JP2001526902A5 - - Google Patents
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- Publication number
- JP2001526902A5 JP2001526902A5 JP2000525570A JP2000525570A JP2001526902A5 JP 2001526902 A5 JP2001526902 A5 JP 2001526902A5 JP 2000525570 A JP2000525570 A JP 2000525570A JP 2000525570 A JP2000525570 A JP 2000525570A JP 2001526902 A5 JP2001526902 A5 JP 2001526902A5
- Authority
- JP
- Japan
- Prior art keywords
- capsular polysaccharide
- chromatography
- polysaccharide
- group
- range
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 description 46
- 150000004676 glycans Chemical class 0.000 description 39
- 229920001282 polysaccharide Polymers 0.000 description 39
- 239000005017 polysaccharide Substances 0.000 description 39
- 239000003153 chemical reaction reagent Substances 0.000 description 14
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical group CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 12
- 238000004587 chromatography analysis Methods 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 230000001580 bacterial effect Effects 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 102000039446 nucleic acids Human genes 0.000 description 6
- 108020004707 nucleic acids Proteins 0.000 description 6
- 150000007523 nucleic acids Chemical class 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- WMFOQBRAJBCJND-UHFFFAOYSA-M Lithium hydroxide Chemical compound [Li+].[OH-] WMFOQBRAJBCJND-UHFFFAOYSA-M 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 108091005461 Nucleic proteins Proteins 0.000 description 3
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 3
- 239000012346 acetyl chloride Substances 0.000 description 3
- YBADLXQNJCMBKR-UHFFFAOYSA-N (4-nitrophenyl)acetic acid Chemical compound OC(=O)CC1=CC=C([N+]([O-])=O)C=C1 YBADLXQNJCMBKR-UHFFFAOYSA-N 0.000 description 2
- SMWZGZIZOHNWBH-UHFFFAOYSA-N 3-bromo-5-phenyl-1,2-oxazole Chemical compound O1N=C(Br)C=C1C1=CC=CC=C1 SMWZGZIZOHNWBH-UHFFFAOYSA-N 0.000 description 2
- 125000003047 N-acetyl group Chemical group 0.000 description 2
- 241000588653 Neisseria Species 0.000 description 2
- 241000588650 Neisseria meningitidis Species 0.000 description 2
- 241000193990 Streptococcus sp. 'group B' Species 0.000 description 2
- 210000003850 cellular structure Anatomy 0.000 description 2
- 239000003636 conditioned culture medium Substances 0.000 description 2
- 239000012228 culture supernatant Substances 0.000 description 2
- 238000005227 gel permeation chromatography Methods 0.000 description 2
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 150000007529 inorganic bases Chemical class 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 108010060123 Conjugate Vaccines Proteins 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 238000013375 chromatographic separation Methods 0.000 description 1
- 229940031670 conjugate vaccine Drugs 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 150000002009 diols Chemical group 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000006268 reductive amination reaction Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6860897P | 1997-12-23 | 1997-12-23 | |
| US60/068,608 | 1997-12-23 | ||
| PCT/US1998/027375 WO1999032653A1 (en) | 1997-12-23 | 1998-12-23 | Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugates vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009206304A Division JP5144613B2 (ja) | 1997-12-23 | 2009-09-07 | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001526902A JP2001526902A (ja) | 2001-12-25 |
| JP2001526902A5 true JP2001526902A5 (2) | 2006-02-16 |
| JP4435413B2 JP4435413B2 (ja) | 2010-03-17 |
Family
ID=22083630
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000525570A Expired - Lifetime JP4435413B2 (ja) | 1997-12-23 | 1998-12-23 | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
| JP2009206304A Expired - Lifetime JP5144613B2 (ja) | 1997-12-23 | 2009-09-07 | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009206304A Expired - Lifetime JP5144613B2 (ja) | 1997-12-23 | 2009-09-07 | ワクチンとしてまたは結合体ワクチンとしてタンパク質に連結して使用するための細菌莢膜多糖の抽出および単離法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6248570B1 (2) |
| EP (3) | EP3118225A1 (2) |
| JP (2) | JP4435413B2 (2) |
| KR (2) | KR100757630B1 (2) |
| AT (1) | ATE468403T2 (2) |
| AU (1) | AU754256C (2) |
| CA (1) | CA2316975C (2) |
| CZ (1) | CZ302615B6 (2) |
| DE (1) | DE69841676D1 (2) |
| DK (1) | DK1051506T4 (2) |
| ES (2) | ES2611464T3 (2) |
| HU (1) | HUP0100623A3 (2) |
| NO (1) | NO331100B1 (2) |
| WO (1) | WO1999032653A1 (2) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA12590A (en) | 2001-01-23 | 2006-06-08 | Aventis Pasteur | Multivalent meningococcal polysaccharide-protein conjugate vaccine. |
| US6693188B2 (en) | 2001-08-08 | 2004-02-17 | Cargill Incorporated | N-acetyl-D-glucosamine and process for producing N-acetyl-D-glucosamine |
| US8222232B2 (en) * | 2001-02-16 | 2012-07-17 | Cargill, Incorporated | Glucosamine and N-acetylglucosamine compositions and methods of making the same fungal biomass |
| US7923437B2 (en) * | 2001-02-16 | 2011-04-12 | Cargill, Incorporated | Water soluble β-glucan, glucosamine, and N-acetylglucosamine compositions and methods for making the same |
| US7816514B2 (en) | 2001-02-16 | 2010-10-19 | Cargill, Incorporated | Glucosamine and method of making glucosamine from microbial biomass |
| US20020115639A1 (en) * | 2001-02-16 | 2002-08-22 | Weiyu Fan | Glucosamine and method of making glucosamine from microbial blomass |
| GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| PT1777236T (pt) * | 2002-03-26 | 2017-02-13 | Glaxosmithkline Biologicals Sa | Sacáridos modificados possuindo estabilidade melhorada em água para utilização como um medicamento |
| AU2003257003A1 (en) * | 2002-07-30 | 2004-02-16 | Baxter Healthcare S.A. | Chimeric multivalent polysaccharide conjugate vaccines |
| US20060058263A1 (en) * | 2002-11-01 | 2006-03-16 | Rogers Brent D | Heat pasturized liquids containing glucosamine |
| US20060003965A1 (en) * | 2002-11-01 | 2006-01-05 | Fosdick Lawrence D | N-acetyl-d-glucosamine (nag) supplemented food products and beverages |
| ES2461350T3 (es) | 2003-01-30 | 2014-05-19 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
| MXPA05014015A (es) * | 2003-06-23 | 2006-03-17 | Baxter Int | Vacunas contra grupo y nisseria meningitidis y combinaciones meningococales del mismo. |
| GB0406013D0 (en) * | 2004-03-17 | 2004-04-21 | Chiron Srl | Analysis of saccharide vaccines without interference |
| US8652334B2 (en) * | 2004-08-12 | 2014-02-18 | Lipoxen Technologies Limited | Fractionation of charged polysaccharide |
| GB0502096D0 (en) * | 2005-02-01 | 2005-03-09 | Chiron Srl | Purification of streptococcal capsular polysaccharide |
| GB0502095D0 (en) | 2005-02-01 | 2005-03-09 | Chiron Srl | Conjugation of streptococcal capsular saccharides |
| CA2604363C (en) | 2005-04-08 | 2015-06-16 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| AU2011253684B8 (en) * | 2005-04-08 | 2013-07-11 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| AU2006283302B2 (en) * | 2005-08-24 | 2012-11-15 | Novartis Vaccines And Diagnostics Srl | Zwitterionization of capsular saccharides |
| GB0522303D0 (en) | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| WO2007084856A2 (en) * | 2006-01-13 | 2007-07-26 | Baxter International Inc. | Method for purifying polysaccharides |
| GB0605757D0 (en) * | 2006-03-22 | 2006-05-03 | Chiron Srl | Separation of conjugated and unconjugated components |
| PL2004225T3 (pl) | 2006-03-22 | 2012-09-28 | Novartis Ag | Schematy immunizacji koniugatami meningokokowymi |
| US10828361B2 (en) | 2006-03-22 | 2020-11-10 | Glaxosmithkline Biologicals Sa | Regimens for immunisation with meningococcal conjugates |
| US8808707B1 (en) | 2006-05-08 | 2014-08-19 | Wyeth Llc | Pneumococcal dosing regimen |
| EP1872791A1 (en) | 2006-06-30 | 2008-01-02 | Institut Pasteur | Use of bacterial polysaccharides for biofilm inhibition |
| JP2010520320A (ja) | 2007-02-28 | 2010-06-10 | リポクセン テクノロジーズ リミテッド | ポリシアル酸におけるエンドトキシンの低減 |
| ES2665002T3 (es) | 2007-03-05 | 2018-04-24 | Om Pharma | Extracto bacteriano para trastornos respiratorios y procedimiento para su preparación |
| PT2129693T (pt) * | 2007-03-23 | 2017-02-14 | Wyeth Llc | Processo de purificação abreviado para a produção de polissacáridos capsulares de streptococcus pneumoniae |
| GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
| JP5339243B2 (ja) * | 2008-04-24 | 2013-11-13 | 株式会社微生物化学研究所 | ストレプトコッカス・スイス感染症予防用ワクチン |
| WO2011005587A1 (en) * | 2009-06-24 | 2011-01-13 | University Of Dubuque | Vaccine compositions and methods of use to protect against infectious disease |
| BR112013024322B1 (pt) * | 2011-03-22 | 2020-04-22 | Serum Inst India Ltd | processo para preparação de polissacarídeos |
| US9400250B2 (en) | 2013-09-30 | 2016-07-26 | Han Sheng Biotech Co., Ltd. | Method for analyzing mushrooms |
| MY186874A (en) * | 2014-02-25 | 2021-08-26 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | A novel downstream process for purifying polysaccharides |
| EP2942396A1 (en) | 2014-05-07 | 2015-11-11 | Novartis AG | Polysaccharides produced by CPSC mutants |
| EP3034516A1 (en) * | 2014-12-19 | 2016-06-22 | Novartis AG | Purification of streptococcal capsular polysaccharide |
| PE20220774A1 (es) | 2015-05-04 | 2022-05-16 | Pfizer | Conjugados proteina-polisacarido de estreptococo grupo b, metodos para producir conjugados, composiciones inmunogenas que comprenden conjugados y sus usos |
| EP3551668A1 (en) * | 2016-12-06 | 2019-10-16 | GlaxoSmithKline Biologicals S.A. | Purification process for capsular polysaccharide |
| JP7319929B2 (ja) * | 2017-05-05 | 2023-08-02 | セラム インスティテュート オブ インディア プライベート リミティド | 細菌性莢膜多糖ベース調製物からの不純物の除去方法 |
| EP3649247A4 (en) * | 2017-07-05 | 2021-03-31 | Inventprise, LLC. | PURIFICATION OF POLYSACCHARIDES FOR VACCINE PRODUCTION USING LYTIC ENZYMES, TANGENTIAL FILTRATION AND MULTIMODAL CHROMATOGRAPHY |
| PT3678654T (pt) | 2017-09-07 | 2024-08-05 | Merck Sharp & Dohme Llc | Polissacáridos pneumocócicos e sua utilização em conjugados imunogénicos de polissacárido-proteína transportadora |
| FR3078977B1 (fr) | 2018-03-16 | 2023-03-17 | Biomerieux Sa | Procede d'extraction d'acides nucleiques |
| JP2023546446A (ja) * | 2020-10-22 | 2023-11-02 | ファイザー・インク | 細菌多糖を精製する方法 |
| CN117512031B (zh) * | 2023-10-16 | 2024-06-25 | 江苏金迪克生物技术股份有限公司 | 一种肺炎球菌荚膜多糖的纯化方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3523801A (en) † | 1966-01-13 | 1970-08-11 | Kyowa Hakko Kogyo Kk | Process for the preparation of seasonings |
| US3577527A (en) † | 1969-01-27 | 1971-05-04 | Us Navy | Neisseria meningitidis antigen |
| US4258029A (en) | 1979-04-23 | 1981-03-24 | Connaught Laboratories Limited | Synthetic adjuvants for stimulation of antigenic responses |
| US4413057A (en) | 1980-04-14 | 1983-11-01 | Merck & Co., Inc. | Group B streptococcal capsular polysaccharides |
| US4356170A (en) † | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4644059A (en) | 1982-07-06 | 1987-02-17 | Connaught Laboratories, Inc. | Haemophilus influenzae B polysaccharide-diptheria toxoid conjugate vaccine |
| EP0238739B1 (en) † | 1986-03-27 | 1992-02-05 | Swiss Serum and Vaccine Institute Berne | Klebsiella capsular polysaccharide vaccine |
| AU586857B2 (en) * | 1986-03-27 | 1989-07-27 | Swiss Serum And Vaccine Institute Berne | Klebsiella capsular polysaccharide vaccine |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5190746A (en) | 1989-05-10 | 1993-03-02 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Plaque inhibiting oligosaccharide |
| DE69019164T2 (de) | 1989-12-14 | 1995-09-07 | National Research Council Of Canada, Ottawa, Ontario | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| NZ239643A (en) | 1990-09-17 | 1996-05-28 | North American Vaccine Inc | Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group. |
| ZA937034B (en) * | 1992-09-24 | 1995-06-23 | Brigham & Womens Hospital | Group B streptococcus type II and type V polysaccharide-protein conjugate vaccines |
| US5811102A (en) * | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
-
1998
- 1998-12-23 WO PCT/US1998/027375 patent/WO1999032653A1/en not_active Ceased
- 1998-12-23 EP EP16182410.7A patent/EP3118225A1/en not_active Withdrawn
- 1998-12-23 KR KR1020067013976A patent/KR100757630B1/ko not_active Expired - Fee Related
- 1998-12-23 DK DK98966468.5T patent/DK1051506T4/da active
- 1998-12-23 AT AT98966468T patent/ATE468403T2/de active
- 1998-12-23 EP EP98966468.5A patent/EP1051506B2/en not_active Expired - Lifetime
- 1998-12-23 AU AU23071/99A patent/AU754256C/en not_active Expired
- 1998-12-23 US US09/221,630 patent/US6248570B1/en not_active Expired - Lifetime
- 1998-12-23 JP JP2000525570A patent/JP4435413B2/ja not_active Expired - Lifetime
- 1998-12-23 KR KR1020007006995A patent/KR100641490B1/ko not_active Expired - Lifetime
- 1998-12-23 ES ES10005184.6T patent/ES2611464T3/es not_active Expired - Lifetime
- 1998-12-23 DE DE69841676T patent/DE69841676D1/de not_active Expired - Lifetime
- 1998-12-23 ES ES98966468T patent/ES2346022T3/es not_active Expired - Lifetime
- 1998-12-23 CA CA002316975A patent/CA2316975C/en not_active Expired - Lifetime
- 1998-12-23 HU HU0100623A patent/HUP0100623A3/hu unknown
- 1998-12-23 EP EP10005184.6A patent/EP2226336B1/en not_active Expired - Lifetime
- 1998-12-23 CZ CZ20002373A patent/CZ302615B6/cs not_active IP Right Cessation
-
2000
- 2000-06-21 NO NO20003226A patent/NO331100B1/no not_active IP Right Cessation
-
2009
- 2009-09-07 JP JP2009206304A patent/JP5144613B2/ja not_active Expired - Lifetime
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