JP2003201211A - Cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a stabilized cosmetic comprising collagen derived from a fish and formulated therein, for further detail, having off-flavor preventing effects during formulation. <P>SOLUTION: This cosmetic comprises the collagen derived from the fish and an antioxidant, especially edetic acid or its salt and/or tocopherol or its derivative. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to the stabilization of cosmetics containing fish-derived collagen, and more particularly to the effect of preventing off-flavors in preparations.

[0002]

BACKGROUND OF THE INVENTION Collagen is generally a raw material commonly used as a moisturizing agent in cosmetics for the purpose of preventing and improving aging such as wrinkles and for keeping skin moisturized. . Among them, fish-derived collagen is collagen extracted and purified from fish, and it is said that collagen having a lower denaturation temperature as a protein is more effective in improving wrinkles and maintaining skin moisture than collagen of mammals.

However, this fish-derived collagen contains a very small amount of fish oil that cannot be removed in the extraction and purification step, and thus has a drawback that when it is incorporated into a cosmetic composition, an offensive odor is generated under the influence of temperature.

Therefore, it has been desired to develop a technique for blending fish-derived collagen with no offensive odor.

[0005]

Means for Solving the Problems As a result of diligent efforts in view of such circumstances, the present inventors have found that a cosmetic containing a specific component described below has an action of preventing the offensive odor of fish-derived collagen. The present invention has been completed.

That is, the present invention is a cosmetic characterized in that it contains fish-derived collagen and an antioxidant, and in particular, it contains edetic acid or a salt thereof and / or tocopherol or a derivative thereof among antioxidants. The cosmetics are characterized by

As the antioxidant used in the present invention,
Preferred examples include natural products such as tocopherol or a derivative thereof, edetic acid or a salt thereof, sesamol, sesamolin, gossypol and phospholipid, and other synthetic products such as butylhydroxyanisole and dibutylhydroxytoluene.

Among them, edetic acid or a salt thereof and / or tocopherol or a derivative thereof have been found to have the highest effect among the above-mentioned antioxidants by the search of the present inventor.

As edetic acid or its salt, edetic acid 2
Examples thereof include sodium, trisodium edetate, tetrasodium edetate dihydrate, and tetrasodium edetate tetrahydrate.

As tocopherol or its derivative,
Examples thereof include tocopherol acetate and tocopherol nicotinate.

The antioxidant used in the present invention may be a natural product or a chemically synthesized product, but the manufacturing method is not particularly limited. A commercially available product can be used as the antioxidant.

The amount of the antioxidant added to the cosmetic of the present invention is not particularly limited, but is 0.005 to 5% by weight (hereinafter simply referred to as "%"), preferably 0.05 to 3%. It is desirable because it has a sufficient effect of preventing offensive odors and has excellent storage stability and usability.

[0013] Of the above antioxidants, one or two or more kinds are blended in the cosmetic of the present invention.

Examples of fish-derived collagen used in the present invention include those shown below. As the fish, for example, the solubilized collagen component was extracted through washing, degreasing, acid filtration, enzyme treatment, salting-out, dialysis, heat treatment, etc. of skins such as salmon, goldfish, codfish, flounder and the like. After that, what can be obtained is mentioned. These are generally commercially available as a fish-derived collagen aqueous solution. It does not need to be an atherogenic treatment or a hydrolysis treatment.

The solution may be used as it is, and if necessary,
It may be used after being subjected to treatments such as concentration, dilution and filtration, and decolorization and deodorization with activated carbon or the like. Furthermore, the extracted solution may be concentrated to dryness, spray-dried, freeze-dried and the like and used as a dried product.

The amount of fish-derived collagen used in the present invention is not particularly limited, but is preferably 0.0001% in terms of solid content based on the total amount of the cosmetic of the present invention.
The above is preferable, and 0.0005 to 50% is more preferable. If it is less than 0.0001%, it is difficult to exert a sufficient effect. When it is blended over 50%, the enhancement of the effect is small and it is uneconomical. Regarding the method of addition, it may be added in advance or may be added during the production, and may be appropriately selected in consideration of workability.

In the cosmetic of the present invention, if necessary,
In addition to the above components, various components usually used in cosmetics, quasi drugs, pharmaceuticals and the like can be appropriately blended as needed, as long as the effects of the present invention are not impaired. Examples of such components include purified water, ethanol, oily substances, moisturizers, thickeners, preservatives, emulsifiers, medicinal components, powders, dyes, fragrances, emulsion stabilizers, pH adjusters and the like. .

The cosmetics of the present invention can be used in both cosmetics and quasi-drugs, and examples of their dosage forms include lotion, cream, emulsion, gel, aerosol, essence, pack, Examples include cleaning agents, bath agents, foundations, dusting powders, lipsticks and the like.

[0019]

EXAMPLES In order to explain the present invention in detail, production examples of the extract used in the present invention, prescription examples of the present invention and experimental examples will be given below, but the present invention is not limited thereto. Absent.

Production Example 1 Acid-Soluble Atherosclerotic Fish-Derived Collagen Solution Salmon skin is washed, defatted, acid-treated, filtered, enzyme-treated, salted out, isoelectrically precipitated, and dialyzed to obtain an acid-soluble collagen solution. For example, an “acid-soluble atelo-ized marine collagen solution” (Ibara Suisan Co., Ltd., dry residue 1%) can be mentioned.

Production Example 2 Water-Soluble Fish-Derived Collagen Solution An acid-soluble collagen solution is obtained by washing, degreasing, acid-treating, filtering, salting-out and dialysis the goldfish snapper skin. For example, "water-soluble marine collagen solution" (Technoble, dry residue 0.3%) can be mentioned.

Example 1 Cream Formulation Amount 1. Disodium edetate 0.05 part 2. Acid-soluble atherinated marine collagen solution (Ihara Suisan) 30.0 3. Squalane 5.5 4. Olive oil 3.0 5. Stearic acid 2.0 6. Beeswax 2.0 7. Octyldodecyl myristate 3.5 8. Polyoxyethylene cetyl ether (20 EO) 3.0 9. Behenyl alcohol 1.5 10. Glycerin monostearate 2.5 11. Fragrance 0.1 12.1, 3-butylene glycol 8.5 13. Ethyl paraoxybenzoate 0.05 14. Methyl paraoxybenzoate 0.2 15. [Manufacturing method] The total amount is 100 with purified water. Components 3 to 10 are dissolved by heating and mixed, and 70
Keep at ℃ and use as oil phase. Components 1, 2 and 12 to 15 are melted by heating and mixed, and the mixture is kept at 75 ° C. to form an aqueous phase. The aqueous phase is added to the oil phase to emulsify, the mixture is cooled with stirring, component 11 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.

Example 2 Lotion Formulation Amount 1. Disodium edetate 0.1 part 2. Acid-soluble atherosclerosis marine collagen solution (made by Ihara Suisan) 0.05 3.1, 3-butylene glycol 8.0 4. Glycerin 2.0 5. Xanthan gum 0.02 6. Citric acid 0.01 7. Sodium citrate 0.1 8. Ethanol 5.0 9. Methyl paraoxybenzoate 0.1 10. Polyoxyethylene hydrogenated castor oil (40 EO) 0.1 11. Perfume proper amount 12. [Production method] The total amount is 100 with purified water Components 1 to 7 and 12 and components 8 to 11 are uniformly dissolved, and both are mixed and filtered to obtain a product.

Example 3 Emulsion formulation Compounding amount 1. Disodium edetate 0.5 part 2. Tocopherol acetate 1.0 3. 3. Acid-soluble atherosclerotic marine collagen solution (manufactured by Ihara Suisan) 1.0 4. Squalane 5.0 5. Olive oil 5.0 6. Jojoba oil 5.0 7. Cetanol 1.5 8. Glycerin monostearate 2.0 9. Polyoxyethylene cetyl ether (20 EO) 3.0 10. Polyoxyethylene sorbitan monooleate (20EO) 2.0 11. Perfume 0.1 12. Propylene glycol 1.0 13. Glycerin 2.0 14. Methyl paraoxybenzoate 0.2 15. [Manufacturing method] The total amount is 100 with purified water. Components 4 to 10 are dissolved by heating and mixed, and 70
Keep at ℃ and use as oil phase. Components 1 to 3 and 12 to 15 are dissolved by heating and mixed, and the mixture is kept at 75 ° C to form an aqueous phase. The aqueous phase is added to the oil phase to emulsify, the mixture is cooled with stirring, component 11 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.

Example 4 Gel formulation Formulation amount 1. Disodium edetate 0.1 part 2. Acid-soluble atherinated marine collagen solution (Ibara Suisan) 20.0 3. Ethanol 5.0 4. Methyl paraoxybenzoate 0.1 5. Polyoxyethylene hydrogenated castor oil (60 EO) 0.1 6. Fragrance suitable amount 7.1,3-butylene glycol 5.0 8. Glycerin 5.0 9. Xanthan gum 0.1 10. Potassium hydroxide 0.2 11. [Manufacturing method] The total amount is 100 with purified water Components 1, 2 and 7 to 11 and components 3 to 6 are uniformly dissolved, and both are mixed to obtain a product.

[0026]   Example 5 Pack Prescription amount 1. Disodium edetate 0.2 parts 2. Water-soluble marine collagen solution (Technoble) 10.0 3. Polyvinyl alcohol 12.0 4. Ethanol 5.0 5.1,3-butylene glycol 8.0 6. Methyl paraoxybenzoate 0.2 7. Polyoxyethylene hydrogenated castor oil (20EO) 0.5 8. Citric acid 0.1 9. Sodium citrate 0.3 10. Fragrance suitable amount 11. Adjust the total volume to 100 with purified water [Production method] Components 1 to 11 are uniformly dissolved to obtain a product.

Example 6 Foundation Formulation Amount 1. Disodium edetate 0.5 part 2. Acid-soluble atherinated marine collagen solution (Ihara Suisan) 0.01 3. Stearic acid 2.4 4. Polyoxyethylene sorbitan monostearate (20EO) 1.0 5. Polyoxyethylene cetyl ether (20 EO) 2.0 6. Cetanol 1.0 7. Liquid lanolin 2.0 8. Liquid paraffin 3.0 9. Isopropyl myristate 6.5 10. Butyl paraoxybenzoate 0.1 11. Carboxymethyl cellulose sodium 0.1 12. Propylene glycol 4.0 13. Triethanolamine 1.1 14. Methyl paraoxybenzoate 0.2 15. Titanium dioxide 8.0 16. Talc 4.0 17. Red iron oxide 1.0 18. Yellow iron oxide 2.0 19. Perfume appropriate amount 20. [Production method] Components 3 to 10 are heated and dissolved in purified water to a total amount of 100 and kept at 80 ° C to form an oil phase. The component 11 is swelled well in the component 20, and subsequently, the components 1, 2 and 12 to 14 are added and mixed uniformly. Components 15 to 18 crushed and mixed with a crusher are added to this, and the mixture is stirred with a homomixer and kept at 75 ° C to form an aqueous phase. Add the oil phase to this water phase while stirring and cool.
Ingredient 19 is added at 5 ° C, and the product is cooled to 30 ° C with stirring.

[0028]   Example 7 Bath agent Prescription amount 1. Disodium edetate 1 part 2. Freeze-dried water-soluble marine collagen solution (Technoble) 5 3. Sodium hydrogen carbonate 50 4. Yellow No. 202 (1) Suitable amount 5. Fragrance suitable amount 6. Adjust the total amount to 100 with anhydrous sodium sulfate [Production method] Components 1 to 6 are uniformly mixed to obtain a product.

Next, in order to explain the effects of the present invention in detail, experimental examples will be given.

Comparative Example 1 Comparative Cream 1 Comparative Example 1 was prepared by replacing the disodium edetate with tocopherol acetate in Example 1.

Comparative Example 2 Comparative Cream 2 Comparative Example 2 was prepared by replacing the disodium edetate in Example 1 with dibutylhydroxytoluene.

Comparative Example 3 Comparative Cream 3 Comparative Example 3 was prepared by replacing the disodium edetate with sesamol in Example 1.

Comparative Example 4 Conventional Cream A conventional cream was prepared by replacing the disodium edetate with purified water in Example 1.

Experimental Example 1 Odor Prevention Test 1 The concentration of disodium edetate in the cream of Example 1 was set to 0.
A test for the effect of preventing off-flavor was conducted using the cream replaced with -5%. That is, all the creams were held in a thermostatic chamber at 40 ° C. for 3 months, and after the holding, the smell of the cream was confirmed by 20 women (25 to 40 years old). As a result, as shown in Table 1, those having no edetate disodium were not observed to have an offensive odor-preventing effect. Was obtained.
However, as a result of observing changes in the cream, the 5% blended product had a good off-odor prevention effect, but was not in a preferable state because disodium edetate was precipitated. Others were good. From these, it was found that the disodium edetate content was more preferably 0.05% to 3%.

[0035]

[Table 1] Table 1. Odor prevention test results

Experimental Example 2 Odor prevention test 2 The concentration of tocopherol acetate in Comparative Cream 1 was 0 to 5%.
A test for the effect of preventing offensive odor was conducted using the cream replaced with. That is, all the creams were kept in a thermostatic chamber at 40 ° C. for 3 months, and after being kept, the smell of the cream was changed by 20 women (25
~ 40 years old). As a result, as shown in Table 2, those having no tocopherol acetate were not observed to have an offensive odor-preventing effect, a slight effect was observed from the 0.005% blended product, and sufficient effect was obtained at 0.05% or more It was However, as a result of observing the change of the cream, the 5% blended product had a good offensive odor-preventing effect, but the tocopherol acetate was separated, which was not a preferable state. Others were good. From these, it was found that the blending amount of tocopherol acetate is more preferably 0.05% to 3%.

[0037]

[Table 2] Table 2. Odor prevention test results

Experimental Example 7 Odor Prevention Test 3 Using the cream of Example 1 and the comparative cream 1 of Comparative Example 1, the comparative cream 2 of Comparative Example 2, the comparative cream 3 of Comparative Example 3 and the conventional cream of Comparative Example 4. A test for the effect of preventing offensive odor was conducted. That is, all the creams were kept in a thermostatic chamber at 40 ° C. for 2 weeks, and the smell of the cream was confirmed by 20 women (25 to 40 years old) after the holding. As a result, as shown in Table 3, the cream containing the antioxidant showed a superior effect to the conventional cream, and the cream of Example 1 and the comparative cream 1 showed a good effect. From these facts, the antioxidant prevents the offensive odor of the fish-derived acid-soluble atelocollagen collagen solution, and among them, the effects of disodium edetate and tocopherol acetate are high, and the addition of the antioxidant exhibits an excellent anti-odor effect. It became clear. Examples 2 to
A similar test was performed on the cosmetic of No. 7, and good results were obtained.

[0039]

[Table 3] Table 3. Odor prevention test results

[0040]

From the above, the present invention is excellent in the effect of preventing offensive odors by containing fish-derived collagen and an antioxidant, particularly by containing edetic acid or its salt, and / or tocopherol or its derivative. Showed the action.

Front page continuation (51) Int.Cl. ⁷ identification code FI theme code (reference) A61K 7/00 A61K 7/00 RU 7/02 7/02 Z 7/48 7/48 7/50 7/50 ( 72) Inventor Satoru Nakata 2-7 Torimicho, Nishi-ku, Nagoya-shi Nippon Menard Cosmetics Co., Ltd. Research Institute F-term (reference) 4C083 AA082 AA122 AB032 AB232 AB242 AB312 AB352 AB432 AC022 AC072 AC102 AC122 AC182 AC242 AC302 AC352 AC422 AC432 AC442 AC482 AC531 AC532 AC542 AC842 AD112 AD272 AD352 AD431 AD432 AD512 AD661 AD662 BB47 CC04 CC05 CC07 CC12 CC25 DD23 DD27 DD31 DD41 EE01 EE41

Claims (5)

[Claims] 1. A cosmetic comprising collagen derived from fish and an antioxidant. 2. The antioxidant is edetic acid or a salt thereof, and / or
Alternatively, the cosmetic according to claim 1, which is tocopherol or a derivative thereof. 3. A collagen content of 0.0 as a solid content.
001 to 50%, the amount of edetic acid or its salt is 0.0
The cosmetic according to claim 2, wherein the content of the tocopherol or its derivative is 0.005 to 5%. 4. The cosmetic material according to claim 1, wherein the collagen is atelolated collagen or water-soluble collagen. 5. The cosmetic material according to claim 4, wherein the collagen is atelocollagen.