JO3663B1 - الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين - Google Patents

الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين

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Publication number
JO3663B1
JO3663B1 JOP/2015/0192A JOP20150192A JO3663B1 JO 3663 B1 JO3663 B1 JO 3663B1 JO P20150192 A JOP20150192 A JO P20150192A JO 3663 B1 JO3663 B1 JO 3663B1
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JO
Jordan
Prior art keywords
span
fragments
antibodies
antigen
rtl
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JOP/2015/0192A
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English (en)
Inventor
Liang Linda
De Waal Malefyt Rene
Fayadat-Dilman Laurence
Raghunathan Gopalan
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Merck Sharp & Dohme
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Publication of JO3663B1 publication Critical patent/JO3663B1/ar

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39566—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against immunoglobulins, e.g. anti-idiotypic antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
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    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
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Abstract

<strong><span dir="RTL">يتعلق الاختراع الحالي بأجسام مضادة و شظايا ربط مولد ضد منها ترتبط نوعيا ب </span>LAG3 <span dir="RTL"> بشري أو لقرد من فصيلة السعادين طويلة الذيل بالإضافة إلى سلاسل جلوبولين مناعي منها وبولي نيكلوتيدات ترمزها بالإضافة إلى أجهزة حقن تتضمن هذه الأجسام المضادة أو الشظايا. تم تضمين لقاحات تتضمن هذه الأجسام المضادة و الشظايا بالإضافة إلى تركيبات تتضمن الأجسام المضادة و الشظايا (مثلا، تتضمن مضادات </span>PD1<span dir="RTL">) في الاختراع. تم أيضا توفير طرق علاج أو الوقاية من السرطان أو العدوى باستخدام هذه التركيبات. علاوة على ذلك، تم في الاختراع الحالي تضمين طرق للتعبير بناتج عودة الارتباط الجيني عن الأجسام المضادة و الشظايا.</span></strong>
JOP/2015/0192A 2014-08-19 2015-08-11 الأجسام المضادة لمضاد lag3 وأجزاء ربط الأنتيجين JO3663B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462039081P 2014-08-19 2014-08-19
US201562171319P 2015-06-05 2015-06-05

Publications (1)

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JO3663B1 true JO3663B1 (ar) 2020-08-27

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US (6) US20170290914A1 (ar)
EP (2) EP3834842A1 (ar)
JP (3) JP2017532059A (ar)
KR (2) KR102321166B1 (ar)
CN (1) CN107001470B (ar)
AP (1) AP2017009763A0 (ar)
AU (3) AU2015305770C1 (ar)
BR (1) BR112017003194B8 (ar)
CA (2) CA3082655A1 (ar)
CL (1) CL2017000311A1 (ar)
CO (1) CO2017001558A2 (ar)
CR (1) CR20170059A (ar)
CY (1) CY1124252T1 (ar)
DK (1) DK3182999T3 (ar)
DO (1) DOP2017000047A (ar)
ES (1) ES2857505T3 (ar)
GE (2) GEAP202114453A (ar)
GT (1) GT201700034A (ar)
HR (1) HRP20210372T1 (ar)
HU (1) HUE053641T2 (ar)
IL (2) IL297053A (ar)
JO (1) JO3663B1 (ar)
LT (1) LT3182999T (ar)
MA (2) MA55347A (ar)
MD (1) MD4716C1 (ar)
MX (2) MX377753B (ar)
MY (1) MY187262A (ar)
NI (1) NI201700018A (ar)
PE (1) PE20170288A1 (ar)
PH (1) PH12017500297B1 (ar)
PL (1) PL3182999T3 (ar)
PT (1) PT3182999T (ar)
RS (1) RS61559B1 (ar)
SG (1) SG11201701090VA (ar)
SI (1) SI3182999T1 (ar)
TN (1) TN2017000025A1 (ar)
TW (3) TWI742395B (ar)
UA (2) UA119571C2 (ar)
WO (1) WO2016028672A1 (ar)
ZA (2) ZA201700956B (ar)

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