JOP20230077A1 - محفزات glp 1/ gip مزدوجة - Google Patents
محفزات glp 1/ gip مزدوجةInfo
- Publication number
- JOP20230077A1 JOP20230077A1 JOJO/P/2023/0077A JOP20230077A JOP20230077A1 JO P20230077 A1 JOP20230077 A1 JO P20230077A1 JO P20230077 A JOP20230077 A JO P20230077A JO P20230077 A1 JOP20230077 A1 JO P20230077A1
- Authority
- JO
- Jordan
- Prior art keywords
- glp
- dual agonists
- gip
- obesity
- gip dual
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Theoretical Computer Science (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Software Systems (AREA)
- Sewing Machines And Sewing (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Data Mining & Analysis (AREA)
Abstract
يتعلق الاختراع الحالي ببولي ببتيد مساعد مزدوج وممتد المفعول مكون من ببتيد شبيه بالجلوكاجون-1 وبولي ببتيد مفرز للإنسولين اعتمادًا على الجلوكوز البشري (GIP) والذي يفيد في علاج النوع 2 من البول السكري (T2D)، والسكري الناتج عن السِمنة، والسِمنة وفرط الدهون في الدم.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202021045240 | 2020-10-17 | ||
| IN202121002837 | 2021-01-20 | ||
| PCT/IB2021/059420 WO2022079639A1 (en) | 2020-10-17 | 2021-10-13 | Glp-1/gip dual agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JOP20230077A1 true JOP20230077A1 (ar) | 2023-04-16 |
Family
ID=78302859
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOJO/P/2023/0077A JOP20230077A1 (ar) | 2020-10-17 | 2023-04-16 | محفزات glp 1/ gip مزدوجة |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20240020543A1 (ar) |
| EP (1) | EP4204440A1 (ar) |
| JP (1) | JP7830441B2 (ar) |
| KR (1) | KR20230088337A (ar) |
| CN (1) | CN116171164A (ar) |
| AU (1) | AU2021361263A1 (ar) |
| BR (1) | BR112023003668A2 (ar) |
| CA (1) | CA3195155A1 (ar) |
| CL (1) | CL2023000960A1 (ar) |
| CO (1) | CO2023001960A2 (ar) |
| IL (1) | IL301109A (ar) |
| JO (1) | JOP20230077A1 (ar) |
| MX (1) | MX2023002906A (ar) |
| PE (1) | PE20231309A1 (ar) |
| TW (1) | TW202229323A (ar) |
| WO (1) | WO2022079639A1 (ar) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4281464A4 (en) | 2021-01-20 | 2025-01-01 | Viking Therapeutics, Inc. | Compositions and methods for the treatment of metabolic and liver disorders |
| CN117980325A (zh) | 2021-05-13 | 2024-05-03 | 卡莫特治疗学股份有限公司 | G-蛋白偶联受体的调节剂 |
| JP7642830B2 (ja) | 2021-09-15 | 2025-03-10 | バイキング・セラピューティクス・インコーポレイテッド | 代謝及び肝臓障害の処置のための組成物及び方法 |
| CN119522233A (zh) * | 2022-07-13 | 2025-02-25 | 杭州中美华东制药有限公司 | Glp-1/gip双激动剂及其制备方法和用途 |
| CA3262093A1 (en) * | 2022-07-20 | 2024-01-25 | Viking Therapeutics, Inc. | Pharmaceutical Formulations and Methods for the Treatment of Metabolic and Liver Disorders |
| WO2024098718A1 (zh) * | 2022-11-07 | 2024-05-16 | 内蒙古博睿精创科技有限公司 | 一种新型长效多肽化合物、组合物及其应用 |
| CN115651075B (zh) * | 2022-12-12 | 2023-04-11 | 杭州信海医药科技有限公司 | 一种Tirzepatide的合成方法 |
| KR20250140132A (ko) * | 2023-01-18 | 2025-09-24 | 상하이 민웨이 바이오테크놀로지 씨오 엘티디 | 삼중 활성을 갖는 융합 단백질 및 그 용도 |
| WO2024165571A2 (en) | 2023-02-06 | 2024-08-15 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| TW202500575A (zh) * | 2023-05-21 | 2025-01-01 | 美商卡默療法股份有限公司 | 具有或不具有體重相關合併症之過重或肥胖成人之治療 |
| KR20260022948A (ko) | 2023-06-09 | 2026-02-20 | 썬 파마슈티컬 인더스트리스 리미티드 | Glp-1/gip 이중 수용체 작용제, glp-1/gcg 이중 수용체 작용제, 및 glp-1/gip/gcg 삼중 수용체 작용제 |
| CN116693652B (zh) * | 2023-08-02 | 2024-01-05 | 北京惠之衡生物科技有限公司 | 一种glp-1/gip受体双重激动剂衍生物及其制备方法和应用 |
| WO2025125576A2 (en) | 2023-12-15 | 2025-06-19 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| EP4686757A1 (en) | 2024-07-31 | 2026-02-04 | e-therapeutics PLC | Inhibitors of expression and/or function |
| WO2025133348A1 (en) | 2023-12-22 | 2025-06-26 | E-Therapeutics Plc | Inhibitors of expression and/or function |
| TW202535911A (zh) * | 2024-01-12 | 2025-09-16 | 大陸商杭州中美華東製藥有限公司 | 長效glp-1/gip雙激動劑的藥物組合物 |
| WO2025163615A1 (en) | 2024-01-31 | 2025-08-07 | Sun Pharmaceutical Industries Ltd. | High level production of glp1 analogues |
| WO2025196502A1 (en) | 2024-03-20 | 2025-09-25 | North Carolina Agricultural & Technical State University | Choline kinase inhibitors as a therapeutic treatment for obesity |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1999259B1 (en) | 2006-03-03 | 2014-06-25 | California Institute of Technology | Site-specific incorporation of amino acids into molecules |
| WO2013164483A1 (en) | 2012-05-03 | 2013-11-07 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| RU2015101697A (ru) * | 2012-06-21 | 2016-08-10 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Аналоги глюкагона, обладающие активностью рецептора gip |
| US10093713B2 (en) | 2013-11-06 | 2018-10-09 | Zealand Pharma A/S | GIP-GLP-1 dual agonist compounds and methods |
| JOP20200119A1 (ar) | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| ES2980707T3 (es) * | 2018-04-05 | 2024-10-02 | Sun Pharmaceutical Ind Ltd | Nuevos análogos de GLP-1 |
| TWI705820B (zh) | 2018-06-22 | 2020-10-01 | 美商美國禮來大藥廠 | Gip/glp1促效劑組合物 |
| WO2020023386A1 (en) | 2018-07-23 | 2020-01-30 | Eli Lilly And Company | Gip/glp1 co-agonist compounds |
| MA53378A (fr) | 2018-07-23 | 2021-06-02 | Lilly Co Eli | Procédé d'utilisation d'un co-agoniste de gip/glp1 contre le diabète |
| TW202216746A (zh) * | 2020-06-22 | 2022-05-01 | 印度商太陽製藥工業有限公司 | 長效型ｇｌｐ－１／ｇｉｐ雙重促效劑 |
-
2021
- 2021-10-13 EP EP21795004.7A patent/EP4204440A1/en active Pending
- 2021-10-13 TW TW110137941A patent/TW202229323A/zh unknown
- 2021-10-13 MX MX2023002906A patent/MX2023002906A/es unknown
- 2021-10-13 AU AU2021361263A patent/AU2021361263A1/en active Pending
- 2021-10-13 CN CN202180051573.5A patent/CN116171164A/zh active Pending
- 2021-10-13 PE PE2023000804A patent/PE20231309A1/es unknown
- 2021-10-13 US US18/249,055 patent/US20240020543A1/en active Pending
- 2021-10-13 KR KR1020237006545A patent/KR20230088337A/ko active Pending
- 2021-10-13 WO PCT/IB2021/059420 patent/WO2022079639A1/en not_active Ceased
- 2021-10-13 CA CA3195155A patent/CA3195155A1/en active Pending
- 2021-10-13 IL IL301109A patent/IL301109A/en unknown
- 2021-10-13 BR BR112023003668A patent/BR112023003668A2/pt unknown
- 2021-10-13 JP JP2023519770A patent/JP7830441B2/ja active Active
-
2023
- 2023-02-22 CO CONC2023/0001960A patent/CO2023001960A2/es unknown
- 2023-03-31 CL CL2023000960A patent/CL2023000960A1/es unknown
- 2023-04-16 JO JOJO/P/2023/0077A patent/JOP20230077A1/ar unknown
-
2024
- 2024-08-22 US US18/812,797 patent/US20240400613A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022079639A1 (en) | 2022-04-21 |
| PE20231309A1 (es) | 2023-08-24 |
| CN116171164A (zh) | 2023-05-26 |
| KR20230088337A (ko) | 2023-06-19 |
| US20240020543A1 (en) | 2024-01-18 |
| TW202229323A (zh) | 2022-08-01 |
| CO2023001960A2 (es) | 2023-05-08 |
| CL2023000960A1 (es) | 2023-11-10 |
| US20240400613A1 (en) | 2024-12-05 |
| BR112023003668A2 (pt) | 2023-04-25 |
| EP4204440A1 (en) | 2023-07-05 |
| MX2023002906A (es) | 2023-04-05 |
| IL301109A (en) | 2023-05-01 |
| CA3195155A1 (en) | 2022-04-21 |
| JP7830441B2 (ja) | 2026-03-16 |
| JP2023545662A (ja) | 2023-10-31 |
| AU2021361263A1 (en) | 2023-02-16 |
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