JP2000511903A - 糖尿病および肥満の治療のための選択性β▲下３▼作動薬としてのオキサジアゾール・ベンゼンスルホンアミド - Google Patents

糖尿病および肥満の治療のための選択性β▲下３▼作動薬としてのオキサジアゾール・ベンゼンスルホンアミド

Info

Publication number: JP2000511903A
Authority: JP; Japan
Prior art keywords: ethyl; phenyl; hydroxy; oxadiazol; amino
Prior art date: 1996-06-07
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP10500782A

Other languages

English (en)

Japanese (ja)

Inventor

ビフテユ，テスフエイ

フオン，タンチン・デニス

フイツシヤー，マイクル・エイチ

クオ，チヤン―フア

リヤン，コイ―バイ

ウエーバー，アン・イー

ネイラー，エリザベス・エム

Original Assignee

メルクエンドカンパニーインコーポレーテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-06-07

Filing date

1997-06-03

Publication date

2000-09-12

1996-07-05 Priority claimed from GBGB9614191.6A external-priority patent/GB9614191D0/en

1997-06-03 Application filed by メルクエンドカンパニーインコーポレーテッド filed Critical メルクエンドカンパニーインコーポレーテッド

2000-09-12 Publication of JP2000511903A publication Critical patent/JP2000511903A/ja

Status Pending legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Emergency Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

JP10500782A 1996-06-07 1997-06-03 糖尿病および肥満の治療のための選択性β▲下３▼作動薬としてのオキサジアゾール・ベンゼンスルホンアミド Pending JP2000511903A (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US1929596P	1996-06-07	1996-06-07
GB60/019,295		1996-07-05
GBGB9614191.6A GB9614191D0 (en)	1996-07-05	1996-07-05	Oxadiazole benzenesulfonamides as selectives B3 agonists for the treatment of diabetes and obesity
GB9614191.6		1996-07-05
PCT/US1997/009536 WO1997046556A1 (en)	1996-06-07	1997-06-03	OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Publications (1)

Publication Number	Publication Date
JP2000511903A true JP2000511903A (ja)	2000-09-12

Family

ID=26309646

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP10500782A Pending JP2000511903A (ja)	1996-06-07	1997-06-03	糖尿病および肥満の治療のための選択性β▲下３▼作動薬としてのオキサジアゾール・ベンゼンスルホンアミド

Country Status (5)

Country	Link
EP (1)	EP0906310A4 (de)
JP (1)	JP2000511903A (de)
AU (1)	AU712057B2 (de)
CA (1)	CA2257206A1 (de)
WO (1)	WO1997046556A1 (de)

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JP5546543B2 (ja) *	2009-08-05	2014-07-09	第一三共株式会社	スルホン誘導体
JP2023541375A (ja) *	2020-08-27	2023-10-02	キュラセンセラピューティクスインコーポレイテッド	α１Ａ－アドレナリン受容体アゴニスト及び使用方法

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IL113410A (en) *	1994-04-26	1999-11-30	Merck & Co Inc	Substituted sulfonamides having an asymmetric center and pharmaceutical compositions containing them

1997
- 1997-06-03 WO PCT/US1997/009536 patent/WO1997046556A1/en not_active Ceased
- 1997-06-03 JP JP10500782A patent/JP2000511903A/ja active Pending
- 1997-06-03 AU AU33748/97A patent/AU712057B2/en not_active Ceased
- 1997-06-03 CA CA002257206A patent/CA2257206A1/en not_active Abandoned
- 1997-06-03 EP EP97929769A patent/EP0906310A4/de not_active Ceased

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2007517010A (ja) *	2003-12-24	2007-06-28	プロシディオン・リミテッド	Ｇｐｃｒ受容体作動薬としてのヘテロ環誘導体
JP5546542B2 (ja) *	2009-08-05	2014-07-09	第一三共株式会社	アミド誘導体
JP5546543B2 (ja) *	2009-08-05	2014-07-09	第一三共株式会社	スルホン誘導体
JP2023541375A (ja) *	2020-08-27	2023-10-02	キュラセンセラピューティクスインコーポレイテッド	α１Ａ－アドレナリン受容体アゴニスト及び使用方法

Also Published As

Publication number	Publication date
AU712057B2 (en)	1999-10-28
EP0906310A1 (de)	1999-04-07
EP0906310A4 (de)	1999-09-01
WO1997046556A1 (en)	1997-12-11
AU3374897A (en)	1998-01-05
CA2257206A1 (en)	1997-12-11

Publication	Publication Date	Title
JP2000511903A (ja)	2000-09-12	糖尿病および肥満の治療のための選択性β▲下３▼作動薬としてのオキサジアゾール・ベンゼンスルホンアミド
US20230286961A1 (en)	2023-09-14	Substituted tetrahydrofurans as modulators of sodium channels
AU728812B2 (en)	2001-01-18	Thiazole benzenesulfonamides as beta3 agonists for the treatment of diabetes and obesity
US6291491B1 (en)	2001-09-18	Amide derivatives as β 3 agonists
JP2000507216A (ja)	2000-06-13	ＰＰＡＲ―γに対するアゴニスト活性を有する置換４―ヒドロキシフェニルアルカン酸誘導体
JP2000516593A (ja)	2000-12-12	糖尿病及び肥満症の治療に用いられる選択的β▲下３▼作動物質としての置換スルホンアミド
JP2002513387A (ja)	2002-05-08	選択的β▲下３▼アドレナリン作動性アゴニスト
JPH09512275A (ja)	1997-12-09	糖尿病および肥満の治療のための選択的β▲下３▼作用物質としての置換スルホンアミド
JPH06510034A (ja)	1994-11-10	アザ環式化合物、それらの製造方法、及びそれらを含む医薬組成物
JP2002539201A (ja)	2002-11-19	プロテアーゼインヒビターとしてのアミン誘導体
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US7241784B2 (en)	2007-07-10	Carboxylic acid derivative and a pharmaceutical composition containing the derivative as active ingredient
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JP2000511903A - 糖尿病および肥満の治療のための選択性β▲下３▼作動薬としてのオキサジアゾール・ベンゼンスルホンアミド - Google Patents

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