IT8822018A0 - Dipeptidi fosfinilcicloalchilcarbonilici e fosfonilcicloalchenilcarbonilici ad azione farmaceutica - Google Patents

Dipeptidi fosfinilcicloalchilcarbonilici e fosfonilcicloalchenilcarbonilici ad azione farmaceutica

Info

Publication number
IT8822018A0
IT8822018A0 IT8822018A IT2201888A IT8822018A0 IT 8822018 A0 IT8822018 A0 IT 8822018A0 IT 8822018 A IT8822018 A IT 8822018A IT 2201888 A IT2201888 A IT 2201888A IT 8822018 A0 IT8822018 A0 IT 8822018A0
Authority
IT
Italy
Prior art keywords
dipeptides
phosphonylcycloalkylcarbonyl
phosphonylcycloalkenylcarbonyl
pharmaceutical action
pharmaceutical
Prior art date
Application number
IT8822018A
Other languages
English (en)
Other versions
IT1227165B (it
Inventor
Harold Norris Weller Iii
Eric M Gordon
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Publication of IT8822018A0 publication Critical patent/IT8822018A0/it
Application granted granted Critical
Publication of IT1227165B publication Critical patent/IT1227165B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT8822018A 1987-09-21 1988-09-20 Dipeptidi fosfinilcicloalchilcarbonilici e fosfonilcicloalchenilcarbonilici ad azione farmaceutica IT1227165B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/098,651 US4849525A (en) 1987-09-21 1987-09-21 Phosphinylcycloalkylcarbonyl and phosphinylcycloalkenylcarbonyl dipeptides

Publications (2)

Publication Number Publication Date
IT8822018A0 true IT8822018A0 (it) 1988-09-20
IT1227165B IT1227165B (it) 1991-03-20

Family

ID=22270313

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8822018A IT1227165B (it) 1987-09-21 1988-09-20 Dipeptidi fosfinilcicloalchilcarbonilici e fosfonilcicloalchenilcarbonilici ad azione farmaceutica

Country Status (7)

Country Link
US (1) US4849525A (it)
JP (1) JP2625523B2 (it)
CA (1) CA1316630C (it)
DE (1) DE3831936A1 (it)
FR (1) FR2620711B1 (it)
GB (1) GB2210043B (it)
IT (1) IT1227165B (it)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011021A (en) * 1996-06-17 2000-01-04 Guilford Pharmaceuticals Inc. Methods of cancer treatment using naaladase inhibitors
US5795877A (en) * 1996-12-31 1998-08-18 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5902817A (en) * 1997-04-09 1999-05-11 Guilford Pharmaceuticals Inc. Certain sulfoxide and sulfone derivatives
HUP9903421A3 (en) 1996-06-17 2001-08-28 Guilford Pharmaceuticals Inc B Use of phosphonic and phosphinic acid derivatives for producing pharmaceutical compositions having naaladase inhibitor activity
US5977090A (en) * 1996-09-27 1999-11-02 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
US6071965A (en) * 1996-06-17 2000-06-06 Guilford Pharmaceuticals Inc. Phosphinic alkanoic acid derivatives
US6384022B1 (en) 1996-06-17 2002-05-07 Guilford Pharmaceuticals Inc. Prodrugs of NAALAdase inhibitors
US6025345A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Inhibitors of NAALADase enzyme activity
US5863536A (en) * 1996-12-31 1999-01-26 Guilford Pharmaceuticals Inc. Phosphoramidate derivatives
US6025344A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
US5672592A (en) * 1996-06-17 1997-09-30 Guilford Pharmaceuticals Inc. Certain phosphonomethyl-pentanedioic acid derivatives thereof
US6046180A (en) * 1996-06-17 2000-04-04 Guilford Pharmaceuticals Inc. NAALADase inhibitors
US6054444A (en) 1997-04-24 2000-04-25 Guilford Pharmaceuticals Inc. Phosphonic acid derivatives
US5962521A (en) 1997-04-04 1999-10-05 Guilford Pharmaceuticals Inc. Hydroxamic acid derivatives
US5981209A (en) * 1997-12-04 1999-11-09 Guilford Pharmaceuticals Inc. Use of NAALADase activity to identify prostate cancer and benign prostatic hyperplasia
US6028216A (en) * 1997-12-31 2000-02-22 Guilford Pharmaceuticals Inc. Asymmetric syntheses and intermediates for preparing enantiomer-enriched hydroxyphosphinyl derivatives
US6121252A (en) * 1998-03-30 2000-09-19 Guilford Pharmaceuticals Inc. Phosphinic acid derivatives
US6265609B1 (en) 1998-07-06 2001-07-24 Guilford Pharmaceuticals Inc. Thio-substituted pentanedioic acid derivatives
US6395718B1 (en) 1998-07-06 2002-05-28 Guilford Pharmaceuticals Inc. Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
CA2337797C (en) 1998-07-06 2009-04-14 Guilford Pharmaceuticals Inc. Naaladase inhibitors useful as pharmaceutical compounds and compositions
US6313159B1 (en) 1999-08-20 2001-11-06 Guilford Pharmaceuticals Inc. Metabotropic glutamate receptor ligand derivatives as naaladase inhibitors
SG170767A1 (en) 2005-12-23 2011-05-30 Zealand Pharma As Modified lysine-mimetic compounds
EP2468724B1 (en) * 2006-12-21 2015-11-18 Zealand Pharma A/S Synthesis of pyrrolidine compounds
CN103397904B (zh) * 2013-08-21 2015-05-13 中交天和机械设备制造有限公司 超大型盾构机穿梭舱井下搬运方法
WO2018202865A1 (en) 2017-05-05 2018-11-08 Zealand Pharma A/S Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4384123A (en) * 1980-12-04 1983-05-17 E. R. Squibb & Sons, Inc. Phosphinylalkanoyl substituted prolines
US4374131A (en) * 1981-04-27 1983-02-15 E. R. Squibb & Sons, Inc. Amino and substituted amino phosphinyl-alkanoyl compounds
US4432971A (en) * 1981-08-03 1984-02-21 E. R. Squibb & Sons, Inc. Phosphonamidate compounds
EP0071544B1 (en) * 1981-08-03 1986-10-08 E.R. Squibb & Sons, Inc. Phosphonamidate compounds
US4381287A (en) * 1982-03-30 1983-04-26 The United States Of America As Represented By The Secretary Of The Interior Separation of zirconium and uranium
US4560681A (en) * 1982-04-22 1985-12-24 E. R. Squibb & Sons, Inc. Phosphinylmethylaminocarbonyl imino acid compounds useful for treating hypertension
US4468519A (en) * 1982-06-14 1984-08-28 E. R. Squibb & Sons, Inc. Esters of phosphinylalkanoyl substituted prolines
US4499079A (en) * 1982-11-18 1985-02-12 E. R. Squibb & Sons, Inc. Carboxy and substituted carboxy alkanoyl and cycloalkanoyl peptides
US4560506A (en) * 1984-05-25 1985-12-24 E. R. Squibb & Sons, Inc. Mercaptocycloalkylcarbonyl and mercaptoarylcarbonyl dipeptides

Also Published As

Publication number Publication date
FR2620711B1 (fr) 1995-03-31
IT1227165B (it) 1991-03-20
JPH01113400A (ja) 1989-05-02
DE3831936A1 (de) 1989-04-06
GB2210043A (en) 1989-06-01
GB8821942D0 (en) 1988-10-19
FR2620711A1 (fr) 1989-03-24
CA1316630C (en) 1993-04-20
US4849525A (en) 1989-07-18
GB2210043B (en) 1991-05-08
JP2625523B2 (ja) 1997-07-02

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Legal Events

Date Code Title Description
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970929