JP2000280417A - Multi-layer sheet for ptp packaging - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a sheet which has a wide range of molding conditions and is almost free from the generation of a curl and further, shows transparency and rigidity required for PTP packaging with an outstanding suitability for molding PVC by forming the sheet of respectively specific resins for the outer, inner and intermediate layers of the sheet under a five-layer structure of an outer layer, an adhesive resin layer, an intermediate layer, an adhesive resin layer and an inner layer. SOLUTION: At least an outer layer and an inner layer constituting a multi- layer sheet of five layers formed of a polypropylene resin and an intermediate layer is formed of a non-crystalline polyethylene terephthalate resin or a polystyrene resin. The polypropylene resin is a polypropylene homopolymer or a mixture thereof or the like and the polystyrene resin is a polybutadiene or the like. In addition, for the non-crystalline polyethylene terephthalate copolymer, a thermoplastic polyester is used which gives superb moldability, curling characteristics, transparency and rigidity to a PTP sheet. Further, for an adhesive resin layer between the inner and outer layers and the intermediate layer, the resin is used which bonds PP with PETG without impairing the basic properties for PTP use applications.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a PTP commonly used for packaging solid preparations in the field of pharmaceutical packaging.
(Press through pack) sheet.

[0002]

2. Description of the Related Art In the field of pharmaceutical packaging, PTP packaging, which is generally used for packaging solid preparations such as tablets and capsules, is mainly made of hard polychlorinated resin in view of transparency, moldability, rigidity and cost. Using a vinyl sheet as the bottom material,
This bottom material is formed into a pocket shape, filled with a solid agent (tablets, capsules, etc.) therein, and sealed with a lid made of aluminum foil. It has been put into practical use in the early 1960s and has been widely used. Was.

[0003] Most of the contents of tablets, capsules and the like are deteriorated or deformed by absorbing moisture.
This has been dealt with by providing secondary packaging such as pillow packaging with a composite film containing aluminum foil, or by using a sheet in which a rigid polyvinyl chloride sheet is composited with a coating of polyvinylidene chloride resin with excellent moisture resistance. These are expensive and have a problem in cost. In addition, the tendency of polyvinyl chloride resin to be avoided due to the problem of disposal is increasing. Therefore, recently, sheets made of polypropylene resin, which is an olefin-based resin, have been attracting attention for their moisture-proof properties, low cost properties, and easy processability.
It has been used as a TP packaging sheet.

[0004] However, polypropylene as a PTP sheet has a problem in that the range of molding conditions is narrower than polyvinyl chloride, and there is a problem in terms of appearance due to curling of the product or compatibility with an automatic packaging line. Furthermore, a dimensional change behavior of the material requires a molded plate dedicated to polypropylene. At present, many molding plates for PTP packaging molding machines are for vinyl chloride, and changing to a polypropylene molding plate is a problem in terms of cost. These problems are attributable to the fact that polypropylene is a crystalline resin, and attempts have been made to increase the crystallinity of polypropylene in order to improve curl, using a nucleating agent or slow cooling during sheeting. In addition, methods such as annealing the sheet were performed, but the moldability was conversely deteriorated, and was not suitable for actual use. Attempts have also been made to reduce the degree of crystallinity by quenching during sheeting in order to improve the formability. However, in this method, the stiffness of the sheet is significantly reduced, and the sheet cannot be used for practical use. Further, in order to improve moldability, a method of suppressing crystallinity by adding a petroleum resin to a homopolymer of polypropylene has been adopted, but this method has a drawback that impact resistance is significantly impaired. I was In order to improve the impact resistance, a method of adding a thermoplastic elastomer (TPE) has been adopted, but the impact resistance is improved with an increase in the amount of TPE added, but at the same time, the rigidity and the moisture resistance are reduced. was there. As described above, the conventional polypropylene sheet could only partially satisfy the required performance of the PTP sheet such as moldability, low curl property, transparency, rigidity, moisture resistance and impact resistance. .

[0005]

SUMMARY OF THE INVENTION An object of the present invention is to provide a wide range of molding conditions, low curl, and PTP.
Excellent transparency and rigidity required for packaging, and PVC
An object of the present invention is to provide a polypropylene-based PTP sheet that can be formed even with a molded plate.

[0006]

According to the present invention, there is provided a multilayer sheet comprising at least five layers of an outer layer / adhesive resin layer / intermediate layer / adhesive resin layer / inner layer, wherein the outer layer and the inner layer are made of a polypropylene resin. The intermediate layer is a PTP packaging multilayer sheet made of an amorphous polyethylene terephthalate resin or a polystyrene resin.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The method for producing the polypropylene resin used for the outer layer and the inner layer of the present invention may be any polymerization method, for example, solvent polymerization, bulk polymerization, gas phase polymerization, etc., any catalyst, for example, trichloride. The catalyst may be manufactured using a titanium catalyst, a magnesium chloride-supported catalyst, a metallocene catalyst, or the like. Examples of the polypropylene resin include a polypropylene homopolymer (homopolymer), an ethylene propylene copolymer, and a mixture thereof. Further, additives such as a crystal nucleating agent, an antistatic agent, an ultraviolet absorber, a lubricant, and an antioxidant may be added as long as the basic performance is not impaired.

The method for producing the polystyrene resin used in the present invention includes any polymerization method, for example, emulsion polymerization, solution polymerization, suspension polymerization, bulk polymerization, and any catalyst such as peroxide, trialkylaluminum, lithium halide. And those manufactured with a nickel-based catalyst.
As the polystyrene resin, a styrene homopolymer may be used, but a copolymer with another monomer is more preferable because it is brittle. For example, soft segments of a styrene-based block copolymer include polybutadiene, polyisoprene, and polyolefin (ethylene and butylene).

The amorphous polyethylene used in the present invention
The terephthalate copolymer may be any as long as it imparts excellent moldability, curl, transparency and rigidity to the PTP sheet, but preferably a part of the glycol component is converted to 1,4-cyclohexanedimethanol. Substituted thermoplastic polyesters such as PETG67
63 (manufactured by Eastman Kodak Company).

[0010] The adhesive resin used in the present invention is not particularly limited, and any resin may be used as long as it adheres PP to PS and PETG without impairing the basic properties for PTP use. Preferably, the following are good.
Admer SF as an adhesive resin between PETG and PP
740, SF700, SF710, SF730 (manufactured by Mitsui Chemicals, Inc.), MODIC-AP F512, F503,
F504, S505, S515 (manufactured by Mitsubishi Chemical Corporation) Adtex ET (manufactured by Nippon Polyolefin Co., Ltd.), Nisseki
N Polymer A1600 (manufactured by Nisseki N Polymer Co., Ltd.), Toyobo-Vibron-200,300 (manufactured by Toyobo Co., Ltd.),
Technolink R-18, R-18E, R-4003 (manufactured by Taoka Chemical Industry Co., Ltd.) Bond First E, 2B, 7
B, VC-40, EVA (manufactured by Sumitomo Chemical Co., Ltd.) and the like. As the adhesive resin between PS and PP, Admer SF600, SF740, SE800 (manufactured by Mitsui Chemicals, Inc.), MODIC-AP F502 (manufactured by Mitsubishi Chemical Corp.), and Romply SPA-13 (Mitsui Chemicals Inc.) , NUC-ACE GE201, GB301
(Manufactured by Nippon Unicar Co., Ltd.), Nisseki N Polymer A1600
(Nisseki N Polymer Co., Ltd.), Bond First E, 2
B, 7B, TX8030, BF-7B, BF-E, WH
-302 (manufactured by Sumitomo Chemical Co., Ltd.).

[0011] The method for producing the multilayer sheet of the present invention includes:
Preferably, a co-extrusion method is used. The sheet thickness is 0.
It is preferably 15 to 0.45 mm, more preferably 0.2 to 0.4 mm, and most preferably 0.2 to 0.4 mm.
3 to 0.35 mm. If the thickness is less than 0.15 mm, the stiffness of the sheet is weakened, the curl is increased, and the appearance is poor. On the other hand, if the thickness exceeds 0.45 mm, the sheet becomes hard and the push-through property deteriorates. The thickness of the outer layer and the inner layer of the present invention is preferably 0.005 to 0.095 mm, more preferably 0.01 to 0.06 m
m. If the thickness of the outer layer and the inner layer is less than 0.005 mm, the moisture resistance may be poor. On the other hand, if the thickness exceeds 0.095 mm, the moldability deteriorates, which is not preferable.

[0012]

EXAMPLES <Examples 1 to 4> Polypropylene, polystyrene or amorphous polyethylene / terephthalate copolymer and an adhesive resin were extruded using five extruders, and the resin was laminated by a co-extrusion method by leading to a multilayer die. Is cooled through a water-cooled chill roll, taken off,
Total thickness 0.3m with the configuration shown in Table 1 (numerical values are thickness ratio%)
m was prepared.

* The raw materials used are as follows. <For outer layer> ・ PP-1: J103 (manufactured by Grand Polymer) homopolypropylene (MFR = 3.5, density = 0.91) <For intermediate layer> ・ PS: SD-120 (manufactured by Asahi Kasei Kogyo Co., Ltd.) Modified styrene copolymer (MFR = 3.5)-PETG: PETG6763 (manufactured by Eastman Kodak) <for adhesive layer>-Adhesive resin: SF740 (manufactured by Mitsui Chemicals, Inc.) (MF
R = 5.6)

[0014]

[Table 1]

(Comparative Example 1) A polypropylene resin melt-extruded using an extruder was passed through a chill roll (chill roll temperature: 60 ° C.) cooled with water to be cooled and taken out.
A single-layer sheet having a thickness of 3 mm was produced. * The current materials used are as follows.・ PP-1: J103 (made by Grand Polymer) (MFR
= 3.5, density = 0.91)

Comparative Example 2 A single-layer PVC-based PTP sheet VSS-1202 (manufactured by Sumitomo Bakelite Co., Ltd.) was used.

The evaluation results of Examples and Comparative Examples are shown in Tables 2 and 3.
Shown in * The evaluation method is as follows. PTP moldability: molded using a PVC tablet mold (diameter 10 mmφ, depth 5 mm) in a PTP molding machine (FBP-M2 manufactured by CKD Co., Ltd.). The molding temperature range was determined by comprehensive evaluation of the followability, the appearance unevenness of the pocket top portion, and the thickness of the top portion, corner portions, and side portions. The mold followability and the appearance unevenness of the top were visually evaluated, and the thickness of the top, corner, and side surfaces were determined by measurement with a dial gauge. The uniformity of the thickness distribution of the molding pocket was divided into two parts by a cutter blade and determined by a photograph of a cross section. Curl after punching: Molded under the best conditions in the above evaluation of the molding temperature range, sealed with aluminum foil at 210 ° C. without filling the contents, slittered at 175 ° C., width 37 mm A molded product punched at a length of 94 mm and a corner of 5 mmR was placed on a flat surface, and the warpage of the molded product 10 minutes after punching was measured. For six molded products,
Six locations beside each forming pocket were measured and the average value was determined for evaluation. The aluminum foil used was a 20 μm hard aluminum foil coated with 5 μm of maleated polypropylene. -Transparency; JIS-K-7105 for the internal haze of the sheet
It measured based on. -Flexural rigidity: measured according to JIS-K-7106. -Impact resistance: by a method in accordance with JIS-K-7211,
The Dupont impact value at 23 ° C. was measured.

[0018]

[Table 2]

[0019]

[Table 3]

[0020]

According to the present invention, it is possible to obtain a multilayer sheet for PTP packaging which is excellent in transparency, moldability, rigidity, etc., has a small curl after aluminum sealing, and can be molded with a molded plate for PVC.

Claims (1)

[Claims] 1. A multilayer sheet comprising at least five layers of an outer layer / adhesive resin layer / intermediate layer / adhesive resin layer / inner layer, wherein the outer layer and the inner layer are made of a polypropylene resin, and the intermediate layer is made of amorphous polyethylene. A multilayer sheet for PTP packaging, comprising a terephthalate resin or a polystyrene resin.