ITMI20042413A1 - Processo per la preparazione di galantamina bromidrato - Google Patents

Processo per la preparazione di galantamina bromidrato

Info

Publication number: ITMI20042413A1
Authority: IT; Italy
Prior art keywords: galanthamine; preparation; butyl; hydrobromide; bromidrate
Prior art date: 2004-12-17

Application number

IT002413A

Other languages

English (en)

Inventor

Bruno Gabetta

Enrico Mercalli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-17

Filing date

2004-12-17

Publication date

2005-03-17

2004-12-17 Application filed by Indena Spa filed Critical Indena Spa

2004-12-17 Priority to IT002413A priority Critical patent/ITMI20042413A1/it

2005-03-17 Publication of ITMI20042413A1 publication Critical patent/ITMI20042413A1/it

2005-11-23 Priority to ES05808194T priority patent/ES2330127T3/es

2005-11-23 Priority to EP05808194A priority patent/EP1861105B1/en

2005-11-23 Priority to HK08102754.4A priority patent/HK1113306B/xx

2005-11-23 Priority to US11/793,097 priority patent/US8013151B2/en

2005-11-23 Priority to CA2592288A priority patent/CA2592288C/en

2005-11-23 Priority to PT05808194T priority patent/PT1861105E/pt

2005-11-23 Priority to CN2005800429800A priority patent/CN101080231B/zh

2005-11-23 Priority to JP2007545863A priority patent/JP5166878B2/ja

2005-11-23 Priority to PCT/EP2005/012521 priority patent/WO2006063666A1/en

2005-11-23 Priority to AT05808194T priority patent/ATE440607T1/de

2005-11-23 Priority to PL05808194T priority patent/PL1861105T3/pl

2005-11-23 Priority to DK05808194T priority patent/DK1861105T3/da

2005-11-23 Priority to SI200530788T priority patent/SI1861105T1/sl

2005-11-23 Priority to KR1020077013259A priority patent/KR101291446B1/ko

2005-11-23 Priority to DE602005016308T priority patent/DE602005016308D1/de

2005-11-23 Priority to RU2007122353/04A priority patent/RU2387656C2/ru

2005-11-23 Priority to AU2005315960A priority patent/AU2005315960B2/en

2007-06-14 Priority to IL183933A priority patent/IL183933A0/en

2007-06-15 Priority to NO20073053A priority patent/NO338724B1/no

Links

ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title abstract 12
229960003980 galantamine Drugs 0.000 title abstract 7
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 abstract 4
LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 abstract 4
BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 abstract 4
IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 abstract 4
241000234270 Amaryllidaceae Species 0.000 abstract 1
241000196324 Embryophyta Species 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
229930013930 alkaloid Natural products 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Medicines Containing Plant Substances (AREA)

IT002413A 2004-12-17 2004-12-17 Processo per la preparazione di galantamina bromidrato ITMI20042413A1 (it)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
IT002413A ITMI20042413A1 (it)	2004-12-17	2004-12-17	Processo per la preparazione di galantamina bromidrato
AU2005315960A AU2005315960B2 (en)	2004-12-17	2005-11-23	Process for the preparation of galanthamine hydrobromide
JP2007545863A JP5166878B2 (ja)	2004-12-17	2005-11-23	臭化水素酸ガランタミンの製造方法
AT05808194T ATE440607T1 (de)	2004-12-17	2005-11-23	Verfahren zur herstellung von galanthaminhydrobromid
HK08102754.4A HK1113306B (en)	2004-12-17	2005-11-23	Process for the preparation of galanthamine hydrobromide
US11/793,097 US8013151B2 (en)	2004-12-17	2005-11-23	Process for the preparation of galanthamine hydrobromide
CA2592288A CA2592288C (en)	2004-12-17	2005-11-23	Process for the preparation of galanthamine hydrobromide
PT05808194T PT1861105E (pt)	2004-12-17	2005-11-23	Processo para a preparação de bromidrato de galantamina
CN2005800429800A CN101080231B (zh)	2004-12-17	2005-11-23	氢溴酸加兰他敏的制备方法
ES05808194T ES2330127T3 (es)	2004-12-17	2005-11-23	Procedimiento de preparacion de bromhidrato de galantamina.
PCT/EP2005/012521 WO2006063666A1 (en)	2004-12-17	2005-11-23	Process for the preparation of galanthamine hydrobromide
EP05808194A EP1861105B1 (en)	2004-12-17	2005-11-23	Process for the preparation of galanthamine hydrobromide
PL05808194T PL1861105T3 (pl)	2004-12-17	2005-11-23	Sposób wytwarzania bromowodorku galantaminy
DK05808194T DK1861105T3 (da)	2004-12-17	2005-11-23	Fremgangsmåde til fremstilling af galanthamin-hydrobromid
SI200530788T SI1861105T1 (sl)	2004-12-17	2005-11-23	Postopek priprave galantamin hidrobromida
KR1020077013259A KR101291446B1 (ko)	2004-12-17	2005-11-23	갈란타민 하이드로브로마이드의 제조 방법
DE602005016308T DE602005016308D1 (de)	2004-12-17	2005-11-23	Verfahren zur herstellung von galanthaminhydrobromid
RU2007122353/04A RU2387656C2 (ru)	2004-12-17	2005-11-23	Способ получения гидробромида галантамина
IL183933A IL183933A0 (en)	2004-12-17	2007-06-14	Process for the preparation fo galanthamine hydrobromide
NO20073053A NO338724B1 (no)	2004-12-17	2007-06-15	Fremgangsmåte for fremstilling av galantaminhydrobromid

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT002413A ITMI20042413A1 (it)	2004-12-17	2004-12-17	Processo per la preparazione di galantamina bromidrato

Publications (1)

Publication Number	Publication Date
ITMI20042413A1 true ITMI20042413A1 (it)	2005-03-17

Family

ID=35784718

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT002413A ITMI20042413A1 (it)	2004-12-17	2004-12-17	Processo per la preparazione di galantamina bromidrato

Country Status (19)

Country	Link
US (1)	US8013151B2 (it)
EP (1)	EP1861105B1 (it)
JP (1)	JP5166878B2 (it)
KR (1)	KR101291446B1 (it)
CN (1)	CN101080231B (it)
AT (1)	ATE440607T1 (it)
AU (1)	AU2005315960B2 (it)
CA (1)	CA2592288C (it)
DE (1)	DE602005016308D1 (it)
DK (1)	DK1861105T3 (it)
ES (1)	ES2330127T3 (it)
IL (1)	IL183933A0 (it)
IT (1)	ITMI20042413A1 (it)
NO (1)	NO338724B1 (it)
PL (1)	PL1861105T3 (it)
PT (1)	PT1861105E (it)
RU (1)	RU2387656C2 (it)
SI (1)	SI1861105T1 (it)
WO (1)	WO2006063666A1 (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT507256B1 (de) *	2008-09-04	2010-10-15	Sanochemia Pharmazeutika Ag	Verwendung von galanthaminiumbromid zur herstellung von ophthalmischen formulierungen zur glaukombehandlung
US8247405B2 (en) *	2008-12-10	2012-08-21	Conopco, Inc.	Skin lightening compositions with acetylcholinesterase inhibitors
CN101787028B (zh) *	2010-01-12	2012-01-04	恩施清江生物工程有限公司	一种从忽地笑中提取加兰他敏的方法
BG110754A (bg)	2010-09-20	2012-03-30	"Ар енд ДИ" ООД	Метод и инсталация за екстракция на растителни суровини
BG66818B1 (bg) *	2013-03-07	2019-01-31	Berbee Beheer B. V.	Състав на екстракт от hippeastrum papilio за производство на лекарствени средства и хранителни добавки
CN104177368B (zh) *	2014-05-27	2016-06-08	天津梅花医药有限公司	一种氢溴酸加兰他敏化合物、制备方法及其药物组合物
CN103980284B (zh) *	2014-05-30	2016-03-09	天津梅花医药有限公司	一种氢溴酸加兰他敏化合物及其制备方法
CN107462656A (zh) *	2017-07-04	2017-12-12	上海市农业科学院	一种快速检测石蒜科植物中加兰他敏含量的方法
BG67337B1 (bg)	2018-05-23	2021-06-15	Софарма Ад	Метод за получаване на пречистен галантамин хидробромид

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB942200A (en)	1959-03-02	1963-11-20	Chimiko Pharmazevtitschen Zd	A method of obtaining galanthamine hydrobromide
GB938767A (en)	1961-12-13	1963-10-09	Vni Chimico Pharmatsevtichesky	The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids
DE19509663A1 (de) *	1995-03-17	1996-09-19	Lohmann Therapie Syst Lts	Verfahren zur Isolierung von Galanthamin
AT403803B (de) *	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
CN1261434C (zh) *	2003-07-28	2006-06-28	浙江一新制药股份有限公司	从石蒜粗提物中分离高纯度加兰他敏的方法
DE102006033591B4 (de)	2006-07-18	2008-10-16	Thüringisches Institut für Textil- und Kunststoff-Forschung e.V.	Verfahren zur Stabilisierung der Spinnlösung bei der Herstellung von cellulosischen Verbundformkörpern

2004
- 2004-12-17 IT IT002413A patent/ITMI20042413A1/it unknown
2005
- 2005-11-23 EP EP05808194A patent/EP1861105B1/en not_active Expired - Lifetime
- 2005-11-23 RU RU2007122353/04A patent/RU2387656C2/ru active
- 2005-11-23 AT AT05808194T patent/ATE440607T1/de active
- 2005-11-23 ES ES05808194T patent/ES2330127T3/es not_active Expired - Lifetime
- 2005-11-23 DK DK05808194T patent/DK1861105T3/da active
- 2005-11-23 US US11/793,097 patent/US8013151B2/en not_active Expired - Fee Related
- 2005-11-23 WO PCT/EP2005/012521 patent/WO2006063666A1/en not_active Ceased
- 2005-11-23 SI SI200530788T patent/SI1861105T1/sl unknown
- 2005-11-23 AU AU2005315960A patent/AU2005315960B2/en not_active Ceased
- 2005-11-23 JP JP2007545863A patent/JP5166878B2/ja not_active Expired - Fee Related
- 2005-11-23 DE DE602005016308T patent/DE602005016308D1/de not_active Expired - Lifetime
- 2005-11-23 CN CN2005800429800A patent/CN101080231B/zh not_active Expired - Fee Related
- 2005-11-23 PT PT05808194T patent/PT1861105E/pt unknown
- 2005-11-23 PL PL05808194T patent/PL1861105T3/pl unknown
- 2005-11-23 KR KR1020077013259A patent/KR101291446B1/ko not_active Expired - Fee Related
- 2005-11-23 CA CA2592288A patent/CA2592288C/en not_active Expired - Lifetime
2007
- 2007-06-14 IL IL183933A patent/IL183933A0/en active IP Right Grant
- 2007-06-15 NO NO20073053A patent/NO338724B1/no unknown

Also Published As

Publication number	Publication date
JP2008524125A (ja)	2008-07-10
CN101080231B (zh)	2010-11-17
EP1861105A1 (en)	2007-12-05
AU2005315960B2 (en)	2012-01-12
WO2006063666A1 (en)	2006-06-22
SI1861105T1 (sl)	2009-12-31
KR20070095897A (ko)	2007-10-01
AU2005315960A1 (en)	2006-06-22
DK1861105T3 (da)	2009-11-16
JP5166878B2 (ja)	2013-03-21
NO20073053L (no)	2007-06-15
ATE440607T1 (de)	2009-09-15
RU2007122353A (ru)	2008-12-20
US8013151B2 (en)	2011-09-06
PT1861105E (pt)	2009-10-22
US20090043092A1 (en)	2009-02-12
CA2592288A1 (en)	2006-06-22
CA2592288C (en)	2014-05-06
KR101291446B1 (ko)	2013-07-30
DE602005016308D1 (de)	2009-10-08
RU2387656C2 (ru)	2010-04-27
HK1113306A1 (en)	2008-10-03
ES2330127T3 (es)	2009-12-04
CN101080231A (zh)	2007-11-28
PL1861105T3 (pl)	2010-02-26
EP1861105B1 (en)	2009-08-26
IL183933A0 (en)	2007-10-31
NO338724B1 (no)	2016-10-10

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