ITPD20040159A1 - Derivati bifunzionali del polietilenglicole loro preparazione e uso. - Google Patents

Derivati bifunzionali del polietilenglicole loro preparazione e uso.

Info

Publication number
ITPD20040159A1
ITPD20040159A1 IT000159A ITPD20040159A ITPD20040159A1 IT PD20040159 A1 ITPD20040159 A1 IT PD20040159A1 IT 000159 A IT000159 A IT 000159A IT PD20040159 A ITPD20040159 A IT PD20040159A IT PD20040159 A1 ITPD20040159 A1 IT PD20040159A1
Authority
IT
Italy
Prior art keywords
bifunctional
peg
bipeg
derivatives
pegs
Prior art date
Application number
IT000159A
Other languages
English (en)
Inventor
Gian Maria Bonora
Pietro Campaner
Sara Drioli
Original Assignee
Univ Degli Studi Trieste
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Trieste filed Critical Univ Degli Studi Trieste
Priority to IT000159A priority Critical patent/ITPD20040159A1/it
Publication of ITPD20040159A1 publication Critical patent/ITPD20040159A1/it
Priority to DE602005004154T priority patent/DE602005004154T2/de
Priority to AT05771854T priority patent/ATE382371T1/de
Priority to EP05771854A priority patent/EP1776143B1/en
Priority to US11/570,926 priority patent/US20080280998A1/en
Priority to PCT/EP2005/052876 priority patent/WO2005123139A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/71—Monoisocyanates or monoisothiocyanates
    • C08G18/714—Monoisocyanates or monoisothiocyanates containing nitrogen in addition to isocyanate or isothiocyanate nitrogen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyethers (AREA)
IT000159A 2004-06-21 2004-06-21 Derivati bifunzionali del polietilenglicole loro preparazione e uso. ITPD20040159A1 (it)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IT000159A ITPD20040159A1 (it) 2004-06-21 2004-06-21 Derivati bifunzionali del polietilenglicole loro preparazione e uso.
DE602005004154T DE602005004154T2 (de) 2004-06-21 2005-06-21 Bifunktionale derivate von polyethylenglykol, ihre herstellung und verwendung
AT05771854T ATE382371T1 (de) 2004-06-21 2005-06-21 Bifunktionale derivate von polyethylenglykol, ihre herstellung und verwendung
EP05771854A EP1776143B1 (en) 2004-06-21 2005-06-21 Bifunctional derivatives of polyethylene glycol, their preparation and use
US11/570,926 US20080280998A1 (en) 2004-06-21 2005-06-21 Bifunctional Derivatives of Polyethylene Glycol, Their Preparation and Use
PCT/EP2005/052876 WO2005123139A1 (en) 2004-06-21 2005-06-21 Bifunctional derivatives of polyethylene glycol, their preparation and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000159A ITPD20040159A1 (it) 2004-06-21 2004-06-21 Derivati bifunzionali del polietilenglicole loro preparazione e uso.

Publications (1)

Publication Number Publication Date
ITPD20040159A1 true ITPD20040159A1 (it) 2004-09-21

Family

ID=34973166

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000159A ITPD20040159A1 (it) 2004-06-21 2004-06-21 Derivati bifunzionali del polietilenglicole loro preparazione e uso.

Country Status (6)

Country Link
US (1) US20080280998A1 (it)
EP (1) EP1776143B1 (it)
AT (1) ATE382371T1 (it)
DE (1) DE602005004154T2 (it)
IT (1) ITPD20040159A1 (it)
WO (1) WO2005123139A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612153B2 (en) * 2004-10-25 2009-11-03 Intezyne Technologies, Inc. Heterobifunctional poly(ethylene glycol) and uses thereof
US7560588B2 (en) * 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
WO2015082495A1 (en) 2013-12-02 2015-06-11 Biocartis N.V. Extraction of circulating nucleic acids
US11725073B2 (en) 2020-12-29 2023-08-15 Hongene Biotech Corporation Compositions and methods for liquid phase oligonucleotide synthesis
US11851454B2 (en) 2021-12-30 2023-12-26 Hongene Biotech Corporation Compositions and methods for liquid phase oligonucleotide synthesis
JP2025521412A (ja) 2022-06-21 2025-07-10 ホンジーン バイオテック コーポレイション 液相オリゴヌクレオチド合成のための組成物および方法
WO2024137756A1 (en) 2022-12-23 2024-06-27 Hongene Biotech Corporation Compounds and methods for liquid phase oligonucleotide synthesis

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268454A (en) * 1991-02-08 1993-12-07 La Jolla Pharmaceutical Company Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier
WO2003031066A1 (en) * 2001-10-11 2003-04-17 California Institute Of Technology Devices utilizing self-assembled gel and method of manufacture
WO2004074345A2 (en) * 2003-02-19 2004-09-02 Pharmacia Corporation Carbonate esters of polyethylene glycol activated by means of oxalate esters

Also Published As

Publication number Publication date
DE602005004154T2 (de) 2008-12-18
US20080280998A1 (en) 2008-11-13
DE602005004154D1 (de) 2008-02-14
EP1776143B1 (en) 2008-01-02
WO2005123139A1 (en) 2005-12-29
EP1776143A1 (en) 2007-04-25
ATE382371T1 (de) 2008-01-15

Similar Documents

Publication Publication Date Title
Pasut et al. Polymer–drug conjugation, recent achievements and general strategies
Chabre et al. Expeditive synthesis of glycodendrimer scaffolds based on versatile TRIS and mannoside derivatives
Zhang et al. Natural barrigenol–like triterpenoids: A comprehensive review of their contributions to medicinal chemistry
EP4480957A3 (en) Exatecan derivatives, linker-payloads, and conjugates and thereof
BRPI0314831B8 (pt) composições farmacêuticas e composição de lipossoma peg compreendendo um conjugado, seus métodos de produção, kit e usos terapêuticos das ditas composições
MXPA05009726A (es) Polimeros ramificados, solubles en agua y sus conjugados.
EP2279758A3 (en) Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
WO2004035629A3 (en) Taxanes covalently bounded to hyaluronic acid or hyaluronic acid derivatives
MX373429B (es) Conjugados polimericos del factor viii.
WO2013012961A3 (en) Sugar alcohol-based crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof
WO2006108052A3 (en) Peg and polysialic lysosomal enzyme conjugates via acid labile linkers for therapeutic targeting
CN1556828A (zh) 具有y形分支的亲水性聚合物衍生物、其制备方法、与药物分子的结合物以及包含该结合物的药物组合物
DE60333937D1 (de) Substituierte quinazolinone verbindungen
EP1874793A4 (en) DISTRIBUTION OF SIRNA BY NEUTRAL LIPID COMPOSITIONS
WO2008106186A3 (en) Activated polyoxazolines and compositions comprising the same
JP2012528857A5 (it)
WO2007019331A3 (en) Conjugates of a g-csf moiety and a polymer
CU23556A1 (es) Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico
WO2008076333A3 (en) Polymer-drug conjugates with tether groups for controlled drug delivery
EP2537533A3 (en) Antitumoral bioconjugates of hyaluronic acid or its derivatives obtained by indirect chemical conjugation
CY1109744T1 (el) Συζυγη και μεθοδοι για την παραγωγη τους, και η χρηση τους για την μεταφορα μοριων δια μεσου βιολογικων μεμβρανων
ATE304709T1 (de) Substanzen mit verzweigten linkermolekülen
ATE382371T1 (de) Bifunktionale derivate von polyethylenglykol, ihre herstellung und verwendung
WO2010080720A3 (en) Conjugates of a lysosomal enzyme moiety and a water soluble polymer
WO2008096547A1 (ja) 組織滞留性キトサンゲルを含有する抗腫瘍剤組成物