JP2000229832A - Skin lotion - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject preparation having excellent effects of preventing and improving a rough skin, by including a combination of collagen, preferably marine collagen, and algae extract as the active ingredients. SOLUTION: This preparation contains, as the active ingredients, (A) collagen, preferably marine collagen, and (B) an algae extract. It is preferable that one or more types of algae selected from the group consisting of red algae (especially Delesseria violacea), green algae (especially chlorella) and brown algae (especially Laminaria japonica) as the component B, and to include (C) saline- evaporated product. It is also preferable to contain the component A at about 0.000001 to 0.1 wt.%, component B at about 0.000001 to 0.2 wt.% and component C at about 0.001 to 10.0 wt.%, all based on the whole preparation. The preparation may be further formulates with vitamin, humectant, ultraviolet ray absorber or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD [0001] The present invention relates to an external preparation for the skin. More specifically, the present invention provides:
The present invention relates to an external preparation for the skin that prevents and improves rough skin such as skin roughness.

[0002]

2. Description of the Related Art For example, it appears as skin swelling.
Preventing and improving rough skin is the basis of skin care.

[0003] This rough skin can be caused by drying, ultraviolet rays,
It is known that the aging is caused by a decrease in skin moisture, a decrease in skin thickness, and the like. In particular, skin damage due to drying, ultraviolet rays, and various oxidizing factors is considered to be a direct cause of rough skin.

Conventionally, various measures have been taken to prevent such rough skin. For example, an external preparation containing various moisturizers to prevent skin roughness due to drying, an external preparation containing an ultraviolet absorber to prevent skin roughness due to ultraviolet rays, and vitamin E to prevent skin roughness due to various oxidation factors. External preparations and the like containing an antioxidant such as the above have been used.

[0005] However, these conventional means for preventing skin roughness have a significant therapeutic effect, and it cannot be said that sufficient measures have been taken against skin roughness.

[0006]

The problem to be solved by the present invention is to find a new element which works to suppress skin roughness and to use this element to effectively prevent and improve rough skin. Is to provide.

[0007]

Means for Solving the Problems The inventor of the present invention has conducted intensive studies in order to find an element that acts to suppress skin roughness. As a result, they have found that excellent preventive and ameliorating effects on skin roughness can be obtained by using collagen, particularly marine collagen, and a seaweed extract as an active ingredient in an external preparation for skin, and completed the present invention.

That is, the present invention is an invention for providing an external preparation for skin containing collagen, particularly marine collagen and seaweed extract as an active ingredient (hereinafter referred to as the external preparation for skin of the present invention).

[0009] In the present invention, "marine collagen" means collagen derived not from animals but from fish. Details of such marine collagen will be described later.

[0010] Further, it is possible to impart a moisturizing effect to the external preparation for skin of the present invention by further mixing a dried seawater with the external preparation for skin of the present invention. An external preparation is also provided.

[0011]

Embodiments of the present invention will be described below. A. Regarding the active ingredient of the external preparation for skin of the present invention : As described above, the active ingredients of the external preparation for skin of the present invention are collagen and seaweed extract.

The collagen used as an active ingredient of the external preparation for skin of the present invention is not particularly limited, and any type I to type XIII collagen can be used. In reality, it is assumed that collagen obtained from various animals and fishes is used as the collagen. However, animals (eg, cows, pigs, etc.) and fishes (eg,
Flounder, salmon, sardine, tuna, etc.) and collagen extraction sites can be bones, skins, tendons, duckfishes (fishes) and the like.

[0013] In the present invention, as described above, marine collagen derived from fish can be used as a preferred collagen. Marine collagen is superior in animal skin collagen in keratin softening effect and safety.

The extraction and purification of collagen from these components can be carried out by a generally known method. Specifically, for example, after crushing a tissue containing collagen such as bone, skin, tendon, and sea urchin, washing with water, extraction with a dilute salt solution, extraction with an acid or alkali solution, pepsin,
The collagen can be obtained by extraction with an enzyme such as trypsin or hyaluronidase and subjecting it to a known purification means such as salting out or dialysis to purify collagen. It is also possible to obtain “regenerated collagen” by a generally known method.

A commercially available collagen [for example, trade name: Collagen MO (Mizuho Trading Co., Ltd.), trade name: PA]
NCOGEN MARIN (Ikeda Bussan Co., Ltd.) etc.] can also be used as an active ingredient of the skin external preparation of the present invention.

The amount of collagen in the external preparation for skin of the present invention can be appropriately selected depending on the amount of other active ingredients, ie, the amount of seaweed extract and the specific dosage form of the external preparation for skin of the present invention. Is not particularly limited,
Generally, the amount is preferably 0.000001 to 0.1% by weight (active component) with respect to the whole agent, and particularly preferably 0.00001 to 0.01% by weight (active component) in consideration of effectiveness and usability. This compounding amount is 0.0000
When the amount is less than 01% by weight (effective amount), it is difficult to exert a sufficient preventive and ameliorating effect on the rough skin, which is not preferable. In addition to the increase in the effect of preventing and improving rough skin corresponding to the increase in the skin roughness, it is difficult to recognize the effect, and the tendency to accompany the sticky feeling becomes strong.

The seaweed extract used as an active ingredient of the external preparation for skin of the present invention is not particularly limited, but usually, in the present invention, seaweed extract extracted from seaweeds belonging to green algae, red algae and / or brown algae Object is used.

Examples of the seaweeds belonging to the green algae include Chara spiders, Echinacea spp., Mills, Janemo, Casanori, Midorige, Shiogusa, Aosa, Hibimidoro, Kawanori, Chlorella, Kungsho, Volvox Examples of seaweeds belonging to red algae include, for example, guinea pigs, masagoshibari, ginatoi, caclates, dars, tengusa, kaginori, sea elephant, narcissus, oxenori,
Seaweeds belonging to chinorimos and the like are mentioned, and seaweeds belonging to brown algae include seaweeds belonging to Honda straw, kelp and the like.

In the present invention, Chlorella belonging to Chlorella is preferable as a green algae because of its excellent effect of promoting collagen synthesis, Numehanori belonging to Igis is preferable as a red algae and a moisturizing effect is preferable. Slimming effect is recognized in Macomb belonging to
preferable.

In the external preparation for skin of the present invention, one or more of these seaweeds are selected and blended with these seaweed extracts to prevent or improve the rough skin, which is the desired effect of the present invention. Can be demonstrated.

These seaweed extracts can be extracted from the selected seaweed using a generally known extraction method. That is, for example, water, a hydrophilic organic solvent (alcohol or the like), a mixed solution of water and a hydrophilic organic solvent, a polyhydric alcohol (glycerin, 1,3-butylene glycol or the like), or a mixed solution of water and a polyhydric alcohol Can be extracted.

Also, various commercially available seaweed extracts [for example,
Product name: Dermochlorelle D (Nikko Chemicals Co., Ltd.), Product name: Rh.Deless HG (Nikko Chemicals Co., Ltd.), Product name: PHYCOL LD BG (Gunze Sangyo Co., Ltd.)
Etc.] can also be used as an active ingredient of the external preparation for skin of the present invention.

The amount of the seaweed extract in the external preparation for skin of the present invention depends on the type of the seaweed extract specifically selected as the other active ingredient, the amount of the collagen as the other active ingredient, and the amount of the skin of the present invention. Depending on the specific dosage form of the external preparation and the like, it can be appropriately selected and is not particularly limited, but is generally 0.000001 to 0.2 with respect to the whole preparation.
% By weight (effective component), preferably from 0.00001 to 0.1%.
1% by weight (active) is particularly preferred. If this compounding amount is less than 0.000001% by weight (active component) with respect to the whole agent, it is difficult to exert a sufficient preventive / improving effect on skin roughness, which is not preferable. Minutes)
When the amount exceeds the above range, it is difficult to enhance the effect of preventing and improving rough skin in proportion to the increase in the amount of the compounded compound, and it is also not preferable because it tends to have a sticky feeling of use.

As described above, by using collagen and seaweed extract in combination as active ingredients, excellent skin roughness prevention / improvement effects can be exerted in the skin external preparation of the present invention.

The external preparation for skin of the present invention comprises a seawater mineral added to the skin of a user by blending a seawater dried product in addition to the above-mentioned collagen such as marine collagen and a seaweed extract. Moisture retention can be improved.

When this seawater dried product is blended in the skin external preparation of the present invention, it is generally preferred that the blending amount is about 0.001 to 10.0% by weight based on the whole preparation. . If this amount is less than 0.001% by weight based on the whole agent, the amount of seawater mineral generally supplied to the skin is not sufficient, and the effect of replenishing seawater minerals is
It is difficult to fully exert the effect, which is not preferable. Conversely, this compounding amount is 10.0% by weight based on the whole agent.
When the amount exceeds the above range, the stability of the agent tends to be generally impaired, which is not preferable. B. Specific embodiments of the external preparation for skin of the present invention : In addition to the above-mentioned active ingredients, the external preparation for skin of the present invention is generally used as needed, as long as the intended effect of the present invention is not impaired. Various components can be blended.

The dosage form of the external preparation for skin of the present invention is arbitrary, for example, an oily preparation, a solubilizing dosage form of a lotion; an emulsifying dosage form such as an emulsion or a cream; an ointment, a dispersion, a powder, etc. Dosage form can be taken without particular restrictions.

In the skin external preparation of the present invention, in order to mainly add a specific pharmacological effect, for example, vitamins,
A moisturizer, an ultraviolet absorber, an anti-inflammatory agent, a whitening agent, an animal or plant extract excluding the active ingredient of the external preparation for skin of the present invention, an activator, a blood circulation promoter, an antiseborrheic agent, and the like can be added.

In order to prepare the skin external preparation of the present invention into a desired dosage form, for example, oils such as liquid fats and oils, solid fats and oils, waxes, hydrocarbon oils; higher fatty acids, higher alcohols and synthetic ester oils , Silicone, various surfactants,
Preservatives, various water-soluble polymers, various powder components, pigments, dyes, fragrances, water, and the like can be added as necessary.

In particular, a herb fragrance is prepared as a fragrance to impart a relaxing scent to the external preparation of the present invention, thereby imparting a relaxing effect to the external preparation of the present invention or imparting a scent of the sea. Using the reproduced fragrance,
The user of the external preparation for skin of the present invention can have a virtual experience as if he were at the seaside, thereby further refreshing the mind and body.

The specific dosage form of the skin external preparation of the present invention will be described in Examples described later.

[0032]

EXAMPLES The present invention will be described more specifically with reference to examples, but the technical scope of the present invention should not be limited thereby. In addition, unless otherwise specified, in this example, the compounding amount is represented by% by weight based on the compounded object.

Active ingredient collagen in the present invention : In the present examples (test examples and prescription examples), collagen was obtained from PANCOGEN MARIN (trade name of Ikeda Bussan Co., Ltd .: selected from flounder, salmon, sardine and tuna skin or bone marrow tissue). Extracted / purified collagen (hereinafter also referred to as fish-derived collagen) or collagen MO (trade name: Mizuho Shoji Co., Ltd .: ether soluble matter obtained from bovine or porcine skin tissue; hereinafter also referred to as animal collagen) Was.

Seaweed extract: In this example, the seaweed extract is trade name Dermochlorella D [Nikko Chemicals Co., Ltd .: low-temperature water extract of green algae (Chlorella vulgaris Chick), hereinafter also referred to as green algae extract]. Rh.Deless
HG (Nikko Chemicals Co., Ltd .: Red algae extract, hereinafter also referred to as Red algae extract), trade name PHYCOL LD BG (Gunze Sangyo Co., Ltd .: Brown algae extract, hereinafter also referred to as Brown algae extract) Using.

Test Example (Test for Roughness Improvement Effect) <Test Method> A 0.1% aqueous solution of sodium lauryl sulfate was applied continuously to the upper arm of a human for three days to artificially create a roughened skin. Thereafter, as shown in Tables 1 and 2, a mixed aqueous solution of collagen and seaweed extract was applied to the upper bowl every day for three weeks continuously, and the rough skin condition of the portion was visually observed. Then, the degree of skin roughness improvement effect was scored and evaluated (n = 5 each).

<Judgment Score> A remarkable improvement effect was recognized: 4 An improvement effect was recognized: 3 A slight improvement effect was recognized: 2 A little improvement effect was not recognized: 1 An improvement effect was not recognized <0 Test Results> The results of this test are shown in Tables 1 to 3. In addition, the indication of the compounding amount of the collagen and the seaweed extract in each table was all expressed by effective components.

[0037]

[Table 1] Table 1 コ ラ ー ゲ ン Improvement of fish-derived collagen red algae extract Effect (average) ─────────────────────────────────── 1 0.15% 0.05% 3.7 2 0.1% 0.05% 3.8 3 0.01% 0.05% 3.8 4 0.005% 0.05% 3.7 Test Example 5 0.001% 0.05% 3.6 6 0.0001% 0.05% 3.5 7 0.00001% 0.05% 3.5 8 0.000001% 0.05% 2.8 9 0.0000001% 0.05% 2.0 Comparative Example 10% 0.05% 1.3%か ら From Table 1, collagen is 0.00001-0.01
% By weight (effective component) is particularly preferable, and the amount of collagen is 0.000001% by weight (active component).
It was found that the effect of preventing and improving skin roughness was weak when the amount was less than the above.

The amount of collagen is 0.1% by weight.
In the above (Test Examples 1 and 2), the test article tended to be sticky.

[0039]

[Table 2] Table II ─────────────────────────────────── Fish-derived collagen Green algae extract Improvement effect (Average) １０ 10 0.001% 0.3% 3.6 11 0.001% 0.2 % 3.7 12 0.001% 0.1% 3.6 13 0.001% 0.05% 3.2 14 0.001% 0.01% 3.0 Test example 15 0.001% 0.001% 2.8 16 0.001% 0.0001% 2.7 170.001% 0.00001 % 2.6 18 0.001% 0.000001% 2.0 19 0.001% 0.0000001% 1.5 Comparative example 2 0.001% 0% 1.2 Comparative example 30% 0% 1.0に よ り According to Table 2, the amount of seaweed extract was 0.00000
1 to 0.2% by weight (effective component) is preferable, and
When the amount is less than 01% by weight (effective amount), it has been found that it is difficult to weaken the effect of preventing and improving rough skin by combination with collagen.

The amount of collagen was 0.2% by weight.
In the above (Test Examples 10 and 11), the test article had a tendency to be sticky.

[0041]

[Table 3] Table III-Fish-derived collagen Green algae extract Brown algae extract Product improvement effect (average) ─────────────────────────────────── Test example 20 0.1% 0.1% 0% 2.8 21 0.1% 0.1% 0.1% 3.9 Comparative example 4 0.1% 0% 0% 1.3 Comparative example 50% 0.1% 0% 1.0 Comparative example 60% 0% 0.1% 1.2%に よ り According to Table 3, the combination of collagen and two kinds of seaweed extract It has been clarified that it is possible to obtain the effect of preventing / preventing rough skin by using such a material.

It should be noted that, in the above test, the effect of improving skin roughness is recognized, of course, that the effect of preventing skin roughness, which prevents the occurrence of new skin roughness, is also recognized.

Hereinafter, specific formulations of the skin external preparation of the present invention will be exemplified as formulation examples. In addition, when the test for the above-mentioned skin roughness improvement effect was performed on the skin external preparations of the present invention in these formulation examples, excellent effects were recognized in all the formulation examples. In addition, the indication of the compounding amount of the collagen and the seaweed extract in these formulation examples was all expressed by effective components.

[0044] Formulation Example 1 Lotion Ingredients Amount (wt%) (1) from fish collagen 0.005 (2) brown algae extract 0.02 (3) Tocopherol acetate 0.01 (4) Glycerol 4. 0 (5) 1,3-butylene glycol 4.0 (6) Ethanol 8.0 (7) Polyoxyethylene (60) hydrogenated castor oil 0.5 (8) Methyl paraben 0.2 (9) Citric acid 0.05 (10) Sodium citrate 0.1 (11) Fragrance 0.05 (11) Residual purified water <Production method> In purified water, fish-derived collagen, brown algae extract, citric acid, sodium citrate, glycerin, 1,3 -Butylene glycol was dissolved. Separately, polyoxyethylene (60) hydrogenated castor oil, tocopherol acetate, perfume, and methyl paraben were dissolved in ethanol, added to the above aqueous phase, solubilized, and filtered to obtain a lotion.

[Formulation Example 2] Cream blending component blending amount (% by weight) (1) cetostearyl alcohol 3.5 (2) squalane 40.0 (3) beeswax 3.0 (4) reduced lanolin 5.0 (5 ) Ethyl paraben 0.3 (6) polyoxyethylene (20) sorbitan monopalmitate 2.0 (7) monoglyceride stearate 2.0 (8) sodium N-stearoyl glutamate 0.5 (9) methoxycinnamic acid Octyl 1.0 (10) Retinol acetate 2.0 (11) Evening primrose oil 0.05 (12) Fragrance 0.03 (13) Fish-derived collagen 0.1 (14) Green algae extract 0.05 (15) Polyethylene glycol 1500 5.0 (16) Residual amount of purified water <Production method> cetostearyl alcohol, squalane, beeswax, reduced lanolin, Ethyl paraben, polyoxyethylene (20) sorbitan monopalmitate, stearic acid monoglyceride, sodium N-stearoylglutamate, octyl methoxycinnamate, retinol acetate, evening primrose oil, and a fragrance were heated and dissolved (oil phase). Separately, purified water, fish-derived collagen, green algae extract,
Polyethylene glycol 1500 was dissolved and kept at 70 ° C. (aqueous phase). The oil phase was added to the aqueous phase with stirring. Next, this was subjected to a homomixer treatment to make the emulsified particles fine, and then rapidly cooled with stirring to obtain a cream.

Formulation Example 3 Emulsion Formulation Component Content (% by Weight) (1) 2-ethylhexyl paradimethylaminobenzoate 0.1 (2) Mono-2-ethylhexyl diparamethoxycinnamate 0.2 (3 ) Stearic acid 1.5 (4) Cetyl alcohol 0.5 (5) Beeswax 2.0 (6) Polyoxyethylene (10) monooleate 2.0 (7) L-arginine 0.3 (8) Seawater Dried product 0.02 (9) PCA-Na 0.05 (10) Fish-derived collagen 0.002 (11) Red algae extract 0.00001 (12) Glycerin 3.0 (13) Ethanol 3.0 (14) Ethylparaben 0.3 (15) Fragrance 0.03 (16) Carboxyvinyl polymer 0.12 (17) Residual purified water <Process> Extraction of fish-derived collagen and red algae into purified water , L
-Arginine, dried seawater, PCA-Na, glycerin, ethanol, carboxyvinyl polymer were added and dissolved by heating, and kept at 70 ° C (aqueous phase). The other components were mixed, dissolved by heating, and kept at 70 ° C. (oil phase). This oil phase was added to the aqueous phase to perform preliminary emulsification, and the mixture was uniformly emulsified with a homomixer. Thereafter, the emulsion was rapidly cooled while stirring to obtain an emulsion.

[Formulation Example 4] Blending amount of foam mask blending component (% by weight) (1) Fish-derived collagen 0.00001 (2) Green alga extract 0.000001 (3) Stearic acid 1.0 (4) Behenic acid 1 2.0 (5) Self-emulsifying glyceryl monostearate 1.5 (6) Polyoxyethylene monostearate (5) glycerin 2.5 (7) Bacyl alcohol 1.5 (8) Fragrance 0.05 (9) Glycerin 5.0 (10) 1,3-butylene glycol 5.0 (11) Polyethylene glycol 1500 3.0 (12) Methyl paraben 0.1 (13) Potassium hydroxide 0.15 (14) Remaining amount of purified water (15) Liquefied petroleum gas 6.0 (16) Dimethyl ether 2.0 <Preparation method> Purified water contains fish-derived collagen, green algae extract, glycerin, 1,3-butylene Glycol, polyethylene glycol 1500, methyl paraben, and potassium hydroxide were added and dissolved by heating at 70 ° C. (aqueous phase). Next, stearic acid, behenic acid, self-emulsifying glyceryl monostearate, polyoxyethylene monostearate (5),
Glycerin, batyl alcohol and fragrance were mixed by heating (oil phase). The oil phase was added to the aqueous phase, and the mixture was uniformly mixed and filled in a container. Finally, a liquefied gas and dimethyl ether were added as a propellant to obtain a foam mask.

[Formulation Example 5] Ointment compounding ingredients (% by weight) (1) Animal-derived collagen 0.005 (2) Red algae extract 0.0025 (3) Brown algae extract 0.0025 (4) Paradimethyl Octyl aminobenzoate 4.0 (5) Butylmethoxybenzoylmethane 0.5 (6) Tocopherol acetate 0.5 (7) Retinol palmitate 1.0 (8) Stearyl alcohol 18.0 (9) Mokurou 20.0 ( 10) Polyoxyethylene (10) monooleate 0.25 (11) Glycerin monostearate 0.3 (12) Vaseline 32.0 (13) Purified water balance <Production method> Purified water and animal-derived collagen , Red algae extract,
The brown algae extract was dissolved and kept at 70 ° C. (aqueous phase). Separately, other components were mixed and dissolved at 70 ° C. (oil phase). The oil phase was added to the aqueous phase, and the mixture was uniformly emulsified with a homomixer and then cooled to obtain an ointment.

[Formulation Example 6] Essence composition (% by weight) (1) Fish-derived collagen 0.001 (2) Green algae extract 0.0001 (3) Concentrated glycerin 30.0 (4) 1, 3 -Butylene glycol 20.0 (5) propylene glycol 20.0 (6) polyethylene glycol 400 15.0 (7) polyoxyethylene (60) hydrogenated castor oil 5.0 (8) squalane 2.0 (9) liquid paraffin 3.0 (10) Fragrance 0.1 (11) Remaining amount of purified water <Production method> (1) to (6) and (11) were mixed. Heat-dissolved (7), (8), (9), and (10) were stirred and mixed with this to obtain a serum.

Formulation Example 7 Cleansing pack compounding ingredients (% by weight) (1) Fish-derived collagen 0.01 (2) Green algae extract 0.1 (3) Brown algae extract 0.05 (4) Red algae Extract 0.05 (5) Glycerin 5.0 (6) 1,3-butylene glycol 3.0 (7) Dipropylene glycol 2.0 (8) Butylparaben 0.05 (9) Bentonite 5.0 (10) ) Behenyl alcohol 1.0 (11) Liquid paraffin 5.0 (12) Polyoxyethylene glycerin monostearate 2.0 (13) Kaolin 10.0 (14) Zinc oxide 2.0 (15) Purified water balance <Production method > (1) to (9) and (15) were mixed. After heating and dissolving (10) to (12), the components (13) and (14) were further mixed to obtain a cleansing pack.

[0051]

Industrial Applicability According to the present invention, there is provided a skin external preparation excellent in the effect of preventing and improving rough skin.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61P 17/00 A61K 31/00 617 17/16 617J A61K 35/80 35/80 Z 38/17 37/12 F-term (reference) 4C083 AA082 AA111 AA112 AA122 AA161 AA162 AB032 AB212 AB442 AC012 AC022 AC072 AC102 AC122 AC172 AC212 AC242 AC302 AC342 AC352 AC402 AC422 AC432 AC442 AC482 AC582 AC662 AD042 AD431 AD432 AD512 AD622 AD662 CC02 CC04 DD05 CC07 DD23 DD 4C084 AA01 AA02 AA18 AA19 CA07 CA45 MA02 MA63 NA14 ZA891 4C088 AA13 AA14 AA15 AC05 BA09 BA10 CA03 MA02 MA11 MA63 NA14 ZA89

Claims (5)

[Claims] 1. An external preparation for skin containing collagen and seaweed extract as active ingredients. 2. The external preparation for skin according to claim 1, wherein the collagen is marine collagen. 3. The seaweed extract is a seaweed extract of one or more seaweeds selected from the group consisting of seaweeds belonging to red algae, seaweeds belonging to green algae and seaweeds belonging to brown algae.
An external preparation for skin according to claim 1 or 2. 4. The external preparation for skin according to claim 3, wherein the seaweed belonging to the red algae is Numehanori and the seaweed belonging to the green algae is Chlorella and the seaweed belonging to the brown algae is Macomb. 5. An external preparation for skin, wherein the external preparation for skin according to any one of claims 1 to 4 is further mixed with a dried seawater.