JOP20190193B1 - ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان - Google Patents

ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان

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Publication number
JOP20190193B1
JOP20190193B1 JOJO/P/2019/0193A JOP20190193A JOP20190193B1 JO P20190193 B1 JOP20190193 B1 JO P20190193B1 JO P20190193 A JOP20190193 A JO P20190193A JO P20190193 B1 JOP20190193 B1 JO P20190193B1
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JO
Jordan
Prior art keywords
compounds
dihydropyridazine
oxo
hythryl
carboxymide
Prior art date
Application number
JOJO/P/2019/0193A
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English (en)
Inventor
Ilona Gutcher
Benjamin Bader
Detlef St?Ckigt
Rafael Carretero
Christina Kober
Lars R?Se
Ludwig Zorn
Michael Platten
Norbert Schmees
Horst Irlbacher
Ulrike R?Hn
Original Assignee
Bayer Ag
Bayer Pharma AG
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Publication of JOP20190193A1 publication Critical patent/JOP20190193A1/ar
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Publication of JOP20190193B1 publication Critical patent/JOP20190193B1/ar

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

يتعلق الاختراع الحالي بمركبات 2-اريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد بالصيغة العامة (I): (I) حيث X، R1، R2، R3، R4، وR5 كما هي موضحة ومحددة في هذه الوثيقة، بطرق لتحضير المركبات المذكورة، بمركبات وسيطة مفيدة في تحضير المركبات المذكورة، بتراكيب وتوليفات صيدلانية تشتمل على المركبات المذكورة، وباستخدام المركبات المذكورة في تصنيع تراكيب صيدلانية مستخدمة في العلاج أو الوقاية من الأمراض، ولا سيما السرطان أو حالات مرضية مقترنة باختلال الاستجابات المناعية وغيرها من الاضطرابات المصاحبة لتأشير AHR الشاذ، كعامل وحيد أو بشكل مؤتلف مع مكونات نشطة أخرى.
JOJO/P/2019/0193A 2017-02-09 2018-02-02 ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان JOP20190193B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17155406 2017-02-09
EP17202882 2017-11-21
PCT/EP2018/052627 WO2018146010A1 (en) 2017-02-09 2018-02-02 2-heteroaryl-3-oxo-2,3-dihydropyridazine-4-carboxamides for the treatment of cancer

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JOP20190193A1 JOP20190193A1 (ar) 2019-08-08
JOP20190193B1 true JOP20190193B1 (ar) 2024-04-18

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