ITMI991950A0 - Procedimento per la sintesi del ritomavir - Google Patents

Procedimento per la sintesi del ritomavir

Info

Publication number
ITMI991950A0
ITMI991950A0 IT99MI001950A ITMI991950A ITMI991950A0 IT MI991950 A0 ITMI991950 A0 IT MI991950A0 IT 99MI001950 A IT99MI001950 A IT 99MI001950A IT MI991950 A ITMI991950 A IT MI991950A IT MI991950 A0 ITMI991950 A0 IT MI991950A0
Authority
IT
Italy
Prior art keywords
ritomavir
synthesis
procedure
Prior art date
Application number
IT99MI001950A
Other languages
English (en)
Inventor
Marco Frigerio
Pietro Bellani
Patrizia Castoldi
Original Assignee
Archimica Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archimica Spa filed Critical Archimica Spa
Publication of ITMI991950A0 publication Critical patent/ITMI991950A0/it
Priority to IT1999MI001950A priority Critical patent/IT1313624B1/it
Priority to PCT/IT2000/000368 priority patent/WO2001021603A1/en
Priority to US09/856,455 priority patent/US6407252B1/en
Priority to JP2001524982A priority patent/JP2003509504A/ja
Priority to HU0104259A priority patent/HUP0104259A3/hu
Priority to EP00964626A priority patent/EP1133485B1/en
Priority to AT00964626T priority patent/ATE348819T1/de
Priority to ES00964626T priority patent/ES2278631T3/es
Priority to DE60032453T priority patent/DE60032453T2/de
Priority to KR1020017006272A priority patent/KR100708581B1/ko
Priority to AU75546/00A priority patent/AU7554600A/en
Publication of ITMI991950A1 publication Critical patent/ITMI991950A1/it
Application granted granted Critical
Publication of IT1313624B1 publication Critical patent/IT1313624B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/10—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Silicon Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT1999MI001950A 1999-09-21 1999-09-21 Procedimento per la sintesi del ritonavir IT1313624B1 (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
IT1999MI001950A IT1313624B1 (it) 1999-09-21 1999-09-21 Procedimento per la sintesi del ritonavir
AT00964626T ATE348819T1 (de) 1999-09-21 2000-09-18 Ein verfahren zur synthese von ritonavir
US09/856,455 US6407252B1 (en) 1999-09-21 2000-09-18 Process for the synthesis of ritonavir
JP2001524982A JP2003509504A (ja) 1999-09-21 2000-09-18 リトナビルの合成方法
HU0104259A HUP0104259A3 (en) 1999-09-21 2000-09-18 A process for the synthesis of ritonavir
EP00964626A EP1133485B1 (en) 1999-09-21 2000-09-18 A process for the synthesis of ritonavir
PCT/IT2000/000368 WO2001021603A1 (en) 1999-09-21 2000-09-18 A process for the synthesis of ritonavir
ES00964626T ES2278631T3 (es) 1999-09-21 2000-09-18 Un procedimiento para la sintesis de ritonavir.
DE60032453T DE60032453T2 (de) 1999-09-21 2000-09-18 Ein verfahren zur synthese von ritonavir
KR1020017006272A KR100708581B1 (ko) 1999-09-21 2000-09-18 리토나비르의 합성 방법
AU75546/00A AU7554600A (en) 1999-09-21 2000-09-18 A process for the synthesis of ritonavir

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI001950A IT1313624B1 (it) 1999-09-21 1999-09-21 Procedimento per la sintesi del ritonavir

Publications (3)

Publication Number Publication Date
ITMI991950A0 true ITMI991950A0 (it) 1999-09-21
ITMI991950A1 ITMI991950A1 (it) 2001-03-21
IT1313624B1 IT1313624B1 (it) 2002-09-09

Family

ID=11383628

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999MI001950A IT1313624B1 (it) 1999-09-21 1999-09-21 Procedimento per la sintesi del ritonavir

Country Status (11)

Country Link
US (1) US6407252B1 (it)
EP (1) EP1133485B1 (it)
JP (1) JP2003509504A (it)
KR (1) KR100708581B1 (it)
AT (1) ATE348819T1 (it)
AU (1) AU7554600A (it)
DE (1) DE60032453T2 (it)
ES (1) ES2278631T3 (it)
HU (1) HUP0104259A3 (it)
IT (1) IT1313624B1 (it)
WO (1) WO2001021603A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006090270A1 (en) * 2005-02-28 2006-08-31 Ranbaxy Laboratories Limited Acid addition salt of 2-isopropyl-4-(((n-methyl)amino)methyl)thiazole and its?use in the preparation of ritonavir
US8501792B2 (en) 2008-02-19 2013-08-06 David A. Potter Treating cancer with desthiazolyl ritonavir
US8598216B1 (en) * 2010-12-17 2013-12-03 Abbvie Inc. Ritonavir bis-hydrochloride
CN108218808A (zh) * 2018-04-04 2018-06-29 盐城迪赛诺制药有限公司 一种利托那韦的制备方法
US11613313B2 (en) 2019-11-11 2023-03-28 Andrus Research Inc. Deployable fairing for transport vehicle

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5354866A (en) 1989-05-23 1994-10-11 Abbott Laboratories Retroviral protease inhibiting compounds
US5552558A (en) 1989-05-23 1996-09-03 Abbott Laboratories Retroviral protease inhibiting compounds
EP1302468B1 (en) * 1992-12-29 2008-12-17 Abbott Laboratories Processes and intermediates for manufacturing retroviral protease inhibiting compounds
US5559158A (en) * 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
US5491253A (en) 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
EP0748801B1 (en) * 1994-03-02 2001-12-19 Daicel Chemical Industries, Ltd. 2-isoxazoline derivative and process for producing the same, and process for producing related derivatives from the same
CA2192836A1 (en) * 1994-07-29 1996-02-15 Anthony R. Haight Process for the preparation of a substituted 2.5-diamino-3-hydroxyhexane
US5567823A (en) * 1995-06-06 1996-10-22 Abbott Laboratories Process for the preparation of an HIV protease inhibiting compound
US6022989A (en) 1996-06-28 2000-02-08 Abbott Laboratories Process for the preparation of an activated amino acid
US5932766A (en) 1997-05-30 1999-08-03 Abbott Laboratories Process for the preparation of substituted keto-enamines
US5959118A (en) 1997-08-29 1999-09-28 Abbott Laboratories Process for the preparation of 5-hydroxymethylthiazoles

Also Published As

Publication number Publication date
HUP0104259A3 (en) 2002-12-28
WO2001021603A1 (en) 2001-03-29
AU7554600A (en) 2001-04-24
KR20010086449A (ko) 2001-09-12
ATE348819T1 (de) 2007-01-15
HUP0104259A2 (en) 2002-08-28
DE60032453D1 (de) 2007-02-01
EP1133485A1 (en) 2001-09-19
JP2003509504A (ja) 2003-03-11
EP1133485B1 (en) 2006-12-20
ES2278631T3 (es) 2007-08-16
ITMI991950A1 (it) 2001-03-21
US6407252B1 (en) 2002-06-18
IT1313624B1 (it) 2002-09-09
DE60032453T2 (de) 2007-10-04
KR100708581B1 (ko) 2007-04-18

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