JOP20250023A1 - مثبطات جسيم التهابي nlrp3 - Google Patents

مثبطات جسيم التهابي nlrp3

Info

Publication number
JOP20250023A1
JOP20250023A1 JOJO/P/2025/0023A JOP20250023A JOP20250023A1 JO P20250023 A1 JOP20250023 A1 JO P20250023A1 JO P20250023 A JOP20250023 A JO P20250023A JO P20250023 A1 JOP20250023 A1 JO P20250023A1
Authority
JO
Jordan
Prior art keywords
nlrp3
nlrp3 inflammatory
inflammatory particle
inhibitors
relates
Prior art date
Application number
JOJO/P/2025/0023A
Other languages
English (en)
Inventor
Xiaobin Ge
Zhicong Shi
Mei Xia
Henri Mattes
Ning Ye
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of JOP20250023A1 publication Critical patent/JOP20250023A1/ar

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات بيريدازين -3-يل فينول جديدة بالصيغة (I): حيث R1، R2، R3، R4 وR5 يتم تعريفها في هذه الوثيقة، حيث تثبّط نشاط جسيم التهابي ببروتين مستقبل 3 يشبه NOD (NLRP3). يتعلق الاختراع أيضا بعمليات لتحضيرها، وتركيبات صيدلانية وأدوية تحتوي عليها، واستخدامها في معالجة أمراض واضطرابات ناتجة عن NLRP3.
JOJO/P/2025/0023A 2022-08-03 2025-01-30 مثبطات جسيم التهابي nlrp3 JOP20250023A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263370300P 2022-08-03 2022-08-03
CN2023097282 2023-05-30
PCT/IB2023/057819 WO2024028782A1 (en) 2022-08-03 2023-08-02 Nlrp3 inflammasome inhibitors

Publications (1)

Publication Number Publication Date
JOP20250023A1 true JOP20250023A1 (ar) 2025-01-30

Family

ID=87580191

Family Applications (1)

Application Number Title Priority Date Filing Date
JOJO/P/2025/0023A JOP20250023A1 (ar) 2022-08-03 2025-01-30 مثبطات جسيم التهابي nlrp3

Country Status (20)

Country Link
US (2) US20240067627A1 (ar)
EP (1) EP4565326A1 (ar)
JP (1) JP2025525866A (ar)
KR (1) KR20250043519A (ar)
CN (2) CN119677725A (ar)
AR (1) AR130094A1 (ar)
AU (1) AU2023318764B2 (ar)
CA (1) CA3262660A1 (ar)
CL (1) CL2025000285A1 (ar)
CO (1) CO2025002057A2 (ar)
CR (1) CR20250063A (ar)
DO (1) DOP2025000013A (ar)
IL (1) IL318533A (ar)
JO (1) JOP20250023A1 (ar)
MA (1) MA71689A (ar)
MX (1) MX2025001273A (ar)
PE (1) PE20251255A1 (ar)
TW (1) TW202406550A (ar)
UY (1) UY40374A (ar)
WO (1) WO2024028782A1 (ar)

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US12331048B2 (en) 2022-10-31 2025-06-17 Ventus Therapeutics U.S., Inc. Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies
WO2026057634A1 (en) * 2024-09-11 2026-03-19 Sanofi Crystalline form of a pyridazine nlrp3 inhibitor

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WO2024028782A1 (en) 2024-02-08
AU2023318764A1 (en) 2025-01-09
JP2025525866A (ja) 2025-08-07
US12378222B2 (en) 2025-08-05
PE20251255A1 (es) 2025-05-06
UY40374A (es) 2024-02-15
US20250034114A1 (en) 2025-01-30
AU2023318764B2 (en) 2026-04-23
CA3262660A1 (en) 2024-02-08
CO2025002057A2 (es) 2025-03-06
AR130094A1 (es) 2024-10-30
EP4565326A1 (en) 2025-06-11
CN119677725A (zh) 2025-03-21
KR20250043519A (ko) 2025-03-28
MX2025001273A (es) 2025-03-07
CR20250063A (es) 2025-03-27
DOP2025000013A (es) 2025-02-28
MA71689A (fr) 2025-05-30
TW202406550A (zh) 2024-02-16
CL2025000285A1 (es) 2025-06-13
CN121873039A (zh) 2026-04-17
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