JO3099B1 - طريقة تصنيع املاح من n- هيدروكسي -3- [4-[[[2-(2-مثيل-h 1-اندول -3-يل)ايثيل]امينو]مثيل]فنيل]-e-2-2بروبان اميد - Google Patents

طريقة تصنيع املاح من n- هيدروكسي -3- [4-[[[2-(2-مثيل-h 1-اندول -3-يل)ايثيل]امينو]مثيل]فنيل]-e-2-2بروبان اميد

Info

Publication number
JO3099B1
JO3099B1 JOP/2007/0221A JOP20070221A JO3099B1 JO 3099 B1 JO3099 B1 JO 3099B1 JO P20070221 A JOP20070221 A JO P20070221A JO 3099 B1 JO3099 B1 JO 3099B1
Authority
JO
Jordan
Prior art keywords
methyl
propenamide
indol
hydroxy
phenyl
Prior art date
Application number
JOP/2007/0221A
Other languages
English (en)
Inventor
S Bajwa Joginder
Slade Joel
John Parker David
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832680&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3099(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of JO3099B1 publication Critical patent/JO3099B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

تحضير املاح N- هيدروكسي -3- [4-[[[2-(2-مثيل-H 1-اندول -3-يل)ايثيل]امينو]مثيل]فنيل]-E2-2-بروبان اميد.بطرق مختلفة ومتنوعة.
JOP/2007/0221A 2006-06-12 2007-06-12 طريقة تصنيع املاح من n- هيدروكسي -3- [4-[[[2-(2-مثيل-h 1-اندول -3-يل)ايثيل]امينو]مثيل]فنيل]-e-2-2بروبان اميد JO3099B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80452906P 2006-06-12 2006-06-12
US85325906P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
JO3099B1 true JO3099B1 (ar) 2017-03-15

Family

ID=38832680

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2007/0221A JO3099B1 (ar) 2006-06-12 2007-06-12 طريقة تصنيع املاح من n- هيدروكسي -3- [4-[[[2-(2-مثيل-h 1-اندول -3-يل)ايثيل]امينو]مثيل]فنيل]-e-2-2بروبان اميد

Country Status (23)

Country Link
US (1) US7989639B2 (ar)
EP (1) EP2032532B8 (ar)
JP (1) JP2009540007A (ar)
KR (1) KR20090026282A (ar)
AR (1) AR061295A1 (ar)
AU (1) AU2007257882B2 (ar)
BR (1) BRPI0713653A2 (ar)
CA (1) CA2654230C (ar)
CL (1) CL2007001690A1 (ar)
EC (1) ECSP088957A (ar)
GT (1) GT200800281A (ar)
IL (1) IL195344A (ar)
JO (1) JO3099B1 (ar)
MA (1) MA30564B1 (ar)
MX (1) MX2008015899A (ar)
MY (1) MY147013A (ar)
NO (1) NO20090136L (ar)
NZ (1) NZ572744A (ar)
PE (1) PE20080365A1 (ar)
RU (1) RU2008151724A (ar)
TN (1) TNSN08508A1 (ar)
TW (1) TWI385142B (ar)
WO (1) WO2007146717A2 (ar)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMP200900002B (it) * 2006-06-12 2010-01-19 Novartis Ag Sali di n-idrossi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]ammino]metil]fenil]-2e-2-propenammide
IN2015DN00910A (ar) * 2006-06-12 2015-07-10 Novartis Ag
AU2008204928B2 (en) * 2007-01-10 2011-03-31 Novartis Ag Formulations of deacetylase inhibitors
JP5485138B2 (ja) * 2008-03-28 2014-05-07 浜理薬品工業株式会社 エチニルチミジン化合物の精製方法
CA2929309C (en) * 2013-12-02 2018-07-03 Suven Life Sciences Limited Process for large scale production of 1-[(2-bromophenyl)sulfonyl]-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1h-indole dimesylate monohydrate
WO2017221163A1 (en) * 2016-06-21 2017-12-28 Alembic Pharmaceuticals Limited Novel salts and polymorphic forms of panobinostat
WO2018092151A1 (en) * 2016-11-21 2018-05-24 Msn Laboratories Private Limited, R&D Center Process for the preparation of 2-(e)-n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl) ethyl]amino]methyl]phenyl]-2-propenamide 2-hydroxypropanoic acid (1:1) and its polymorphs thereof
WO2018163114A1 (en) * 2017-03-10 2018-09-13 Shilpa Medicare Limited Amorphous panobinostat and its lactate salt
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
US12084450B2 (en) * 2022-06-27 2024-09-10 Abion Inc. Mesylate salts of triazolopyrazine derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH342565A (de) 1954-04-14 1959-11-30 Thomae Gmbh Dr K Verfahren zur Herstellung von basischen Äthern endocyclisch substituierter Carbinole oder ihren nicht quaternären Salzen
GB891413A (en) 1958-10-06 1962-03-14 Smith Kline French Lab Tris-(dialkylaminoalkyl) phosphates and a method for their preparation
GB8600397D0 (en) 1986-01-08 1986-02-12 Glaxo Group Ltd Chemical compounds
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
DE60215028T2 (de) * 2001-08-14 2007-03-15 Eli Lilly And Co., Indianapolis Indol derivate als beta-3-adrenerge agonisten zur behandlung von typ 2 diabetes
NZ544689A (en) 2001-11-06 2007-08-31 Novartis Ag Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination
US20040224952A1 (en) * 2003-05-07 2004-11-11 Cowart Marlon D. Fused bicyclic-substituted amines as histamine-3 receptor ligands
WO2005105740A2 (en) 2004-04-26 2005-11-10 Teva Pharmaceutical Industries Ltd. Preparation of tegaserod and tegaserod maleate
TW200613275A (en) 2004-08-24 2006-05-01 Recordati Ireland Ltd Lercanidipine salts

Also Published As

Publication number Publication date
US7989639B2 (en) 2011-08-02
HK1126495A1 (en) 2009-09-04
BRPI0713653A2 (pt) 2012-10-23
CA2654230C (en) 2012-09-11
AR061295A1 (es) 2008-08-20
TNSN08508A1 (en) 2010-04-14
NO20090136L (no) 2009-03-06
KR20090026282A (ko) 2009-03-12
MX2008015899A (es) 2009-04-01
TWI385142B (zh) 2013-02-11
EP2032532B8 (en) 2015-07-01
IL195344A (en) 2014-11-30
NZ572744A (en) 2011-05-27
CL2007001690A1 (es) 2008-05-16
MY147013A (en) 2012-10-15
RU2008151724A (ru) 2010-07-20
PE20080365A1 (es) 2008-05-07
GT200800281A (es) 2009-03-18
MA30564B1 (fr) 2009-07-01
WO2007146717A3 (en) 2008-03-27
JP2009540007A (ja) 2009-11-19
AU2007257882B2 (en) 2011-09-08
WO2007146717A2 (en) 2007-12-21
US20090187029A1 (en) 2009-07-23
TW200808692A (en) 2008-02-16
IL195344A0 (en) 2009-08-03
ECSP088957A (es) 2009-01-30
EP2032532B1 (en) 2015-04-22
CA2654230A1 (en) 2007-12-21
AU2007257882A1 (en) 2007-12-21
EP2032532A2 (en) 2009-03-11

Similar Documents

Publication Publication Date Title
MY147013A (en) Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
MY149337A (en) Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
JO3138B1 (ar) املاح n- هيدروكسي -3- [4-[[[2-(2-مثيل-h1-اندول -3-يل)ايثيل]امينو]مثيل]فنيل]-e2-2-بروبيناميد
UA95289C2 (en) Salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
ZA200809651B (en) Process for making salts of N-hydroxy-3[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide
UA97243C2 (en) Crystalline anhydrous form of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
TNSN08507A1 (en) Process for making n-hydroxy -3- [4-[[[2-(2-metyl -1h- indol -3- yl) ethyl] amino] methyl]phenyl] -2e -2- propenamide and starting materials therefor
HK1132509A (en) Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
CY1117493T1 (el) Αλατα του ν-υδροξυ-3-[4-[[[2-(2-μεθυλ-1η-ινδολ-3-υλ)αιθυλ]αμινο]μεθυλο]φαινυλο]-2ε-2-προπεναμιδιου
DOP2008000069A (es) Sales de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]]fenil]-2e-2-propenamida.