ATE440607T1 - Verfahren zur herstellung von galanthaminhydrobromid - Google Patents

Verfahren zur herstellung von galanthaminhydrobromid

Info

Publication number: ATE440607T1
Authority: AT; Austria
Prior art keywords: galanthamine; hydrobromide; butyl; galanthamin; producing
Prior art date: 2004-12-17

Application number

AT05808194T

Other languages

English (en)

Inventor

Bruno Gabetta

Enrico Mercalli

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-12-17

Filing date

2005-11-23

Publication date

2009-09-15

2005-11-23 Application filed by Indena Spa filed Critical Indena Spa

2009-09-15 Application granted granted Critical

2009-09-15 Publication of ATE440607T1 publication Critical patent/ATE440607T1/de

Links

ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 title abstract 5
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 abstract 10
229960003980 galantamine Drugs 0.000 abstract 6
HPOIPOPJGBKXIR-UHFFFAOYSA-N 3,6-dimethoxy-10-methyl-galantham-1-ene Natural products O1C(C(=CC=2)OC)=C3C=2CN(C)CCC23C1CC(OC)C=C2 HPOIPOPJGBKXIR-UHFFFAOYSA-N 0.000 abstract 4
LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 abstract 4
BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 abstract 4
IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 abstract 4
241000234270 Amaryllidaceae Species 0.000 abstract 1
241000196324 Embryophyta Species 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
229930013930 alkaloid Natural products 0.000 abstract 1
238000002425 crystallisation Methods 0.000 abstract 1
230000008025 crystallization Effects 0.000 abstract 1
238000000605 extraction Methods 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Medicines Containing Plant Substances (AREA)

AT05808194T 2004-12-17 2005-11-23 Verfahren zur herstellung von galanthaminhydrobromid ATE440607T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT002413A ITMI20042413A1 (it)	2004-12-17	2004-12-17	Processo per la preparazione di galantamina bromidrato
PCT/EP2005/012521 WO2006063666A1 (en)	2004-12-17	2005-11-23	Process for the preparation of galanthamine hydrobromide

Publications (1)

Publication Number	Publication Date
ATE440607T1 true ATE440607T1 (de)	2009-09-15

Family

ID=35784718

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT05808194T ATE440607T1 (de)	2004-12-17	2005-11-23	Verfahren zur herstellung von galanthaminhydrobromid

Country Status (19)

Country	Link
US (1)	US8013151B2 (de)
EP (1)	EP1861105B1 (de)
JP (1)	JP5166878B2 (de)
KR (1)	KR101291446B1 (de)
CN (1)	CN101080231B (de)
AT (1)	ATE440607T1 (de)
AU (1)	AU2005315960B2 (de)
CA (1)	CA2592288C (de)
DE (1)	DE602005016308D1 (de)
DK (1)	DK1861105T3 (de)
ES (1)	ES2330127T3 (de)
IL (1)	IL183933A0 (de)
IT (1)	ITMI20042413A1 (de)
NO (1)	NO338724B1 (de)
PL (1)	PL1861105T3 (de)
PT (1)	PT1861105E (de)
RU (1)	RU2387656C2 (de)
SI (1)	SI1861105T1 (de)
WO (1)	WO2006063666A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT507256B1 (de) *	2008-09-04	2010-10-15	Sanochemia Pharmazeutika Ag	Verwendung von galanthaminiumbromid zur herstellung von ophthalmischen formulierungen zur glaukombehandlung
US8247405B2 (en) *	2008-12-10	2012-08-21	Conopco, Inc.	Skin lightening compositions with acetylcholinesterase inhibitors
CN101787028B (zh) *	2010-01-12	2012-01-04	恩施清江生物工程有限公司	一种从忽地笑中提取加兰他敏的方法
BG110754A (bg)	2010-09-20	2012-03-30	"Ар енд ДИ" ООД	Метод и инсталация за екстракция на растителни суровини
BG66818B1 (bg) *	2013-03-07	2019-01-31	Berbee Beheer B. V.	Състав на екстракт от hippeastrum papilio за производство на лекарствени средства и хранителни добавки
CN104177368B (zh) *	2014-05-27	2016-06-08	天津梅花医药有限公司	一种氢溴酸加兰他敏化合物、制备方法及其药物组合物
CN103980284B (zh) *	2014-05-30	2016-03-09	天津梅花医药有限公司	一种氢溴酸加兰他敏化合物及其制备方法
CN107462656A (zh) *	2017-07-04	2017-12-12	上海市农业科学院	一种快速检测石蒜科植物中加兰他敏含量的方法
BG67337B1 (bg)	2018-05-23	2021-06-15	Софарма Ад	Метод за получаване на пречистен галантамин хидробромид

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB942200A (en) *	1959-03-02	1963-11-20	Chimiko Pharmazevtitschen Zd	A method of obtaining galanthamine hydrobromide
GB938767A (en) *	1961-12-13	1963-10-09	Vni Chimico Pharmatsevtichesky	The preparation of galanthamine from the amaryllidaceae and its separation from associated alkaloids
DE19509663A1 (de) *	1995-03-17	1996-09-19	Lohmann Therapie Syst Lts	Verfahren zur Isolierung von Galanthamin
AT403803B (de) *	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
CN1261434C (zh) *	2003-07-28	2006-06-28	浙江一新制药股份有限公司	从石蒜粗提物中分离高纯度加兰他敏的方法
DE102006033591B4 (de)	2006-07-18	2008-10-16	Thüringisches Institut für Textil- und Kunststoff-Forschung e.V.	Verfahren zur Stabilisierung der Spinnlösung bei der Herstellung von cellulosischen Verbundformkörpern

2004
- 2004-12-17 IT IT002413A patent/ITMI20042413A1/it unknown
2005
- 2005-11-23 DK DK05808194T patent/DK1861105T3/da active
- 2005-11-23 ES ES05808194T patent/ES2330127T3/es not_active Expired - Lifetime
- 2005-11-23 CN CN2005800429800A patent/CN101080231B/zh not_active Expired - Fee Related
- 2005-11-23 AU AU2005315960A patent/AU2005315960B2/en not_active Ceased
- 2005-11-23 PL PL05808194T patent/PL1861105T3/pl unknown
- 2005-11-23 AT AT05808194T patent/ATE440607T1/de active
- 2005-11-23 JP JP2007545863A patent/JP5166878B2/ja not_active Expired - Fee Related
- 2005-11-23 EP EP05808194A patent/EP1861105B1/de not_active Expired - Lifetime
- 2005-11-23 SI SI200530788T patent/SI1861105T1/sl unknown
- 2005-11-23 PT PT05808194T patent/PT1861105E/pt unknown
- 2005-11-23 CA CA2592288A patent/CA2592288C/en not_active Expired - Lifetime
- 2005-11-23 DE DE602005016308T patent/DE602005016308D1/de not_active Expired - Lifetime
- 2005-11-23 KR KR1020077013259A patent/KR101291446B1/ko not_active Expired - Fee Related
- 2005-11-23 US US11/793,097 patent/US8013151B2/en not_active Expired - Fee Related
- 2005-11-23 RU RU2007122353/04A patent/RU2387656C2/ru active
- 2005-11-23 WO PCT/EP2005/012521 patent/WO2006063666A1/en not_active Ceased
2007
- 2007-06-14 IL IL183933A patent/IL183933A0/en active IP Right Grant
- 2007-06-15 NO NO20073053A patent/NO338724B1/no unknown

Also Published As

Publication number	Publication date
WO2006063666A1 (en)	2006-06-22
ITMI20042413A1 (it)	2005-03-17
HK1113306A1 (en)	2008-10-03
AU2005315960A1 (en)	2006-06-22
KR101291446B1 (ko)	2013-07-30
NO338724B1 (no)	2016-10-10
RU2387656C2 (ru)	2010-04-27
KR20070095897A (ko)	2007-10-01
DK1861105T3 (da)	2009-11-16
JP5166878B2 (ja)	2013-03-21
JP2008524125A (ja)	2008-07-10
US8013151B2 (en)	2011-09-06
IL183933A0 (en)	2007-10-31
CA2592288C (en)	2014-05-06
EP1861105B1 (de)	2009-08-26
CN101080231B (zh)	2010-11-17
EP1861105A1 (de)	2007-12-05
US20090043092A1 (en)	2009-02-12
CA2592288A1 (en)	2006-06-22
RU2007122353A (ru)	2008-12-20
PT1861105E (pt)	2009-10-22
SI1861105T1 (sl)	2009-12-31
ES2330127T3 (es)	2009-12-04
PL1861105T3 (pl)	2010-02-26
NO20073053L (no)	2007-06-15
CN101080231A (zh)	2007-11-28
AU2005315960B2 (en)	2012-01-12
DE602005016308D1 (de)	2009-10-08

Legal Events

Date

Code

Title

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2010-02-15

UEP

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