ATE169631T1 - Verfahren zur herstellung von 9-beta-d- arabinofuranosyl-2-fluoroadenin 5'-phosphaten - Google Patents
Verfahren zur herstellung von 9-beta-d- arabinofuranosyl-2-fluoroadenin 5'-phosphatenInfo
- Publication number
- ATE169631T1 ATE169631T1 AT91913406T AT91913406T ATE169631T1 AT E169631 T1 ATE169631 T1 AT E169631T1 AT 91913406 T AT91913406 T AT 91913406T AT 91913406 T AT91913406 T AT 91913406T AT E169631 T1 ATE169631 T1 AT E169631T1
- Authority
- AT
- Austria
- Prior art keywords
- fluoroadenine
- arabinofuranosyl
- beta
- phosphates
- producing
- Prior art date
Links
- HBUBKKRHXORPQB-FJFJXFQQSA-N (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O HBUBKKRHXORPQB-FJFJXFQQSA-N 0.000 title abstract 3
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 230000000719 anti-leukaemic effect Effects 0.000 abstract 1
- 239000000063 antileukemic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 230000026731 phosphorylation Effects 0.000 abstract 1
- 238000006366 phosphorylation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54474690A | 1990-06-27 | 1990-06-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE169631T1 true ATE169631T1 (de) | 1998-08-15 |
Family
ID=24173421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91913406T ATE169631T1 (de) | 1990-06-27 | 1991-06-26 | Verfahren zur herstellung von 9-beta-d- arabinofuranosyl-2-fluoroadenin 5'-phosphaten |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0487719B1 (de) |
| JP (1) | JPH0678352B2 (de) |
| AT (1) | ATE169631T1 (de) |
| AU (1) | AU633755B2 (de) |
| CA (1) | CA2064723C (de) |
| DE (1) | DE69129971T2 (de) |
| DK (1) | DK0487719T3 (de) |
| ES (1) | ES2118752T3 (de) |
| WO (1) | WO1992000312A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5602246A (en) * | 1992-11-25 | 1997-02-11 | Schering Aktiengesellschaft | Process for the preparation of fludarabine or fludarabine phosphate from guanosine |
| AU739574B2 (en) * | 1997-12-11 | 2001-10-18 | Alcafleu Management Gmbh & Co. Kg | Method for producing fludarabin phosphate lithium, sodium, potassium, calcium and magnesium salts, purification method for producing fludarabin phosphate and fludarabin phosphate which is at least 99.5 per cent pure |
| ITMI20031994A1 (it) * | 2003-10-15 | 2005-04-16 | Adorkem Technology Spa | Procedimento per la preparazione di fludarabina fosfato |
| CN104592337B (zh) * | 2013-10-31 | 2018-09-07 | 山东新时代药业有限公司 | 一种9-β-D-阿拉伯呋喃糖基-2-氟代腺嘌呤-5’-磷酸酯的制备方法 |
| EA023851B1 (ru) * | 2014-02-20 | 2016-07-29 | Республиканское Унитарное Производственное Предприятие "Белмедпрепараты" (Руп "Белмедпрепараты") | Способ получения флударабин фосфата |
| CN105859812B (zh) * | 2016-05-03 | 2019-07-26 | 河南师范大学 | 一种磷酸氟达拉滨的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1645896C3 (de) * | 1965-03-17 | 1975-01-02 | Ajinomoto Co., Inc., Tokio | Verfahren zur Herstellung von 5'-Ribonucleotiden nd S'-Desoxyribonucleotiden |
| US4093714A (en) * | 1974-03-15 | 1978-06-06 | Icn Pharmaceuticals, Inc. | 9β-D-Arabinofuranosylpurine nucleotides and method of use |
| GB1562899A (en) * | 1975-06-17 | 1980-03-19 | Wellcome Found | Pharmaceutical compositions containing substituted 9-( -d-arabnofuranosyl)purine-5'-phosphate and salts thereof |
| US4123609A (en) * | 1976-11-03 | 1978-10-31 | Warner-Lambert Company | Process for the production of 9-(β-D-arabinofuranosyl)adenine, 5'-phosphate |
| US4357324A (en) * | 1981-02-24 | 1982-11-02 | The United States Of America As Represented By The Department Of Health And Human Services | Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine |
-
1991
- 1991-06-26 DE DE69129971T patent/DE69129971T2/de not_active Expired - Fee Related
- 1991-06-26 ES ES91913406T patent/ES2118752T3/es not_active Expired - Lifetime
- 1991-06-26 AU AU82838/91A patent/AU633755B2/en not_active Ceased
- 1991-06-26 DK DK91913406T patent/DK0487719T3/da active
- 1991-06-26 EP EP91913406A patent/EP0487719B1/de not_active Expired - Lifetime
- 1991-06-26 JP JP3512640A patent/JPH0678352B2/ja not_active Expired - Fee Related
- 1991-06-26 AT AT91913406T patent/ATE169631T1/de not_active IP Right Cessation
- 1991-06-26 CA CA002064723A patent/CA2064723C/en not_active Expired - Fee Related
- 1991-06-26 WO PCT/US1991/004566 patent/WO1992000312A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2118752T3 (es) | 1998-10-01 |
| JPH05500375A (ja) | 1993-01-28 |
| JPH0678352B2 (ja) | 1994-10-05 |
| WO1992000312A1 (en) | 1992-01-09 |
| AU633755B2 (en) | 1993-02-04 |
| EP0487719B1 (de) | 1998-08-12 |
| CA2064723C (en) | 1997-09-09 |
| EP0487719A4 (en) | 1992-10-28 |
| DK0487719T3 (da) | 1999-05-17 |
| AU8283891A (en) | 1992-01-23 |
| CA2064723A1 (en) | 1991-12-28 |
| DE69129971T2 (de) | 1998-12-24 |
| EP0487719A1 (de) | 1992-06-03 |
| DE69129971D1 (de) | 1998-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |