JP2000513026A - ９−オキシムエリスロマイシン誘導体 - Google Patents

９−オキシムエリスロマイシン誘導体

Info

Publication number: JP2000513026A
Authority: JP; Japan
Prior art keywords: deoxy; hydrazo; desosaminol; deoxo; carbamate
Prior art date: 1997-06-11
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP11501928A

Other languages

English (en)

Japanese (ja)

Inventor

ウー，ヨン−ジン

Original Assignee

ファイザー・プロダクツ・インク

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-11

Filing date

1998-05-15

Publication date

2000-10-03

1998-05-15 Application filed by ファイザー・プロダクツ・インク filed Critical ファイザー・プロダクツ・インク

2000-10-03 Publication of JP2000513026A publication Critical patent/JP2000513026A/ja

Status Pending legal-status Critical Current

Links

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125000000623 heterocyclic group Chemical group 0.000 claims description 39
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MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 description 1
208000001203 Smallpox Diseases 0.000 description 1
241001575049 Sonia Species 0.000 description 1
241001312524 Streptococcus viridans Species 0.000 description 1
241000429524 Strophosoma sus Species 0.000 description 1
241000870995 Variola Species 0.000 description 1
241000219094 Vitaceae Species 0.000 description 1
AKZWRTCWNXHHFR-PDIZUQLASA-N [(3S)-oxolan-3-yl] N-[(2S,3S)-4-[(5S)-5-benzyl-3-[(2R)-2-carbamoyloxy-2,3-dihydro-1H-inden-1-yl]-4-oxo-3H-pyrrol-5-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate Chemical compound NC(=O)O[C@@H]1Cc2ccccc2C1C1C=N[C@](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)O[C@H]2CCOC2)(Cc2ccccc2)C1=O AKZWRTCWNXHHFR-PDIZUQLASA-N 0.000 description 1
238000012937 correction Methods 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
229960003276 erythromycin Drugs 0.000 description 1
YVTFLQUPRIIRFE-QUMKBVJLSA-N erythronolide A Chemical compound CC[C@H]1OC(=O)[C@H](C)[C@@H](O)[C@H](C)[C@@H](O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O YVTFLQUPRIIRFE-QUMKBVJLSA-N 0.000 description 1
238000000605 extraction Methods 0.000 description 1
210000005255 gram-positive cell Anatomy 0.000 description 1
235000021021 grapes Nutrition 0.000 description 1
206010023332 keratitis Diseases 0.000 description 1
229940115932 legionella pneumophila Drugs 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
238000012746 preparative thin layer chromatography Methods 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
SRVJKTDHMYAMHA-WUXMJOGZSA-N thioacetazone Chemical compound CC(=O)NC1=CC=C(\C=N\NC(N)=S)C=C1 SRVJKTDHMYAMHA-WUXMJOGZSA-N 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

JP11501928A 1997-06-11 1998-05-15 ９−オキシムエリスロマイシン誘導体 Pending JP2000513026A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4934997P	1997-06-11	1997-06-11
US60/049,349		1997-06-11
PCT/IB1998/000741 WO1998056800A1 (en)	1997-06-11	1998-05-15	9-oxime erythromycin derivatives

Publications (1)

Publication Number	Publication Date
JP2000513026A true JP2000513026A (ja)	2000-10-03

Family

ID=21959341

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP11501928A Pending JP2000513026A (ja)	1997-06-11	1998-05-15	９−オキシムエリスロマイシン誘導体

Country Status (31)

Country	Link
EP (1)	EP0988308A1 (cs)
JP (1)	JP2000513026A (cs)
KR (1)	KR20010013660A (cs)
CN (1)	CN1259135A (cs)
AP (1)	AP9801253A0 (cs)
AR (1)	AR012244A1 (cs)
AU (1)	AU7226798A (cs)
BG (1)	BG103947A (cs)
BR (1)	BR9810021A (cs)
CA (1)	CA2293335A1 (cs)
CO (1)	CO4940506A1 (cs)
CZ (1)	CZ9904388A3 (cs)
EA (1)	EA199901016A1 (cs)
GT (1)	GT199800074A (cs)
HN (1)	HN1998000073A (cs)
HR (1)	HRP980316A2 (cs)
HU (1)	HUP0002252A3 (cs)
ID (1)	ID24529A (cs)
IL (1)	IL132767A0 (cs)
IS (1)	IS5251A (cs)
MA (1)	MA26505A1 (cs)
NO (1)	NO996108L (cs)
OA (1)	OA11225A (cs)
PA (1)	PA8451801A1 (cs)
PE (1)	PE79899A1 (cs)
PL (1)	PL337606A1 (cs)
TN (1)	TNSN98083A1 (cs)
TR (1)	TR199902995T2 (cs)
TW (1)	TW448174B (cs)
WO (1)	WO1998056800A1 (cs)
ZA (1)	ZA985018B (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
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HN1998000159A (es) *	1997-10-29	1999-02-09	Monsanto Co	Derivados de 9- amino - 3 ceto eritromicina
ES2243066T3 (es) *	1998-09-22	2005-11-16	Pfizer Products Inc.	Antibioticos de carbamato y carbazato cetolida.
FR2786188B1 (fr) *	1998-11-24	2002-10-31	Hoechst Marion Roussel Inc	Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
US6258785B1 (en)	1998-12-02	2001-07-10	Pfizer Inc.	Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
EP1298138B1 (en) *	1998-12-10	2006-11-02	Pfizer Products Inc.	Carbamate and Carbazate Ketolide Antibiotics
US6284732B1 (en) *	1998-12-18	2001-09-04	Bio-Rad Laboratories, Inc.	Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
ATE340183T1 (de) *	1999-04-16	2006-10-15	Kosan Biosciences Inc	Antiinfektiöse makrolidderivate
HUP0201516A3 (en)	1999-05-24	2003-03-28	Pfizer Prod Inc	13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
EP1181300B1 (en) *	1999-06-07	2003-09-17	Abbott Laboratories	6-o-carbamate ketolide derivatives
ID27331A (id) *	1999-09-29	2001-03-29	Pfizer Prod Inc	Pembuatan antibiotik-antibiotik ketolida karbamat
EP1114826A3 (en) *	1999-12-29	2001-10-31	Pfizer Products Inc.	Novel antibacterial and prokinetic macrolides
EP1439186A3 (en) *	1999-12-29	2004-11-03	Pfizer Products Inc.	Intermediates for novel antibacterial and prokinetic macrolides
US6946446B2 (en)	2000-02-24	2005-09-20	Abbott Laboratories	Anti-infective agents useful against multidrug-resistant strains of bacteria
US6403776B1 (en)	2000-07-05	2002-06-11	Pfizer Inc.	Synthesis of carbamate ketolide antibiotics
WO2003090761A1 (en) *	2002-04-25	2003-11-06	Abbott Laboratories	9-oxime macrolide antibacterials
TW200420573A (en)	2002-09-26	2004-10-16	Rib X Pharmaceuticals Inc	Bifunctional heterocyclic compounds and methods of making and using same
EP1638549A4 (en) *	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	NEW ANTIBACTERIAL AGENTS
EP1723159B1 (en)	2004-02-27	2019-06-12	Melinta Therapeutics, Inc.	Macrocyclic compounds and methods of making and using the same
EP2214484A4 (en)	2007-10-25	2013-01-02	Cempra Pharmaceuticals Inc	PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
JP5711135B2 (ja)	2008-10-24	2015-04-30	センプラファーマシューティカルズ，インコーポレイテッド	胃腸疾患を治療するための方法
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
ES2608285T3 (es)	2009-09-10	2017-04-07	Cempra Pharmaceuticals, Inc.	Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
CN102146085B (zh) *	2010-02-09	2014-03-26	北京理工大学	一种9-肟醚酮内酯衍生物、制备方法及其药物组合物
MX361413B (es)	2010-03-22	2018-12-05	Cempra Pharmaceuticals Inc Star	Formas cristalinas de un macrólido y usos para las mismas.
CN102917708B (zh)	2010-05-20	2015-11-25	森普拉制药公司	制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en)	2010-09-10	2014-01-15	Cempra Pharmaceuticals Inc	HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
NZ700182A (en)	2012-03-27	2017-02-24	Cempra Pharmaceuticals Inc	Parenteral formulations for administering macrolide antibiotics
AU2014239959A1 (en)	2013-03-14	2015-10-01	Cempra Pharmaceuticals, Inc.	Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh)	2013-03-15	2015-12-23	森普拉制药公司	用于制备大环内酯抗菌剂的收敛方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5527780A (en) *	1992-11-05	1996-06-18	Roussel Uclaf	Erythromycin derivatives
FR2718450B1 (fr) *	1994-04-08	1997-01-10	Roussel Uclaf	Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

1998
- 1998-05-15 EP EP98919394A patent/EP0988308A1/en not_active Withdrawn
- 1998-05-15 ID IDW991570A patent/ID24529A/id unknown
- 1998-05-15 KR KR1019997011672A patent/KR20010013660A/ko not_active Ceased
- 1998-05-15 IL IL13276798A patent/IL132767A0/xx unknown
- 1998-05-15 CN CN98805848A patent/CN1259135A/zh active Pending
- 1998-05-15 CZ CZ19994388A patent/CZ9904388A3/cs unknown
- 1998-05-15 BR BR9810021-1A patent/BR9810021A/pt not_active IP Right Cessation
- 1998-05-15 HU HU0002252A patent/HUP0002252A3/hu unknown
- 1998-05-15 EA EA199901016A patent/EA199901016A1/ru unknown
- 1998-05-15 WO PCT/IB1998/000741 patent/WO1998056800A1/en not_active Ceased
- 1998-05-15 TR TR1999/02995T patent/TR199902995T2/xx unknown
- 1998-05-15 PL PL98337606A patent/PL337606A1/xx unknown
- 1998-05-15 JP JP11501928A patent/JP2000513026A/ja active Pending
- 1998-05-15 CA CA002293335A patent/CA2293335A1/en not_active Abandoned
- 1998-05-15 AU AU72267/98A patent/AU7226798A/en not_active Abandoned
- 1998-05-19 HN HN1998000073A patent/HN1998000073A/es unknown
- 1998-05-21 PA PA19988451801A patent/PA8451801A1/es unknown
- 1998-06-04 AP APAP/P/1998/001253A patent/AP9801253A0/en unknown
- 1998-06-05 GT GT199800074A patent/GT199800074A/es unknown
- 1998-06-08 PE PE1998000470A patent/PE79899A1/es not_active Application Discontinuation
- 1998-06-08 TW TW087109086A patent/TW448174B/zh active
- 1998-06-09 AR ARP980102703A patent/AR012244A1/es unknown
- 1998-06-10 ZA ZA9805018A patent/ZA985018B/xx unknown
- 1998-06-10 MA MA25105A patent/MA26505A1/fr unknown
- 1998-06-10 TN TNTNSN98083A patent/TNSN98083A1/fr unknown
- 1998-06-11 CO CO98033538A patent/CO4940506A1/es unknown
- 1998-06-11 HR HR60/049,349A patent/HRP980316A2/hr not_active Application Discontinuation
1999
- 1999-11-16 IS IS5251A patent/IS5251A/is unknown
- 1999-12-03 BG BG103947A patent/BG103947A/xx unknown
- 1999-12-03 OA OA9900269A patent/OA11225A/en unknown
- 1999-12-10 NO NO996108A patent/NO996108L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO996108D0 (no)	1999-12-10
CN1259135A (zh)	2000-07-05
CZ9904388A3 (cs)	2002-10-16
AR012244A1 (es)	2000-09-27
HUP0002252A3 (en)	2002-01-28
BR9810021A (pt)	2000-09-19
HUP0002252A2 (hu)	2000-12-28
GT199800074A (es)	1999-11-27
CA2293335A1 (en)	1998-12-17
BG103947A (en)	2000-07-31
TW448174B (en)	2001-08-01
CO4940506A1 (es)	2000-07-24
ID24529A (id)	2000-07-20
OA11225A (en)	2003-07-17
MA26505A1 (fr)	2004-12-20
PL337606A1 (en)	2000-08-28
PA8451801A1 (es)	2000-05-24
WO1998056800A1 (en)	1998-12-17
KR20010013660A (ko)	2001-02-26
HRP980316A2 (en)	1999-04-30
EA199901016A1 (ru)	2000-06-26
TNSN98083A1 (fr)	2005-03-15
TR199902995T2 (xx)	2000-02-21
PE79899A1 (es)	1999-08-25
HN1998000073A (es)	1999-01-08
AU7226798A (en)	1998-12-30
NO996108L (no)	2000-02-10
IL132767A0 (en)	2001-03-19
AP9801253A0 (en)	1999-12-04
ZA985018B (en)	1999-12-10
IS5251A (is)	1999-11-16
EP0988308A1 (en)	2000-03-29

Publication	Publication Date	Title
JP2000513026A (ja)	2000-10-03	９−オキシムエリスロマイシン誘導体
KR100396168B1 (ko)	2003-08-27	4″-치환된-9-데옥소-9ａ-아자-9ａ-호모에리트로마이신 Ａ유도체
EP0988309B1 (en)	2005-11-23	C-4''-substituted macrolide derivatives
EP0941998B1 (en)	2004-09-01	3,6-ketal macrolide antibiotics
JP3842973B2 (ja)	2006-11-08	１３員アザリド類および抗生物質としてのそれらの使用
US6576749B2 (en)	2003-06-10	C-4″-substituted macrolide derivatives
EP0984019B1 (en)	2004-06-02	C11 carbamates of macrolide antibacterials
US6518251B1 (en)	2003-02-11	Macrolides
US6162794A (en)	2000-12-19	Erythromycin derivatives
US6248719B1 (en)	2001-06-19	Tricyclic 3-keto derivatives of 6-O-methylerthromycin
US20020151507A1 (en)	2002-10-17	9-oxime erythromycin derivatives
US6482801B2 (en)	2002-11-19	9a, 11b-dehydro derivatives of 9-oxime-3-keto-6-O- methylerythromycin
MXPA99011494A (en)	2000-07-01	9-oxime erythromycin derivatives
HK1127924A (en)	2009-10-09	13-membered azalides and their use as antibiotic agents
MXPA01005055A (en)	2001-12-04	13-membered azalides and their use as antibiotic agents
EP1437360A2 (en)	2004-07-14	C11 Carbamates of macrolide antibacterials
MXPA99011495A (en)	2001-05-17	4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

JP2000513026A - ９−オキシム エリスロマイシン誘導体 - Google Patents