ITMI20031994A1 - Procedimento per la preparazione di fludarabina fosfato - Google Patents

Procedimento per la preparazione di fludarabina fosfato

Info

Publication number
ITMI20031994A1
ITMI20031994A1 IT001994A ITMI20031994A ITMI20031994A1 IT MI20031994 A1 ITMI20031994 A1 IT MI20031994A1 IT 001994 A IT001994 A IT 001994A IT MI20031994 A ITMI20031994 A IT MI20031994A IT MI20031994 A1 ITMI20031994 A1 IT MI20031994A1
Authority
IT
Italy
Prior art keywords
fludarabina
fosfato
procedure
preparation
fludarabina fosfato
Prior art date
Application number
IT001994A
Other languages
English (en)
Inventor
Giovanni Cotticelli
Barbara Verzola
Original Assignee
Adorkem Technology Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adorkem Technology Spa filed Critical Adorkem Technology Spa
Priority to IT001994A priority Critical patent/ITMI20031994A1/it
Priority to CNA2004800302735A priority patent/CN1867575A/zh
Priority to PCT/EP2004/011494 priority patent/WO2005040183A2/en
Priority to EP04817262A priority patent/EP1673379A2/en
Priority to US10/575,660 priority patent/US20070060745A1/en
Publication of ITMI20031994A1 publication Critical patent/ITMI20031994A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
IT001994A 2003-10-15 2003-10-15 Procedimento per la preparazione di fludarabina fosfato ITMI20031994A1 (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT001994A ITMI20031994A1 (it) 2003-10-15 2003-10-15 Procedimento per la preparazione di fludarabina fosfato
CNA2004800302735A CN1867575A (zh) 2003-10-15 2004-10-13 氟达拉滨磷酸酯的制备方法
PCT/EP2004/011494 WO2005040183A2 (en) 2003-10-15 2004-10-13 Process for the preparation of fludarabine phosphate
EP04817262A EP1673379A2 (en) 2003-10-15 2004-10-13 Process for the preparation of fludarabine phosphate
US10/575,660 US20070060745A1 (en) 2003-10-15 2004-10-13 Process for the preparation of fludarabine phosphate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001994A ITMI20031994A1 (it) 2003-10-15 2003-10-15 Procedimento per la preparazione di fludarabina fosfato

Publications (1)

Publication Number Publication Date
ITMI20031994A1 true ITMI20031994A1 (it) 2005-04-16

Family

ID=34509447

Family Applications (1)

Application Number Title Priority Date Filing Date
IT001994A ITMI20031994A1 (it) 2003-10-15 2003-10-15 Procedimento per la preparazione di fludarabina fosfato

Country Status (5)

Country Link
US (1) US20070060745A1 (it)
EP (1) EP1673379A2 (it)
CN (1) CN1867575A (it)
IT (1) ITMI20031994A1 (it)
WO (1) WO2005040183A2 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102079766A (zh) * 2009-11-29 2011-06-01 海南中化联合制药工业股份有限公司 一种单磷酸阿糖腺苷的制备方法
CN104592337B (zh) * 2013-10-31 2018-09-07 山东新时代药业有限公司 一种9-β-D-阿拉伯呋喃糖基-2-氟代腺嘌呤-5’-磷酸酯的制备方法
EA023851B1 (ru) * 2014-02-20 2016-07-29 Республиканское Унитарное Производственное Предприятие "Белмедпрепараты" (Руп "Белмедпрепараты") Способ получения флударабин фосфата
WO2017036356A1 (zh) * 2015-08-28 2017-03-09 浙江海正药业股份有限公司 磷酸氟达拉滨的晶型及其制备方法和用途
CN109072272A (zh) * 2016-01-20 2018-12-21 浙江海正药业股份有限公司 一种酶法制备磷酸氟达拉滨的方法
CN105998047A (zh) * 2016-05-09 2016-10-12 中山大学肿瘤防治中心 一种治疗癌症的新联合用药方案
CN110028538A (zh) * 2019-05-17 2019-07-19 连云港杰瑞药业有限公司 一种磷酸氟达拉滨原料药的干燥方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
DE69129971T2 (de) * 1990-06-27 1998-12-24 Ash Stevens Inc., Detroit, Mich. Verfahren zur herstellung von 9-beta-d-arabinofuranosyl-2-fluoroadenin 5'-phosphaten

Also Published As

Publication number Publication date
CN1867575A (zh) 2006-11-22
WO2005040183A3 (en) 2005-06-30
EP1673379A2 (en) 2006-06-28
WO2005040183A2 (en) 2005-05-06
US20070060745A1 (en) 2007-03-15

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