JO3042B1 - مشتقات السيكلوبيرازول-لاكتام كمثبطات لل 11-بيتا-هيدروكسي ستيرويد داي هيدروجينيز 1 - Google Patents

مشتقات السيكلوبيرازول-لاكتام كمثبطات لل 11-بيتا-هيدروكسي ستيرويد داي هيدروجينيز 1

Info

Publication number
JO3042B1
JO3042B1 JOP/2007/0149A JOP20070149A JO3042B1 JO 3042 B1 JO3042 B1 JO 3042B1 JO P20070149 A JOP20070149 A JO P20070149A JO 3042 B1 JO3042 B1 JO 3042B1
Authority
JO
Jordan
Prior art keywords
cyclohexylpyrazole
inhibitors
beta
compounds
hydroxysteroid dehydrogenase
Prior art date
Application number
JOP/2007/0149A
Other languages
English (en)
Inventor
Saeed Ashraf
Pavlovych Krasutsky Alexei
Brendan Waalace Owen
Biagio Anzeveno Peter
Edward Mabry Thomas
Daniel Aicher Thomas
Alan Stephenson Gregory
Li Renhua
Larry Winneroski Junior Leonard
June Snyder Nancy
Tian Hongqi
Xu Yanping
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of JO3042B1 publication Critical patent/JO3042B1/ar

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يقدم الاختراع الحالي مركب جديد من الصيغه I: له تاثير فسيولوجي ل 11 B- HSD type 1 وكذلك طريقة تحضيره، وفي تجسيد اخر يقدم الاختراع تركيبات صيدلانية تتضمن مركبات من الصيغه I وكذلك طريقة استخدامه ومكوناته لعلاج داء السكري وارتفاع نسبة السكر بالدم والسمنة وارتفاع ضغط الدم وارتفاع نسبة الدهون بالدم واعراض التمثيل الحيوي المضطرب، كما يعالج أي ظروف اخرى مصاحبة لنشاط 11 B- HSD type 1.
JOP/2007/0149A 2006-04-21 2007-04-18 مشتقات السيكلوبيرازول-لاكتام كمثبطات لل 11-بيتا-هيدروكسي ستيرويد داي هيدروجينيز 1 JO3042B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74532006P 2006-04-21 2006-04-21

Publications (1)

Publication Number Publication Date
JO3042B1 true JO3042B1 (ar) 2016-09-05

Family

ID=38595048

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2007/0149A JO3042B1 (ar) 2006-04-21 2007-04-18 مشتقات السيكلوبيرازول-لاكتام كمثبطات لل 11-بيتا-هيدروكسي ستيرويد داي هيدروجينيز 1

Country Status (29)

Country Link
US (1) US7981918B2 (ar)
EP (1) EP2029579B1 (ar)
JP (1) JP5161869B2 (ar)
KR (1) KR101055576B1 (ar)
CN (1) CN101426783B (ar)
AR (1) AR060618A1 (ar)
AU (1) AU2007240550B2 (ar)
BR (1) BRPI0710229A2 (ar)
CA (1) CA2647677C (ar)
CO (1) CO6140026A2 (ar)
CR (1) CR10400A (ar)
DO (1) DOP2007000078A (ar)
EA (1) EA015675B1 (ar)
EC (1) ECSP088839A (ar)
ES (1) ES2533263T3 (ar)
IL (1) IL194835A (ar)
JO (1) JO3042B1 (ar)
MA (1) MA30476B1 (ar)
MX (1) MX2008013484A (ar)
MY (1) MY148128A (ar)
NO (1) NO20084403L (ar)
NZ (1) NZ571175A (ar)
PE (1) PE20080362A1 (ar)
SV (1) SV2008003070A (ar)
TN (1) TNSN08405A1 (ar)
TW (1) TWI347321B (ar)
UA (1) UA95798C2 (ar)
WO (1) WO2007124254A2 (ar)
ZA (1) ZA200808686B (ar)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101541747B (zh) 2006-04-21 2012-11-14 伊莱利利公司 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的联苯基酰胺内酰胺衍生物
AU2007240450B2 (en) 2006-04-21 2011-12-22 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
AU2007244955B2 (en) * 2006-04-24 2011-12-08 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
AU2007244960B2 (en) 2006-04-24 2012-03-01 Eli Lilly And Company Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA016415B1 (ru) 2006-04-24 2012-04-30 Эли Лилли Энд Компани Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1
EP2016071B1 (en) * 2006-04-25 2013-07-24 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
BRPI0710050A2 (pt) 2006-04-25 2011-08-02 Lilly Co Eli composto, composição farmacêutica, e, intermediário
ATE471311T1 (de) 2006-04-25 2010-07-15 Lilly Co Eli Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1
BRPI0710469A2 (pt) 2006-04-28 2011-08-16 Lilly Co Eli composto, composição farmacêutica, e, intermediário
EP2125750B1 (en) 2007-02-26 2014-05-21 Vitae Pharmaceuticals, Inc. Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR069207A1 (es) 2007-11-07 2010-01-06 Vitae Pharmaceuticals Inc Ureas ciclicas como inhibidores de la 11 beta - hidroxi-esteroide deshidrogenasa 1
JP5490014B2 (ja) 2007-12-11 2014-05-14 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の環状尿素阻害剤
CA2722427A1 (en) 2008-05-01 2009-11-05 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
RU2539979C2 (ru) 2008-07-25 2015-01-27 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
JP5777030B2 (ja) 2008-07-25 2015-09-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング １１β−ヒドロキシステロイドデヒドロゲナーゼ１の阻害剤
WO2010010150A1 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1
WO2010089303A1 (en) 2009-02-04 2010-08-12 Boehringer Ingelheim International Gmbh CYCLIC INHIBITORS OF 11 β-HYDROXYSTEROID DEHYDROGENASE 1
EP2393813B1 (en) * 2009-02-04 2013-07-31 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11 ß-hydroxysteroid dehydrogenase 1 useful for the treatment of diseases related to elevated level of cortisol
EP2243479A3 (en) 2009-04-20 2011-01-19 Abbott Laboratories Novel amide and amidine derivates and uses thereof
MA33216B1 (ar) 2009-04-30 2012-04-02 Boehringer Ingelheim Int مثبطات حلقية 11 بيتا ـ هيدروكسي ستيرويد دشيدروجيناز1
EP2440537A1 (en) 2009-06-11 2012-04-18 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1 based on the 1,3 -oxazinan- 2 -one structure
WO2011002910A1 (en) 2009-07-01 2011-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5750449B2 (ja) 2009-11-05 2015-07-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規キラルリンリガンド
WO2011068927A2 (en) * 2009-12-04 2011-06-09 Abbott Laboratories 11-β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11B-HSD1) INHIBITORS AND USES THEREOF
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2576570A1 (en) 2010-05-26 2013-04-10 Boehringer Ingelheim International GmbH 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
EP2582698B1 (en) 2010-06-16 2016-09-14 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
JP5813106B2 (ja) 2010-06-25 2015-11-17 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 代謝障害の処置のための１１−β−ＨＳＤ１のインヒビターとしてのアザスピロヘキサノン
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
BR112013010021A2 (pt) 2010-11-02 2019-09-24 Boehringer Ingelheim Int combinações farmacêuticas para o tratamento de distúrbios metabólicos.
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
LT2772484T (lt) 2011-10-18 2017-12-27 Astellas Pharma Inc. Biciklinis heterociklinis junginys
TW201625605A (zh) * 2014-04-04 2016-07-16 賽諾菲公司 用於治療糖尿病、肥胖、血脂異常及相關病症之作為ｇｐｒ１１９調節劑的經取代之稠合雜環類
WO2017117447A1 (en) 2015-12-31 2017-07-06 Karyopharm Therapeutics Inc. Multicyclic compounds and uses thereof
AU2022224918B2 (en) 2021-02-25 2023-04-13 Aptabio Therapeutics Inc. Novel pyrazole derivatives

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004056744A1 (en) 2002-12-23 2004-07-08 Janssen Pharmaceutica N.V. Adamantyl acetamides as hydroxysteroid dehydrogenase inhibitors
CN101001836B (zh) * 2004-05-07 2010-12-22 詹森药业有限公司 作为11-β羟基类固醇脱氢酶抑制剂的吡咯烷-2-酮和哌啶-2-酮衍生物
NZ551076A (en) 2004-05-07 2009-05-31 Janssen Pharmaceutica Nv Adamantyl pyrrolidin-2-one derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors
US8138342B2 (en) 2004-10-12 2012-03-20 High Point Pharmacueticals, LLC 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds
ES2318577T3 (es) 2004-10-29 2009-05-01 Eli Lilly And Company Derivados de cicloalquil lactama como inhibidores de 11-beta-hidroxiesteroide deshidrogenasa 1'.
KR101368228B1 (ko) 2004-11-10 2014-02-27 인사이트 코포레이션 락탐 화합물 및 약제로서의 이의 용도
ATE399546T1 (de) * 2004-12-20 2008-07-15 Lilly Co Eli Cycloalkyl-lactam-derivate als inhibitoren von 11-beta-hydroxysteroiddehydrogenase 1
US7834194B2 (en) * 2004-12-21 2010-11-16 Eli Lilly And Company Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
US20090264650A1 (en) * 2005-03-31 2009-10-22 Nobuo Cho Prophylactic/Therapeutic Agent for Diabetes
ES2322727B1 (es) 2005-07-28 2010-04-22 Universidad Del Pais Vasco Metodo para cuantificar la union receptor acoplado a proteina g (gpcr)-proteina g mediante el empleo de un array de membranas celulares.
WO2007084314A2 (en) 2006-01-12 2007-07-26 Incyte Corporation MODULATORS OF 11-ß HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME
CN101541747B (zh) * 2006-04-21 2012-11-14 伊莱利利公司 作为11-β-羟基甾族化合物脱氢酶1的抑制剂的联苯基酰胺内酰胺衍生物
AU2007240450B2 (en) * 2006-04-21 2011-12-22 Eli Lilly And Company Cyclohexylimidazole lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
AU2007244960B2 (en) * 2006-04-24 2012-03-01 Eli Lilly And Company Substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EA016415B1 (ru) * 2006-04-24 2012-04-30 Эли Лилли Энд Компани Ингибиторы 11-бета-гидроксистероид-дегидрогеназы типа 1
AU2007244955B2 (en) * 2006-04-24 2011-12-08 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
EP2016071B1 (en) * 2006-04-25 2013-07-24 Eli Lilly And Company Inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
BRPI0710050A2 (pt) 2006-04-25 2011-08-02 Lilly Co Eli composto, composição farmacêutica, e, intermediário
ATE471311T1 (de) * 2006-04-25 2010-07-15 Lilly Co Eli Inhibitoren von11-beta- hydroxysteroiddehydrogenase 1
BRPI0710469A2 (pt) * 2006-04-28 2011-08-16 Lilly Co Eli composto, composição farmacêutica, e, intermediário
CL2008001839A1 (es) 2007-06-21 2009-01-16 Incyte Holdings Corp Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades.

Also Published As

Publication number Publication date
ZA200808686B (en) 2009-12-30
CA2647677A1 (en) 2007-11-01
JP5161869B2 (ja) 2013-03-13
MA30476B1 (fr) 2009-06-01
TW200811141A (en) 2008-03-01
MY148128A (en) 2013-02-28
ECSP088839A (es) 2008-11-27
EP2029579A2 (en) 2009-03-04
WO2007124254A3 (en) 2007-12-27
TNSN08405A1 (en) 2010-04-14
SV2008003070A (es) 2010-01-18
NZ571175A (en) 2011-10-28
BRPI0710229A2 (pt) 2011-08-02
AU2007240550B2 (en) 2012-02-23
US7981918B2 (en) 2011-07-19
ES2533263T3 (es) 2015-04-08
CR10400A (es) 2009-01-14
NO20084403L (no) 2008-11-14
EA200870460A1 (ru) 2009-04-28
PE20080362A1 (es) 2008-04-25
IL194835A (en) 2015-04-30
AR060618A1 (es) 2008-07-02
KR20080109867A (ko) 2008-12-17
MX2008013484A (es) 2008-10-30
CN101426783B (zh) 2013-10-30
HK1126493A1 (en) 2009-09-04
WO2007124254A2 (en) 2007-11-01
US20090111800A1 (en) 2009-04-30
EP2029579B1 (en) 2014-12-31
IL194835A0 (en) 2009-08-03
TWI347321B (en) 2011-08-21
EA015675B1 (ru) 2011-10-31
CN101426783A (zh) 2009-05-06
JP2009534398A (ja) 2009-09-24
KR101055576B1 (ko) 2011-08-08
CO6140026A2 (es) 2010-03-19
CA2647677C (en) 2014-03-18
AU2007240550A1 (en) 2007-11-01
DOP2007000078A (es) 2007-11-15
UA95798C2 (ru) 2011-09-12

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