JOP20200024A1 - Dihydrooxadiazinones - Google Patents

Dihydrooxadiazinones

Info

Publication number
JOP20200024A1
JOP20200024A1 JOP/2020/0024A JOP20200024A JOP20200024A1 JO P20200024 A1 JOP20200024 A1 JO P20200024A1 JO P20200024 A JOP20200024 A JO P20200024A JO P20200024 A1 JOP20200024 A1 JO P20200024A1
Authority
JO
Jordan
Prior art keywords
compounds
aforementioned
dihydrooxadiazinones
diseases
dihydroxydiazinone
Prior art date
Application number
JOP/2020/0024A
Other languages
Arabic (ar)
Inventor
Lange Martin
Greulich Heidi
Meyerson Matthew
Ellermann Manuel
Sulzle Detlev
Timothy Lewis A
Lienau Philip
Burgin Alex
Nikolaus Gradl Stefan
Christine Kopitz Charlotte
Wu Xiaoyun
Hegele-Hartung Christa
Tersteegen Adrian
Original Assignee
Bayer Ag
Bayer Pharma AG
Dana Farber Cancer Inst Inc
Broad Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Bayer Pharma AG, Dana Farber Cancer Inst Inc, Broad Inst Inc filed Critical Bayer Ag
Publication of JOP20200024A1 publication Critical patent/JOP20200024A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines having two or more nitrogen atoms in the same ring, e.g. oxadiazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C07D273/04—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

مركبات ثنائي هيدروكساديازينون الملخص يزود الاختراع الحالي مركبات ثنائي هيدروكسي ديازينون بالصيغة العامة (I): " معادلة" (I)، حيث R1، R2، R3، و R4 كما هي معرفة هنا، طرق لتحضير المركبات المذكورة، مركبات وسيطة مفيدة لتحضير المركبات المذكورة، تراكيب صيدلانية وتوليفات تتضمن المركبات المذكورة واستخدام المركبات المذكورة لتصنيع تراكيب صيدلانية لعلاج أو الوقاية من الأمراض، وتحديداً أمراض فرط التكاثر، في صورة عامل وحيد أوDihydroxadiazinon Compounds Abstract The present invention provides dihydroxydiazinone compounds with the general formula (I): “Equation” (I), where R1, R2, R3, and R4 as defined herein, methods for preparing the said compounds, useful intermediaries for the preparation of the said compounds, Pharmaceutical formulations and combinations that include the aforementioned compounds and the use of the aforementioned compounds to manufacture pharmaceutical formulas to treat or prevent diseases, specifically hyperproliferative diseases, in the form of a single agent or

JOP/2020/0024A 2017-08-04 2018-08-01 Dihydrooxadiazinones JOP20200024A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762541627P 2017-08-04 2017-08-04
PCT/EP2018/071039 WO2019025562A1 (en) 2017-08-04 2018-08-02 Dihydrooxadiazinones

Publications (1)

Publication Number Publication Date
JOP20200024A1 true JOP20200024A1 (en) 2020-02-02

Family

ID=63207725

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0024A JOP20200024A1 (en) 2017-08-04 2018-08-01 Dihydrooxadiazinones

Country Status (26)

Country Link
US (3) US11427553B2 (en)
EP (1) EP3661517B1 (en)
JP (2) JP7676141B2 (en)
KR (1) KR20200036914A (en)
CN (1) CN111212647B (en)
AR (1) AR112402A1 (en)
AU (1) AU2018309356B2 (en)
BR (1) BR112020002351A2 (en)
CA (1) CA3071800A1 (en)
CL (1) CL2020000303A1 (en)
CO (1) CO2020001242A2 (en)
CR (1) CR20200057A (en)
CU (1) CU24608B1 (en)
EA (1) EA202090448A1 (en)
EC (1) ECSP20008441A (en)
IL (1) IL272098B2 (en)
JO (1) JOP20200024A1 (en)
MA (1) MA49750A (en)
MX (1) MX2020001404A (en)
PE (1) PE20200936A1 (en)
PH (1) PH12020500134A1 (en)
SG (1) SG11201913775UA (en)
TW (1) TWI791581B (en)
UA (1) UA125731C2 (en)
UY (1) UY37832A (en)
WO (1) WO2019025562A1 (en)

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JOP20200024A1 (en) 2017-08-04 2020-02-02 Bayer Ag Dihydrooxadiazinones
CA3071795A1 (en) 2017-08-04 2019-02-07 Bayer Aktiengesellschaft 6-phenyl-4,5-dihydropyridazin-3(2h)-one derivatives as pde3a and pde3b inhibitors for treating cancer
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WO2020157188A1 (en) * 2019-02-01 2020-08-06 Bayer Aktiengesellschaft Dihydrooxadiazinones for the treatment of hyperproliferative diseases
AR117929A1 (en) 2019-02-01 2021-09-01 Bayer Ag 1,2,4-TRIAZIN-3 (2H) -ONE COMPOUNDS
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WO2020092998A1 (en) 2018-11-01 2020-05-07 The Broad Institute, Inc. Identification of pde3 modulator responsive cancers
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Also Published As

Publication number Publication date
US11773070B2 (en) 2023-10-03
MX2020001404A (en) 2020-03-12
CN111212647B (en) 2024-05-14
AU2018309356B2 (en) 2022-12-15
SG11201913775UA (en) 2020-01-30
KR20200036914A (en) 2020-04-07
CA3071800A1 (en) 2019-02-07
JP2020529439A (en) 2020-10-08
CR20200057A (en) 2020-06-16
EP3661517A1 (en) 2020-06-10
EP3661517B1 (en) 2023-09-13
AU2018309356A1 (en) 2020-01-30
CN111212647A (en) 2020-05-29
US11427553B2 (en) 2022-08-30
MA49750A (en) 2020-06-10
PE20200936A1 (en) 2020-09-17
CO2020001242A2 (en) 2020-02-18
UY37832A (en) 2019-02-28
US20230017200A1 (en) 2023-01-19
TWI791581B (en) 2023-02-11
ECSP20008441A (en) 2020-05-29
EA202090448A1 (en) 2020-05-21
JP2023115065A (en) 2023-08-18
IL272098B1 (en) 2023-03-01
WO2019025562A1 (en) 2019-02-07
IL272098B2 (en) 2023-07-01
UA125731C2 (en) 2022-05-25
IL272098A (en) 2020-03-31
TW201917126A (en) 2019-05-01
BR112020002351A2 (en) 2020-09-08
CU20200008A7 (en) 2020-11-30
CU24608B1 (en) 2022-06-06
AR112402A1 (en) 2019-10-23
JP7676141B2 (en) 2025-05-14
US12258323B2 (en) 2025-03-25
CL2020000303A1 (en) 2020-11-13
US20220396554A1 (en) 2022-12-15
US20200369633A1 (en) 2020-11-26
PH12020500134A1 (en) 2021-01-25

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