ITRM20090578A1 - Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti. - Google Patents

Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.

Info

Publication number
ITRM20090578A1
ITRM20090578A1 IT000578A ITRM20090578A ITRM20090578A1 IT RM20090578 A1 ITRM20090578 A1 IT RM20090578A1 IT 000578 A IT000578 A IT 000578A IT RM20090578 A ITRM20090578 A IT RM20090578A IT RM20090578 A1 ITRM20090578 A1 IT RM20090578A1
Authority
IT
Italy
Prior art keywords
leucemies
chemoresistent
leukemic
treatment
new compositions
Prior art date
Application number
IT000578A
Other languages
English (en)
Inventor
Annarosa Arcangeli
Andrea Becchetti
Lorenzo Emanuele De
Marika Masselli
Serena Pillozzi
Original Assignee
Noi Per Voi Onlus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noi Per Voi Onlus filed Critical Noi Per Voi Onlus
Priority to IT000578A priority Critical patent/ITRM20090578A1/it
Priority to ITRM2010A000048A priority patent/IT1398376B1/it
Priority to ITRM2010A000047A priority patent/IT1398375B1/it
Priority to EP10807721.5A priority patent/EP2498773B1/en
Priority to PCT/IB2010/055112 priority patent/WO2011058508A2/en
Priority to PCT/IB2010/055113 priority patent/WO2011058509A1/en
Priority to US13/508,402 priority patent/US20120309704A1/en
Publication of ITRM20090578A1 publication Critical patent/ITRM20090578A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57505—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the blood, e.g. leukaemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT000578A 2009-11-10 2009-11-10 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti. ITRM20090578A1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT000578A ITRM20090578A1 (it) 2009-11-10 2009-11-10 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000048A IT1398376B1 (it) 2009-11-10 2010-02-09 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000047A IT1398375B1 (it) 2009-11-10 2010-02-09 Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche.
EP10807721.5A EP2498773B1 (en) 2009-11-10 2010-11-10 Compositions for the treatment of chemoresistant leukaemia and/or of potentially chemoresistant leukaemia
PCT/IB2010/055112 WO2011058508A2 (en) 2009-11-10 2010-11-10 New compositions for the treatment of chemioresitant and/or potentially chemioresistant leukaemias
PCT/IB2010/055113 WO2011058509A1 (en) 2009-11-10 2010-11-10 Method and kit for the prevention and/or the monitoring of chemioresistance of leukaemia forms
US13/508,402 US20120309704A1 (en) 2009-11-10 2010-11-10 Compositions for treatment of chemoresistant and/or potentially chemoresistant leukaemias

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000578A ITRM20090578A1 (it) 2009-11-10 2009-11-10 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.

Publications (1)

Publication Number Publication Date
ITRM20090578A1 true ITRM20090578A1 (it) 2011-05-11

Family

ID=42236559

Family Applications (3)

Application Number Title Priority Date Filing Date
IT000578A ITRM20090578A1 (it) 2009-11-10 2009-11-10 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000048A IT1398376B1 (it) 2009-11-10 2010-02-09 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000047A IT1398375B1 (it) 2009-11-10 2010-02-09 Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ITRM2010A000048A IT1398376B1 (it) 2009-11-10 2010-02-09 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000047A IT1398375B1 (it) 2009-11-10 2010-02-09 Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche.

Country Status (4)

Country Link
US (1) US20120309704A1 (it)
EP (1) EP2498773B1 (it)
IT (3) ITRM20090578A1 (it)
WO (2) WO2011058509A1 (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201318659D0 (en) * 2013-10-22 2013-12-04 Ucl Business Plc Beta-catenin
EP3177647B1 (en) * 2014-08-08 2018-10-10 Universita' Degli Studi di Firenze Anti-herg1 antibodies
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
US11071739B1 (en) 2020-09-29 2021-07-27 Genus Lifesciences Inc. Oral liquid compositions including chlorpromazine

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH681780A5 (en) * 1991-02-25 1993-05-28 Patrinove Anticancer compsns. - consists of a cytotoxic agent with a agent to prevent multi:drug resistance, e.g. in liposome(s)
WO2001047507A2 (en) * 1999-12-27 2001-07-05 Novartis Ag Combinations of receptor tyrosine kinase inhibitor with an a1-acidic glycoprotein binding compound
WO2004006842A2 (en) * 2002-07-11 2004-01-22 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms
WO2009070331A2 (en) * 2007-11-27 2009-06-04 Stc.Unm Compounds and methods for the selective inhibition of abcb1, abcc1 and abcg2 transporters and the treatment of cancers, especially drug resistant cancers and high throughput flow cytometry assay to detect selective inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070009534A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Treatment of cancer patients exhibiting activation of the P-glycoprotein efflux pump mechanism
MX2011010971A (es) * 2009-04-17 2012-01-19 Biogen Idec Inc Composiciones y metodos para tratar leucemia mielogena aguda.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH681780A5 (en) * 1991-02-25 1993-05-28 Patrinove Anticancer compsns. - consists of a cytotoxic agent with a agent to prevent multi:drug resistance, e.g. in liposome(s)
WO2001047507A2 (en) * 1999-12-27 2001-07-05 Novartis Ag Combinations of receptor tyrosine kinase inhibitor with an a1-acidic glycoprotein binding compound
WO2004006842A2 (en) * 2002-07-11 2004-01-22 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms
WO2009070331A2 (en) * 2007-11-27 2009-06-04 Stc.Unm Compounds and methods for the selective inhibition of abcb1, abcc1 and abcg2 transporters and the treatment of cancers, especially drug resistant cancers and high throughput flow cytometry assay to detect selective inhibitors

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
ARCANGELI A ET AL: "Targeting ion channels in cancer: A novel frontier in antineoplastic therapy", CURRENT MEDICINAL CHEMISTRY 2009 NL LNKD- DOI:10.2174/092986709787002835, vol. 16, no. 1, 2009, pages 66 - 93, XP002587815, ISSN: 0929-8673 *
BLOOD, vol. 110, no. 11, Part 1, November 2007 (2007-11-01), 49TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ATLANTA, GA, USA; DECEMBER 08 -11, 2007, pages 222A, ISSN: 0006-4971 *
BLOOD, vol. 112, no. 11, November 2008 (2008-11-01), 50TH ANNUAL MEETING OF THE AMERICAN- SOCIETY-OF-HEMATOLOGY; SAN FRANCISCO, CA, USA; DECEMBER 06 -09, 2008, pages 575 - 576, ISSN: 0006-4971 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 2007 (2007-11-01), PILLOZZI SERENA ET AL: "Expression and role of hERG1 channels in pediatric acute lymphoblastic Leukemias: Shortcoming of drug resistance by hERG1 channel inhibitors in stoma-supported leukaemia cell cultures in vitro.", XP002587814, Database accession no. PREV200800215997 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; November 2008 (2008-11-01), PILLOZZI SERENA ET AL: "A Macromolecular Signaling Complex Formed by CXCR4, VLA4 and hERG1 K+ Channels Mediates Bone Marrow-Induced Chemo-Resistance in Childhood Acute Lymphoblastic Leukemias: Shortcoming Effects of hERG1 Channels Inhibitors", XP002587813, Database accession no. PREV200900258328 *
PAJEVA I K ET AL: "Membrane interactions of some catamphiphilic drugs and relation to their multidrug-resistance-reversing ability", JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, SPRINGER INTERNATIONAL, BERLIN, DE, vol. 122, no. 1, 1 January 1996 (1996-01-01), pages 27 - 40, XP008123342, ISSN: 0171-5216 *
PILLOZZI S ET AL: "HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors.", LEUKEMIA : OFFICIAL JOURNAL OF THE LEUKEMIA SOCIETY OF AMERICA, LEUKEMIA RESEARCH FUND, U.K SEP 2002 LNKD- PUBMED:12200695, vol. 16, no. 9, September 2002 (2002-09-01), pages 1791 - 1798, XP002587818, ISSN: 0887-6924 *
SOLARY E ET AL: "SUFFICIENT LEVELS OF QUININE IN THE SERUM CIRCUMVENT THE MULTIDRUG RESISTANCE OF THE HUMAN LEUKEMIC CELL LINE K562-ADM", CANCER, vol. 68, no. 8, 1991, pages 1714 - 1719, XP002587817, ISSN: 0008-543X *
TSURUO T ET AL: "EFFECTS OF QUINIDINE AND RELATED COMPOUNDS ON CYTOTOXICITY AND CELLULAR ACCUMULATION OF VINCRISTINE AND ADRIAMYCIN IN DRUG-RESISTANT TUMOR CELLS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER REREARCH, US, vol. 44, no. 10, 1 October 1984 (1984-10-01), pages 4303 - 4307, XP008038937, ISSN: 0008-5472 *
WANG LI ET AL: "Reversal of anticancer drug resistance by macrolide antibiotics in vitro and in vivo", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol. 27, no. 8, August 2000 (2000-08-01), pages 587 - 593, XP002587816, ISSN: 0305-1870 *

Also Published As

Publication number Publication date
EP2498773B1 (en) 2015-07-29
IT1398376B1 (it) 2013-02-22
ITRM20100048A1 (it) 2011-05-11
EP2498773A2 (en) 2012-09-19
WO2011058509A1 (en) 2011-05-19
ITRM20100047A1 (it) 2011-05-11
WO2011058508A3 (en) 2011-10-06
US20120309704A1 (en) 2012-12-06
IT1398375B1 (it) 2013-02-22
WO2011058508A2 (en) 2011-05-19

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IT1398376B1 (it) Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.