic subjects, based on the continuous monitoring of the patient's glucose, obtained without blood withdrawal
CA2202038C (en) Central venous oxygen saturation measurement
JP2786646B2 (ja) グルコース濃度決定のための方法、装置および測定セル組立品
DE69025646T2 (de) Kunst-Pankreas
US7736309B2 (en) Implantable sensor method and system
US5002054A (en) Interstitial filtration and collection device and method for long-term monitoring of physiological constituents of the body
US4854322A (en) Capillary filtration and collection device for long-term monitoring of blood constituents
US4777953A (en) Capillary filtration and collection method for long-term monitoring of blood constituents
US7166074B2 (en) Reusable analyte sensor site and method of using the same
JP3378289B2 (ja) 中央静脈酸素飽和度測定用カテーテル
US20090312622A1 (en) Device And Method For Determining A Value Of A Physiological Parameter Of A Body Fluid
CN103071195A (zh) 用于促进透析之间的血液循环的装置
KR20070052781A (ko) 센서
US6954665B2 (en) Catheter system
US9717434B2 (en) Perfusion cannula with integrated sensor technology
CN103732283A (zh) 用于治疗间室综合症的系统和方法
US20200390375A1 (en) Peripheral fiberoptic intravascular blood metric probe modular device and method
AU685108B2 (en) Remote sensing tonometric catheter apparatus and method
JPH02246986A (ja) 生体内案内具
EP1898799A1 (en) Device for and method of delivery and removal of substances in and from a tissue or vessel
CN210409108U (zh) 腹膜透析套管针
CN215424653U (zh) 一种采血装置
CN109200383A (zh) 一种一次性静脉留置针固定装置
Fritschka et al. Removal of 14-C-palmitate during ventriculocisternal perfusion in conscious dogs in insulin-induced hypoglycemia
JPS6041237Y2 (ja) 血管插入用医療器具