JOP20200073A1 - مركبات أميد إيميدازوبيريدين تحمل بدائل واستخداماتها - Google Patents

مركبات أميد إيميدازوبيريدين تحمل بدائل واستخداماتها

Info

Publication number
JOP20200073A1
JOP20200073A1 JOP/2020/0073A JOP20200073A JOP20200073A1 JO P20200073 A1 JOP20200073 A1 JO P20200073A1 JO P20200073 A JOP20200073 A JO P20200073A JO P20200073 A1 JOP20200073 A1 JO P20200073A1
Authority
JO
Jordan
Prior art keywords
prophylaxis
treatment
substituted imidazopyridine
amides
diseases
Prior art date
Application number
JOP/2020/0073A
Other languages
English (en)
Inventor
Straub Alexander
Mondritzki Thomas
Stampfuss Jan
Lobell Mario
Meyer Jutta
Meibom Daniel
Alexandra Scheerer Nina
Collins Karl
Munter Klaus
Leineweber Kirsten
Matthias Gericke Kersten
Schamberger Jens
Freudenberger Till
Wunder Frank
Ortega Hernandez Nuria
Kroh Walter
Original Assignee
Bayer Pharma AG
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=60162133&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20200073(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Pharma AG, Bayer Ag filed Critical Bayer Pharma AG
Publication of JOP20200073A1 publication Critical patent/JOP20200073A1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

الملخص يتعلق الطلب الحالي بمركبات أميد إيميدازوبيريدين جديدة تحمل بدائل ذات الصيغة (I)، ويتعلق الاختراع الحالي بعمليات لتحضيرها، استخدامها، لوحدها أو في توليفات، لمعالجة و/ أو الوقاية من الأمراض ويتعلق الاختراع الحالي باستخدامها لإنتاج أدوية لمعالجة و/ أو الوقاية من الأمراض، وبالتحديد لمعالجة و/ أو الوقاية من أمراض القلب والأوعية الدموية، الأمراض المتعلقة بالأعصاب والجهاز العصبي المركزي بالإضافة إلى الاضطرابات الأيضية.
JOP/2020/0073A 2017-10-24 2018-10-18 مركبات أميد إيميدازوبيريدين تحمل بدائل واستخداماتها JOP20200073A1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17198021 2017-10-24
PCT/EP2018/078653 WO2019081353A1 (de) 2017-10-24 2018-10-18 Substituierte imidazopyridinamide und ihre verwendung

Publications (1)

Publication Number Publication Date
JOP20200073A1 true JOP20200073A1 (ar) 2020-04-29

Family

ID=60162133

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2020/0073A JOP20200073A1 (ar) 2017-10-24 2018-10-18 مركبات أميد إيميدازوبيريدين تحمل بدائل واستخداماتها

Country Status (27)

Country Link
US (1) US20200339567A1 (ar)
EP (1) EP3700903A1 (ar)
JP (1) JP2021500366A (ar)
KR (1) KR20200076686A (ar)
CN (1) CN111225917A (ar)
AR (1) AR113790A1 (ar)
AU (1) AU2018354785A1 (ar)
BR (1) BR112020007967A2 (ar)
CA (1) CA3084422A1 (ar)
CL (1) CL2020001075A1 (ar)
CO (1) CO2020004968A2 (ar)
CR (1) CR20200173A (ar)
CU (1) CU20200041A7 (ar)
DO (1) DOP2020000072A (ar)
EA (1) EA202091020A1 (ar)
EC (1) ECSP20023043A (ar)
IL (1) IL273954A (ar)
JO (1) JOP20200073A1 (ar)
MA (1) MA50440A (ar)
MX (1) MX2020004190A (ar)
NI (1) NI202000029A (ar)
PE (1) PE20201280A1 (ar)
PH (1) PH12020550472A1 (ar)
SG (1) SG11202003641RA (ar)
TW (1) TW201932462A (ar)
UY (1) UY37947A (ar)
WO (1) WO2019081353A1 (ar)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20190292188A1 (en) 2018-02-27 2019-09-26 Incyte Corporation Imidazopyrimidines and triazolopyrimidines as a2a / a2b inhibitors
MA52940A (fr) 2018-05-18 2021-04-28 Incyte Corp Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b
CN113166153B (zh) 2018-07-05 2024-11-01 因赛特公司 作为a2a/a2b抑制剂的稠合吡嗪衍生物
KR20210116488A (ko) 2018-12-20 2021-09-27 인사이트 코포레이션 액티빈 수용체-유사 키나제-2의 억제제로서의 이미다조피리다진 및 이미다조피리딘 화합물
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
WO2020216669A1 (de) * 2019-04-23 2020-10-29 Bayer Aktiengesellschaft Phenylsubstituierte imidazopyridinamide und ihre verwendung
WO2023086390A1 (en) * 2021-11-09 2023-05-19 Tufts Medical Center, Inc. Methods and compositions for providing myocardial protection and treating myocardial stress and fibrosis
CN117510444B (zh) * 2024-01-06 2024-03-08 成都瑞尔医药科技有限公司 一种呋塞米的精制工艺

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
JP3729343B2 (ja) 2000-04-27 2005-12-21 アステラス製薬株式会社 縮合ヘテロアリール誘導体
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
HUP0401076A2 (hu) 2001-07-20 2004-09-28 Oy Juvantia Pharma Ltd. Alfa-2B-andrenoceptor antagonista vegyületek és alkalmazásuk gyógyszerkészítmények előállítására
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
WO2008027812A2 (en) 2006-08-28 2008-03-06 Forest Laboratories Holdings Limited Imidazopyridine and imidazopyrimidine derivatives
WO2008134553A1 (en) 2007-04-26 2008-11-06 Xenon Pharmaceuticals Inc. Methods of using bicyclic compounds in treating sodium channel-mediated diseases
GB0720041D0 (en) * 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
EP2334676B1 (en) 2008-09-17 2016-07-06 Allergan, Inc. Substituted 3-amino-1-oxo or thioxo-1,2,5,6,7,8-hexahydro-2,7-naphthyridine-4-carbonitriles as selective alpha 2b antagonists
DE102010001064A1 (de) 2009-03-18 2010-09-23 Bayer Schering Pharma Aktiengesellschaft Substituierte 2-Acetamido-5-Aryl-1,2,4-triazolone und deren Verwendung
AU2011219746B2 (en) 2010-02-27 2015-04-23 Bayer Intellectual Property Gmbh Bisaryl-bonded aryltriazolones and use thereof
DE102010021637A1 (de) * 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
CN103298468A (zh) * 2011-02-01 2013-09-11 协和发酵麒麟株式会社 稠环杂环衍生物
WO2012112363A1 (en) 2011-02-14 2012-08-23 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
DE102011007272A1 (de) 2011-04-13 2012-10-18 Bayer Pharma Aktiengesellschaft Verzweigte 3-Phenylpropionsäure-Derivate und ihre Verwendung
BR112015000675B1 (pt) 2012-07-13 2022-07-12 UCB Biopharma SRL Derivados de imidazopiridina como moduladores da atividade de tnf
BR112015001211B1 (pt) 2012-07-20 2020-12-15 Bayer Pharma Aktiengesellschaft Ácidos 5-aminotetra-hidroquinolina-2-carboxílicos, processos para a sua preparação, seus usos no tratamento e/ou prevenção de doenças e seus medicamentos
US9624214B2 (en) 2012-11-05 2017-04-18 Bayer Pharma Aktiengesellschaft Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
JP2016510010A (ja) 2013-03-01 2016-04-04 バイエル・ファルマ・アクティエンゲゼルシャフト トリフルオロメチル置換環縮合ピリミジンおよびその使用
EA032137B1 (ru) 2014-11-03 2019-04-30 Байер Фарма Акциенгезельшафт Производные гидроксиалкил-замещенного фенилтриазола и их применение

Also Published As

Publication number Publication date
EA202091020A1 (ru) 2020-07-24
EP3700903A1 (de) 2020-09-02
UY37947A (es) 2019-05-31
CU20200041A7 (es) 2021-03-11
PH12020550472A1 (en) 2021-03-15
KR20200076686A (ko) 2020-06-29
CR20200173A (es) 2020-06-26
SG11202003641RA (en) 2020-05-28
BR112020007967A2 (pt) 2020-10-20
AU2018354785A1 (en) 2020-04-23
DOP2020000072A (es) 2020-08-31
JP2021500366A (ja) 2021-01-07
AR113790A1 (es) 2020-06-10
CO2020004968A2 (es) 2020-05-05
CN111225917A (zh) 2020-06-02
MX2020004190A (es) 2020-08-03
WO2019081353A1 (de) 2019-05-02
IL273954A (en) 2020-05-31
CL2020001075A1 (es) 2021-01-22
PE20201280A1 (es) 2020-11-24
ECSP20023043A (es) 2020-06-30
MA50440A (fr) 2020-09-02
CA3084422A1 (en) 2019-05-02
US20200339567A1 (en) 2020-10-29
TW201932462A (zh) 2019-08-16
NI202000029A (es) 2020-10-09

Similar Documents

Publication Publication Date Title
JOP20200073A1 (ar) مركبات أميد إيميدازوبيريدين تحمل بدائل واستخداماتها
PH12012501699A1 (en) Bisaryl-bonded aryltriazolones and use thereof
JO3199B1 (ar) مركبات 5- فلورو-1h- بيرازولوبيريدينات مستبدلة واستخدامها
PH12015500106A1 (en) Novel 5-aminotetrahydroquinoline-2-carboxylic acids and use thereof
TN2015000169A1 (en) Amino-substituted imidazo[1,2-a]pyridinecarboxamides and their use
MY156777A (en) Substituted 2-acetamido-5-ary1-1,2,4-triazolones and use thereof
PH12016500065A1 (en) Benzyl-1h-pyrazolo[3,4-b]pyridines and use thereof
PH12014501963A1 (en) Inhibitors of beta-secretase
PH12017502224A1 (en) Positive allosteric modulators of muscarinic md receptor
PH12017501758A1 (en) Heterocyclymethyl-thienouracile as antagonists of the adenosine-a2b-receptor
PH12016500608A1 (en) Cyclic thienouracil-carboxamides and use thereof
TN2016000107A1 (en) Substituted phenylalanine derivatives
MX2015002570A (es) Inhibidores de la beta-secretasa.
MX2013002261A (es) N-fenetiltriazolonacetamidas sustituidas y su uso.
WO2015165933A3 (de) Imidazo[1,2-a]pyridine als stimulatoren der löslichen guanylatcyclase zur behandlung von kardiovaskulären erkrankungen
TN2013000243A1 (en) Substituted 1-benzylcycloalkylcarboxlic acids and use thereof