JOP20180025A1 - مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك - Google Patents

مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

Info

Publication number
JOP20180025A1
JOP20180025A1 JOP/2018/0025A JOP20180025A JOP20180025A1 JO P20180025 A1 JOP20180025 A1 JO P20180025A1 JO P20180025 A JOP20180025 A JO P20180025A JO P20180025 A1 JOP20180025 A1 JO P20180025A1
Authority
JO
Jordan
Prior art keywords
viral replication
compounds
replication inhibitors
indoline derivatives
dengue viral
Prior art date
Application number
JOP/2018/0025A
Other languages
English (en)
Inventor
Dorothée Alice Marie-Eve Bardiot
Jean-François Bonfanti
Pierre Jean-Marie Bernard Raboisson
Erwin Coesemans
Bart Rudolf Romanie Kesteleyn
Arnaud Didier M Marchand
Original Assignee
Janssen Pharmaceuticals Inc
Katholieke Univ Leuven Ku Leuven Research & Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Katholieke Univ Leuven Ku Leuven Research & Development filed Critical Janssen Pharmaceuticals Inc
Publication of JOP20180025A1 publication Critical patent/JOP20180025A1/ar
Application granted granted Critical
Publication of JOP20180025B1 publication Critical patent/JOP20180025B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

يتعلق الاختراع الحالي بمشتقات اندولين مستبدلة وبطرق لمنع او معالجة الاصابات الفيروسية باستخدام المركبات المذكورة. وكما يتعلق بالمركبات المذكورة بخصوص استخدامها كدواء والافضل لاستخدامها كعلاج لمنع أو معالجة الاصابات الفيروسية لحمى الفنك. كما يتعلق الاختراع الحالي بتركيبات صيدلانية أو مستحضرات متحدة من المركبات، وبالتركيبات أو المستحضرات لاستخدامها كدواء، والافضل لمنع أو معالجة الاصابات الفيروسية لحمى الفنك. كما يتعلق الاختراع بعمليات و طرق لتحضير هذه المركبات.
JOP/2018/0025A 2017-03-31 2018-03-26 مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك JOP20180025B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17164048 2017-03-31

Publications (2)

Publication Number Publication Date
JOP20180025A1 true JOP20180025A1 (ar) 2019-01-30
JOP20180025B1 JOP20180025B1 (ar) 2021-08-17

Family

ID=58464340

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2018/0025A JOP20180025B1 (ar) 2017-03-31 2018-03-26 مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك

Country Status (32)

Country Link
US (1) US11083707B2 (ar)
EP (1) EP3601266B1 (ar)
JP (1) JP7203752B2 (ar)
KR (1) KR102530832B1 (ar)
CN (1) CN110461831B (ar)
AR (1) AR111314A1 (ar)
AU (1) AU2018246301B2 (ar)
BR (1) BR112019020175A2 (ar)
CA (1) CA3055867C (ar)
CL (1) CL2019002745A1 (ar)
CO (1) CO2019010295A2 (ar)
CR (1) CR20190446A (ar)
DK (1) DK3601266T3 (ar)
EA (1) EA039784B1 (ar)
EC (1) ECSP19070369A (ar)
ES (1) ES2884151T3 (ar)
HR (1) HRP20210942T1 (ar)
HU (1) HUE054678T2 (ar)
IL (1) IL269658B (ar)
JO (1) JOP20180025B1 (ar)
LT (1) LT3601266T (ar)
MX (1) MX386782B (ar)
NI (1) NI201900099A (ar)
PE (1) PE20191650A1 (ar)
PH (1) PH12019502201A1 (ar)
SG (1) SG11201908786VA (ar)
SI (1) SI3601266T1 (ar)
TW (1) TWI795393B (ar)
UA (1) UA126288C2 (ar)
UY (1) UY37645A (ar)
WO (1) WO2018178240A1 (ar)
ZA (1) ZA201906395B (ar)

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CN112159325B (zh) * 2020-10-10 2022-11-25 浙江工业大学 一种合成2-氨基-3-硝基甲苯的方法
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Also Published As

Publication number Publication date
CL2019002745A1 (es) 2019-12-27
ECSP19070369A (es) 2019-10-31
TW201900635A (zh) 2019-01-01
CN110461831A (zh) 2019-11-15
JP7203752B2 (ja) 2023-01-13
EA039784B1 (ru) 2022-03-14
LT3601266T (lt) 2021-07-12
EA201992329A1 (ru) 2020-02-20
US20200121647A1 (en) 2020-04-23
TWI795393B (zh) 2023-03-11
BR112019020175A2 (pt) 2020-06-02
KR102530832B1 (ko) 2023-05-09
SG11201908786VA (en) 2019-10-30
AR111314A1 (es) 2019-06-26
EP3601266B1 (en) 2021-04-28
IL269658A (en) 2019-11-28
WO2018178240A1 (en) 2018-10-04
IL269658B (en) 2022-01-01
ES2884151T3 (es) 2021-12-10
HRP20210942T1 (hr) 2021-10-15
CA3055867A1 (en) 2018-10-04
CO2019010295A2 (es) 2019-10-09
DK3601266T3 (da) 2021-07-19
UY37645A (es) 2018-09-28
EP3601266A1 (en) 2020-02-05
PH12019502201A1 (en) 2020-09-28
NI201900099A (es) 2020-03-11
ZA201906395B (en) 2021-05-26
CA3055867C (en) 2024-01-02
PE20191650A1 (es) 2019-11-07
SI3601266T1 (sl) 2021-08-31
UA126288C2 (uk) 2022-09-14
MX386782B (es) 2025-03-19
HUE054678T2 (hu) 2021-09-28
KR20190137108A (ko) 2019-12-10
CR20190446A (es) 2019-11-29
US11083707B2 (en) 2021-08-10
CN110461831B (zh) 2022-11-01
JOP20180025B1 (ar) 2021-08-17
JP2020512355A (ja) 2020-04-23
AU2018246301B2 (en) 2021-08-19
MX2019011606A (es) 2019-11-08
AU2018246301A1 (en) 2019-09-19

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