ITMI20031302A0 - Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plg - Google Patents

Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plg

Info

Publication number
ITMI20031302A0
ITMI20031302A0 IT2003MI001302A ITMI20031302A ITMI20031302A0 IT MI20031302 A0 ITMI20031302 A0 IT MI20031302A0 IT 2003MI001302 A IT2003MI001302 A IT 2003MI001302A IT MI20031302 A ITMI20031302 A IT MI20031302A IT MI20031302 A0 ITMI20031302 A0 IT MI20031302A0
Authority
IT
Italy
Prior art keywords
plasticizer
ethanol
active ingredients
implants containing
subcutaneous implants
Prior art date
Application number
IT2003MI001302A
Other languages
English (en)
Inventor
Patrice Mauriac
Pierre Marion
Original Assignee
Mediolanum Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mediolanum Pharmaceuticals Ltd filed Critical Mediolanum Pharmaceuticals Ltd
Priority to IT001302A priority Critical patent/ITMI20031302A1/it
Publication of ITMI20031302A0 publication Critical patent/ITMI20031302A0/it
Priority to AU2004251456A priority patent/AU2004251456B2/en
Priority to CA2530117A priority patent/CA2530117C/en
Priority to BRPI0411759-0A priority patent/BRPI0411759A/pt
Priority to MXPA05013697A priority patent/MXPA05013697A/es
Priority to KR1020057024514A priority patent/KR101143771B1/ko
Priority to EP04741884A priority patent/EP1638534B1/en
Priority to PL04741884T priority patent/PL1638534T3/pl
Priority to JP2006516183A priority patent/JP2009513165A/ja
Priority to DE602004014496T priority patent/DE602004014496D1/de
Priority to CNB2004800177773A priority patent/CN100509060C/zh
Priority to PCT/EP2004/051226 priority patent/WO2005000277A1/en
Priority to ES04741884T priority patent/ES2308195T3/es
Priority to AT04741884T priority patent/ATE398447T1/de
Priority to HK06110518.6A priority patent/HK1089954B/en
Priority to PT04741884T priority patent/PT1638534E/pt
Priority to US10/562,707 priority patent/US8206621B2/en
Publication of ITMI20031302A1 publication Critical patent/ITMI20031302A1/it
Priority to CY20081101000T priority patent/CY1108346T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/141—Plasticizers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
IT001302A 2003-06-26 2003-06-26 Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga. ITMI20031302A1 (it)

Priority Applications (18)

Application Number Priority Date Filing Date Title
IT001302A ITMI20031302A1 (it) 2003-06-26 2003-06-26 Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga.
US10/562,707 US8206621B2 (en) 2003-06-26 2004-06-24 Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a PLGA matrix
JP2006516183A JP2009513165A (ja) 2003-06-26 2004-06-24 Ｐｌｇａマトリックス中に分散された熱不安定性活性成分を含有する皮下インプラントを製造するための可塑剤としてのエタノールの使用
CNB2004800177773A CN100509060C (zh) 2003-06-26 2004-06-24 乙醇作为增塑剂来制备含分散于plga基质中的不耐热有效成分的皮下植入物的用途
BRPI0411759-0A BRPI0411759A (pt) 2003-06-26 2004-06-24 uso do etanol como plastificante para preparar implantes subcutáneos contendo princìpios ativos termolábeis dispersos em uma matriz plga
MXPA05013697A MXPA05013697A (es) 2003-06-26 2004-06-24 Utilizacion de etanol como plastificante para preparar implantes subcutaneos que contienen principios activos termoabiles dispersos en una matriz plga.
KR1020057024514A KR101143771B1 (ko) 2003-06-26 2004-06-24 Ｐｌｇａ 매트릭스에 분산된 열불안정성 활성 성분을함유하는 피하 삽입물을 제조하기 위한 가소제로서에탄올의 용도
EP04741884A EP1638534B1 (en) 2003-06-26 2004-06-24 Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a plga matrix
PL04741884T PL1638534T3 (pl) 2003-06-26 2004-06-24 Zastosowanie etanolu jako zmiękczacza do wytwarzania podskórnych implantów zawierających termolabilne substancje czynne rozproszone w matrycy PLGA
AU2004251456A AU2004251456B2 (en) 2003-06-26 2004-06-24 Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a PLGA matrix
DE602004014496T DE602004014496D1 (de) 2003-06-26 2004-06-24 Verwendung von ethanol als weichmacher zur herstellung von subkutanen implantaten , welche in einer plga matrize dispergierte thermolabile wirkstoffe enthalten
CA2530117A CA2530117C (en) 2003-06-26 2004-06-24 Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a plga matrix
PCT/EP2004/051226 WO2005000277A1 (en) 2003-06-26 2004-06-24 Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a plga matrix
ES04741884T ES2308195T3 (es) 2003-06-26 2004-06-24 Uso de etanol como plastificante para preparar implantes subcutaneos que contienen principios activos termolabiles dispersos en una matriz de plga.
AT04741884T ATE398447T1 (de) 2003-06-26 2004-06-24 Verwendung von ethanol als weichmacher zur herstellung von subkutanen implantaten , welche in einer plga matrize dispergierte thermolabile wirkstoffe enthalten
HK06110518.6A HK1089954B (en) 2003-06-26 2004-06-24 Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a plga matrix
PT04741884T PT1638534E (pt) 2003-06-26 2004-06-24 Uso de etanol como plastificante para preparar implantes subcutâneos contendo princípios activos termolabiais dispersados numa matriz plga
CY20081101000T CY1108346T1 (el) 2003-06-26 2008-09-17 Χρηση της αιθανολης ως πλαστικοποιητης για την προετοιμασια υποδοριων εμφυτευματων που περιεχουν θερμοευαισθητα ενεργα στοιχεια τα οποια διαλυονται σε μια μητρα plga

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001302A ITMI20031302A1 (it) 2003-06-26 2003-06-26 Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga.

Publications (2)

Publication Number Publication Date
ITMI20031302A0 true ITMI20031302A0 (it) 2003-06-26
ITMI20031302A1 ITMI20031302A1 (it) 2004-12-27

Family

ID=30131301

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001302A ITMI20031302A1 (it) 2003-06-26 2003-06-26 Uso di etanolo come plasticizzante per preparare impianti sottocutanei contenenti principi attivi termolabili dispersi in una matrice di plga.

Country Status (17)

Country Link
US (1) US8206621B2 (it)
EP (1) EP1638534B1 (it)
JP (1) JP2009513165A (it)
KR (1) KR101143771B1 (it)
CN (1) CN100509060C (it)
AT (1) ATE398447T1 (it)
AU (1) AU2004251456B2 (it)
BR (1) BRPI0411759A (it)
CA (1) CA2530117C (it)
CY (1) CY1108346T1 (it)
DE (1) DE602004014496D1 (it)
ES (1) ES2308195T3 (it)
IT (1) ITMI20031302A1 (it)
MX (1) MXPA05013697A (it)
PL (1) PL1638534T3 (it)
PT (1) PT1638534E (it)
WO (1) WO2005000277A1 (it)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7666445B2 (en) 2000-10-20 2010-02-23 The Trustees Of The University Of Pennsylvania Polymer-based surgically implantable haloperidol delivery systems and methods for their production and use
AU2006269927B2 (en) * 2004-01-12 2013-05-16 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8329203B2 (en) 2004-01-12 2012-12-11 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
US8221778B2 (en) 2005-01-12 2012-07-17 The Trustees Of The University Of Pennsylvania Drug-containing implants and methods of use thereof
WO2006078320A2 (en) 2004-08-04 2006-07-27 Brookwood Pharmaceuticals, Inc. Methods for manufacturing delivery devices and devices thereof
ITMI20061539A1 (it) * 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
CA2667890C (en) 2006-10-31 2015-01-27 Surmodics Pharmaceuticals, Inc. Spheronized polymer particles
WO2009085952A1 (en) 2007-12-20 2009-07-09 Brookwood Pharmaceuticals, Inc. Process for preparing microparticles having a low residual solvent volume
US9498431B2 (en) * 2008-12-10 2016-11-22 Jianjian Xu Controlled releasing composition
WO2012003210A1 (en) * 2010-06-30 2012-01-05 Surmodics Pharmaceuticals, Inc. Implant processing methods for thermally labile and other bioactive agents and implants prepared from same
GB201314312D0 (en) * 2013-08-09 2013-09-25 Regentec Ltd Composition and delivery system
CN103623415B (zh) * 2013-12-04 2015-03-25 北京诺康达医药科技有限公司 一种用于生物多肽制剂的plga与乙醇的复合物
WO2016020308A1 (en) * 2014-08-04 2016-02-11 Janssen Sciences Ireland Uc Compacted solid dosage form
GB201702475D0 (en) * 2017-02-15 2017-03-29 Locate Therapeutics Ltd Tissue scaffold and scaffold composition
EP3459527B1 (en) * 2017-09-20 2022-11-23 Tillotts Pharma Ag Method for preparing a solid dosage form comprising antibodies by wet granulation, extrusion and spheronization

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0549629A (ja) * 1991-08-23 1993-03-02 Konica Corp 医用放射線画像読影装置
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
IT1304152B1 (it) * 1998-12-10 2001-03-08 Mediolanum Farmaceutici Srl Composizioni comprendenti un peptide ed acido polilattico-glicolicoatte alla preparazione di impianti sottocutanei aventi un prolungato
JP5170935B2 (ja) * 2001-11-14 2013-03-27 デュレクト コーポレーション 注入可能なデポー組成物

Also Published As

Publication number Publication date
CN1812770A (zh) 2006-08-02
ITMI20031302A1 (it) 2004-12-27
WO2005000277A1 (en) 2005-01-06
CY1108346T1 (el) 2014-02-12
EP1638534B1 (en) 2008-06-18
HK1089954A1 (en) 2006-12-15
KR101143771B1 (ko) 2012-05-11
DE602004014496D1 (de) 2008-07-31
JP2009513165A (ja) 2009-04-02
MXPA05013697A (es) 2006-05-17
PT1638534E (pt) 2008-09-29
KR20060079146A (ko) 2006-07-05
CA2530117C (en) 2012-01-10
AU2004251456B2 (en) 2009-12-03
ATE398447T1 (de) 2008-07-15
CA2530117A1 (en) 2005-01-06
AU2004251456A1 (en) 2005-01-06
ES2308195T3 (es) 2008-12-01
CN100509060C (zh) 2009-07-08
EP1638534A1 (en) 2006-03-29
US8206621B2 (en) 2012-06-26
US20060171987A1 (en) 2006-08-03
PL1638534T3 (pl) 2009-02-27
BRPI0411759A (pt) 2006-08-08

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