ATE502944T1 - 2-amino-5,7-dihydro-6h-pyrroloä3,4- düpyrimidinderivate als hsp-90-inhibitoren zur behandlung von krebs - Google Patents

2-amino-5,7-dihydro-6h-pyrroloä3,4- düpyrimidinderivate als hsp-90-inhibitoren zur behandlung von krebs

Info

Publication number
ATE502944T1
ATE502944T1 AT08702335T AT08702335T ATE502944T1 AT E502944 T1 ATE502944 T1 AT E502944T1 AT 08702335 T AT08702335 T AT 08702335T AT 08702335 T AT08702335 T AT 08702335T AT E502944 T1 ATE502944 T1 AT E502944T1
Authority
AT
Austria
Prior art keywords
pyrroloä3
düpyrimidene
hsp
dihydro
inhibitors
Prior art date
Application number
AT08702335T
Other languages
English (en)
Inventor
Michael Bennett
Luke Zehnder
Sacha Ninkovic
Pei-Pei Kung
Jerry Meng
Buwen Huang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of ATE502944T1 publication Critical patent/ATE502944T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT08702335T 2007-02-06 2008-01-25 2-amino-5,7-dihydro-6h-pyrroloä3,4- düpyrimidinderivate als hsp-90-inhibitoren zur behandlung von krebs ATE502944T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88843307P 2007-02-06 2007-02-06
US2066108P 2008-01-11 2008-01-11
PCT/IB2008/000200 WO2008096218A1 (en) 2007-02-06 2008-01-25 2-amin0-5, 7-dihydr0-6h- pyrrolo [3, 4-d] pyrimidine derivatives as hsp-90 inhibitors for treating cancer

Publications (1)

Publication Number Publication Date
ATE502944T1 true ATE502944T1 (de) 2011-04-15

Family

ID=39367692

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08702335T ATE502944T1 (de) 2007-02-06 2008-01-25 2-amino-5,7-dihydro-6h-pyrroloä3,4- düpyrimidinderivate als hsp-90-inhibitoren zur behandlung von krebs

Country Status (22)

Country Link
US (1) US20100093696A1 (de)
EP (1) EP2118111B1 (de)
JP (1) JP4523073B2 (de)
KR (1) KR20090116789A (de)
AP (1) AP2009004954A0 (de)
AT (1) ATE502944T1 (de)
AU (1) AU2008212645A1 (de)
BR (1) BRPI0807165A2 (de)
CA (1) CA2677365A1 (de)
CO (1) CO6220971A2 (de)
CR (1) CR10963A (de)
CU (1) CU20090141A7 (de)
DE (1) DE602008005715D1 (de)
DO (1) DOP2009000200A (de)
EA (1) EA200970669A1 (de)
EC (1) ECSP099565A (de)
IL (1) IL200169A0 (de)
MA (1) MA31170B1 (de)
MX (1) MX2009008386A (de)
NI (1) NI200900155A (de)
TN (1) TN2009000329A1 (de)
WO (1) WO2008096218A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010018481A1 (en) * 2008-08-13 2010-02-18 Pfizer Inc. 2-amino pyrimidine compounds as potent hsp-90 inhibitors
GB0907284D0 (en) 2009-04-28 2009-06-10 Queen Mary & Westfield College Compounds for inducing cellular apoptosis
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
CA2788450A1 (en) 2009-12-30 2011-07-07 Arqule, Inc. Substituted naphthalenyl-pyrimidine compounds
EP2752201A1 (de) * 2013-01-04 2014-07-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. C-terminale HSP90-Hemmer zur Behandlung von Hypophysenadenomen
US9447025B2 (en) 2013-03-14 2016-09-20 Kalyra Pharmaceuticals, Inc. Bicyclic analgesic compounds
US10189780B2 (en) 2013-12-12 2019-01-29 Zeno Royalties & Milestones, LLC Bicyclic alkyl compounds and synthesis
CN106232567B (zh) 2014-03-07 2021-11-02 里科瑞尔姆Ip控股有限责任公司 螺桨烷衍生物及合成
EP3154547B1 (de) 2014-06-13 2023-06-07 Yuma Therapeutics, Inc. Pyrimidinverbindungen und verfahren zur verwendung davon
CN106999451B (zh) 2014-09-17 2021-04-02 里科瑞尔姆Ip控股有限责任公司 双环化合物
US10227029B2 (en) * 2015-08-07 2019-03-12 Kawasaki Jukogyo Kabushiki Kaisha Container holder attached to utility vehicle
EP3628043A4 (de) 2017-05-15 2021-04-28 Recurium IP Holdings, LLC Analgetische verbindungen
WO2020243457A1 (en) * 2019-05-29 2020-12-03 Viogen Biosciences, Llc Compounds and therapeutic uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
HRP20020751B1 (hr) 2000-02-15 2011-01-31 Sugen Pirolom supstituirani 2-indolinoni kao inhibitori protein kinaze
MXPA04007191A (es) * 2002-01-23 2005-03-31 Bayer Pharmaceuticals Corp Derivados de pirimidina como inhibidores de rho-quinasa.
US7312330B2 (en) * 2003-12-24 2007-12-25 Renovis, Inc. Bicycloheteroarylamine compounds as ion channel ligands and uses thereof
BRPI0609509A2 (pt) * 2005-03-30 2010-04-13 Conforma Therapeutics Corp composto ou um polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável do mesmo, composição farmacêutica, e, uso do composto, polimorfo, solvato, tautÈmero, enanciÈmero, pró-droga ou sal farmaceuticamente aceitável

Also Published As

Publication number Publication date
BRPI0807165A2 (pt) 2014-05-06
CU20090141A7 (es) 2011-04-26
CR10963A (es) 2009-08-27
AP2009004954A0 (en) 2009-08-31
IL200169A0 (en) 2010-04-15
CO6220971A2 (es) 2010-11-19
US20100093696A1 (en) 2010-04-15
EA200970669A1 (ru) 2010-02-26
CA2677365A1 (en) 2008-08-14
MX2009008386A (es) 2009-10-16
WO2008096218A1 (en) 2008-08-14
MA31170B1 (fr) 2010-02-01
DOP2009000200A (es) 2009-09-15
JP4523073B2 (ja) 2010-08-11
NI200900155A (es) 2010-06-30
JP2010518066A (ja) 2010-05-27
DE602008005715D1 (de) 2011-05-05
KR20090116789A (ko) 2009-11-11
ECSP099565A (es) 2009-09-29
TN2009000329A1 (fr) 2010-12-31
AU2008212645A1 (en) 2008-08-14
EP2118111A1 (de) 2009-11-18
EP2118111B1 (de) 2011-03-23

Similar Documents

Publication Publication Date Title
DE602008005715D1 (de) 2-amino-5,7-dihydro-6h-pyrroloä3,4-düpyrimidinderivate als hsp-90-inhibitoren zur behandlung von krebs
DK3289876T3 (da) Forbindelser til behandling af cancer
DK2195015T3 (da) Sammensætning til behandling af prostatacancer
BRPI0812293A2 (pt) Derivados de 2-oxo-3-benzilbenzoxazol-2 -ona e compostos relacionados como inibidores de met quinase para o tratamento de tumores
SMAP200900085A (it) 3-imidazolil-indoli per il trattamento di malattieproliferative
PL3354276T3 (pl) Kompozycje do leczenia zapalenia przewodu pokarmowego
LT2478907T (lt) Kompozicijos vėžiui gydyti
DK2426106T3 (da) Piperidin- og piperazinderivat til behandling af tumorer
PL2338519T3 (pl) Środek do leczenia zwłóknienia szpiku
HUE039731T2 (hu) l,3-difenilprop-2-én-l-on-származékok alkalmazása májbetegségek kezelésére
DK3517534T3 (da) Forbindelser, der er anvendelige til behandling af cancer
BRPI0810206A2 (pt) Método de tratar câncer
ATE550329T1 (de) Heterobicyclische sulfonamidderivate zur behandlung von diabetes
DK3456707T3 (da) 4-(p-quinonyl)-2-hydroxybutanamidderivater til behandling af mitokondriesygdomme
EA201171367A1 (ru) Винилиндазолильные соединения
BRPI0820544A2 (pt) 4-pirazolil-n-arilpirimidin-2-aminas e pirazolil-n-heteroarilpirimidin-2-aminas como inibidores de janus cinase
BRPI0921321A2 (pt) métodos para o tratamento de indwcções e tumores
BRPI0811516A2 (pt) Compostos e composições como inibidores de c-kit e pdgfr cinase
EA200900798A1 (ru) Производные индол-4-илпиримидинил-2-иламина и их применение в качестве ингибиторов циклинзависимой киназы
DK2452189T3 (da) Fremgangsmåde til identifikation af forbindelser til behandling af cancer
SE0702104L (sv) Förfarande för behandling av avfall
ATE532507T1 (de) Neramexane zur behandlung von subakuten tinnitus
EP2175873A4 (de) Behandlung von angstzuständen
BRPI0912683A2 (pt) tratamento de tumores metastáticos
BR112013009935A2 (pt) compostos, composição, método e semente tratada

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties