JOP20190100A1 - بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها - Google Patents

بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها

Info

Publication number
JOP20190100A1
JOP20190100A1 JOP/2019/0100A JOP20190100A JOP20190100A1 JO P20190100 A1 JOP20190100 A1 JO P20190100A1 JO P20190100 A JOP20190100 A JO P20190100A JO P20190100 A1 JOP20190100 A1 JO P20190100A1
Authority
JO
Jordan
Prior art keywords
methods
binding proteins
gitr antigen
abps
gitr
Prior art date
Application number
JOP/2019/0100A
Other languages
English (en)
Inventor
William Winston
Nels P Nielsen
Daniel Hicklin
Heather Brodkin
Jose-Andres Salmeron-Garcia
Sonja Kleffel
Seidel-Dugan Cynthia
Original Assignee
Potenza Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Potenza Therapeutics Inc filed Critical Potenza Therapeutics Inc
Publication of JOP20190100A1 publication Critical patent/JOP20190100A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

يتعلق الاختراع الحالي ببروتينات رابطة لمولد ضد (ABPs) ترتبط بانتقائية بـ GITR وصوره المتماثلة ونظائره، وتركيبات تشتمل على ABPs. ويتم أيضا تقديم طرق استخدام ABPs، مثل الطرق العلاجية والتشخيصية.
JOP/2019/0100A 2016-11-19 2017-06-16 بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها JOP20190100A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662497428P 2016-11-19 2016-11-19
US201762448644P 2017-01-20 2017-01-20

Publications (1)

Publication Number Publication Date
JOP20190100A1 true JOP20190100A1 (ar) 2019-05-01

Family

ID=62146165

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2019/0100A JOP20190100A1 (ar) 2016-11-19 2017-06-16 بروتينات ربط مولد ضد مضاد لـ gitr وطرق استخدامها

Country Status (17)

Country Link
US (2) US10988545B2 (ar)
EP (1) EP3541845A1 (ar)
JP (1) JP7572147B2 (ar)
KR (1) KR102574071B1 (ar)
CN (1) CN110248960A (ar)
AU (1) AU2017362721A1 (ar)
BR (1) BR112019010128A2 (ar)
CO (1) CO2019006424A2 (ar)
IL (1) IL266720A (ar)
JO (1) JOP20190100A1 (ar)
MA (1) MA46844A (ar)
MX (1) MX2019005821A (ar)
PH (1) PH12019501108A1 (ar)
TW (1) TWI783953B (ar)
UA (1) UA126389C2 (ar)
WO (1) WO2018094300A1 (ar)
ZA (1) ZA201902939B (ar)

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US10994021B1 (en) * 2020-04-11 2021-05-04 Bliss Biopharmaceutical (Hangzhou) Co., Ltd. Tetravalent antibody-drug conjugates and use thereof
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EP4339209A4 (en) * 2021-05-10 2025-05-28 MediMabbio Inc. ANTI-GITR ANTIBODIES AND THEIR USES
EP4437112A1 (en) * 2021-11-24 2024-10-02 Formycon AG Improved ace2 fusion proteins
IL314907A (en) 2022-03-15 2024-10-01 Yeda Res & Dev Antibodies against GITR and their uses

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ZA201902939B (en) 2022-08-31
EP3541845A1 (en) 2019-09-25
MA46844A (fr) 2019-09-25
CN110248960A (zh) 2019-09-17
PH12019501108A1 (en) 2019-07-29
BR112019010128A2 (pt) 2019-10-08
JP2019537449A (ja) 2019-12-26
KR102574071B1 (ko) 2023-09-06
TWI783953B (zh) 2022-11-21
WO2018094300A8 (en) 2019-05-02
US10988545B2 (en) 2021-04-27
WO2018094300A1 (en) 2018-05-24
US20210269542A1 (en) 2021-09-02
AU2017362721A1 (en) 2019-05-23
JP7572147B2 (ja) 2024-10-23
RU2019118800A (ru) 2020-12-21
IL266720A (en) 2019-07-31
TW201819416A (zh) 2018-06-01
KR20190095298A (ko) 2019-08-14
CO2019006424A2 (es) 2019-08-20
US20180208665A1 (en) 2018-07-26
UA126389C2 (uk) 2022-09-28
RU2019118800A3 (ar) 2021-03-23
MX2019005821A (es) 2019-10-07

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