MA53822A - Protéines de fusion fc hétérodimères d'il -12 - Google Patents

Protéines de fusion fc hétérodimères d'il -12

Info

Publication number
MA53822A
MA53822A MA053822A MA53822A MA53822A MA 53822 A MA53822 A MA 53822A MA 053822 A MA053822 A MA 053822A MA 53822 A MA53822 A MA 53822A MA 53822 A MA53822 A MA 53822A
Authority
MA
Morocco
Prior art keywords
heterodimer
fusion proteins
fusion
proteins
Prior art date
Application number
MA053822A
Other languages
English (en)
Inventor
Matthew Bernett
John R Desjarlais
Nargess Hassanzadeh-Kiabi
Ke Liu
Rumana Rashid
Rajat Varma
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of MA53822A publication Critical patent/MA53822A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA053822A 2018-10-03 2019-10-03 Protéines de fusion fc hétérodimères d'il -12 MA53822A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862740813P 2018-10-03 2018-10-03
US201962810038P 2019-02-25 2019-02-25
US201962848512P 2019-05-15 2019-05-15

Publications (1)

Publication Number Publication Date
MA53822A true MA53822A (fr) 2021-08-11

Family

ID=68425252

Family Applications (1)

Application Number Title Priority Date Filing Date
MA053822A MA53822A (fr) 2018-10-03 2019-10-03 Protéines de fusion fc hétérodimères d'il -12

Country Status (12)

Country Link
US (3) US11358999B2 (fr)
EP (1) EP3861016A2 (fr)
JP (2) JP7612571B2 (fr)
KR (1) KR102884523B1 (fr)
CN (1) CN113195523B (fr)
AU (1) AU2019355971B2 (fr)
CA (1) CA3115096A1 (fr)
IL (1) IL281962A (fr)
MA (1) MA53822A (fr)
MX (1) MX2021003765A (fr)
SG (1) SG11202103192RA (fr)
WO (1) WO2020072821A2 (fr)

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TW202323287A (zh) 2016-11-28 2023-06-16 日商中外製藥股份有限公司 包含抗原結合域與運送部分的多胜肽
US12195528B2 (en) 2017-11-28 2025-01-14 Chugai Seiyaku Kabushiki Kaisha Ligand-binding molecule having adjustable ligand-binding activity
MX2020005220A (es) 2017-11-28 2020-08-24 Chugai Pharmaceutical Co Ltd Polipeptido que incluye dominio de union al antigeno y seccion de transporte.
US20220002370A1 (en) 2018-09-27 2022-01-06 Xilio Development, Inc. Masked cytokine polypeptides
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AU2019366956B2 (en) * 2018-10-23 2025-10-30 Dragonfly Therapeutics, Inc. Heterodimeric Fc-fused proteins
EP4037700A2 (fr) 2019-10-03 2022-08-10 Xencor, Inc. Protéines de fusion fc hétérodimères d'il-12 ciblées
CA3172641A1 (fr) * 2020-04-01 2021-10-07 Xilio Development, Inc. Cytokines il-12 masquees et leurs produits de clivage
WO2021212083A2 (fr) * 2020-04-17 2021-10-21 The Board Of Trustees Of The Leland Stanford Junior University Polypeptides d'il-12 et d'il-23 modifiés et leur utilisation
WO2021216916A1 (fr) * 2020-04-22 2021-10-28 Dragonfly Therapeutics, Inc. Formulation, schéma posologique et procédé de fabrication de protéines fusionnées avec fc hétérodimères
US20230399371A1 (en) * 2020-10-29 2023-12-14 Proviva Therapeutics (Hong Kong) Limited Il-12 compositions and methods of use thereof
TW202235431A (zh) 2020-11-25 2022-09-16 美商艾希利歐發展股份有限公司 腫瘤特異性可裂解連接子
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WO2022192898A2 (fr) * 2021-03-10 2022-09-15 Immunowake Inc. Molécules immunomodulatrices et leurs utilisations
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TW202321282A (zh) 2021-07-19 2023-06-01 美商再生元醫藥公司 Il12受體促效劑及其使用方法
MX2024003940A (es) * 2021-09-29 2024-04-22 Zymeworks Bc Inc Proteinas de la subunidad p40 de interleucinas modificadas y metodos para su uso.
CA3234437A1 (fr) * 2021-10-20 2023-04-27 Scott Mccauley Variants p40 d'il-12 humaine et leurs utilisations
IL312221A (en) 2021-10-20 2024-06-01 Synthekine Inc Heterodimeric fc cytokines and uses thereof
WO2023133540A1 (fr) * 2022-01-07 2023-07-13 Lyell Immunopharma, Inc. Variants de l'il-12 à affinité modifiée
EP4466290A4 (fr) * 2022-01-20 2026-02-11 Repertoire Immune Medicines Inc Protéines de fusion il-12 ciblant cd8
CA3259654A1 (fr) * 2022-06-17 2023-12-21 Pfizer Inc. Variants d'il-12, anticorps anti-pd1, protéines de fusion et leurs utilisations
CN119486749A (zh) * 2022-06-22 2025-02-18 武汉厚先生物医药有限公司 Il-12和ox40l组合物在肿瘤免疫治疗中的应用
EP4547701A1 (fr) 2022-07-01 2025-05-07 Sutro Biopharma, Inc. Mutants d'il-12 à toxicité réduite, leurs compositions et leurs procédés d'utilisation
CN116162171B (zh) * 2022-10-13 2025-06-03 深圳市百士通科技开发有限公司 抗体突变方法在治疗性抗体药物中的应用
WO2024086739A1 (fr) 2022-10-20 2024-04-25 Synthekine, Inc. Procédés et compositions de mutéines il12 et de mutéines il2
WO2025012105A2 (fr) 2023-07-07 2025-01-16 Technische Universitaet Muenchen, In Vertretung Des Freistaates Bayern Mutéines d'interleukine 12 humaine
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CA3115096A1 (fr) 2020-04-09
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US20200216509A1 (en) 2020-07-09
AU2019355971A1 (en) 2021-05-06
CN113195523B (zh) 2025-11-04
JP2025066711A (ja) 2025-04-23
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SG11202103192RA (en) 2021-04-29
US20220396605A1 (en) 2022-12-15
US11655277B2 (en) 2023-05-23
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MX2021003765A (es) 2021-07-15
WO2020072821A3 (fr) 2020-06-18
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WO2020072821A9 (fr) 2020-05-22
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IL281962A (en) 2021-05-31
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US20230027540A1 (en) 2023-01-26

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