JP2000503652A - 合成ｉｌ―１０類似体 - Google Patents

合成ｉｌ―１０類似体

Info

Publication number: JP2000503652A
Authority: JP; Japan
Prior art keywords: amino acid; peptide; group; seq; substance
Prior art date: 1996-01-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

JP9525609A

Other languages

English (en)

Japanese (ja)

Other versions

JP2000503652A5 (2

Inventor

グレンヘイ・ラーセン，クリスチャン

イエセール，ボルバラ

Original Assignee

スティーノ・リサーチ・グループ・アクティーゼルスカブ

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-18

Filing date

1997-01-16

Publication date

2000-03-28

1997-01-16 Application filed by スティーノ・リサーチ・グループ・アクティーゼルスカブ filed Critical スティーノ・リサーチ・グループ・アクティーゼルスカブ

2000-03-28 Publication of JP2000503652A publication Critical patent/JP2000503652A/ja

2004-11-11 Publication of JP2000503652A5 publication Critical patent/JP2000503652A5/ja

Status Ceased legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5428—IL-10
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Biophysics (AREA)
Pharmacology & Pharmacy (AREA)
Biochemistry (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

JP9525609A 1996-01-18 1997-01-16 合成ｉｌ―１０類似体 Ceased JP2000503652A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
WO96/00029		1996-01-18
PCT/DK1996/000029 WO1997026278A1 (en)	1996-01-18	1996-01-18	Synthetic il-10 analogues
PCT/DK1997/000021 WO1997026279A1 (en)	1996-01-18	1997-01-16	Synthetic il-10 analogues

Publications (2)

Publication Number	Publication Date
JP2000503652A true JP2000503652A (ja)	2000-03-28
JP2000503652A5 JP2000503652A5 (2)	2004-11-11

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ID=8155499

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Application Number	Title	Priority Date	Filing Date
JP9525609A Ceased JP2000503652A (ja)	1996-01-18	1997-01-16	合成ｉｌ―１０類似体

Country Status (14)

Country	Link
US (1)	US6936586B1 (2)
EP (1)	EP0879245A1 (2)
JP (1)	JP2000503652A (2)
KR (1)	KR19990077344A (2)
CN (1)	CN1226899A (2)
AP (1)	AP883A (2)
AR (1)	AR006517A1 (2)
AU (2)	AU4385696A (2)
BR (1)	BR9707036A (2)
CA (1)	CA2243275A1 (2)
PL (1)	PL327928A1 (2)
RU (1)	RU2194054C2 (2)
WO (2)	WO1997026278A1 (2)
ZA (1)	ZA9784B (2)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4385696A (en) *	1996-01-18	1997-08-11	Christian Gronhoj Larsen	Synthetic il-10 analogues
AU6887096A (en) *	1996-09-11	1998-04-02	Patrick T. Prendergast	Immune direction therapy
EP1021173A1 (en) *	1997-10-10	2000-07-26	Imperial College Innovations Limited	Use of csaid?tm compounds for the management of uterine contractions
DE19851675A1 (de) *	1998-11-10	2000-05-11	Bayer Ag	Menschliche Interleukin-10 Mutantenproteine
WO2000037096A2 (en) *	1998-12-22	2000-06-29	Schering Corporation	Treatment of hepatitis c virus infections with interleukin-10
AU4545301A (en) *	2000-03-14	2001-09-24	Nat Jewish Med & Res Center	Method and composition for treating airway hyperresponsiveness
US20070160576A1 (en) *	2001-06-05	2007-07-12	Genentech, Inc.	IL-17A/F heterologous polypeptides and therapeutic uses thereof
US6797722B2 (en) *	2002-05-03	2004-09-28	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Use of 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole for the treatment of autoimmune diseases
RU2260598C2 (ru) *	2003-10-29	2005-09-20	Российский кардиологический научно-производственный комплекс Министерства здравоохранения РФ	Пептид, обладающий способностью ингибировать миграцию моноцитарных клеток, стимулированную белком мср-1
GB0500643D0 (en) *	2005-01-13	2005-02-23	Renovo Ltd	Medicaments
EP2952522B1 (en)	2007-01-31	2019-10-30	Dana-Farber Cancer Institute, Inc.	Stabilized p53 peptides and uses thereof
AU2008232709C1 (en)	2007-03-28	2015-01-15	President And Fellows Of Harvard College	Stitched polypeptides
AU2014201269B2 (en) *	2008-02-08	2016-09-15	Aileron Therapeutics, Inc.	Therapeutic peptidomimetic macrocycles
KR20100126361A (ko) *	2008-02-08	2010-12-01	에일러론 테라퓨틱스 인코포레이티드	치료용 펩티드유사 거대고리
AR088392A1 (es)	2011-10-18	2014-05-28	Aileron Therapeutics Inc	Macrociclos peptidomimeticos
CA2862038C (en)	2012-02-15	2021-05-25	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles
HK1205454A1 (en)	2012-02-15	2015-12-18	Aileron Therapeutics, Inc.	Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2014138429A2 (en)	2013-03-06	2014-09-12	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and use thereof in regulating hif1alpha
WO2016049359A1 (en)	2014-09-24	2016-03-31	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
US10253067B2 (en)	2015-03-20	2019-04-09	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and uses thereof
JP2018528217A (ja)	2015-09-10	2018-09-27	エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎＴｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ．	Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
US10610104B2 (en)	2016-12-07	2020-04-07	Progenity, Inc.	Gastrointestinal tract detection methods, devices and systems
EP3600414A1 (en)	2017-03-30	2020-02-05	Progenity Inc.	Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist
US20220249814A1 (en)	2018-11-19	2022-08-11	Progenity, Inc.	Methods and devices for treating a disease with biotherapeutics
BR102019007044A2 (pt) *	2019-04-05	2021-12-28	Universidade Federal de Uberlândia	Peptídeos sintéticos com afinidade ao receptor de interleucina-10, composição farmacêutica e uso dos mesmos como imunomuduladores no tratamento de doenças autoimunes, inflamatórias ou alérgicas
CN121197633A (zh)	2019-12-13	2025-12-26	比特比德科有限责任公司	用于将治疗剂递送至胃肠道的可摄取装置

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4235871A (en)	1978-02-24	1980-11-25	Papahadjopoulos Demetrios P	Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en)	1983-01-06	1985-02-26	Technology Unlimited, Inc.	Masking of liposomes from RES recognition
US4837028A (en)	1986-12-24	1989-06-06	Liposome Technology, Inc.	Liposomes with enhanced circulation time
IL94878A (en) *	1989-06-28	2003-01-12	Schering Corp	Cytokine synthesis inhibitory factor, antagonists thereof and methods of using same
US5624823A (en) *	1991-11-22	1997-04-29	The General Hospital Corporation	DNA encoding procine interleukin-10
EP0629130A1 (en)	1992-03-04	1994-12-21	Schering Corporation	Use of interleukin-10 to suppress graft-vs.-host disease
RU2051922C1 (ru) *	1992-06-19	1996-01-10	Людмила Яковлевна Соловьева	СПОСОБ ВЫДЕЛЕНИЯ РЕКОМБИНАНТНОГО ИНТЕРЛЕЙКИНА - 1β ИЗ БИОМАССЫ МИКРООРГАНИЗМОВ
CA2085291A1 (en)	1992-07-30	1994-01-31	Martin L. Breitman	Novel receptor tyrosine kinase
US5328989A (en) *	1993-03-05	1994-07-12	Schering-Plough	Purification of human interleukin-10 from a cell culture medium
US5446128A (en)	1993-06-18	1995-08-29	The Board Of Trustees Of The University Of Illinois	Alpha-helix mimetics and methods relating thereto
FI960353A7 (fi)	1993-07-26	1996-01-26	Schering Corp	Ihmisen interleukiini-10:n agonistit ja antagonistit
US6159937A (en) *	1994-07-05	2000-12-12	Steeno Research Group A/S	Immunomodulators
US5654276A (en) *	1995-06-07	1997-08-05	Affymax Technologies N.V.	Peptides and compounds that bind to the IL-5 receptor
AU4385696A (en) *	1996-01-18	1997-08-11	Christian Gronhoj Larsen	Synthetic il-10 analogues

1996
- 1996-01-18 AU AU43856/96A patent/AU4385696A/en not_active Abandoned
- 1996-01-18 WO PCT/DK1996/000029 patent/WO1997026278A1/en not_active Ceased
1997
- 1997-01-06 ZA ZA9700084A patent/ZA9784B/xx unknown
- 1997-01-16 JP JP9525609A patent/JP2000503652A/ja not_active Ceased
- 1997-01-16 BR BR9707036-0A patent/BR9707036A/pt not_active Application Discontinuation
- 1997-01-16 AU AU13011/97A patent/AU718476B2/en not_active Ceased
- 1997-01-16 CN CN97193092A patent/CN1226899A/zh active Pending
- 1997-01-16 US US09/101,825 patent/US6936586B1/en not_active Expired - Fee Related
- 1997-01-16 PL PL97327928A patent/PL327928A1/xx unknown
- 1997-01-16 WO PCT/DK1997/000021 patent/WO1997026279A1/en not_active Ceased
- 1997-01-16 KR KR1019980705491A patent/KR19990077344A/ko not_active Ceased
- 1997-01-16 AP APAP/P/1998/001295A patent/AP883A/en active
- 1997-01-16 RU RU98115293/04A patent/RU2194054C2/ru not_active IP Right Cessation
- 1997-01-16 EP EP97900549A patent/EP0879245A1/en not_active Withdrawn
- 1997-01-16 CA CA002243275A patent/CA2243275A1/en not_active Abandoned
- 1997-01-17 AR ARP970100194A patent/AR006517A1/es unknown

Also Published As

Publication number	Publication date
WO1997026278A1 (en)	1997-07-24
CN1226899A (zh)	1999-08-25
AU4385696A (en)	1997-08-11
US6936586B1 (en)	2005-08-30
CA2243275A1 (en)	1997-07-24
AR006517A1 (es)	1999-09-08
ZA9784B (en)	1997-07-17
AP883A (en)	2000-10-25
AU718476B2 (en)	2000-04-13
BR9707036A (pt)	1999-08-31
EP0879245A1 (en)	1998-11-25
PL327928A1 (en)	1999-01-04
RU2194054C2 (ru)	2002-12-10
AP9801295A0 (en)	1998-09-30
AU1301197A (en)	1997-08-11
KR19990077344A (ko)	1999-10-25
WO1997026279A1 (en)	1997-07-24

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