IT8423264A1 - Nuovo processo per la preparazione dell'acido 2(4-fluorofenil)a -metil-5-benzoxazoloacetico - Google Patents

Nuovo processo per la preparazione dell'acido 2(4-fluorofenil)a -metil-5-benzoxazoloacetico

Info

Publication number: IT8423264A1
Authority: IT; Italy
Prior art keywords: fluorophenyl; acid; methyl; benzoxazole; reacted
Prior art date: 1984-10-22

Application number

IT1984A23264A

Other languages

English (en)

Other versions

IT1177017B (it

IT8423264A0 (it

Original Assignee

Ravizza Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-22

Filing date

1984-10-22

Publication date

1986-04-22

1984-10-22 Application filed by Ravizza Spa filed Critical Ravizza Spa

1984-10-22 Priority to IT23264/84A priority Critical patent/IT1177017B/it

1984-10-22 Publication of IT8423264A0 publication Critical patent/IT8423264A0/it

1985-10-07 Priority to EP85112699A priority patent/EP0182061B1/en

1985-10-07 Priority to AT85112699T priority patent/ATE70832T1/de

1985-10-07 Priority to US06/784,892 priority patent/US4652654A/en

1985-10-07 Priority to DE8585112699T priority patent/DE3585022D1/de

1985-10-18 Priority to JP60231423A priority patent/JPS61100574A/ja

1986-04-22 Publication of IT8423264A1 publication Critical patent/IT8423264A1/it

1987-08-26 Application granted granted Critical

1987-08-26 Publication of IT1177017B publication Critical patent/IT1177017B/it

Links

239000002253 acid Substances 0.000 title abstract 2
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 title 1
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
AOZKIUFHHMUPGU-UHFFFAOYSA-N 2-(3-amino-4-hydroxyphenyl)acetic acid Chemical compound NC1=CC(CC(O)=O)=CC=C1O AOZKIUFHHMUPGU-UHFFFAOYSA-N 0.000 abstract 1
KBFHXGWZGIITPB-UHFFFAOYSA-N 2-[2-(4-fluorophenyl)-1,3-benzoxazol-5-yl]acetic acid Chemical compound N=1C2=CC(CC(=O)O)=CC=C2OC=1C1=CC=C(F)C=C1 KBFHXGWZGIITPB-UHFFFAOYSA-N 0.000 abstract 1
CZKLEJHVLCMVQR-UHFFFAOYSA-N 4-fluorobenzoyl chloride Chemical compound FC1=CC=C(C(Cl)=O)C=C1 CZKLEJHVLCMVQR-UHFFFAOYSA-N 0.000 abstract 1
NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 abstract 1
229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
WYACBZDAHNBPPB-UHFFFAOYSA-N diethyl oxalate Chemical compound CCOC(=O)C(=O)OCC WYACBZDAHNBPPB-UHFFFAOYSA-N 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
235000019441 ethanol Nutrition 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
KHPXUQMNIQBQEV-UHFFFAOYSA-L oxaloacetate(2-) Chemical compound [O-]C(=O)CC(=O)C([O-])=O KHPXUQMNIQBQEV-UHFFFAOYSA-L 0.000 abstract 1
229910000027 potassium carbonate Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IT23264/84A 1984-10-22 1984-10-22 Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico IT1177017B (it)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
IT23264/84A IT1177017B (it)	1984-10-22	1984-10-22	Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
EP85112699A EP0182061B1 (en)	1984-10-22	1985-10-07	New process for preparing 2(4-fluorophenyl) alpha methyl-5-benzoxazole acetic acid
AT85112699T ATE70832T1 (de)	1984-10-22	1985-10-07	Verfahren zur herstellung von 2-(4-fluorphenyl)alpha-methyl-5-benzoxazolessigs\|ure.
US06/784,892 US4652654A (en)	1984-10-22	1985-10-07	Process for preparing 2(4-fluorophenyl)alpha-methyl-5-benzoxazole acetic acid
DE8585112699T DE3585022D1 (de)	1984-10-22	1985-10-07	Verfahren zur herstellung von 2-(4-fluorphenyl)-alpha-methyl-5-benzoxazolessigsaeure.
JP60231423A JPS61100574A (ja)	1984-10-22	1985-10-18	２（４‐フルオロフエニル）α‐メチル‐５‐ベンゾオキサゾール酢酸の製造方法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT23264/84A IT1177017B (it)	1984-10-22	1984-10-22	Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico

Publications (3)

Publication Number	Publication Date
IT8423264A0 IT8423264A0 (it)	1984-10-22
IT8423264A1 true IT8423264A1 (it)	1986-04-22
IT1177017B IT1177017B (it)	1987-08-26

Family

ID=11205428

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT23264/84A IT1177017B (it)	1984-10-22	1984-10-22	Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico

Country Status (6)

Country	Link
US (1)	US4652654A (it)
EP (1)	EP0182061B1 (it)
JP (1)	JPS61100574A (it)
AT (1)	ATE70832T1 (it)
DE (1)	DE3585022D1 (it)
IT (1)	IT1177017B (it)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1233836B (it) *	1988-01-13	1992-04-21	Euroresearch Srl	Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
GB9312853D0 (en) *	1993-06-22	1993-08-04	Euro Celtique Sa	Chemical compounds
US5591776A (en) *	1994-06-24	1997-01-07	Euro-Celtique, S.A.	Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) *	1994-06-24	1999-07-13	Euro-Celtique, S.A.	Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
US6372770B1 (en)	1994-10-12	2002-04-16	Euro-Celtique, S.A.	Benzoxazoles
US5665737B1 (en) *	1994-10-12	1999-02-16	Euro Celtique Sa	Substituted benzoxazoles
EP0785927B1 (en) *	1994-10-12	2003-08-27	Euroceltique S.A.	Novel benzoxazoles
US6066641A (en) *	1994-12-13	2000-05-23	Euro-Celtique S.A.	Aryl thioxanthines
US6025361A (en) *	1994-12-13	2000-02-15	Euro-Celtique, S.A.	Trisubstituted thioxanthines
EP0799040B1 (en) *	1994-12-13	2003-08-20	Euroceltique S.A.	Trisubstituted thioxanthines
US6166041A (en) *	1995-10-11	2000-12-26	Euro-Celtique, S.A.	2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) *	1996-04-10	2000-06-13	Euro-Celtique S.A.	6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
US5864037A (en)	1996-06-06	1999-01-26	Euro-Celtique, S.A.	Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5744473A (en) *	1996-09-16	1998-04-28	Euro-Celtique, S.A.	PDE IV inhibitors: "bis-compounds"
DE69834601T2 (de)	1997-02-03	2007-05-03	Fuji Photo Film Co., Ltd., Minami-Ashigara	Silberhalogenid enthaltendes farbphotographisches material, phenidonverbindungen zu seiner herstellung und verfahren zur herstellung dieser phenidonverbindungen
KR20120016651A (ko) *	2009-05-15	2012-02-24	사노피	Ｔａｆｉａ의 억제제로서 유용한 화합물의 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3962452A (en) *	1972-05-18	1976-06-08	Lilly Industries, Ltd.	Benzoxazole derivatives as therapeutics
GB1435721A (en) *	1972-05-18	1976-05-12	Lilly Industries Ltd	Benzoxazole derivatives
US4025636A (en) *	1973-10-23	1977-05-24	Lilly Industries, Ltd.	2-(Optionally substituted)phenyl-5 or 6-substituted benzoxazoles

1984
- 1984-10-22 IT IT23264/84A patent/IT1177017B/it active
1985
- 1985-10-07 EP EP85112699A patent/EP0182061B1/en not_active Expired - Lifetime
- 1985-10-07 US US06/784,892 patent/US4652654A/en not_active Expired - Lifetime
- 1985-10-07 DE DE8585112699T patent/DE3585022D1/de not_active Expired - Fee Related
- 1985-10-07 AT AT85112699T patent/ATE70832T1/de not_active IP Right Cessation
- 1985-10-18 JP JP60231423A patent/JPS61100574A/ja active Granted

Also Published As

Publication number	Publication date
IT1177017B (it)	1987-08-26
EP0182061B1 (en)	1991-12-27
US4652654A (en)	1987-03-24
EP0182061A1 (en)	1986-05-28
ATE70832T1 (de)	1992-01-15
IT8423264A0 (it)	1984-10-22
JPH0368026B2 (it)	1991-10-25
JPS61100574A (ja)	1986-05-19
DE3585022D1 (de)	1992-02-06

Legal Events

Date	Code	Title	Description
1999-10-27	TA	Fee payment date (situation as of event date), data collected since 19931001	Effective date: 19971029

Publication	Publication Date	Title
IT8423264A1 (it)	1986-04-22	Nuovo processo per la preparazione dell'acido 2(4-fluorofenil)a -metil-5-benzoxazoloacetico
GB1435887A (en)	1976-05-19	Oxygenated alicyclic derivatives useful as odoriferous and flavouring ingredients
ATE229013T1 (de)	2002-12-15	Verfahren zur herstellung von hydroxysubstituierten gamma-butyrolactonen
ES2062205T3 (es)	1994-12-16	Metodo para producir 2,2-dimetil-3-hidroxipropil-2,2-dimetil-3-hidroxipropionato.
HU910939D0 (en)	1991-10-28	Process and intermediate products for the production of 2r-benzyl-chromane-6-carbaldehyde
ATE46694T1 (de)	1989-10-15	Verfahren zur herstellung von meldrumsaeure.
DE69211936D1 (de)	1996-08-08	Verfahren zur Herstellung von niedrigem Alkyl-2-oxo-L-Gulonat
ATE207139T1 (de)	2001-11-15	Verfahren zur herstellung von butantetracarbonsäure
KR100214903B1 (en)	1999-08-02	Process for producing aminomethanephosphonic acid and aminomethylphosphinic acids
HUT46316A (en)	1988-10-28	Process for producing 4-amino-6-fluor-chromane-4-carboxylic acid and its /2r/-methyl ester
IT8521530A0 (it)	1985-07-11	Processo per produrre acido cinnamico.
DE3674122D1 (de)	1990-10-18	Verfahren zur herstellung optisch aktiver alpha-haloalkylarylketone.
ES8305326A1 (es)	1983-04-01	"procedimiento para la preparacion de l-prolina".
ATE130839T1 (de)	1995-12-15	Verfahren zur herstellung von carboxylierten 2- allylphenolen.
ES8506630A1 (es)	1985-07-16	Procedimiento para la preparacion de esteres de acido 6-metil-nicotinico
IT1175512B (it)	1987-07-01	Processo per la preparazione di esteri alchilici dell'acido metilartronico
IT1113932B (it)	1986-01-27	Processo per la idrogenazione stereoselettiva dell'acido 2i(6'-metossi-2'-naftil)-acrilico
ATE35679T1 (de)	1988-07-15	Verfahren zur herstellung von cis-3,3,5trimethylcyclohexyl-d,l-alpha-(3-pyridincarboxy - phenylacetat.
IL99380A (en)	1997-01-10	Process for the preparation of acid addition salt of 3-amino-4-arylethyl-2-oxoazetidine acetic acid derivatives and n-beta-methyl acrylic acid ester intermediate therefor
ES8105779A1 (es)	1981-06-01	Un metodo para producir acido l-glutamico