JO3630B1 - توليفة أليسيرتيب وباكليتاكسيل لعلاج السرطان - Google Patents

توليفة أليسيرتيب وباكليتاكسيل لعلاج السرطان

Info

Publication number
JO3630B1
JO3630B1 JOP/2013/0075A JOP20130075A JO3630B1 JO 3630 B1 JO3630 B1 JO 3630B1 JO P20130075 A JOP20130075 A JO P20130075A JO 3630 B1 JO3630 B1 JO 3630B1
Authority
JO
Jordan
Prior art keywords
span
alesertib
cancer
treatment
paclitaxel combination
Prior art date
Application number
JOP/2013/0075A
Other languages
English (en)
Inventor
Arijit Chakravarty
Robert W Kleinfield
Kha N Le
Wen Chyi Shyu
Jeffrey A Ecsedy
Karthik Venkatakrishnan
Original Assignee
Millennium Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharm Inc filed Critical Millennium Pharm Inc
Application granted granted Critical
Publication of JO3630B1 publication Critical patent/JO3630B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

<span dir="RTL">يتعلق الاختراع بالكشف عن طرق لمعالجة اضطرابات تكاثر الخلية المختلفة. يتم الكشف بالتحديد عن طرق لمعالجة اضطرابات تكاثر الخلية المختلفة عن طريق إعطاء مثبط انتقائي ليكناز </span>A Aurora<span dir="RTL"> في توليفة مع كروماتوجراف بأساس تاكسان، مثل باكليتاكسيل أو دوكسيتاكسيل. </span>
JOP/2013/0075A 2012-03-20 2013-03-18 توليفة أليسيرتيب وباكليتاكسيل لعلاج السرطان JO3630B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261613258P 2012-03-20 2012-03-20

Publications (1)

Publication Number Publication Date
JO3630B1 true JO3630B1 (ar) 2020-08-27

Family

ID=48048255

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2013/0075A JO3630B1 (ar) 2012-03-20 2013-03-18 توليفة أليسيرتيب وباكليتاكسيل لعلاج السرطان

Country Status (24)

Country Link
US (2) US20130303519A1 (ar)
EP (1) EP2827855B1 (ar)
JP (1) JP6373252B2 (ar)
KR (1) KR102128866B1 (ar)
CN (1) CN104271129A (ar)
AU (1) AU2013235275B2 (ar)
CA (1) CA2868024A1 (ar)
EA (1) EA036434B1 (ar)
ES (1) ES2746946T3 (ar)
GE (2) GEAP201813599A (ar)
IL (1) IL234686B (ar)
IN (1) IN2014DN08477A (ar)
JO (1) JO3630B1 (ar)
MA (1) MA37438A1 (ar)
MX (1) MX358411B (ar)
MY (1) MY175225A (ar)
NZ (1) NZ700744A (ar)
PH (1) PH12014502109A1 (ar)
SG (2) SG10201607741RA (ar)
TN (1) TN2014000387A1 (ar)
TW (1) TWI649082B (ar)
UA (1) UA117455C2 (ar)
WO (1) WO2013142491A1 (ar)
ZA (1) ZA201407551B (ar)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
EP3236948A4 (en) * 2014-12-23 2018-10-03 Millennium Pharmaceuticals, Inc. Combination of raf inhibitors and aurora kinase inhibitors
EP3317427B1 (en) * 2015-07-02 2020-12-23 Millennium Pharmaceuticals, Inc. Biomarkers of response to selective inhibitors of aurora a kinase
CN110833544B (zh) * 2018-08-17 2022-08-09 深圳微芯生物科技股份有限公司 组蛋白去乙酰化酶抑制剂与蛋白激酶抑制剂之组合及其制药用途

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4099012A (en) 1975-08-28 1978-07-04 Ciba-Geigy Corporation 2-pyrazolyl-benzophenones
FR2450833A1 (fr) 1979-02-07 1980-10-03 Hoffmann La Roche Derives de benzazepine
US4481142A (en) 1979-02-07 1984-11-06 Hoffmann-La Roche Inc. Pyrimido-2-benzazepines
US4469633A (en) 1980-05-16 1984-09-04 Hoffmann-La Roche Inc. N-oxides of 5-oxo-1-phenyl-2-benzazepines
EP0273697A3 (en) 1986-12-30 1989-11-29 Merck & Co. Inc. 2-benzazepines with 5- and 6- membered heterocyclic rings
US5166151A (en) 1988-03-25 1992-11-24 Merck & Co., Inc. 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof
US5210082A (en) 1991-05-16 1993-05-11 Merck & Co., Inc. 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders
US6096331A (en) 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5747487A (en) 1993-07-29 1998-05-05 American Cyanamid Company Tricyclic benzazepine vasopressin antagonists
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
CA2247453A1 (en) 1996-03-08 1997-09-12 Joseph James Lewis Azolobenzazepine derivatives as neurologically active agents
US6057329A (en) 1996-12-23 2000-05-02 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives
GB9713087D0 (en) 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
NZ503601A (en) 1997-09-29 2002-02-01 Meiji Seika Kaisha Tricyclic triazolobenzazepine derivatives for use as antiallergic medicaments
US6277844B1 (en) 1998-09-14 2001-08-21 Sydney Spector Compound for selective treatment of malignant cells by inhibiting cell cycle progression, decreasing Bcl2, and increasing apoptosis
WO2000067754A1 (en) 1999-05-12 2000-11-16 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
AP2003002762A0 (en) 2000-09-15 2003-03-31 Vertex Pharma Pyrazole compounds useful as protein kinase inhibitors
AU2002255452B2 (en) 2000-12-21 2006-06-08 Vertex Pharmaceuticals Incorporated Pyrazole compounds useful as protein kinase inhibitors
SI20848A (sl) 2001-03-14 2002-10-31 Lek, Tovarna Farmacevtskih In Kemijskih Izdelkov, D.D. Farmacevtska formulacija, ki vsebuje atorvastatin kalcij
US6686352B2 (en) 2001-05-18 2004-02-03 Hoffmann-La Roche Inc. Substituted imidazo [1,5-a] pyrimido [5,4-d] [1] benzazepine derivatives
DE10135457A1 (de) 2001-07-20 2003-02-06 Adc Automotive Dist Control Optische Sensoranordnung
IL159963A0 (en) 2001-08-09 2004-06-20 Actelion Pharmaceuticals Ltd Novel benzo-fused heterocycles as endothelin antagonisits
CN1897950A (zh) 2003-10-14 2007-01-17 惠氏公司 稠合芳基和杂芳基衍生物及其使用方法
CA2554271A1 (en) 2004-02-10 2005-08-25 Santarus, Inc. Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent
EP2261226B1 (en) 2004-05-14 2015-04-01 Millennium Pharmaceuticals, Inc. Methods for preparing aurora kinase inhibitors
WO2006055831A2 (en) 2004-11-17 2006-05-26 Miikana Therapeutics, Inc. Kinase inhibitors
EP1836188A1 (en) 2004-12-30 2007-09-26 Astex Therapeutics Limited Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases
CN101389324A (zh) 2005-12-23 2009-03-18 史密丝克莱恩比彻姆公司 Aurora激酶的氮杂吲哚抑制剂
WO2007080601A1 (en) 2006-01-16 2007-07-19 Jubilant Organosys Limited Stable pharmaceutical formulation of an acid labile compound and process for preparing the same
AR059838A1 (es) 2006-03-14 2008-04-30 Ranbaxy Lab Ltd Formulaciones para dosis estabilizantes de estatina
DE102006012301A1 (de) 2006-03-15 2007-09-20 Cemag-Anlagenbau-Dessau Gmbh Herstellung von Zementklinker
US7718648B2 (en) 2006-08-09 2010-05-18 Millennium Pharmaceuticals, Inc. Pyridobenzazepine compounds and methods for inhibiting mitotic progression
CN101528237A (zh) 2006-10-31 2009-09-09 艾其林医药公司 艾夫他滨药物组合物
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
PE20081891A1 (es) 2007-03-22 2008-12-27 Opko Health Inc Formulaciones de comprimidos que contienen sales de 8-[{1-(3,5-bis-(trifluorometil)fenil)-etoxi}-metil]-8-fenil-1,7-diaza-spiro[4.5]decan-2-ona y comprimidos elaborados a partir de estas
US20090203671A1 (en) 2007-11-27 2009-08-13 Abbott Laboratories Method of treating cancer
US20110033461A1 (en) * 2008-03-12 2011-02-10 Vladimir Ratushny Combination Therapy for the Treatment of Cancer
KR101848095B1 (ko) 2008-06-26 2018-04-11 안테리오스, 인코퍼레이티드 경피 운반
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
JO3434B1 (ar) 2009-07-31 2019-10-20 Millennium Pharm Inc مركبات صيدلانية لمعالجة السرطان وامراض واضطرابات اخري
BR112012020557A8 (pt) 2010-02-19 2018-01-02 Millennium Pharm Inc formas cristalinas de 4-{[9-cloro-7-(2-flúor-6-metoifenil)-5h-pirimido[5,4-d][2]benzazepin-2-il]amino}-2-metoxibenzoato de sódio
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors

Also Published As

Publication number Publication date
KR20140144215A (ko) 2014-12-18
MA37438A1 (fr) 2016-05-31
IN2014DN08477A (ar) 2015-05-08
MX2014011324A (es) 2014-12-05
KR102128866B1 (ko) 2020-07-01
IL234686A0 (en) 2014-11-30
WO2013142491A1 (en) 2013-09-26
NZ700744A (en) 2016-09-30
EP2827855B1 (en) 2019-06-26
EA036434B1 (ru) 2020-11-10
US20160193224A1 (en) 2016-07-07
EP2827855A1 (en) 2015-01-28
GEAP201813599A (en) 2018-06-25
US20130303519A1 (en) 2013-11-14
SG10201607741RA (en) 2016-11-29
UA117455C2 (uk) 2018-08-10
TN2014000387A1 (en) 2015-12-21
US10213436B2 (en) 2019-02-26
TWI649082B (zh) 2019-02-01
MY175225A (en) 2020-06-16
EA201491727A1 (ru) 2015-01-30
CA2868024A1 (en) 2013-09-26
TW201343169A (zh) 2013-11-01
HK1206253A1 (en) 2016-01-08
ES2746946T3 (es) 2020-03-09
IL234686B (en) 2020-01-30
SG11201405621UA (en) 2014-10-30
JP2015510945A (ja) 2015-04-13
ZA201407551B (en) 2019-01-30
AU2013235275A1 (en) 2014-10-23
CN104271129A (zh) 2015-01-07
PH12014502109A1 (en) 2014-12-10
MX358411B (es) 2018-08-20
GEP20186900B (en) 2018-10-10
JP6373252B2 (ja) 2018-08-15
AU2013235275B2 (en) 2017-12-07

Similar Documents

Publication Publication Date Title
WO2013177187A3 (en) Synergistic tumor treatment with extended-pk il-2 and therapeutic agents
EA201992251A1 (ru) Противораковые вакцины и способы лечения с их применением
BR112015023038A2 (pt) composições para salto de exon para o tratamento da distrofia muscular
CR20120202A (es) Métodos y composiciones para tratar cáncer
PL3791896T3 (pl) Terapia skojarzona obejmująca przeciwciała przeciwko klaudynie 18.2 do leczenia nowotworu
HK1216853A1 (zh) 治療胰腺癌的方法
MX2015011713A (es) Compuestos para el tratamiento de cancer.
MX2020004986A (es) Composiciones mejoradas para tratar distrofia muscular.
EA201591178A1 (ru) Улучшенные композиции для пропускания экзона для лечения мышечной дистрофии
EA201590997A1 (ru) Соединения и способы их применения
MX2016004678A (es) Composiciones para el tratamiento del cancer.
EA201590987A1 (ru) Соединения и способы их применения
MX2015010791A (es) Metodos para tratar el cancer y prevenir la resistencia a farmacos.
HK1220155A1 (zh) 治疗癌症的方法
PH12015502112A1 (en) Cancer treatment using antibodies that bind cell surface grp78
TW201611843A (en) Methods of treatment with arginine deiminase
EA201591925A1 (ru) Терапевтические композиции и их применение
MX356755B (es) Compuestos de tipo fumagilol y metodos para su elaboración y uso.
WO2016160621A3 (en) Nk-92 cells in combination therapy with cancer drugs
MX2016000131A (es) Nanoparticulas polimericas de docetaxel para el tratamiento de cancer.
WO2013134407A3 (en) Procaspase 3 activation by combination therapy
MX379271B (es) Compuestos desestabilizadores de microtubulina para usarse en el tratamiento del cáncer.
MX2014001766A (es) Anticuerpos de neuregulina y sus usos.
MX2017007054A (es) Composiciones y métodos para usar solabegron de liberación modificada para sintomas del tracto urinario inferior.
WO2013106460A3 (en) Compositions and methods for treating malignant astrocytomas