JP2000206471A - Cleaning solution for hard contact lenses - Google Patents

Abstract

(57) [Summary] (with correction) [Problem] To remove dirt attached to hard contact lenses
Provided is a cleaning solution for hard contact lenses for removing by simple rubbing and imparting antifouling property and hydrophilicity. A component represented by the following general formula [I]: Specifically, for example, [Wherein, R ¹ represents a hydrogen atom or a methyl group;
4 is an integer. A homopolymer of a phosphorylcholine-like group-containing (meth) acrylate represented by the general formula [I], or 0.001 to 50% by weight of a copolymer with another vinyl monomer copolymerizable with the general formula [I]; And 0.1 to 30% by weight of an abrasive of solid particles having an average particle diameter of 0.1 to 10 micrometers, and surfactants 0 to 4 as a C component.
0% by weight, and 30 to 99% by weight of a solvent as D component
A cleaning solution for hard contact lenses, comprising:

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a cleaning solution for hard contact lenses. More specifically, the present invention relates to a cleaning solution for hard contact lenses for cleaning and removing dirt attached to hard contact lenses, and at the same time, imparting antifouling property and hydrophilicity.

[0002]

2. Description of the Related Art Conventionally used contact lenses can be classified into non-hydrous contact lenses and hydrous contact lenses. Hard contact lenses and soft contact lenses are known as non-hydrous contact lenses, and soft contact lenses are known as hydrous contact lenses. Non-hydrous contact lenses are more stable in material and easier to maintain than hydrous contact lenses. For example, those using methyl methacrylate as a main component, and recently, high oxygen permeable hard contact lenses mainly using silyl methacrylate or fluorine methacrylate whose influence on the eyes is reduced are used.

[0003] However, non-hydrous hard contact lenses have poor wearing sensation due to their hydrophobic surface, and particularly high oxygen permeable hard contact lenses have higher hydrophobicity, and thus have a poor wearing sensation. There is a disadvantage that the decrease is remarkable and soil such as proteins, lipids and calcium easily accumulates over a long period of use. For this reason,
Detergents such as surfactants and proteolytic enzymes are often used to remove these contaminants. However, depending on the type of dirt or the type of lens, a sufficient cleaning effect may not be obtained, and it is often difficult to remove dirt with accumulation and denaturation over a long period of time.

Therefore, a contact lens cleaner containing an abrasive for physically removing contaminants has been proposed (Japanese Patent Application Laid-Open No. 56-6215). However, in general, the abrasive has a large specific gravity, and it is difficult to uniformly disperse the abrasive in the cleaner. For this reason, water-soluble polymers such as polyvinyl alcohol, polyacrylamide, polyvinylpyrrolidone, hydroxyethylcellulose, carboxymethylcellulose, and polyethylene glycol are added as thickeners, and the dispersibility of abrasives is improved by adding soluble salts and surfactants. It is designed to make it work.
However, although these cleaners are effective for cleaning and removing dirt, they cannot obtain the effects of hydrophilizing the lens surface and imparting antifouling properties.

On the other hand, as a method for improving the feeling of wearing the lens surface by making it hydrophilic, for example, a method of immersing a contact lens in a solution containing a water-soluble polymer such as polyvinyl alcohol, hydroxyethylcellulose, polyvinylpyrrolidone, or the like. (Japanese Patent Publication No. 48-37910). U.S. Pat.
No. 1,748 discloses the use of polyvinyl alcohol and soluble cellulose by artificial tears composed of a physiological saline solution. However, in all of these methods, when the lens is washed with a commercially available cleaning solution for contact lenses, the effects such as hydrophilicity are completely lost, and further, there is a limit to hydrophilization of the contact lens, improvement in wearing feeling, and the like. Further, it is not effective for washing and preventing adhesion of dirt such as proteins and lipids. Further, JP-A-5-107512, JP-A-6-43407, and JP-A-7-166154 propose a method using a solution containing a polymer having a phosphorylcholine group. However, although this method can suppress the adhesion of dirt, it cannot always sufficiently clean dirt once adhered to the hard contact lens.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to remove dirt attached to a hard contact lens,
It is an object of the present invention to provide a hard contact lens cleaning solution capable of imparting hydrophilicity to a surface of a hard contact lens, improving a feeling of wearing, and suppressing adhesion and deposition of dirt such as proteins and lipids.

[0007]

Means for Solving the Problems In view of the above problems, the present inventors have conducted intensive studies, and as a result, have solved the problems by combining a specific polymer and an abrasive, and if necessary, a surfactant. They found what they could do and completed the invention. That is, the present invention includes the following (1) and (2). (1) A component represented by the following general formula [I]

[0008]

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[In the formula, R ¹ represents a hydrogen atom or a methyl group, and R ² represents a — (CHR ⁵ ) m- group or — (CH ₂ CHR)
⁵ O) represents an m-CH ₂ CHR ⁴ — group (provided that R ⁵ represents a hydrogen atom or a methyl group, and m represents an integer of 1 to 18);
R ³ is - (CH ₂₎ shows the n- group (where, n is an integer of 2 to 4), R ⁴ represents an alkyl or hydroxyalkyl group having 1 to 8 carbon atoms. A homopolymer of a phosphorylcholine-like group-containing (meth) acrylate or a copolymer with another vinyl monomer copolymerizable with the general formula [I], 0.01 to 50% by weight, and B As components, 0.1 to 30% by weight of an abrasive of solid particles having an average particle diameter of 0.1 to 10 micrometers, 0 to 40% by weight of surfactant as C component, and 30 to 9% of solvent as D component.
A cleaning solution for hard contact lenses, comprising 9% by weight.

(2) The compound represented by the general formula [I] of the component A is represented by the following general formula [II]

[0011]

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Wherein R ¹ represents a hydrogen atom or a methyl group, and n represents an integer of 2 to 4), and is a phosphorylcholine-like group-containing (meth) acrylate represented by the formula:
When the weight average molecular weight of the polymer is 2,000 to 5,000,000,
00, the abrasive of solid particles having an average particle diameter of 0.1 to 10 micrometers of the B component is inorganic or organic, and the inorganic material is alumina, silica, zirconium oxide, chromium oxide, iron oxide, At least one selected from the group consisting of cerium oxide, kaolin, calcium carbonate, silicon carbide, titanium oxide, ceramic, zeolite and diamond, wherein the organic material is water-insoluble of polymethyl methacrylate, polystyrene and nylon. 1 selected from the group consisting of polymer fine particles of
Or more, and the surfactant of the C component is at least one selected from anionic, nonionic, cationic and amphoteric surfactants, and the solvent of the D component is water, alcohol, The cleaning solution for hard contact lenses, which is at least one selected from the group consisting of diols, polyols and ketones.

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION A compound used as a component constituting a copolymer (hereinafter referred to as a PC polymer) in a cleaning solution for hard contact lenses of the present invention is a (meth) acrylate monomer having a phosphorylcholine-like group. (Hereinafter referred to as PC (meth) acrylate). As the PC (meth) acrylate, specifically, for example, 2- (meth) acryloyloxyethyl-2′-
(Trimethylammonio) ethyl phosphate, 3-
(Meth) acryloyloxypropyl-2 '-(trimethylammonio) ethyl phosphate, 4- (meth) acryloyloxybutyl-2'-(trimethylammonio) ethyl phosphate, 2- (meth) acryloyloxyethyl-2'- (Triethylammonio) ethyl phosphate, 2- (meth) acryloyloxyethyl-
2 ′-(tributylammonio) ethyl phosphate,
2- (meth) acryloyloxyethoxyethyl-2 '
-(Trimethylammonio) ethyl phosphate, 2-
(Meth) acryloyloxydiethoxyethyl-2'-
(Trimethylammonio) ethyl phosphate, 2-
(Meth) acryloyloxyethyl-2 ′-(2 ″ -trihydroxyethylammonio) ethyl phosphate, etc. From the viewpoint of availability and the like, more preferably 2- (meth) acryloyloxyethyl-2 ′.
-(Trimethylammonio) ethyl phosphate. More preferably, 2-methacryloyloxyethyl-2 ′-(trimethylammonio) ethyl phosphate (hereinafter abbreviated as MPC) is exemplified. Such PC (meth) acrylate can impart water solubility, antifouling property, solid particle dispersibility, hydrophilicity, and the like to the obtained polymer.

The PC polymer of the component A is the above-mentioned PC (meth)
It is a polymer obtained by polymerizing acrylate alone or a polymer obtained by copolymerizing PC (meth) acrylate represented by the general formula [I] and another copolymerizable vinyl monomer. Other copolymerizable vinyl monomers include:
Styrene, methylstyrene, methyl (meth) acrylate, ethyl (meth) acrylate, n-butyl (meth)
Acrylate, 2-ethylhexyl (meth) acrylate, 2-hydroxyethyl (meth) acrylate, diethylene glycol mono (meth) acrylate, polyethylene glycol mono (meth) acrylate, glyceroyl (meth) acrylate, fluorine-containing alkyl (meth)
Acrylate, silicon-containing (meth) acrylate,
(Meth) acrylic acid, (meth) acrylamide, N-
Vinyl pyrrolidone, ethyl vinyl ether, n-butyl vinyl ether, N, N-dimethyl (meth) acrylamide, acrylonitrile and the like can be mentioned. These one
A mixed monomer of two or more species is preferred.

The content of the polymer (PC) (meth) acrylate as a component in the polymer of the present invention is at least 30% by weight, and preferably at least 50% by weight in order to have high hydrophilicity. If the amount is less than 30% by weight, the effect of the PC (meth) acrylate cannot be exhibited, which is not preferable. The copolymerizable vinyl monomer is useful for controlling the balance between hydrophilicity and hydrophobicity of the polymer, the interaction with the material, and the dispersibility of the solid particles, and is selected and used as needed.

The PC polymer of the component A can impart hydrophilicity and antifouling property to a hard contact lens in a cleaning solution for a hard contact lens, but is further used as a viscosity modifier or an abrasive dispersant for the solution. Works.

The above-mentioned PC polymer as the component A is prepared by substituting the above-mentioned respective monomer components with an inert gas such as nitrogen, carbon dioxide, helium or the like in the presence of a radical polymerization initiator, or performing radical polymerization in an atmosphere. For example, it can be adjusted by a known method such as bulk polymerization, suspension polymerization, emulsion polymerization, and solution polymerization.

The polymerization initiator is not particularly limited as long as it is a usual radical polymerization initiator. For example, benzoyl peroxide, lauroyl peroxide, diisopropylperoxydicarbonate, t-butylperoxy-2-ethyl Hexanoate, t-butylperoxypivalate, t-butylperoxydiisobutyrate, azobisisobutyronitrile, azobisisodimethylvaleronitrile, persulfate and persulfate-bisulfite system, etc. it can.

The amount of the polymerization initiator to be charged is preferably 0.0001 to 10% by weight based on the monomer, and more preferably 0.1 to 10% by weight.
It is desirably from 0.01 to 5% by weight. The polymerization temperature is 20 to 10
0 ° C is preferable, and the polymerization time is preferably 0.5 to 72 hours.

Further, the molecular weight of the obtained PC polymer varies depending on the polymerization temperature, the amount of a polymerization initiator and the amount of a polymerization degree modifier used, but the weight average molecular weight is 2,000 to 5,
It is preferably from 1,000,000 to 2,000,000, particularly from the viewpoint of solubility in a hard contact lens solution, viscosity of the solution and adhesion to a hard contact lens.

In the cleaning solution for a hard contact lens of the present invention, the content of the PC polymer of the component A is 0.1%.
The range is from 01 to 50% by weight, more preferably from 0.05 to 30% by weight. When the content of the PC polymer of the component A is less than 0.01% by weight, the effect of the polymer of the component A is insufficient, and when it exceeds 50% by weight, the viscosity becomes high and removal by washing or the like becomes difficult.

The abrasive for the solid particles of the component B used in the cleaning solution for hard contact lenses of the present invention may be either inorganic or organic. Examples of the inorganic material include alumina, silica, zirconium oxide, chromium oxide, and oxide. Examples include iron, cerium oxide, kaolin, calcium carbonate, silicon carbide, titanium oxide, ceramics, zeolites, and diamonds. Organic materials include water-insoluble polymer fine particles such as polymethyl methacrylate, polystyrene, and nylon. Can be used alone or in combination of two or more. The average particle diameter of the solid particles is 0.1 to 10 micrometers, and if less than 0.1 micrometer, the polishing and cleaning effect on the hard contact lens is insufficient. Absent. Further, the content of the solid particles in the cleaning solution for a hard contact lens of the present invention is in the range of 0.1 to 30% by weight, and when less than 0.1% by weight, the polishing and cleaning effect is insufficient.
If it exceeds 30% by weight, the fluidity of the cleaning liquid is reduced, making it difficult to use.

The surfactant of the C component of the cleaning solution for hard contact lenses of the present invention is mainly used for removing stains on the material surface and improving the dispersibility of the solid abrasive, and can be dissolved or dispersed in the cleaning solution. If it is a thing, it will not be specifically limited. The surfactant of the component C may be any of anionic, nonionic, cationic and amphoteric surfactants. Examples of the anionic surfactant include sodium alkyl sulfate, sodium olefin sulfate, sodium alkyl benzene sulfonate, sodium alkyl naphthalene sulfonate, acyl methyl taurine, sodium fatty acid, sodium dialkyl sulfosuccinate, N-alkyl-N, N- Dimethyl oxide and the like. As nonionic surfactants, for example, polyoxyethylene alkyl ether,
Examples include polyoxyethylene fatty acid esters, polyoxyalkylphenol ethers, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and sucrose fatty acid esters. Examples of the cationic surfactant include trimethylaminoethylalkylamide halogenide, alkylpyridium sulfate, and alkyltrimethylammonium halide.
Examples of the amphoteric surfactant include alkyl betaine and alkyl diethylene triamino acetic acid. Anionic or nonionic surfactants are preferred from the viewpoint of detergency.

The content of the surfactant as the component C is 0
-40% by weight, preferably 0.01-30% by weight. When the content of the surfactant exceeds 40% by weight, A
The effect of imparting hydrophilicity and antifouling property to the lens given by the component polymer is reduced.

The cleaning solution for a hard contact lens of the present invention is obtained by dissolving and dispersing the above-mentioned components in a solvent. As the solvent, the polymer of the component A and the surfactant of the component C can be dissolved, and solid particles of the component B can be dispersed. At the same time, the hard contact lens has little influence on the hard contact lens. Requires a solvent that can be washed away. Specifically, for example, water such as purified water can be preferably mentioned. Further, alcohols such as methanol, ethanol and isopropanol; glycols such as ethylene glycol, propylene glycol and diethylene glycol; polyols such as glycerin, diglycerin and triglycerin, and ketones such as acetone are included. A mixture of one or more of these solvents can also be used. The amount of the solvent used is in the range of 30 to 99% by weight.

When preparing the cleaning solution for a hard contact lens of the present invention, the polymer of the component A as it is or the solution of the polymer, the solid particles of the component B and the surfactant of the component C are mixed in a predetermined solvent. It can be obtained by adding at a temperature of ８０80 ° C. and dispersing and dissolving for 10 minutes to 3 hours by mechanical stirring such as a stirrer, emulsifier, high-speed disperser or ultrasonic disperser.

In addition to the above-mentioned components, an inorganic chloride can be added to the cleaning solution for hard contact lenses of the present invention in order to adjust the dispersibility of the abrasive of solid particles. These are not particularly limited, but preferably include, for example, sodium chloride, potassium chloride, magnesium chloride or a mixture thereof. Also, a buffer may be added to adjust the pH of the solution. These are not particularly limited, for example, hydrochloric acid, acetic acid, citric acid, sodium hydroxide; boric acid, borate salts such as boric acid sand; monosodium phosphate, disodium phosphate, monopotassium phosphate, Phosphates such as dipotassium phosphate; citrates such as potassium citrate and sodium citrate; and tris (hydroxymethyl) aminomethane or a mixture thereof can be preferably exemplified.

Further, for the stability of the solution and the like, chelating agents such as ethylenediaminetetraacetic acid, cyclohexanediaminetetraacetic acid and alkali metal salts thereof; chlorobutanol, benzalkonium chloride, thimerosal, chlorhexidine gluconate solution, paraoxybenzoate Preservatives such as acid esters; polyethylene glycol, polypropylene glycol,
Water-soluble polymers such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxymethyl cellulose, a block copolymer of ethylene oxide and propylene oxide, and a copolymer of maleic anhydride and methyl vinyl ether can also be added.

As a method of using the cleaning solution for hard contact lenses of the present invention, the cleaning solution for hard contact lenses is dropped or applied to the hard contact lens.
Rub with a finger or cloth at room temperature for about 10 seconds to 10 minutes,
Further, by rinsing with water, physiological saline and a suitable cleaning solution, the stains on the hard contact lens are removed,
It can hydrophilize the surface and further prevent dirt such as proteins and lipids from adhering and depositing. By utilizing this effect, it can be used as a surface cleaning liquid for materials such as spectacle lenses, glass for vehicles such as cars and trains, window glasses, camera lenses, and mirrors, in addition to removing dirt from hard contact lenses. .

[0030]

According to the cleaning solution for hard contact lenses of the present invention, the adhered proteins, lipids and calcium can be removed by a simple operation of rubbing and cleaning a dirty hard contact lens, rinsing with water or wiping. For example, it is possible to wash and remove dirt on the surface, and to impart wettability to the lens and prevent adhesion and fixation of dirt.

[0031]

EXAMPLES Hereinafter, the present invention will be described in detail by reference examples and examples, but the present invention is not limited to these examples. Synthesis Example 1 50 g of 2-methacryloyloxyethyl-2 ′-(trimethylammonio) ethyl phosphate (MPC) and 0.025 g of azobisisobutyronitrile (AIBN) were dissolved in 100 g of ethanol solvent, and the solution was placed in a reactor and replaced with nitrogen. After that, polymerization was carried out at 50 ° C. for 10 hours in a thermostat. After completion of the polymerization, reprecipitation purification was performed using a mixed solvent of ethanol and diisopropyl ether, followed by vacuum drying to obtain a polymer. The yield of the polymer was 92% by weight, and the weight average molecular weight determined by GPC analysis using polyethylene glycol as a standard substance was 550,000.

Synthesis Example 2 Synthesis Example 1 except that 45 g of MPC and 5 g of n-butyl methacrylate (BMA) were used instead of 50 g of MPC.
A copolymer was obtained in the same manner as described above. The yield of the polymer was 95% by weight, and the weight average molecular weight determined by GPC analysis was 61%.
It was 0000. Further, the elemental analysis of the obtained polymer confirmed that the content of BMA was 10.5% by weight.

Preparation of Hard Contact Lens Test Piece Tris (trimethylsiloxy) silylpropyl methacrylate 40 g, trifluoroethyl methacrylate 30
g, 10 g of methyl methacrylate, 15 g of triethylene glycol dimethacrylate, 5 g of methacrylic acid and 0.2 g of azobisisobutyronitrile were injected into a test tube, sealed after replacement with nitrogen, and kept at 60 ° C. for 24 hours in the test tube. The raw material monomer was cured by heating to obtain a colorless and transparent polymer. The obtained polymer was cut and polished by a usual processing method to prepare a hard contact lens test piece having a predetermined shape.

Examples 1 and 2 5 g of each of the copolymers obtained in Synthesis Examples 1 and 2,
5 g of Aerosil (Nippon Aerosil Co., Ltd.) as silica microparticles of 2 micrometers is added to 40 g of purified water,
Stir for 10 minutes with high speed disperser. Thereafter, 50 g of purified water was further added, and the mixture was stirred for 10 minutes to obtain a washing solution. The cleaning liquid was evaluated by the following method. The composition and the evaluation results are shown in Table 1.

(1) Detergency: albumin 0.39% by weight, lysozyme 0.17% by weight, γ-globulin 0.1
Hard contact lens test pieces were placed in a saline solution containing 1% by weight and 0.1% by weight of oleic acid at 60 ° C.
For 24 hours to contaminate the lens. Two or three drops of the above cleaning solution were applied to the lens, rubbed for 1 minute, and then rinsed with running water. The dynamic contact angle of the test piece before and after the cleaning was measured using a dynamic contact angle measuring device (manufactured by Orientec Co., Ltd.). The advancing angle evaluated the hydrophilicity of the lens.

(2) Antifouling property: Hard contact lens test piece before contamination, and after cleaning of the contaminated lens, 0.39% by weight of albumin, 0.17% by weight of lysozyme, 0.11% by weight of γ-globulin And immersed in physiological saline containing 0.1% by weight of oleic acid at 60 ° C. for 24 hours, washed with tap water, and washed protein from the lens with an aqueous solution of 1% sodium dodecyl sulfate {manufactured by Wako Pure Chemical Industries, Ltd.} Peel off and measure the amount of protein in the solution to micro B
The measurement was performed using a CA kit (manufactured by Pierce), and the results are shown in the table as the protein removal rate (%).

Examples 3 and 4 5 g of each of the copolymers obtained in Synthesis Examples 1 and 2
3 micrometer alumina fine particles (Univers
al) and 1 g of polyethylene glycol nonylphenyl ether as a surfactant (Nippon Oil & Fats Co., Ltd.)
Nonion NS-210｝ is put in 40 g of purified water, and 1 m
The mixture was stirred with 30 g of m-diameter glass beads for 10 minutes. Then add another 50 g of purified water and stir for 10 minutes.
A washing solution was obtained. The cleaning liquid was evaluated in the same manner as in Examples 1 and 2.

Comparative Example 1 A cleaning solution was prepared in exactly the same manner as in Examples 1 and 2, except that the copolymers obtained in Synthesis Examples 1 and 2 were not used, and a hard contact lens test piece was treated. An evaluation was performed. The results are shown in Table 1.

Comparative Example 2 A cleaning solution was prepared in exactly the same manner as in Examples 3 and 4 except that the copolymers obtained in Synthesis Examples 1 and 2 were not used, and a hard contact lens test piece was treated. An evaluation was performed. The results are shown in Table 1.

[0040]

[Table 1]

The following were found from the results of the examples and comparative examples. The contact angle of the hard contact lens test piece to which dirt is adhered is significantly reduced by the treatment with the cleaning liquids of Examples 1 to 4, and the detergency and antifouling effect are seen. In Comparative Examples 1 and 2, the decrease in the contact angle was small, and no effect was observed on the anti-staining property.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Kazuhiko Ishihara 3-16-37, Josuihonmachi, Kodaira-shi, Tokyo (72) Inventor Norio Nakabayashi 5-6-20 Koganehara, Matsudo-shi, Chiba F-term (reference) 2H006 DA08 DA09 4H003 AC11 BA10 DA16 EA25 EB28 ED02 FA05

Claims (2)

[Claims] 1. A compound represented by the following general formula [I]: [Wherein, R ¹ represents a hydrogen atom or a methyl group, and R ² represents-
(CHR ⁵⁾ m-group or ^{_{- (CH 2 CHR 5 O)}} m-CH 2
A CHR ⁵ — group (where R ⁵ represents a hydrogen atom or a methyl group, m represents an integer of 1 to 18), and R ³ represents — (C
H ₂ ) represents an n-group (where n represents an integer of 2 to 4), and R ⁴ represents an alkyl group or a hydroxyalkyl group having 1 to 8 carbon atoms. A homopolymer of a phosphorylcholine-like group-containing (meth) acrylate or a copolymer of another vinyl monomer copolymerizable with the general formula [I] in an amount of 0.01 to 50% by weight; And 0.1 to 30% by weight of an abrasive of solid particles having an average particle diameter of 0.1 to 10 micrometers, and surfactants 0 to 4 as a C component.
A cleaning solution for hard contact lenses, comprising 0% by weight and 30 to 99% by weight of a solvent as a D component. 2. A compound represented by the above general formula [I] of the component A is represented by the following general formula [II]: [Wherein, R ¹ represents a hydrogen atom or a methyl group;
4 is an integer. A phosphorylcholine-like group-containing (meth) acrylate represented by the formula (I), and the polymer has a weight average molecular weight of 2,000 to 5,000,000,
The abrasive of solid particles having an average particle diameter of component B of 0.1 to 10 micrometers is inorganic or organic, and the inorganic material is alumina, silica, zirconium oxide, chromium oxide, iron oxide, cerium oxide, kaolin. And at least one selected from the group consisting of calcium carbonate, silicon carbide, titanium oxide, ceramic, zeolite and diamond, wherein the organic material comprises water-insoluble polymer fine particles of polymethyl methacrylate, polystyrene and nylon. One or more selected from a group,
The surfactant of the component C is at least one selected from anionic, nonionic, cationic and amphoteric surfactants, and the solvent of the component D is water, alcohol, diol, or polyol. The cleaning solution for a hard contact lens according to claim 1, wherein the cleaning solution is at least one selected from the group consisting of ketones and ketones.