JP2000239176A - Hydrophobic licorice extract-containing composition - Google Patents
Hydrophobic licorice extract-containing compositionInfo
- Publication number
- JP2000239176A JP2000239176A JP11038681A JP3868199A JP2000239176A JP 2000239176 A JP2000239176 A JP 2000239176A JP 11038681 A JP11038681 A JP 11038681A JP 3868199 A JP3868199 A JP 3868199A JP 2000239176 A JP2000239176 A JP 2000239176A
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- Prior art keywords
- licorice extract
- composition
- weight
- hydrophobic licorice
- fatty acid
- Prior art date
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- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
(57)【要約】 （修正有）
【課題】 疎水性甘草エキスを安定に含有する組成物、
及びこれを用いた安定性の高い製剤を得る。
【解決手段】 多価アルコール脂肪酸エステルと疎水性
甘草エキスと油脂とを含有する疎水性甘草エキス含有組
成物。この組成物は外用剤あるいは化粧料として使用で
きる(57) [abstract] (with correction) [PROBLEMS] A composition stably containing a hydrophobic licorice extract,
And a highly stable preparation using the same. SOLUTION: A hydrophobic licorice extract-containing composition containing a polyhydric alcohol fatty acid ester, a hydrophobic licorice extract and an oil or fat. This composition can be used as an external preparation or cosmetic
Description
【０００１】[0001]
【発明の属する技術分野】本発明は水及び油に溶解しな
い疎水性甘草エキスを含有する組成物及びこれを含有す
る外用剤、化粧料に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition containing a hydrophobic licorice extract which is insoluble in water and oil, and an external preparation and cosmetic containing the composition.
【０００２】[0002]
【従来の技術】カンゾウ（Glycyrrhiza glabra, G.ural
ensis, G.inflata等のGlycyrrhiza 属植物）の根又は根
茎を、エタノール、クロロホルム、塩化メチレン、酢酸
エチル等の有機溶媒で抽出した抽出液又はその溶媒を除
去した抽出物及びその抽出物を脱色、脱臭等精製処理し
たいわゆる「疎水性甘草エキス」は、グラブリジン、グ
ラブレン等のフラボノイドを主成分とし、美白作用、チ
ロシナーゼ活性阻害作用、抗酸化作用、抗菌作用、SOD
様作用があることが確認されており、様々な化粧料や外
用剤等に使用される。2. Description of the Related Art Glycyrrhiza glabra, G.ural
ensis, G. inflata and other Glycyrrhiza genus plants) extracted with an organic solvent such as ethanol, chloroform, methylene chloride and ethyl acetate, or an extract obtained by removing the solvent, and decolorizing the extract. The so-called “hydrophobic licorice extract” purified by deodorization and the like is mainly composed of flavonoids such as glabridine and glabrene, and has a whitening effect, tyrosinase activity inhibitory effect, antioxidant effect, antibacterial effect, SOD
It has been confirmed that it has a similar effect, and is used in various cosmetics and external preparations.
【０００３】疎水性甘草エキスは、水及び一般的な油に
はほとんど溶解せず、適当な溶剤に溶解させて使用され
ており、従来溶剤として用いられてきたものとしては、
エタノール、プロピレングリコール、１，３−ブチレン
グリコール等がある。[0003] Hydrophobic licorice extract is hardly soluble in water and common oils, but is used by dissolving it in a suitable solvent.
Examples include ethanol, propylene glycol, and 1,3-butylene glycol.
【０００４】しかしながら、これらはエマルション等の
化粧品処方に用いると、これらの溶剤が水相に移行する
ために疎水性甘草エキスが析出してしまう問題があっ
た。[0004] However, when these are used in cosmetic formulations such as emulsions, there is a problem that the hydrophobic licorice extract is precipitated because these solvents move to the aqueous phase.
【０００５】また析出した疎水性甘草エキスは着色する
等不安定なことが知られており、このための安定化剤と
してトコフェロール、没食子酸類、フラボノイド、アス
コルビン酸類、ソルビン酸類、クエン酸類等が用いられ
たが、疎水性甘草エキスの主成分であるグラブリジンの
安定化効果は十分ではなかった。また、安定化剤として
ピロ亜硫酸塩或いは亜硫酸塩を用いる試みもあるが、こ
れらは化粧品の添加物として好ましいものではないた
め、実用的ではない。[0005] It is known that the precipitated hydrophobic licorice extract is unstable, such as being colored, and as such stabilizers, tocopherol, gallic acids, flavonoids, ascorbic acids, sorbic acids, citric acids and the like are used. However, the stabilizing effect of glabridine, which is the main component of the hydrophobic licorice extract, was not sufficient. There are also attempts to use pyrosulfites or sulfites as stabilizers, but these are not practical as additives for cosmetics and are not practical.
【０００６】更に疎水性甘草エキスの溶解性の問題を改
善するために、中鎖脂肪酸トリグリセリドを利用する試
みが見られる。しかし中鎖脂肪酸エステルは化粧品に望
まれる感触性に問題がある場合が多く、また僅かの加水
分解による中鎖脂肪酸の感作性は大きいため、化粧品と
して好ましいものではなかった。Attempts have been made to utilize medium chain fatty acid triglycerides to further improve the solubility problem of the hydrophobic licorice extract. However, medium-chain fatty acid esters are often unsuitable for cosmetics because they often have a problem in the feel desired for cosmetics and the sensitization of medium-chain fatty acids by slight hydrolysis is large.
【０００７】[0007]
【発明が解決しようとする課題】このように疎水性甘草
エキスは外用剤又は化粧料として優れた効能を有する
が、水或いは油に溶解しないために利用が困難であっ
た。As described above, the hydrophobic licorice extract has an excellent effect as an external preparation or a cosmetic, but has been difficult to use because it does not dissolve in water or oil.
【０００８】本発明は、安定で取り扱い性の良い疎水性
甘草エキス含有組成物を得ること、またこれを用いた安
定性の高い製剤を得ることを目的とする。An object of the present invention is to obtain a composition containing a hydrophobic licorice extract which is stable and easy to handle, and to obtain a highly stable preparation using the composition.
【０００９】[0009]
【課題を解決するための手段】本発明者らは安全性の高
い成分の中から疎水性甘草エキスを安定に溶解すべく種
々検討した結果、多価アルコール脂肪酸エステルを油脂
に配合することにより、安定性に優れた疎水性甘草エキ
ス含有組成物が得られることを見出し、本発明を完成す
るに至った。また、この組成物を用いて化粧品処方を調
製したところ、疎水性甘草エキスの安定性の良好な化粧
品を容易に得られることを見出した。Means for Solving the Problems The present inventors have conducted various studies to stably dissolve hydrophobic licorice extract from ingredients having high safety, and as a result, by blending a polyhydric alcohol fatty acid ester with fats and oils, The present inventors have found that a composition containing a hydrophobic licorice extract having excellent stability can be obtained, and have completed the present invention. In addition, when a cosmetic formulation was prepared using this composition, it was found that a cosmetic having good stability of the hydrophobic licorice extract could be easily obtained.
【００１０】すなわち、本発明は、多価アルコール脂肪
酸エステルと疎水性甘草エキスと油脂とを含有する疎水
性甘草エキス含有組成物、並びに該組成物を含有する外
用剤及び化粧料を提供する。That is, the present invention provides a hydrophobic licorice extract-containing composition containing a polyhydric alcohol fatty acid ester, a hydrophobic licorice extract and an oil and fat, and an external preparation and a cosmetic containing the composition.
【００１１】本発明において、疎水性甘草エキスとは、
カンゾウ（Glycyrrhiza glabra, G.uralensis, G.infla
ta等のGlycyrrhiza 属植物）の根又は根茎を、エタノー
ル、クロロホルム、塩化メチレン、酢酸エチル等の有機
溶媒で抽出した抽出液又はその溶媒を除去した抽出物及
びその抽出物を脱色、脱臭等精製処理したものであり、
主成分にグラブリジン、グラブレン等を含有する。疎水
性甘草エキスの市販品としては、油溶性甘草エキスP-TH
（丸善製薬株式会社製）、油溶性甘草エキスP-T （丸善
製薬株式会社製）、油溶性甘草エキスP-T(40) （丸善製
薬株式会社製）等を使用することができる。In the present invention, the hydrophobic licorice extract is
Daylily (Glycyrrhiza glabra, G.uralensis, G.infla
Extracts obtained by extracting the roots or rhizomes of Glycyrrhiza plants such as ta) with organic solvents such as ethanol, chloroform, methylene chloride, and ethyl acetate, or extracts obtained by removing the solvents, and purification treatments such as decolorization and deodorization of the extracts. Was done,
The main component contains glabridine, grabrene, and the like. As a commercially available hydrophobic licorice extract, oil-soluble licorice extract P-TH
(Maruzen Pharmaceutical Co., Ltd.), oil-soluble licorice extract PT (Maruzen Pharmaceutical Co., Ltd.), oil-soluble licorice extract PT (40) (Maruzen Pharmaceutical Co., Ltd.) and the like can be used.
【００１２】本発明に用いられる多価アルコール脂肪酸
エステルにおいて、「多価アルコール」とは、同一分子
内に水酸基を２個以上もつアルコールをいい、水酸基の
数により、二価アルコール、三価アルコール等があり、
五価アルコールや六価アルコール等、単糖類の還元によ
って生成する糖アルコールも含まれる。多価アルコール
としては、例えば、プロピレングリコール、1,3-ブチレ
ングリコール、エチレングリコール、グリセリン、グル
コース、マルトース、マルチトール、蔗糖、フラクトー
ス、キシリトール、イノシトール、ペンタエリスリトー
ル、トレハロース等や、ジグリセリン、トリグリセリ
ン、テトラグリセリン等のポリグリセリン等が挙げら
れ、重合度２以上のポリグリセリンが好ましい。また、
脂肪酸は炭素数12〜22の脂肪酸が挙げられ、具体的に
は、イソステアリン酸、ステアリン酸、ラウリン酸、ミ
リスチン酸、オレイン酸等が挙げられる。また、多価ア
ルコール脂肪酸エステルはHLB が7.5 以下、特に4.5 〜
7.5 のものが好ましい。本発明においては、モノイソス
テアリン酸ジグリセリル等のジグリセリンモノ脂肪酸エ
ステルが特に好ましく、その中でもHLB が7.5 以下のも
のが更に好ましい。In the polyhydric alcohol fatty acid ester used in the present invention, the term "polyhydric alcohol" means an alcohol having two or more hydroxyl groups in the same molecule, and depending on the number of hydroxyl groups, dihydric alcohol, trihydric alcohol, etc. There is
Sugar alcohols generated by reduction of monosaccharides, such as pentahydric alcohols and hexahydric alcohols, are also included. Examples of polyhydric alcohols include, for example, propylene glycol, 1,3-butylene glycol, ethylene glycol, glycerin, glucose, maltose, maltitol, sucrose, fructose, xylitol, inositol, pentaerythritol, trehalose, etc., diglycerin, triglycerin And polyglycerin such as tetraglycerin, etc., and polyglycerin having a degree of polymerization of 2 or more is preferable. Also,
Fatty acids include fatty acids having 12 to 22 carbon atoms, specifically, isostearic acid, stearic acid, lauric acid, myristic acid, oleic acid, and the like. Polyhydric alcohol fatty acid esters have an HLB of 7.5 or less, especially 4.5 to
7.5 is preferred. In the present invention, diglycerin monofatty acid esters such as diglyceryl monoisostearate are particularly preferred, and among them, those having an HLB of 7.5 or less are more preferred.
【００１３】本発明に用いられる油脂は、常温で流動性
を示すものが好ましく、特に適度な溶解性と流動性を持
つ炭酸ジアルキルが好ましく用いられる。炭酸ジアルキ
ルは市販されているアルキル基の炭素数が12〜15のもの
を利用することができる。その他の油脂としては、オク
タン酸セチル、オクタン酸ステアリル、ラウリン酸ヘキ
シル、ミリスチン酸イソプロピル、ミリスチン酸ブチ
ル、ミリスチン酸イソセチル、ミリスチン酸オクチルド
デシル、パルミチン酸イソプロピル、パルミチン酸オク
チル、アジピン酸ジソプロピル、セバシン酸ジエチル、
トリオクタン酸グリセリル、トリオクタン酸トリメチロ
ールプロパン、その他の天然動植物油等が挙げられる。The oils and fats used in the present invention preferably exhibit fluidity at room temperature, and in particular, dialkyl carbonate having appropriate solubility and fluidity is preferably used. As the dialkyl carbonate, commercially available alkyl groups having 12 to 15 carbon atoms can be used. Other fats and oils include cetyl octanoate, stearyl octanoate, hexyl laurate, isopropyl myristate, butyl myristate, isocetyl myristate, octyl dodecyl myristate, isopropyl palmitate, octyl palmitate, disopropyl adipate, and diethyl sebacate. ,
Examples thereof include glyceryl trioctanoate, trimethylolpropane trioctanoate, and other natural animal and vegetable oils.
【００１４】本発明の組成物の製造方法を具体的に説明
すると、下記の通りである。 (1) まず、疎水性甘草エキスを炭酸ジアルキル等の油脂
に分散させる。 (2) この分散液に多価アルコール脂肪酸エステルを加え
て撹拌し透明な溶液を得る。 上記(1) 、(2) において、各成分の混合比、混合条件
（温度、撹拌速度等）の諸条件は限定されない。The method for producing the composition of the present invention will be specifically described as follows. (1) First, a hydrophobic licorice extract is dispersed in fats and oils such as dialkyl carbonate. (2) Polyhydric alcohol fatty acid ester is added to this dispersion and stirred to obtain a transparent solution. In the above (1) and (2), various conditions such as the mixing ratio of each component and the mixing conditions (temperature, stirring speed, etc.) are not limited.
【００１５】本発明の組成物の組成の一例を挙げると、
多価アルコール脂肪酸エステル10〜50重量％、疎水性甘
草エキス１〜20重量％、残部の油脂である。特に多価ア
ルコール脂肪酸エステル10〜50重量％、疎水性甘草エキ
ス１〜20重量％、残部の炭酸ジアルキルを含有する透明
な溶液状組成物が挙げられる。As an example of the composition of the composition of the present invention,
It is 10 to 50% by weight of a polyhydric alcohol fatty acid ester, 1 to 20% by weight of a hydrophobic licorice extract, and the rest of fats and oils. In particular, a clear solution composition containing 10 to 50% by weight of a polyhydric alcohol fatty acid ester, 1 to 20% by weight of a hydrophobic licorice extract, and the balance of dialkyl carbonate is exemplified.
【００１６】本発明の組成物は、皮膚科用の軟膏等の皮
膚治療薬等の外用剤として有用である。また、本発明の
疎水性甘草エキス含有組成物は、化粧料として特に有用
である。本発明の疎水性甘草エキス含有組成物を用いて
なる化粧料に限定はないが、例えばエモリエントクリー
ム等のクリーム類、乳液類等、口紅類等が挙げられ、こ
れらにビタミン類、その他の薬剤を配合して薬効を持た
せたものも挙げられる。The composition of the present invention is useful as an external preparation such as a skin treatment agent such as a dermatological ointment. Further, the composition containing the hydrophobic licorice extract of the present invention is particularly useful as a cosmetic. Cosmetics using the hydrophobic licorice extract-containing composition of the present invention are not limited, but include, for example, creams such as emollient cream, emulsions, lipsticks and the like, and vitamins and other drugs. There may also be mentioned those having a medicinal effect by being blended.
【００１７】[0017]
【発明の効果】本発明の組成物は、高濃度に疎水性甘草
エキスを含有するが、透明溶液であり、安定性に優れ長
期保存安定性を維持できる。また人体に安全な成分を用
いているために外用剤や化粧品に好ましい。更にエマル
ションに添加した場合も疎水性甘草エキスの安定性が保
持される。Industrial Applicability The composition of the present invention contains a hydrophobic licorice extract at a high concentration, but is a transparent solution and has excellent stability and can maintain long-term storage stability. In addition, it is preferred for external preparations and cosmetics because it uses ingredients that are safe for the human body. Further, when added to the emulsion, the stability of the hydrophobic licorice extract is maintained.
【００１８】[0018]
【発明の実施の形態】以下、本発明の組成物を用いた実
施例を示すが、本発明はこれらに限定されるものではな
い。Hereinafter, Examples using the composition of the present invention will be described, but the present invention is not limited thereto.
【００１９】実施例１ ＜疎水性甘草エキス含有組成物の調製＞表１に示す量の
疎水性甘草エキスを、約70℃に加温した表１に示す量の
炭酸ジアルキルに分散させる。およそ５分間撹拌後、表
１に示す量の多価アルコール脂肪酸エステルを加え更に
撹拌を続け、種々の疎水性甘草エキス含有組成物（以
下、単に組成物という場合もある）を得た。ここで用い
た疎水性甘草エキスは、油溶性甘草エキスP-TH（丸善製
薬株式会社製）である。Example 1 <Preparation of composition containing hydrophobic licorice extract> The amount of hydrophobic licorice extract shown in Table 1 is dispersed in the amount of dialkyl carbonate shown in Table 1 heated to about 70 ° C. After stirring for about 5 minutes, the polyhydric alcohol fatty acid ester in the amount shown in Table 1 was added, and stirring was further continued to obtain various hydrophobic licorice extract-containing compositions (hereinafter sometimes simply referred to as compositions). The hydrophobic licorice extract used here is oil-soluble licorice extract P-TH (manufactured by Maruzen Pharmaceutical Co., Ltd.).
【００２０】＜組成物の安定性＞上記で調製した組成物
を、５℃（一般に疎水性甘草エキスの析出が起こるとさ
れている温度）で３ヶ月放置した後の溶解状態を下記の
基準で評価した。その結果を表１に示す。 溶解状態 ５：結晶の析出は見られず透明な状態 ４：ごくわずかに曇りが見られるが、結晶の析出は認め
られない ３：若干濁りが認められるが、結晶の析出は認められな
い ２：濁りが認められるが、結晶の析出は認められない １：結晶が析出し分散した状態<Stability of Composition> The composition prepared above was allowed to stand at 5 ° C. (a temperature at which precipitation of a hydrophobic licorice extract generally occurs) for 3 months. evaluated. Table 1 shows the results. Dissolution state 5: Transparent state without precipitation of crystals 4: Extremely slight cloudiness, but no precipitation of crystals 3: Slightly turbid, but no precipitation of crystals 2: Turbidity is observed, but no precipitation of crystals is observed 1: Crystals are precipitated and dispersed
【００２１】[0021]
【表１】 [Table 1]
【００２２】実施例２＜水相と接触する油相中での安定
性＞ 実施例１で調製した組成物の、水相と接触する油相中で
の疎水性甘草エキスの安定性を定量的に確認するため、
組成物／水〔系(A) 〕、及び流動パラフィン希釈組成物
／水〔系(B) 〕の２つの系での疎水性甘草エキスの定量
値の経時変化を測定した。系(A) 、(B) の組成を表２に
示す。なお、用いた組成物は(A) 、(B)とも実施例１の
表１の組成物1-2 である。試験操作は、各系を調製後３
分間十分に振り混ぜ、遠心分離後５℃で７日放置後、上
層の油相を取出しグラブリジンの吸収に基づく282 nmの
吸光度を測定し、予め作成してある検量線より油相中の
甘草エキスの含有量を測定した。その結果を表２に示す
が、系(A) 、(B) とも甘草エキスの残存率は97％以上で
あり、甘草エキスは安定に油相中に存在していることが
示された。Example 2 <Stability in oil phase in contact with water phase> The stability of the hydrophobic licorice extract of the composition prepared in Example 1 in the oil phase in contact with the water phase was quantitatively determined. To confirm
The change over time of the quantitative value of the hydrophobic licorice extract in two systems, the composition / water [system (A)] and the liquid paraffin-diluted composition / water [system (B)], was measured. Table 2 shows the compositions of the systems (A) and (B). The compositions used were both (A) and (B), the composition 1-2 in Table 1 of Example 1. The test operation was performed after preparing each system.
After shaking well for 3 minutes, centrifuge and leave at 5 ° C for 7 days, remove the upper oil phase, measure the absorbance at 282 nm based on the absorption of glabridine, and extract the licorice extract in the oil phase from the calibration curve prepared in advance. Was measured. The results are shown in Table 2. The residual ratio of the licorice extract was 97% or more in both systems (A) and (B), indicating that the licorice extract was stably present in the oil phase.
【００２３】[0023]
【表２】 [Table 2]
【００２４】実施例３（美白クリーム） 下記の油相と水相とからなる美白クリームを調製した。 ：油相 組成物（実施例１の組成物1-2 ） 2.0重量％ スクワラン 8.0重量％ トリ２−エチルヘキサン酸グリセリル 8.0重量％ ベヘニルアルコール 5.0重量％ セラキルアルコール 0.2重量％ ポリオキシエチレン（20）セチルエーテル 1.0重量％ モノステアリン酸ポリエチレングリコール(40EO) 1.0重量％ プロピルパラベン 0.1重量％ ：水相 キサンタンガム（２重量％水溶液） 15.0重量％ 濃グリセリン 5.0重量％ メチルパラベン 0.2重量％ 精製水 54.2重量％。Example 3 (Whitening Cream) A whitening cream comprising the following oil phase and aqueous phase was prepared. : Oil phase composition (composition 1-2 of Example 1) 2.0% by weight Squalane 8.0% by weight Glyceryl tri-2-ethylhexanoate 8.0% by weight Behenyl alcohol 5.0% by weight Seraalkyl alcohol 0.2% by weight Polyoxyethylene (20) cetyl Ether 1.0% by weight Polyethylene glycol monostearate (40EO) 1.0% by weight Propyl paraben 0.1% by weight: aqueous phase Xanthan gum (2% by weight aqueous solution) 15.0% by weight Concentrated glycerin 5.0% by weight Methyl paraben 0.2% by weight Purified water 54.2% by weight.
【００２５】実施例４（口紅） 下記の組成からなる口紅を調製した。 組成物（実施例１の組成物1-2 ） 2.0重量％ ヒマシ油 59.0重量％ オクチルドデカノール 20.0重量％ セレシン710 5.0重量％ 流動パラフィン (135 °F) 4.0重量％ カルナウバ蝋 2.0重量％ 蜜蝋 4.0重量％ キャンデリラワックス 4.0重量％。Example 4 (lipstick) A lipstick having the following composition was prepared. Composition (composition 1-2 of Example 1) 2.0% by weight Castor oil 59.0% by weight Octyldodecanol 20.0% by weight Celesin 710 5.0% by weight Liquid paraffin (135 ° F) 4.0% by weight Carnauba wax 2.0% by weight Beeswax 4.0% by weight % Candelilla wax 4.0% by weight.
【００２６】実施例５（口紅） 下記の組成からなる口紅を調製した。 組成物（実施例１の組成物1-2 ） 2.0重量％ リンゴ酸ジイソステアリル 59.0重量％ オクチルドデカノール 20.0重量％ セレシン710 5.0重量％ パラフィン (135 °F) 4.0重量％ カルナウバ蝋 2.0重量％ 蜜蝋 4.0重量％ キャンデリラワックス 4.0重量％Example 5 (Lipstick) A lipstick having the following composition was prepared. Composition (composition 1-2 of Example 1) 2.0% by weight Diisostearyl malate 59.0% by weight Octyl dodecanol 20.0% by weight Celesin 710 5.0% by weight Paraffin (135 ° F) 4.0% by weight Carnauba wax 2.0% by weight Beeswax 4.0% by weight Candelilla wax 4.0% by weight
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 47/14 Ａ６１Ｋ 47/14 47/44 47/44 (72)発明者 李 金華 東京都板橋区蓮根３−24−３ 日本サーフ ァクタント工業株式会社内 (72)発明者 池田 孝夫 広島県尾道市向東町14703番地の10 丸善 製薬株式会社内 (72)発明者 堤 龍彦 広島県尾道市向東町14703番地の10 丸善 製薬株式会社内 Ｆターム(参考） 4C076 AA07 BB31 CC18 DD37 DD38 DD45R DD47E EE01 EE23 EE30 EE52E EE58A FF15 4C083 AA081 AA082 AA111 AA112 AA121 AA122 AC012 AC022 AC072 AC092 AC122 AC182 AC351 AC352 AC391 AC402 AC421 AC422 AC482 AD352 CC05 CC13 DD27 DD31 EE16 4C088 AB60 AC11 AC13 BA08 BA10 BA11 MA63 NA03 ZA89 ZA90 ZB35 ZC20 ZC21 ──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. 7 Identification FI FI Theme Court ゛ (Reference) A61K 47/14 A61K 47/14 47/44 47/44 (72) Inventor Li Jinhua 3 Hasune, Itabashi-ku, Tokyo -24-3 Inside Japan Surfactant Industry Co., Ltd. (72) Inventor Takao Ikeda 14703, Mukotocho, Onomichi City, Hiroshima Prefecture Inside Maruzen Pharmaceutical Co., Ltd. (72) Inventor Tatsuhiko Tsutsumi 14703, Mukohitocho, Onomichi City, Hiroshima Prefecture Maruzen Pharmaceutical Co., Ltd. 4C088 AB60 AC11 AC13 BA08 BA10 BA11 MA63 NA03 ZA89 ZA90 ZB35 ZC20 ZC21
Claims (9)
甘草エキスと油脂とを含有する疎水性甘草エキス含有組
成物。1. A hydrophobic licorice extract-containing composition comprising a polyhydric alcohol fatty acid ester, a hydrophobic licorice extract and an oil or fat.
7.5 以下である請求項１記載の組成物。2. HLB of polyhydric alcohol fatty acid ester is
A composition according to claim 1 which is not more than 7.5.
度２以上のポリグリセリン脂肪酸エステルである請求項
１又は２記載の組成物。3. The composition according to claim 1, wherein the polyhydric alcohol fatty acid ester is a polyglycerin fatty acid ester having a degree of polymerization of 2 or more.
リセリンモノ脂肪酸エステルである請求項３記載の組成
物。4. The composition according to claim 3, wherein the polyhydric alcohol fatty acid ester is a diglycerin monofatty acid ester.
重量％含有する請求項１〜４の何れか１項記載の組成
物。5. A polyhydric alcohol fatty acid ester of 10 to 50.
The composition according to any one of claims 1 to 4, which contains 0.1% by weight.
る請求項１〜５の何れか１項記載の組成物。6. The composition according to claim 1, comprising 1 to 20% by weight of a hydrophobic licorice extract.
６の何れか１項記載の組成物。7. The method according to claim 1, wherein the fat or oil is a dialkyl carbonate.
The composition according to any one of claims 6 to 10.
を含有することを特徴とする外用剤。8. An external preparation comprising the composition according to claim 1. Description:
を含有することを特徴とする化粧料。9. A cosmetic comprising the composition according to claim 1.
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| JP03868199A JP4418550B2 (en) | 1999-02-17 | 1999-02-17 | Hydrophobic licorice extract-containing composition |
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|---|---|---|---|
| JP03868199A JP4418550B2 (en) | 1999-02-17 | 1999-02-17 | Hydrophobic licorice extract-containing composition |
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| JP2000239176A true JP2000239176A (en) | 2000-09-05 |
| JP4418550B2 JP4418550B2 (en) | 2010-02-17 |
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Cited By (5)
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| WO2005011672A1 (en) * | 2003-07-31 | 2005-02-10 | Kaneka Corporation | Processed fat composition for preventing/ameliorating lifestyle-related diseases |
| JP2005281203A (en) * | 2004-03-30 | 2005-10-13 | Hayashibara Biochem Lab Inc | External preparation for skin, grabridine glycoside and method for producing the same |
| US7524975B2 (en) | 2001-10-11 | 2009-04-28 | Kaneka Corporation | Peroxisome proliferator activated receptor ligand and process for producing the same |
| JP2023146362A (en) * | 2022-03-29 | 2023-10-12 | 丸善製薬株式会社 | Novel ketone compounds, radical scavengers, hyaluronidase activity inhibitors, PGE2 production inhibitors, tyrosinase activity inhibitors, elastase activity inhibitors, type I collagen production promoters, and dermal papilla cell proliferation promoters |
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1999
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| US7524975B2 (en) | 2001-10-11 | 2009-04-28 | Kaneka Corporation | Peroxisome proliferator activated receptor ligand and process for producing the same |
| US7888388B2 (en) | 2001-10-11 | 2011-02-15 | Kaneka Corporation | Peroxisome proliferator activated receptor ligand and process for producing the same |
| WO2003084556A1 (en) * | 2002-04-04 | 2003-10-16 | Kaneka Corporation | Process for producing fat composition containing hydrophobic components of glycyrrhiza |
| JPWO2003084556A1 (en) * | 2002-04-04 | 2005-08-11 | 株式会社カネカ | Process for producing oil and fat composition containing licorice hydrophobic component |
| RU2279226C2 (en) * | 2002-04-04 | 2006-07-10 | Канека Корпорейшн | METHOD FOR PRODUCTION OF OIL AND FAT COMPOSITION CONTAINING HYDROPHOBIC COMPONENTS FROM Glycyrrhiza, OIL AND FAT COMPOSITION AND OIL-AND-FAT CONTAINING FOODSTUFF |
| US7166311B2 (en) | 2002-04-04 | 2007-01-23 | Kaneka Corporation | Process for producing fat composition containing hydrophobic components of glycyrrhiza |
| JP4685355B2 (en) * | 2002-04-04 | 2011-05-18 | 株式会社カネカ | Process for producing oil and fat composition containing licorice hydrophobic component |
| WO2005011672A1 (en) * | 2003-07-31 | 2005-02-10 | Kaneka Corporation | Processed fat composition for preventing/ameliorating lifestyle-related diseases |
| JPWO2005011672A1 (en) * | 2003-07-31 | 2006-10-19 | 株式会社カネカ | Oil processing composition for prevention and improvement of lifestyle-related diseases |
| JP2005281203A (en) * | 2004-03-30 | 2005-10-13 | Hayashibara Biochem Lab Inc | External preparation for skin, grabridine glycoside and method for producing the same |
| JP2023146362A (en) * | 2022-03-29 | 2023-10-12 | 丸善製薬株式会社 | Novel ketone compounds, radical scavengers, hyaluronidase activity inhibitors, PGE2 production inhibitors, tyrosinase activity inhibitors, elastase activity inhibitors, type I collagen production promoters, and dermal papilla cell proliferation promoters |
| JP7772369B2 (en) | 2022-03-29 | 2025-11-18 | 丸善製薬株式会社 | Novel ketone compounds, radical scavengers, hyaluronidase activity inhibitors, PGE2 production inhibitors, tyrosinase activity inhibitors, elastase activity inhibitors, type I collagen production promoters, and hair papilla cell proliferation promoters |
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