JP2000290174A - Transdermal absorbent product separator - Google Patents

Abstract

PROBLEM TO BE SOLVED: To easily form a release treatment layer, to exhibit a stable release property with a smooth surface, to have a small adsorption amount of a medicinal component of a transdermal absorbent, and to release by a printing ink. There is no problem of curing inhibition of the agent, and there is a stiffness, so the handleability during use and workability during manufacture are good, and the handling method of the separator, precautions, product name, etc. can be specified, and after removal and removal It is an object of the present invention to provide a transdermal absorbent product separator having a discriminating property in which the separator can be easily visually recognized. The separator (A) is provided in contact with the transdermal absorbent layer (B). This separator (A) is the innermost layer
(11) and the outermost layer (12) are both transparent resin layers, and these two layers (11), the laminated body (13) having a discrimination layer (13) having a visibility imparting function in the middle of (12) 1) and has a structure in which a release treatment layer (2) with a release agent is formed on at least one surface of the laminate (1).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an improvement in a separator provided in contact with a transdermal absorbent layer in a transdermal absorbent product.

[0002]

2. Description of the Related Art As a separator (release sheet) for an adhesive transdermal absorbent product, a material obtained by applying a release treatment agent on one or both sides of a substrate and fixing by heating is generally used. . Here, as the substrate, a paper substrate such as glassine paper, a laminated paper obtained by laminating polyethylene or the like on paper, a film substrate such as a biaxially stretched polyester film, etc. are used. As the release agent, for example, a silicone-based release agent is used.

[0003] Adhesive-type transdermal absorbent products using this separator typically have a layer structure of "separator / adhesive layer containing percutaneously absorbable drug / support layer". In this method, the separator is peeled off from the product, and the remaining sheet is adhered to the skin with the adhesive layer side.

Japanese Patent Application Laid-Open No. 9-263532 discloses a method having a support, a pressure-sensitive adhesive layer, and a release liner, wherein a drug dispersed in a pressure-sensitive adhesive layer or a drug in a drug storage layer is subjected to the pressure-sensitive adhesive. A percutaneous absorption preparation in which a support and / or a release liner is a polyethylene naphthalate film is shown as a percutaneous absorption preparation which is configured to be absorbed into the body from the skin surface to which it is applied via an adhesive layer. ing.

Japanese Patent Application Laid-Open No. 9-156 filed by the present applicant
No. 060 discloses, as a release sheet mainly for an adhesive type transdermal absorbent product, (a) a resin film is provided on at least one surface of a biaxially stretched polyester film, and a silicone-based release film is provided on at least one of the resin films. (B) A release sheet having a structure in which a resin layer containing a silicone-based release agent is provided on at least one surface of a biaxially stretched polyester film.

JP-A-9-157 filed by the present applicant
No. 608 discloses that a biaxially stretched polyester film is provided with an aluminum foil on at least one side as a release sheet mainly for an adhesive-type transdermal absorbent product, and at least one of the aluminum foils is treated with a silicone-based release agent. A release sheet having a configuration provided with a layer is shown.

[0007]

In a separator obtained by directly treating a paper such as glassine paper with a release agent, the active ingredient of the transdermal absorbent is adsorbed to the separator. There is a problem that it is reduced. Separators in which the polyethylene layer side of a laminated paper obtained by laminating a thermoplastic resin such as polyethylene on paper is treated with a release agent are not suitable for long-term storage because some types of medicinal components are adsorbed to the polyethylene layer. There is.

A separator using a transparent film substrate typified by a biaxially stretched polyester film is not noticed even if the separator falls on the floor or the like after use, and slips when stepping on a foot to cause an unexpected accident. There is a problem that there is a possibility that there is a possibility that there is a possibility that punching in a manufacturing process and stiffness in use are insufficient. JP-A-9-2
The same applies to the case where a polyethylene naphthalate film is used as a film substrate (release liner) as in JP-A-63532.

[0009] Among the release sheets disclosed in JP-A-9-156060, a resin film is provided on a biaxially stretched polyester film as shown in (a) and the resin film is peeled off, and a biaxial film is obtained as shown in (b). A stretched polyester film provided with a release agent-containing resin coating on at least one surface does not cause a problem in storage stability of the medicinal component, but has a problem in visibility.

[0010] After printing on the surface of the biaxially stretched polyester film, it is conceivable to apply a release treatment to the printed surface. However, in this separator, the printing ink adsorbs the medicinal component of the transdermal absorbent. In addition, there are problems that the curing of the release agent may be hindered by the printing ink, and that the release processing surface becomes uneven due to the printing pattern, so that the release performance is not stable.

It is also conceivable that after printing on the surface of the biaxially stretched polyester film, a release treatment is performed on the surface opposite to the printed surface (back surface of the printed film). The components are adsorbed by the printing layer of the separator, and in the case where the printing is partial printing, an easy-adhesion surface such as a corona discharge treatment applied for the purpose of enhancing the adhesion of the printing ink is exposed in a portion without printing. For this reason, when the separator is wound up in a roll shape, the release-treated surface comes into contact with the easy-adhesion surface, and the release performance may be unstable.

A release sheet having a layer structure of biaxially stretched polyester film / aluminum foil / release treatment layer disclosed in Japanese Patent Application Laid-Open No. 9-157608 has a limitation in transparency and design due to the presence of an aluminum foil. Since it is relatively expensive, there is a problem that it is disadvantageous in terms of cost.

Under such a background, the present invention can easily form a release-treated layer, exhibit a smooth and stable release property, and reduce the adsorption amount of a medicinal component of a transdermal absorbent. , There is no problem of the curing inhibition of the release agent by the printing ink, there is a stiffness, good handling at the time of use and workability at the time of manufacture, and also the handling method of the separator, precautions, product name, etc. can be specified, It is still another object of the present invention to provide a transdermal absorbent product separator having a discriminating property that allows the separator after peeling and removal to be easily visually recognized.

[0014]

The percutaneous absorbent separator of the present invention is a separator (A) provided in contact with the percutaneous absorbent layer (B), wherein the separator (A) is , The innermost layer (1
1) and the outermost layer (12) are both transparent resin layers, and a laminate (1) in which a discriminating layer (13) having a visibility imparting function is located between the two layers (11) and (12). ) And having a structure in which a release treatment layer (2) with a release agent is formed on at least one surface of the laminate (1).

[0015]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail.

<Separator (A)> In the separator (A), both the innermost layer (11) and the outermost layer (12) are transparent resin layers,
The laminate (1) includes a discrimination layer (13) having a visibility-imparting function located between the two layers (11) and (12). On at least one surface of the laminate (1), a release treatment layer (2) is formed by a release agent.

As the transparent resin layer forming the innermost layer (11) and the outermost layer (12), for example, polyester, polyamide, polyethylene, polypropylene, polymethylpentene, polystyrene, polyurethane, polycarbonate, polyacrylonitrile, polyvinyl chloride And films such as polyvinylidene chloride, polymethyl methacrylate, polyvinyl alcohol, ethylene-vinyl alcohol copolymer, and cellulose triacetate. The film may be unstretched or biaxially stretched.
Among these, a biaxially stretched polyester film is particularly suitable in consideration of the mechanical properties (strength, rigidity / rigidity, dimensional stability, etc.), non-adsorption of medicinal components, incineration, printing suitability, cost, etc. is there. Here, the polyester is a general term for polyethylene terephthalate, polybutylene terephthalate, polytrimethylene terephthalate, polyethylene naphthalate and the like.

The transparent resin layer forming the innermost layer (11) or the outermost layer (12) may be an epoxy resin, a urethane resin, or a resin coating as described in JP-A-9-156060.
It may be a resin layer formed by applying a polyester resin, an amino alkyd resin, an ester acrylate resin, a cellulose resin, or the like.

The thickness of the resin layer forming the innermost layer (11) and the outermost layer (12) is not particularly limited, but is 0.1 to 20 respectively.
It is often selected from the range of about 0 μm, especially about 0.1 to 150 μm. However, when one of them is extremely thin, the other is set to be thick to secure necessary strength and waist. The resin layer of the innermost layer (11) and the resin layer of the outermost layer (12)
The same type or different types may be used, and even in the case of the same type, the thickness may be different.

The laminate (1), in which both the innermost layer (11) and the outermost layer (12) are transparent resin layers, is formed by a method such as dry lamination, extrusion lamination, thermocompression bonding (thermal lamination), or coating. Can be obtained by laminating

Between the innermost layer (11) and the outermost layer (12),
The discrimination layer (13) having the visibility imparting function is positioned. A representative discriminating layer (13) includes a printing layer (13a) and a paper layer (13b).
Or a colored adhesive layer (13c), which may be a combination of two or more.

The printing layer (13a) is a layer for imparting discriminability to the separator (A), and includes a handling method, precautions,
A product name or the like can also be displayed. The printing layer (13a)
It may be a partial print layer or a full print layer. The printing layer (13a) is formed by using a known printing method (such as a gravure printing method) using an arbitrary printing ink. Printing layer (13
a) is provided on the inner surface of the innermost layer (11) or the outermost layer (12) of the laminate (1), or on at least one surface of a paper layer (13b) described later.

The paper layer (13b) is a layer for imparting discriminability to the separator (A), and various papers such as high quality paper, medium quality paper, kraft paper and recycled paper are used. This paper layer (13b) also plays a role in giving the separator (A) a stiffness, thereby improving the punching suitability in the manufacturing process of the transdermal absorbent product, and omitting the printing layer (13a). Therefore, it is preferable in terms of cost.
When the discriminating layer (13) is a paper layer (13b), it is particularly preferable to use a biaxially stretched polyester film as the innermost layer (11) and the outermost layer (12).

The colored adhesive layer (13c) is also used as a separator.
(A) is a layer for imparting discriminability, the dye layer and the adhesive in the lamination of the innermost layer (11) and the outermost layer (12), the above-mentioned printing layer (13a ) And paper layer
Even when (13b) is not provided, discrimination can be ensured.

When laminating the innermost layer (11) and the outermost layer (12) through an adhesive layer (ad), the adhesive layer
Since (ad) can be designed freely in type and thickness,
Even if the above paper layer (13b) is not provided,
Even if (13b) is thin, the necessary waist can be obtained. When a colored adhesive is used as the adhesive layer (ad), the colored adhesive layer (13c) as the above-described discrimination layer (13) is obtained.

On the inner surface side of the resin layer forming the innermost layer (11) and the outermost layer (12), prior to the installation of the discriminating layer (13) and the adhesive layer (ad), the adhesion is improved by corona discharge treatment or the like. It is preferable to perform a treatment.

Examples of preferred layer constitutions of the laminate (1) are: innermost layer (11) / printed layer (13a) / outermost layer (12); innermost layer (11) / printed layer (13a) / adhesive Layer (ad) / Outermost layer (1
2), ・ Innermost layer (11) / adhesive layer (ad) / printing layer (13a) / outermost layer (1
2), ・ Innermost layer (11) / adhesive layer (ad) / paper layer (13b) / adhesive layer (a
d) / outermost layer (12) ・ Innermost layer (11) / printing layer (13a) / adhesive layer (ad) / paper layer (13)
b) / adhesive layer (ad) / outermost layer (12), innermost layer (11) / adhesive layer (ad) / paper layer (13b) / adhesive layer (a
d) / printing layer (13a) / outermost layer (12), innermost layer (11) / adhesive layer (ad) / printing layer (13a) / paper layer (13)
b) / printing layer (13a) / adhesive layer (15) / outermost layer (12), innermost layer (11) / adhesive layer (ad) / paper layer (13b) / printing layer (13)
a) / adhesive layer (ad) / outermost layer (12), innermost layer (11) / adhesive layer (ad) / printing layer (13a) / paper layer (13)
b) / adhesive layer (ad) / outermost layer (12), ・ innermost layer (11) / colored adhesive layer (13c) / outermost layer (12), ・ innermost layer (11) / printing layer (13a) / Colored adhesive layer (13c) / outermost layer (12), innermost layer (11) / colored adhesive layer (13c) / printing layer (13a) / outermost layer (12), etc. Variations are possible.

The separator (A) is made of such a laminate (1)
A release treatment layer with a release agent on at least one surface of
(2) has a structure formed. Release treatment layer
(2) is typically applied by diluting the release agent with a solvent,
It is formed by heat fixing.

As the release agent used for forming the release treatment layer (2), any release agent may be used, and a silicone release agent having excellent and stable release performance is particularly preferred. The thickness of the release treatment layer (2) is suitably about 0.01 to 3 g / m ² , particularly about 0.05 to 1 g / m ² , based on the solid content, when applied by a coating method.

The formation of the release treatment layer (2) with the release agent is carried out, for example, at the stage after the laminate (1) is obtained, or at the innermost layer (1) before the lamination.
It can be carried out at the stage of 1) or the outermost layer (12), the stage of the innermost layer (11) or the outermost layer (12) provided with the printed layer (13) before lamination.

When the innermost layer (11) or the outermost layer (12) is formed of a resin coating as described in JP-A-9-156060, the release treatment layer (2) is separated into the resin coating. Alternatively, a release agent (2) with a release agent is formed on at least one surface of the laminate (1).

<Transdermal Absorbent Layer (B)> As the transdermal absorbent layer (B), for example, a patch component (acrylic adhesive or the like)
And a layer of a composition in which a medicinal ingredient (various medicinal ingredients including indomethacin, ketoprofen, salicylic acid, nitroglycerin, nicotinic acid and the like) and, if necessary, an auxiliary agent (such as a penetrant) are included.

<Adhesive type transdermal absorbent product> The transdermal absorbent product is typically composed of a separator (A) / a transdermal absorbent layer (B).
/ Support layer (C) and packaged in a suitable packaging material. Among them, as the support layer (C), for example, a woven fabric, a nonwoven fabric, a knitted fabric, a film and the like are used.

When using this adhesive transdermal absorbent product, the separator (A) is first peeled off and then the transdermal absorbent layer (B) side of the remaining sheet is brought into contact with the skin to adhere. Just wear it. In order to complete the sticking, an adhesive sheet may be further stuck on the sticking sheet. The medicinal components contained in the transdermal absorbent layer (B) are gradually absorbed from the skin, and the desired medicinal effects are exerted for a long time.

[0035]

The present invention will be further described with reference to the following examples.

<Manufacture of Separator (A)> Example 1 FIG. 1 is an explanatory view schematically showing a separator (A) of the present invention including its manufacturing process and method of use.

In FIG. 1, (1) is a laminate, (11) is the innermost layer, (1)
2) is the outermost layer, (13a) is a printing layer as an example of the discriminating layer (13), and (ad) is an adhesive layer. The release treatment layer (2) is shown by a dotted line so as not to be confused with other layers. (corona) is a corona discharge treated surface. (A) is a separator, (B) is a transdermal absorbent layer, and (C) is a support layer.

Thickness of 25 μm with one surface subjected to corona discharge treatment in advance
m on a corona discharge treated surface of a biaxially stretched polyethylene terephthalate film ("Lumirror H-10" manufactured by Toray Industries, Inc.) (an example of the outermost layer (12)). Pack Super Grass Color ") was printed on a 1 cm × 1 cm grid pattern using a gravure coater, and dried at 60 ° C. for 6 seconds to form a print layer (13a) to prepare a printing material.

Separately from this, an adhesive (“AD308 A & B” manufactured by Toyo Morton Co., Ltd.) is applied to the corona discharge treated surface of the same biaxially stretched polyethylene terephthalate film (an example of the innermost layer (11)) on a dry basis. Then, the coating was applied so as to have a concentration of 3 g / m ² , and then bonded to the surface of the printing raw material on the side of the printing layer (13a).

Thus, “the innermost layer (11) / adhesive layer (ad)
/ Printed layer (13a) / Outermost layer (12) "
Since (1) was obtained, a silicone release agent for release paper (manufactured by Dow Corning Toray Silicone Co., Ltd.) was placed on one side of the laminate (1) (the surface on the innermost layer (11) side in FIG. 1). Of “SD7229”) was applied at a dry basis of 0.2 g / m ² , dried, cured and fixed at 120 ° C. for 30 seconds to form a release-treated layer (2). The desired separator (A) was obtained.

Example 2 In Example 1, the outermost layer (12) was printed on the entire surface by printing.
A separator (A) was obtained in the same manner as in Example 1 except that (13a) was provided.

Example 3 A separator (A) was obtained in the same manner as in Example 2 except that "KS-847" manufactured by Shin-Etsu Chemical Co., Ltd. was used as the silicone-based release agent.

Comparative Example 1 The same printing ink as in Example 1 was applied to the corona discharge treated surface of a 50 μm-thick biaxially stretched polyethylene terephthalate film (“Lumirror H-10” manufactured by Toray Industries, Inc.) which had been subjected to corona discharge treatment on one side in advance. 1cm x 1 with gravure coater
The sheet was printed on a square grid pattern and dried at 60 ° C. for 6 seconds to prepare a printing material. The same silicone-based release agent as in Example 1 was applied to the surface opposite to the printing surface of the printing material, dried and cured to obtain a separator (A).

Comparative Example 2 The same printing ink as in Example 2 was applied to the corona-discharge-treated surface of a biaxially stretched polyethylene terephthalate film ("Lumirror H-10" manufactured by Toray Industries, Ltd.) having a thickness of 50 μm and having one surface subjected to corona discharge treatment in advance. The entire surface was printed with a gravure coater and dried at 60 ° C. for 6 seconds to prepare a printing material. The same silicone-based release agent as in Example 2 was applied to the printing surface of the printing material, dried and cured to form a separator (A).
I got

<Measurement Method> Using the separators (A) prepared in Examples 1 to 3 and Comparative Examples 1 and 2, the peeling force, the residual adhesion rate, and the drug adsorbability were measured by the following methods.

(1) Peeling Force A polyester adhesive tape (“No. 31B” manufactured by Nitto Denko Corporation) is adhered to the surface of the separator (A) prepared in Examples and Comparative Examples on the side of the peeling treatment layer (2). In total, 20
Heat treatment at 70 ° C. for 20 hours under a load of g / cm ² . This is applied to a tensile tester, and the resistance value when peeling the polyester tape from the separator (A) at an angle of 180 ° and at a speed of 0.3 m / min is defined as a peeling force. The measurement was performed four times, and the average of the measured values and the minimum-maximum range of the measured values were obtained.

(2) Residual Adhesion Rate A polyester adhesive tape (“No. 31B” manufactured by Nitto Denko Corporation) was applied to the surface of the separator (A) prepared in Examples and Comparative Examples on the side of the release treatment layer (2). Paste, 20
g / cm ² and heat treatment at 70 ° C for 20 hours.
This is peeled off from the separator (A) and attached to a stainless steel plate. On the other hand, the tape obtained by attaching the tape to a stainless steel plate is used as a blank, and each of the blanks is subjected to a tensile tester to measure the resistance value when peeled off, and the percentage is calculated based on the blank. It is determined that the closer the obtained value is to 100%, the better the residual adhesion ratio is.

(3) Drug Adsorbability A commercially available anti-inflammatory and analgesic product with a separator (“NOBINOBI” manufactured by Hisamitsu Pharmaceutical Co., Ltd.) is provided on the surface of the separator (A) prepared in Examples and Comparative Examples on the side of the release treatment layer (2). Salon ship ")
The percutaneous absorbent layer (B) / the support layer (C) and the percutaneous absorbent layer (B) of the support layer (C) from which the separator has been peeled off are adhered. This is put in a bag made of an aluminum foil laminated film, and then the opened part is heat-sealed to make it hermetically sealed and left in an oven at 40 ° C. for one month. On the other hand, the above-mentioned commercially available anti-inflammatory analgesic product with a separator is placed in the same bag as it is and left under the same conditions as a blank. Then, the amount of L-menthol contained in each separator after standing is measured by liquid chromatography, and the percentage is calculated based on the blank. The higher the value obtained, the smaller the amount of drug (transdermal absorbent) adsorbed by the separator (A).

<Measurement Results> The results are shown in Table 1 below. Table 1
From the comparison between Examples 1 and 2 and Comparative Example 1 and Example 3 and Comparative Example 2, the examples show that the peeling force is more stable, and that the residual adhesion rate of the examples is better. It can be seen that the amount of drug adsorbed by the separator (A) is clearly smaller in the example.

[0050]

[Table 1]

Embodiment 4 FIG. 2 is an explanatory view schematically showing another example of the separator (A) of the present invention. In FIG. 2, (13b) is a paper layer as an example of the discrimination layer (13), and (ad) is an adhesive layer.

[0052] high-quality paper having a basis weight 78 g / m ² on both surfaces of the (paper layer (an example of 13b)), using a polyurethane adhesive (4-6 g / m ² on a dry basis per each side), thickness 16μm A biaxially stretched polyethylene terephthalate film (an example of the innermost layer (11) and the outermost layer (12)) was dry-laminated.

Thus, “the innermost layer (11) / adhesive layer (ad)”
/ Paper layer (13b) / adhesive layer (ad) / outermost layer (12), a laminate (1) was obtained. One side of the laminate (1) (the innermost layer in FIG. 2) was obtained. (11) side), a solvent solution of a silicone-based release agent for release paper (“SD7229” manufactured by Dow Corning Toray Silicone Co., Ltd.) on a dry basis.
Coated to 0.2 g / m ² and dried, then 120 ° C x 30
Cured and fixed under the conditions of seconds, the target separator
(A) was obtained. An anti-inflammatory analgesic product using the separator (A) (the active ingredient in the transdermal absorbent layer (B) is ketoprofen)
Was prepared.

The results are shown below. This separator (A)
It had the same favorable workability as conventional paper-based release paper and was difficult to adsorb drugs.・ Thickness: 138μm (JIS P 8118) ・ Tensile strength (MD direction): 17kgf / 15mm (JIS P 8113) ・ Elongation (MD direction): 4.4% (JIS P 8132) ・ Tear strength (TD direction): 125gf ( (JIS P 8116)-Peeling force: 160gf / 50mm (rubber adhesive)-Peeling force: 35gf / 50mm (acrylic adhesive)-Residual adhesive rate: 100% (acrylic tape)-Drug adsorption: no ketoprofen adsorption

Embodiment 5 FIG. 3 is an explanatory view schematically showing still another example of the separator (A) of the present invention. In FIG. 3, (13a) indicates the printing layer, and (1a)
3b) is the paper layer.

A basis weight 11 having a printing layer (13a) on both sides in advance
0g / m2 ^high quality paper (an example of paper layer (13b))
By extrusion lamination using a 0 μm polyethylene layer as an adhesive layer (ad), a 16 μm thick biaxially stretched polyethylene terephthalate film (the innermost layer (11) and the outermost layer)
(Example of (12)) was laminated.

Thus, “the innermost layer (11) / adhesive layer (ad)
/ Printing layer (13a) / Paper layer (13b) / Printing layer (13a) / Adhesive layer
(ad) / outermost layer (12) ", a release treatment layer (2) was formed on one surface of the laminate (1) in the same manner as in Example 4. And the intended separator (A)
I got An anti-inflammatory analgesic product (the active ingredient in the transdermal absorbent layer (B) was ketoprofen) was prepared using this separator (A).

The results are shown below. This separator (A)
It had the same favorable workability as conventional paper-based release paper and was difficult to adsorb drugs.・ Thickness: 171μm (JIS P 8118) ・ Tensile strength (MD direction): 18kgf / 15mm (JIS P 8113) ・ Elongation (MD direction): 4.0% (JIS P 8132) ・ Tear strength (TD direction): 136gf ( (JIS P 8116)-Peeling force: 313gf / 50mm (rubber adhesive)-Peeling force: 33gf / 50mm (acrylic adhesive)-Residual adhesive rate: 100% (acrylic tape)-Drug adsorption: no ketoprofen adsorption

Embodiment 6 FIG. 4 is an explanatory view schematically showing the separator (A) of the present invention including its manufacturing steps.

In the sixth embodiment, the adhesive layer (ad) in the first embodiment is replaced with a colored adhesive layer (13c) (an example of the discrimination layer (13)) obtained by adding a coloring agent to the adhesive. It is.

[0061]

EFFECTS OF THE INVENTION The separator for percutaneous absorbent products of the present invention has the following features:-The release treatment layer (2) is easily formed on the laminate (1), and the surface has a smooth and stable release property.・ The amount of the medicinal component adsorbed from the transdermal absorbent layer (B) by the separator (A) is small. ・ When the discriminating layer (13) is the printing layer (13a), the layer is Because it is provided inside, there is no problem of curing of the release agent by the printing ink. ・ The printing layer is formed on the innermost layer (11) or outermost layer (12) or the paper layer (13b) constituting the laminate (1). By providing (13a),
Separator layer (13) (print layer (13a), paper layer (13b), colored adhesive layer (13c)) can be specified. The separator (A) peeled and removed from the percutaneous absorbent product has discrimination properties.When a paper layer (13b) is provided as the discrimination layer (13), the preferred processing is the same as that of conventional paper base release paper. A suitable separator (A) is obtained, and the incineration treatment at the time of disposal is also facilitated. ・ The laminate of the innermost layer (11) and the outermost layer (12) is bonded to the adhesive layer (a
When performing through d), the adhesive layer (ad) or the colored adhesive layer (13c) can be designed freely in type and thickness, so even if the above-described paper layer (13b) is not provided. Also, even when the paper layer (13b) to be provided is thin, it is possible to obtain a necessary stiffness.

[Brief description of the drawings]

FIG. 1 is an explanatory view schematically showing a separator (A) of the present invention, including its manufacturing process and method of use.

FIG. 2 is an explanatory view schematically showing another example of the separator (A) of the present invention.

FIG. 3 is an explanatory view schematically showing still another example of the separator (A) of the present invention.

FIG. 4 is an explanatory view schematically showing a separator (A) of the present invention including its manufacturing steps.

[Explanation of symbols]

(A) ... separator, (B) ... transdermal absorbent layer, (C) ... support layer, (1) ... laminate, (11) ... innermost layer, (12) ... outermost layer, (13)
... discriminating layer, (13a) ... printing layer, (13b) ... paper layer, (13c) ... colored adhesive layer, (ad) ... adhesive layer, (2) ... release treatment layer,
(corona): Corona discharge treated surface

 ────────────────────────────────────────────────── ─── Continuing on the front page (72) Inventor Moto Kiriya 1-4-16 Nimagashi Bakurocho, Chuo-ku, Tokyo F-term in Fujimori Industries Co., Ltd. 4C076 AA71 BB31 CC05 DD37 EE24 EE27 FF01 FF70 4F100 AK01A AK01B AK42 AK52H AR00D AS00C BA04 BA07 BA10A BA10B BA13 CA30D CB00C CC00 DG10C EJ55 GB66 GB90 HB31 HB31C JL11C JL14D JN01A JN01B

Claims (4)

[Claims] 1. A separator (A) disposed in contact with a transdermal absorbent layer (B), wherein the separator (A) is an innermost layer (1).
1) and the outermost layer (12) are both transparent resin layers, and a laminate (1) in which a discriminating layer (13) having a visibility imparting function is located between the two layers (11) and (12). And a laminate having a structure in which a release treatment layer (2) is formed on at least one surface of the laminate (1) with a release agent. 2. The method according to claim 1, wherein the discriminating layer is a printing layer.
The separator for a transdermal absorbent product according to the above. 3. The separator for a transdermal absorbent product according to claim 1, wherein the discriminating layer (13) is a paper layer (13b). 4. The separator for a transdermal absorbent product according to claim 1, wherein the discriminating layer (13) is a colored adhesive layer (13c).