IT9020300A0 - 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline e processi per la loro preparazione - Google Patents

3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline e processi per la loro preparazione

Info

Publication number
IT9020300A0
IT9020300A0 IT9020300A IT2030090A IT9020300A0 IT 9020300 A0 IT9020300 A0 IT 9020300A0 IT 9020300 A IT9020300 A IT 9020300A IT 2030090 A IT2030090 A IT 2030090A IT 9020300 A0 IT9020300 A0 IT 9020300A0
Authority
IT
Italy
Prior art keywords
fluoroantra
cyclines
deamino
deoxy
amino
Prior art date
Application number
IT9020300A
Other languages
English (en)
Other versions
IT1241927B (it
IT9020300A1 (it
Inventor
Fabio Aminati
Paolo Lombardi
Federico Arcamone
Original Assignee
Menarini Farma Ind Farmaceuticheriun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Menarini Farma Ind Farmaceuticheriun filed Critical Menarini Farma Ind Farmaceuticheriun
Publication of IT9020300A0 publication Critical patent/IT9020300A0/it
Priority to IT20300A priority Critical patent/IT1241927B/it
Priority to NO911798A priority patent/NO174963C/no
Priority to CS911358A priority patent/CS135891A3/cs
Priority to FI912269A priority patent/FI912269A7/fi
Priority to EP91107628A priority patent/EP0457215B1/en
Priority to AT91107628T priority patent/ATE133177T1/de
Priority to DK91107628.9T priority patent/DK0457215T3/da
Priority to MX25747A priority patent/MX25747A/es
Priority to DE69116423T priority patent/DE69116423T2/de
Priority to ES91107628T priority patent/ES2084724T3/es
Priority to CA002042463A priority patent/CA2042463A1/en
Priority to TW080103704A priority patent/TW228524B/zh
Priority to SU914895527A priority patent/RU2095365C1/ru
Priority to HU911595A priority patent/HU209458B/hu
Priority to IE163491A priority patent/IE911634A1/en
Priority to MA22423A priority patent/MA22153A1/fr
Priority to AU76493/91A priority patent/AU638574B2/en
Priority to IL98117A priority patent/IL98117A0/xx
Priority to YU83691A priority patent/YU83691A/sh
Priority to PL29023691A priority patent/PL290236A1/xx
Priority to RO147541A priority patent/RO108792B1/ro
Priority to PT97663A priority patent/PT97663B/pt
Priority to TNTNSN91036A priority patent/TNSN91036A1/fr
Priority to CN91103091A priority patent/CN1031192C/zh
Priority to BR919101973A priority patent/BR9101973A/pt
Priority to JP3136954A priority patent/JPH04226972A/ja
Priority to KR1019910007747A priority patent/KR910020025A/ko
Priority to ZA913644A priority patent/ZA913644B/xx
Priority to US07/699,898 priority patent/US5807835A/en
Publication of IT9020300A1 publication Critical patent/IT9020300A1/it
Application granted granted Critical
Publication of IT1241927B publication Critical patent/IT1241927B/it
Priority to GR950403698T priority patent/GR3018716T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrane Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT20300A 1990-05-14 1990-05-14 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono IT1241927B (it)

Priority Applications (30)

Application Number Priority Date Filing Date Title
IT20300A IT1241927B (it) 1990-05-14 1990-05-14 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono
NO911798A NO174963C (no) 1990-05-14 1991-05-08 Analogifremgangsmåte for fremstilling av terapeutisk aktive 8-fluorantracyklinglucosider
CS911358A CS135891A3 (en) 1990-05-14 1991-05-08 8-fluoroanthracyclin glycosides
FI912269A FI912269A7 (fi) 1990-05-14 1991-05-10 3'-deamino - 4'deoxi - 4'-amino- 8 -fluorantracykliner och framstaellningsfoerfaranden foer dessa.
EP91107628A EP0457215B1 (en) 1990-05-14 1991-05-10 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and processes for their preparation
AT91107628T ATE133177T1 (de) 1990-05-14 1991-05-10 3'-deamino-4'-deoxy-4'-amino-8-fluoranthracycli e und verfahren zu ihrer herstellung
DK91107628.9T DK0457215T3 (da) 1990-05-14 1991-05-10 3-deamino-4-desoxy-4-amino-8-fluoranthracycliner samt fremgangsmåder til fremstilling deraf
MX25747A MX25747A (es) 1990-05-14 1991-05-10 3'-desamino-4' -desoxi-4' -amino-8-fluoroantraciclinas y procedimiento para su preparacion.
DE69116423T DE69116423T2 (de) 1990-05-14 1991-05-10 3'-Deamino-4'-deoxy-4'-amino-8-fluoranthracycline und Verfahren zu ihrer Herstellung
ES91107628T ES2084724T3 (es) 1990-05-14 1991-05-10 3'-desamino-4'-desoxi-4'-amino-8-fluoroantraciclinas y procedimientos de preparacion.
IE163491A IE911634A1 (en) 1990-05-14 1991-05-13 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and¹processes for their preparation
TW080103704A TW228524B (it) 1990-05-14 1991-05-13
SU914895527A RU2095365C1 (ru) 1990-05-14 1991-05-13 8-фторантрациклингликозиды или их фармацевтически приемлемые соли присоединения кислот, способ их получения, фармацевтическая композиция, промежуточные соединения и способ их получения
HU911595A HU209458B (en) 1990-05-14 1991-05-13 Process for preparing 3'-deamino-4'-deoxy-4'-amino-8-fluoranthracyclin derivatives and pharmaceutical compositions containing them as active agents
CA002042463A CA2042463A1 (en) 1990-05-14 1991-05-13 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and processes for their preparation
MA22423A MA22153A1 (fr) 1990-05-14 1991-05-13 3'-deamino-4'-deoxy-4'-amino-8-fluoro- anthracyclines et procede pour leur preparation
AU76493/91A AU638574B2 (en) 1990-05-14 1991-05-13 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and processes for their preparation
IL98117A IL98117A0 (en) 1990-05-14 1991-05-13 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines,their preparation and pharmaceutical compositions containing them
YU83691A YU83691A (sh) 1990-05-14 1991-05-13 3'-diamino-4'-deoksi-4'-amino-8-fluoroantraciklini i postupak za njihovu proizvodnju
PL29023691A PL290236A1 (en) 1990-05-14 1991-05-13 Method of obtaining novel 8-fluoroanthracyclin glycosides
PT97663A PT97663B (pt) 1990-05-14 1991-05-14 Processo de preparacao de 3'-desamino-4'-desoxi-4'-amino-8-fluoro-antraciclinas, de composicoes farmaceuticas que as contem e de seus intermediarios
RO147541A RO108792B1 (ro) 1990-05-14 1991-05-14 Derivati de 8-fluoroantraciclinglicozide, procedeu de preparare a acestora si compusi intermediari
TNTNSN91036A TNSN91036A1 (fr) 1990-05-14 1991-05-14 3'-deamino-4' deoxy-4'-amino-8-fluoro-anthracyclines et leur procede de fabrication
CN91103091A CN1031192C (zh) 1990-05-14 1991-05-14 3′-脱氨基-4′-脱氧-4′-氨基-8-氟蒽环苷类的制备方法
BR919101973A BR9101973A (pt) 1990-05-14 1991-05-14 Compostos quimicos,processo para a sua preparacao e composicoes farmaceutica e terapeutica
JP3136954A JPH04226972A (ja) 1990-05-14 1991-05-14 ３′−デアミノ−４′−デオキシ−４′−アミノ−８−フルオロアントラサイクリン及びそれらの調製方法
KR1019910007747A KR910020025A (ko) 1990-05-14 1991-05-14 3'-데아미노-4'-데옥시-4'-아미노-8-플루오로안트라사이클린 및 이의 제조방법
ZA913644A ZA913644B (en) 1990-05-14 1991-05-14 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and processes for their preparation
US07/699,898 US5807835A (en) 1990-05-14 1991-05-14 3'-Deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines
GR950403698T GR3018716T3 (en) 1990-05-14 1996-01-18 3'-deamino-4'-deoxy-4'-amino-8-fluoroanthracyclines and processes for their preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20300A IT1241927B (it) 1990-05-14 1990-05-14 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono

Publications (3)

Publication Number Publication Date
IT9020300A0 true IT9020300A0 (it) 1990-05-14
IT9020300A1 IT9020300A1 (it) 1991-11-14
IT1241927B IT1241927B (it) 1994-02-01

Family

ID=11165542

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20300A IT1241927B (it) 1990-05-14 1990-05-14 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono

Country Status (30)

Country Link
US (1) US5807835A (it)
EP (1) EP0457215B1 (it)
JP (1) JPH04226972A (it)
KR (1) KR910020025A (it)
CN (1) CN1031192C (it)
AT (1) ATE133177T1 (it)
AU (1) AU638574B2 (it)
BR (1) BR9101973A (it)
CA (1) CA2042463A1 (it)
CS (1) CS135891A3 (it)
DE (1) DE69116423T2 (it)
DK (1) DK0457215T3 (it)
ES (1) ES2084724T3 (it)
FI (1) FI912269A7 (it)
GR (1) GR3018716T3 (it)
HU (1) HU209458B (it)
IE (1) IE911634A1 (it)
IL (1) IL98117A0 (it)
IT (1) IT1241927B (it)
MA (1) MA22153A1 (it)
MX (1) MX25747A (it)
NO (1) NO174963C (it)
PL (1) PL290236A1 (it)
PT (1) PT97663B (it)
RO (1) RO108792B1 (it)
RU (1) RU2095365C1 (it)
TN (1) TNSN91036A1 (it)
TW (1) TW228524B (it)
YU (1) YU83691A (it)
ZA (1) ZA913644B (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1262565B (it) * 1993-09-30 1996-07-04 Menarini Farma Ind Disaccaridi di antracicline, loro processi di preparazione e composizioni farmaceutiche che li contengono.
US6143864A (en) * 1994-06-28 2000-11-07 Merck & Co., Inc. Peptides
IT1271689B (it) * 1994-08-04 1997-06-04 Menarini Farma Ind 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono
US8357785B2 (en) * 2008-01-08 2013-01-22 Solux Corporation Method of aralkylation of 4′-hydroxyl group of anthracylins
CN104098628B (zh) * 2014-07-31 2017-07-18 大连大学 一类n‑三氟乙酰柔红霉素的硒代衍生物，其制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663445A (en) * 1985-03-20 1987-05-05 The Ohio State Research Foundation 1-fluoro, 4-fluoro, and 1,4-difluoro-2'-halo anthracycline antibiotics
GB8803076D0 (en) * 1988-02-10 1988-03-09 Erba Carlo Spa 3'-deamino-4'-deoxy-4'-amino anthracyclines
GB8902709D0 (en) * 1989-02-07 1989-03-30 Erba Carlo Spa New 4'-epi-4'-amino anthracyclines

Also Published As

Publication number Publication date
MA22153A1 (fr) 1991-12-31
RU2095365C1 (ru) 1997-11-10
CN1056500A (zh) 1991-11-27
GR3018716T3 (en) 1996-04-30
JPH04226972A (ja) 1992-08-17
TW228524B (it) 1994-08-21
AU7649391A (en) 1991-11-14
EP0457215B1 (en) 1996-01-17
AU638574B2 (en) 1993-07-01
CS135891A3 (en) 1992-02-19
ZA913644B (en) 1992-02-26
RO108792B1 (ro) 1994-08-30
YU83691A (sh) 1994-01-20
NO174963C (no) 1994-08-10
IL98117A0 (en) 1992-06-21
CN1031192C (zh) 1996-03-06
TNSN91036A1 (fr) 1992-10-25
IT1241927B (it) 1994-02-01
MX25747A (es) 1994-03-31
DE69116423D1 (de) 1996-02-29
PT97663A (pt) 1992-03-31
HUT57227A (en) 1991-11-28
FI912269A7 (fi) 1991-11-15
ATE133177T1 (de) 1996-02-15
NO911798D0 (no) 1991-05-08
NO174963B (no) 1994-05-02
HU209458B (en) 1994-06-28
DK0457215T3 (da) 1996-06-10
ES2084724T3 (es) 1996-05-16
BR9101973A (pt) 1991-12-24
US5807835A (en) 1998-09-15
PL290236A1 (en) 1992-07-27
NO911798L (no) 1991-11-15
EP0457215A1 (en) 1991-11-21
DE69116423T2 (de) 1996-06-27
IT9020300A1 (it) 1991-11-14
KR910020025A (ko) 1991-12-19
IE911634A1 (en) 1991-11-20
PT97663B (pt) 1998-09-30
FI912269A0 (fi) 1991-05-10
CA2042463A1 (en) 1991-11-15

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19960531